Clinical trials: Eye Manifestations
Diabetes Mellitus, Corneal Endothelial Cell Loss
Effect of Intracameral Dexamethasone After Phacoemulsification in Diabetics on Corneal Endothelial Cell Density
The prevalence of diabetes mellitus (DM) is rapidly growing worldwide. One major concern with diabetes mellitus is how it may affect vision in different ways; including the increased risk of developing cataract.
- Conditions
- Diabetes Mellitus, Corneal Endothelial Cell Loss, Dexamethasone Adverse Reaction, Corneal Endothelial Decompensation
- Trial name
- DIABEDEX (NCT03361709)
- Testing
- Dexamethasone, Saline Solutions, Intraocular
- Sponsor
- Cairo University
Ocular Motility Disorders, Strabismus
Clinical Validation of AI-Based Quantitative Eye Movement Analysis From Smartphone 9-Gaze Videos (Glandy EOM)
This prospective, multicenter, multinational observational study evaluates the clinical validity of an AI-based quantitative eye movement analysis system (Glandy EOM) that analyzes smartphone-recorded 9-gaze videos.
- Conditions
- Ocular Motility Disorders, Strabismus, Extraocular Muscle Dysfunction, Thyroid Eye Disease
- Trial name
- GLANDY-EOM-VAL (NCT07623837)
- Testing
- Glandy EOM (AI-based quantitative eye movement analysis software)
- Where
- United States
- Volunteers
- 1,000 people
- Sponsor
- THYROSCOPE INC.
Behcet Syndrome, Uveal Disease
Etanercept: Single Blind Control Study in Ocular Manifestations of Behcet's Disease
The purpose of this study is to find if Etanercept can improve the outcome of ocular lesions of Behcet's Disease treated with Methotrexate and Prednisolone
- Trial name
- NCT00931957
- Testing
- Etanercept, Methotrexate, Prednisolone
- Where
- Iran
- Volunteers
- 80 people
- Sponsor
- Tehran University of Medical Sciences
Core Stability, Core Stabilization
Investigation of the Relationship Between Core Stability and Reaction Time, Hand-Eye Coordination, Pain, and Functional Status in Individuals With Rotator Cuff Lesions
Rotator cuff lesions are among the most common problems within musculoskeletal disorders. The prevalence of these lesions increases with age, and they encompass a wide spectrum of various injuries and pathological conditions.
- Conditions
- Core Stability, Core Stabilization, Reaction Time, Pain
- Trial name
- NCT07089628
- Testing
- Assessment
- Where
- Turkey (Türkiye)
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Bandırma Onyedi Eylül University
Amblyopia
An Evaluation of Treatment of Amblyopia in Children 7 To <18 Years Old
The goals of this study are: To determine the response rate of treatment of amblyopia in 7 to <18 year olds. To determine the frequency of recurrence of amblyopia in 7 to <18 year olds after discontinuation of amblyopia treatment.
- Trial name
- NCT00094692
- Testing
- Eye patch, spectacles, atropine
- Where
- 3 sites in United States
- Volunteers
- 507 people
- Sponsor
- Jaeb Center for Health Research
Amblyopia
Morning Versus Evening Patching in Childhood Amblyopia
To determine whether the time of day at which daily occlusion therapy is administered-morning, with 2 hours of patching completed within 07:00-10:00, versus evening, with 2 hours completed within 17:00-20:00-affects visual-acuity…
- Trial name
- NCT07294599
- Testing
- eye-patching
- Where
- 2 sites in Jordan
- Volunteers
- 84 people
- Sponsor
- Yarmouk University
Macular Degeneration, Central Visual Impairment
Scotoma Perimetry Oculomotor Training
The proposed research is relevant to public health because a greater understanding of plasticity after central vision loss can inform new therapies for treating low vision and has potential to benefit millions of individuals…
- Trial name
- SPOT (NCT05456581)
- Testing
- 'Scotoma awareness' Training, Control Training
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- University of Alabama at Birmingham
Non-proliferative Diabetic Retinopathy
A Study to Evaluate the Efficacy and Safety of Intravitreal KSI-301 in Non-proliferative Diabetic Retinopathy (NPDR)
This Phase 3 Study will evaluate the efficacy and safety of KSI-301 in participants with moderately severe to severe non-proliferative diabetic retinopathy (NPDR).
- Trial name
- GLOW (NCT05066230)
- Testing
- KSI-301
- Where
- 61 sites in United States, Czechia and 5 more
- Volunteers
- 253 people
- Sponsor
- Kodiak Sciences Inc
Optic Neuritis
Assessment of Clemastine Fumarate as a Remyelinating Agent in Acute Optic Neuritis (ReCOVER)
The main purpose of this study is to assess clemastine as a remyelinating agent in patients with acute optic neuritis.The study will also evaluate the tolerability of clemastine, originally approved as first-generation…
- Trial name
- ReCOVER (NCT02521311)
- Testing
- Clemastine
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- University of California, San Francisco
Ocular Pain
A Study to Assess Safety, Tolerability, and Pharmacokinetics of Ascending Concentrations of Topical Ocular BL1332 in Healthy Volunteers
Single-Center, Phase 1 study to assess the ocular and systemic safety and tolerability of ascending concentrations of topical BL1332 ophthalmic solution eye drops compared with BL1332 vehicle in healthy volunteers, identifying…
- Trial name
- NCT06978244
- Testing
- BL1332 ophthalmic solution, BL1332 ophthalmic vehicle
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Bausch & Lomb Incorporated
Eye Allergies
Comparing Patient Satisfaction With Pataday or Bepreve
The purpose of this study is to compare patient satisfaction with Pataday (Olopatadine hydrochloride 0.2%) one daily (QD) and Bepreve (Bepotastine besilate ophthalmic solution 1.5%) two times a day (BID).
- Trial name
- NCT01450176
- Testing
- Olopatadine hydrochloride 0.2%, Bepotastine besilate ophthalmic solution 1.5%
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- McCabe Vision Center
Brain Diseases, Amblyopia
MRI-based Biomarkers for Predicting Punctate White Matter Lesions in Neonates
As a common white matter (WM) disease in preterm neonates, punctate white matter lesion (PWML) frequently leads to the abnormalities of brain development (e.g.
- Conditions
- Brain Diseases, Amblyopia, Brain Damage, Chronic, Cerebral Palsy
- Trial name
- PWML (NCT02637817)
- Where
- China
- Volunteers
- 600 people
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University
Ocular Pain, OSDI
Validation of Ocular Pain Questionnaire: Single-center, Prospective Observational Study
This study will be a single-center, observational, prospective validation study with survey and sample characteristics comparable to similar validation studies in the literature.
- Conditions
- Ocular Pain, OSDI, OPAS
- Trial name
- NCT06656260
- Volunteers
- 333 people
- Sponsor
- IRCCS Ospedale San Raffaele
Progressive Supranuclear Palsy, Multiple System Atrophy
NMR Based Metabolomic Study of Serum Biomarkers in Patients With Parkinson's Disease and Atypical Parkinsonian Syndrome
At present, the diagnosis of Parkinsons disease(PD) mainly relies on clinical symptoms and is easily confused with atypical Parkinsonian syndrome(APS) in the early stages. There is an urgent need for reliable biomarkers.
- Conditions
- Progressive Supranuclear Palsy, Multiple System Atrophy, Parkinson's Disease
- Trial name
- NCT06490926
- Where
- China
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Fujian Medical University Union Hospital
Retinal Vein Occlusion
Extension Study to Compare Long-term Efficacy and Safety of Ranibizumab Intravitreal Injections Versus Dexamethasone Intravitreal Implant in Patients With RVO
The study is intended to characterize the clinical benefit regarding safety and efficacy of a long term treatment with Lucentis in comparison with Ozurdex over an additional 6 months and a 3-month follow-up period, following the…
- Trial name
- NCT01580020
- Testing
- RFB002, Dexamethasone
- Where
- 37 sites in Germany
- Volunteers
- 175 people
- Sponsor
- Novartis Pharmaceuticals
Amblyopia, Amblyopia Unilateral
Non-invasive Induction of Metaplasticity for Amblyopia
The goal of this clinical trial is to determine the efficacy of flicker therapy as an adjunct therapy to treat amblyopia beyond the critical period in adolescents and adults aged 14-40 years who have amblyopia of ≥3 lines of…
- Conditions
- Amblyopia, Amblyopia Unilateral, Amblyopia, Anisometropic, Amblyopia Strabismic
- Trial name
- NIMA (NCT07846397)
- Testing
- Flicker
- Volunteers
- 10 people
- Sponsor
- Boston Children's Hospital
Amblyopia
Levodopa for the Treatment of Residual Amblyopia
The purpose of this study is to evaluate the efficacy and safety of oral levodopa and patching versus oral placebo and patching as treatment for residual amblyopia in children 7 to <13 years old with visual acuity of 20/50 to…
- Trial name
- ATS17 (NCT01190813)
- Testing
- Levodopa/Carbidopa, Patching
- Where
- United States
- Volunteers
- 139 people
- Sponsor
- Jaeb Center for Health Research
Amblyopia
Dichoptic Treatment for Amblyopia in Children 8 to 12 Years of Age
Participants eligible for the study will be randomly allocated (1:1:1) to receive either Luminopia dichoptic treatment while wearing optical correction if needed, Vivid Vision dichoptic treatment while wearing optical correction…
- Trial name
- ATS24 (NCT06524882)
- Testing
- Vivid Vision, Luminopia, Optical Correction
- Where
- 58 sites in United States
- Volunteers
- 252 people
- Sponsor
- Jaeb Center for Health Research
Neurodegenerative Diseases, Alzheimer Disease
Sociodemographic Factors and Criminal Behaviour Preceding Neurodegenerative Disease - Retrospective Register Study
In this retrospective register study, clinically classified individuals with neurodegenerative disease from the years 2010-2021 will be verified from the clinical records from KUH and Oulu University Hospital (OUH).
- Conditions
- Neurodegenerative Diseases, Alzheimer Disease, Frontotemporal Dementia, Lewy Body Disease
- Trial name
- DEGERWD (NCT06209515)
- Where
- Finland
- Volunteers
- 61,292 people
- Sponsor
- Kuopio University Hospital
Hemianopia, Brain Tumor
Visual Rehabilitation in Children With Homonymous Hemianopia: a Pilot Study on Virtual-reality Stimulation
There are currently no visual rehabilitation strategies for children presenting visual field defects consecutive to a brain tumor or its treatment.
- Conditions
- Hemianopia, Brain Tumor, Children, Only
- Trial name
- HH-IVR (NCT05065268)
- Testing
- Immersive Virtual-Reality Stimulation
- Where
- 2 sites in Canada
- Volunteers
- 10 people
- Sponsor
- The Hospital for Sick Children
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