Clinical trials: Eye Manifestations
Stuttering, Adult
Using Transcranial Magnetic Stimulation to Treat Stuttering
The goal of this clinical trial is to learn if repeated transcranial magnetic stimuli (rTMS) can treat stuttering in adults. The main questions it aims to answer are: Will there be changes in the brains of people who stutter…
- Trial name
- NCT07389694
- Testing
- Transcranial Magnetic Stimulation
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Kansas State University
Dry Eye, Dry Eye Syndrome
DRy Eye Outcome and Prescription Study
The DRy eye Outcome and Prescription Study (DROPS) is a large observational multicentre study exploring the 'real world' effectiveness of artificial tears in dry eye disease and determinants of efficacy.
- Conditions
- Dry Eye, Dry Eye Syndrome, Blepharitis, Meibomian Gland Dysfunction
- Trial name
- DROPS (NCT03652415)
- Testing
- Artificial tears (classified by MHRA as a medical device)
- Where
- 2 sites in United Kingdom
- Volunteers
- 635 people
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Branch Retinal Vein Occlusion
Efficacy and Safety of Ranibizumab With or Without Laser in Comparison to Laser in Branch Retinal Vein Occlusion
This study will generate comparative data for 0.5-mg ranibizumab using PRN dosing administered with or without adjunctive laser treatment versus laser photocoagulation (the current standard of care) up to Month 6 in patients with…
- Trial name
- BRIGHTER (NCT01599650)
- Testing
- Ranibizumab, Laser
- Where
- 82 sites in Australia, Canada and 15 more
- Volunteers
- 455 people
- Sponsor
- Novartis Pharmaceuticals
Dry Eye, Neuropathic Pain
Neurosensory Abnormalities in SymptomAtic Ocular Surface Patients (NASA)
This study is designed to measure how common nerve abnormalities are within a group of patients who feel discomfort within their eyes.
- Trial name
- NASA (NCT04838223)
- Testing
- Hyperosmolar Response, Proparacaine Challenge Test, Contact Lens Dry Eye Questionnaire-8 (CLDEQ-8) Optional; only for Contact Lens Wearers
- Where
- 16 sites in United States
- Volunteers
- 1,000 people
- Sponsor
- Tufts Medical Center
Vision Disorders
A Predictive Score for the Ischemic Etiology of a Transient Visual Disturbances (VASCO)
The transient visual disturbances (TVD) are defined by a short abnormality of visual function. Their etiology may be ophthalmological, neurological non-ischemic or of ischemic origin.
- Trial name
- VASCO (NCT02485054)
- Testing
- Clinical, ophthalmological and neurological evaluation
- Where
- 2 sites in France
- Volunteers
- 403 people
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
Healthy, Blindness
Multisensory Body and Space Representations (BASES-EXTINCTION)
To accurately control body movements to interact with objects, our brain needs representations of the body and the nearby space.
- Trial name
- NCT03201341
- Testing
- Electrooculogram (EOG), Surface Electromyography (EMG), Electrodermal response
- Where
- France
- Volunteers
- 1,540 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon
Health Knowledge, Intellectual Developmental Disorder
Easy-to-Read Content Effectiveness Evaluation
Individuals with intellectual disabilities face challenges in accessing medical services and health education due to communication barriers and limited support tools.
- Conditions
- Health Knowledge, Intellectual Developmental Disorder, Visual Impairment
- Trial name
- NCT07036575
- Testing
- Standard Visual Health Education, Easy-Read Instructor-Guided Education, Easy-Read Audio-Based Self-Learning
- Where
- Taiwan
- Volunteers
- 250 people
- Sponsor
- National Taiwan University Hospital
Parkinson Disease
" Visual Characterization of Parkinson's Patients and Oculomotor or Perceptual Therapy"
Parkinson's disease (PD) is the second most common neurodegenerative condition worldwide, characterised by motor symptoms, but with other symptoms such as visual impairment.
- Trial name
- NCT06032130
- Testing
- Clinical measurements, Oculomotor or perceptual therapy
- Where
- Spain
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- University of Valencia
Amblyopia
Trial Comparing Patching Versus Atropine for Amblyopia in 7 to < 13 Year Olds
The purpose of this study is: To compare the effectiveness of weekend atropine plus near activities and daily patching plus near activities for moderate amblyopia (20/40 to 20/100) and severe amblyopia (20/125 to 20/400) in…
- Trial name
- ATS9 (NCT00315328)
- Testing
- Atropine, Patching, Near activities
- Where
- 2 sites in United States
- Volunteers
- 233 people
- Sponsor
- Jaeb Center for Health Research
Eye Manifestations
Intraoperative OCT Guidance of Intraocular Surgery
The purpose of this study is to investigate the use of optical coherence tomography imaging integrated with an operating microscope (MIOCT) in ophthalmic surgeries.
- Trial name
- MIOCT (NCT01588041)
- Where
- 2 sites in United States
- Volunteers
- 269 people, healthy volunteers welcome
- Sponsor
- Duke University
Refractive Error - Myopia Axial, Astigmatism
Refractive Accuracy of "2WIN" and Portable Autorefractors
Youth and some adults have photoscreening refractions and hand-held auto refraction before cycloplegia refraction during new and follow up eye examinations.
- Conditions
- Refractive Error - Myopia Axial, Astigmatism, Accomodation, Visual Impairment
- Trial name
- NCT04249505
- Testing
- "2WIN" Photoscreener, "Plusoptix A12", "Retinomax"
- Where
- United States
- Volunteers
- 708 people, healthy volunteers welcome
- Sponsor
- Alaska Blind Child Discovery
Children with Low Vision
Investigation of the Effects of Balance Coordination and Strengthening Training on Gait, Mobility and Posture in Children with Low Vision
The aim of this research is to examine and evaluate the effects of balance coordination and strengthening training on gait, mobility and posture in children with low vision The hypotheses of our study: H1: Balance coordination…
- Trial name
- NCT05917457
- Testing
- balance coordination and strengthening training
- Where
- Turkey (Türkiye)
- Volunteers
- 22 people
- Sponsor
- Pamukkale University
Eye-tracking, Facial Palsy
Eye-Tracking FP "A Pilot Study of the Quantitative Evaluation of the Attention Paid to Faces With Facial Palsy by the Eye-tracking Technology.
The facial palsy concerns between 15 and 40 people per 100000 inhabitants. They are of various etiologies such as infectious, tumoral, traumatic or idiopathic.
- Trial name
- EyeTrackingFP (NCT04886245)
- Testing
- Video sequences
- Where
- France
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Progressive Supranuclear Palsy
A Pilot Clinical Trial of Pyruvate, Creatine, and Niacinamide in Progressive Supranuclear Palsy.
This study intends to study the safety and tolerance of the combination of pyruvate, creatine, and niacinamide over 6 months in patients with PSP.
- Trial name
- NCT00605930
- Testing
- Pyruvate, creatine, niacinamide
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Louisville
COVID-19, Ocular Surface Disease
A Cross-sectional Study of Ocular Manifestations During the Covid-19 Pandemic in Hubei Province
To investigate the clinical features of ocular manifestations during the novel coronavirus pneumonia pandemic in Hubei at the end of 2022
- Trial name
- NCT06355128
- Testing
- NOT
- Where
- China
- Volunteers
- 16,000 people
- Sponsor
- Zhongnan Hospital
Retinal Vein Occlusion, Retinal Vein Thrombosis
Atorvastatin for the Treatment of Retinal Vein Occlusion
The ATORVO study is designed to determine whether atorvastatin (Lipitor) can improve vision, when compared to placebo
- Conditions
- Retinal Vein Occlusion, Retinal Vein Thrombosis, Central Retinal Vein Occlusion, Branch Retinal Vein Occlusion
- Trial name
- ATORVO (NCT00517257)
- Testing
- Atorvastatin
- Where
- Canada
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Progressive Supranuclear Palsy, Healthy Volunteers
Evaluation of [18F]APN-1607 as a PET Biomarker
The overall goal of this protocol is to evaluate [18F]APN-1607 as a PET radiotracer for measuring longitudinal change in tau pathology in participants with PSP.
- Trial name
- NCT05005819
- Testing
- [18F] APN-1607
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Invicro
Blepharospasm, Hemifacial Spasm
Post Marketing Surveillance Study of Dysport
The purpose of this study is to provide further information regarding the risks and benefits of Dysport in marketed indications.
- Conditions
- Blepharospasm, Hemifacial Spasm, Cervical Dystonia, Spasmodic Torticollis
- Trial name
- NCT00210431
- Where
- 36 sites in France, Germany and 1 more
- Volunteers
- 783 people
- Sponsor
- Ipsen
Neonatal Pain, Retinopathy of Prematurity (ROP)
Fentanyl Intranasal for Retinopathy of Prematurity Screening in Preterm Infants
The goal of this clinical trial is to learn whether intranasal fentanyl (a pain medicine given as a nasal spray) can reduce pain and is safe to use during routine eye examinations for retinopathy of prematurity (ROP) in preterm…
- Conditions
- Neonatal Pain, Retinopathy of Prematurity (ROP), Pain Management, Infant, Premature
- Trial name
- FIREFLY (NCT07112430)
- Testing
- Fentanyl Citrate (Intranasal)
- Where
- Canada
- Volunteers
- 58 people
- Sponsor
- Marsha Campbell-Yeo
Amblyopia, Infant
Validation of the GoCheck Kids® Eye Screeningtest in Infants in Flanders
The aim is to validate the new GoCheck Kids application as automatic eye screener for preschool children (<3 years of age) at 'Child and Family' agency.
- Trial name
- NCT05484453
- Testing
- Complete Eye Examination by Ophthalmologist
- Where
- Belgium
- Volunteers
- 460 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
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