Clinical trials: Eye Manifestations
Anterior Ischemic Optic Neuropathy
PDE5 Inhibitor Use and Non-arteritic Anterior Ischemic Optic Neuropathy (NAION)
The primary objective of this study is to determine whether the use of PDE5 inhibitors (vardenafil, sildenafil, or tadalafil) increases the risk for the development of NAION.
- Trial name
- NCT00867815
- Testing
- Diagnostic procedures
- Where
- 13 sites in United States, Australia and 1 more
- Volunteers
- 10 people
- Sponsor
- Bayer
Low Vision
Community Access Through Remote Eyesight (CARE) Study
Study is a randomized clinical trial evaluating the efficacy of novel mobile application technologies (including Seeing AI, Aira, and Supervision+) to improve quality of life in older adults with low vision by expanding community…
- Trial name
- CARE (NCT04926974)
- Testing
- Low Vision Rehabilitation
- Where
- 2 sites in United States
- Volunteers
- 145 people, healthy volunteers welcome
- Sponsor
- New England College of Optometry
Retinopathy of Prematurity
Inhaled Nitrous Oxide for Pain Relief During Eye Exam in the Pre-term Infant
The primary objective of the proposed study is to show that inhaled equimolar mixture of oxygen and nitrous oxide (EMONO) will reduce pain associated with retinal exam in the preterm infant, as compared to the current standard…
- Trial name
- NCT00623220
- Testing
- N2O, oxygen
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- Nabeel Ali
Amblyopia
Luminopia One Pilot Study
A single-arm, multi-center, open-label pilot study to evaluate the feasibility, safety, and efficacy of the Luminopia One digital therapeutic in improving visual acuity in a pediatric amblyopia population.
- Trial name
- NCT02782117
- Testing
- Luminopia One
- Where
- 9 sites in United States
- Volunteers
- 84 people
- Sponsor
- Luminopia
Low Vision, Age Related Macular Degeneration
Early Feasibility Study Using IOPCL MAG to Improve Near Vision in ARMD Subjects
This early feasibility study aims to improve near vision in subjects 55 years or older who have a clinical diagnosis of Age-Related Macular Degeneration.
- Trial name
- NCT04984590
- Testing
- IOPCL AMD MAG
- Where
- United States
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- OnPoint Vision Inc
Seasonal Affective Disorder, Visual Impairment
Seasonal Affective Disorder and Visual Impairment
As a subtype of major depressive disorder, seasonal affective disorder (SAD) or winter depression causes severe reductions in both quality of life and productivity and results in high morbidity and frequent sick leave (1).
- Trial name
- NCT03403959
- Testing
- light therapy
- Where
- Denmark
- Volunteers
- 18 people
- Sponsor
- Psychiatric Centre Rigshospitalet
Mitochondrial Myopathies, Mitochondrial Pathology
Study to Evaluate Efficacy and Safety of Elamipretide in Subjects With Primary Mitochondrial Disease From Nuclear DNA Mutations (nPMD)
SPIMD-301 is a 48-week, randomized, double-blind, parallel-group, placebo-controlled trial to assess efficacy and safety of single daily subcutaneous (SC) administration of elamipretide as a treatment for subjects with primary…
- Conditions
- Mitochondrial Myopathies, Mitochondrial Pathology, Mitochondrial DNA Mutation, Mitochondrial Diseases
- Trial name
- NuPower (NCT05162768)
- Testing
- Elamipretide
- Where
- 32 sites in United States, Australia and 8 more
- Volunteers
- 102 people
- Sponsor
- Stealth BioTherapeutics Inc.
Age Related Maculopathy, Retinal Degeneration
A Multi-Center Study of Reading Rehabilitation in Macular Disease
The purpose of this study is to measure the effectiveness of a newly-designed oculomotor training program for patients with macular disease, including age-related macular degeneration.
- Trial name
- NCT00746668
- Testing
- Module 1: Visual Awareness and Eccentric Viewing, Module 2: Control of Reading Eye Movements, Module 3: Reading Practice with RSVP
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- US Department of Veterans Affairs
Visual Impairment, Cerebral Visual Impairment
Promoting Psychophysical Well-being in Children and Adolescents With Visual Impairment
Visual impairment (VI) has significant implications not only for visual functioning, but also for the motor development, psychological well-being, and social participation of children and adolescents.
- Conditions
- Visual Impairment, Cerebral Visual Impairment, Visual Impairments
- Trial name
- VIPPSTAR_UNITN (NCT07703150)
- Testing
- Adapted Physical Activity Programme
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- Università degli Studi di Trento
Amblyopia, Myopia
Performance of a Photoscreener for Vision Screening in a Haitian Pediatric Population
Screening of haitian children between the ages of 3 and 6 years old for amblyogenic risk factors with the use of the Spot photoscreener. The photoscreener results will be compared to the complete ophthalmologic evaluation.
- Conditions
- Amblyopia, Myopia, Hyperopia, Astigmatism
- Trial name
- POPH (NCT02655432)
- Testing
- Spot photoscreener, Ophthalmologic evaluation, Cyclopleged refraction
- Where
- 3 sites in Haiti
- Volunteers
- healthy volunteers welcome
- Sponsor
- Université de Montréal
Amblyopia, Child
Early Vision Screening in High-risk Children
To evaluate the effect of early vision screening with automated photorefraction device in high risk children
- Trial name
- NCT02678468
- Where
- Taiwan
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Far Eastern Memorial Hospital
Pain, Bladder Cancer
Study of D-Methadone in Patients With Chronic Pain
The purpose of this study is to determine the safest dose of d-methadone that can be given, without causing severe side effects in most patients with chronic pain.
- Conditions
- Pain, Bladder Cancer, Breast Cancer, CNS Cancer
- Trial name
- NCT00588640
- Testing
- d-Methadone
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Hemianopsia, Homonymous
Testing of a Functional Outcome Measure for Those With Visual Field Defects
This study is designed in two Phases. In phase 1, the Functional Outcome Measure will be tested to determine its validity and reliability in three populations, subjects that have not had a stroke and have no visual field defect…
- Trial name
- FOM (NCT00731796)
- Testing
- Functional Outcome Measure
- Where
- 3 sites in United States
- Volunteers
- 190 people, healthy volunteers welcome
- Sponsor
- NovaVision, Inc.
Corneal Abrasions
Proparacaine vs Placebo for Corneal Injuries
Introduction: Traumatic injuries to the outer covering of the eye (the cornea) are a common emergency department complaint. They cause significant patient distress including pain, loss of sleep and missed work days.
- Trial name
- Dogma (NCT00620997)
- Testing
- Proparacaine drops 0.05%, saline drops
- Where
- Canada
- Volunteers
- 43 people
- Sponsor
- London Health Sciences Centre
Achromatopsia
Clinical and Genetic Characterization of Individuals With Achromatopsia
The purpose of this study is to identify individuals with achromatopsia caused by mutations in the CNGB3 gene and characterize their clinical condition using several tests of visual function every 6 months for up to 1.5 years.
- Trial name
- NCT01846052
- Where
- 5 sites in United States
- Volunteers
- 56 people
- Sponsor
- Beacon Therapeutics
Eye Allergies
Comparing Patient Satisfaction With Pataday or Bepreve
The purpose of this study is to compare patient satisfaction with Pataday (Olopatadine hydrochloride 0.2%) one daily (QD) and Bepreve (Bepotastine besilate ophthalmic solution 1.5%) two times a day (BID).
- Trial name
- NCT01450176
- Testing
- Olopatadine hydrochloride 0.2%, Bepotastine besilate ophthalmic solution 1.5%
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- McCabe Vision Center
Cerebral Palsy, Visual Impairment
Turkish Validity and Reliability of the Visual Function Classification System (VFCS)
Cerebral Palsy (CP) is the most common childhood disorder that occurs with a lesion in the developing infant brain, seen in 2-3/1000 live births.
- Conditions
- Cerebral Palsy, Visual Impairment, Visual Disorder, Cerebral Visual Impairment
- Trial name
- NCT05102955
- Testing
- Observational questionnaires
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people
- Sponsor
- Kahramanmaras Sutcu Imam University
Brain Diseases, Amblyopia
MRI-based Biomarkers for Predicting Punctate White Matter Lesions in Neonates
As a common white matter (WM) disease in preterm neonates, punctate white matter lesion (PWML) frequently leads to the abnormalities of brain development (e.g.
- Conditions
- Brain Diseases, Amblyopia, Brain Damage, Chronic, Cerebral Palsy
- Trial name
- PWML (NCT02637817)
- Where
- China
- Volunteers
- 600 people
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University
Chronic Ocular Pain
Study of Efficacy and Safety of SAF312 Eye Drops in Subjects With Post-operative Corneal Induced Chronic Pain (CICP)
The study was designed to demonstrate the safety and efficacy of two dose concentrations of SAF312 eye drops (5 mg/mL and 15 mg/mL) in subjects with CICP persisting at least for 4 months after refractive or cataract surgery and…
- Trial name
- NCT04630158
- Testing
- SAF312
- Where
- 28 sites in United States, Japan and 1 more
- Volunteers
- 153 people
- Sponsor
- Novartis Pharmaceuticals
Vertigo
Validation of a Simultaneous Ocular/Cervical VEMP With Mastoid Vibration by B250
A Validation study in which the standard separate cVEMP and oVEMP will be compared with a new protocol in which the cVEMP and oVEMP can be recorded simultaneously in response to a mastoid vibration by bone transducer B250
- Trial name
- BCVEMP By B250 (NCT05889676)
- Testing
- VEMP by bone conduction
- Where
- Sweden
- Volunteers
- 120 people
- Sponsor
- Region Stockholm
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