Clinical trials: Eye Manifestations
Intrinsic Capacity, Frailty
Project ICOPE Brazil: Assessment of Intrinsic Capacity in Brazilian Older Adults
The ICOPE Brazil study aims to understand aging trajectories in Brazil, especially healthy aging trends based on intrinsic capacity, a collective of mental and physical capacities one may have to maintain their functional ability…
- Conditions
- Intrinsic Capacity, Frailty, Aging, Healthy Aging
- Trial name
- ICOPE-BR (NCT06968702)
- Volunteers
- 3,838 people
- Sponsor
- University of Sao Paulo
Binocular Dysfunction, Vertical Heterophoria
Effects of Prismatic Spectacle Lenses on Symptoms of Dizziness, Headache and Anxiety as Caused by Vertical Heterophoria
The purpose of this study is to demonstrate whether, in patients diagnosed with Vertical Heterophoria, the symptoms of dizziness, headache and / or anxiety are reduced or eliminated when a kind of correction called vertical prism…
- Conditions
- Binocular Dysfunction, Vertical Heterophoria, Vision, Binocular, Vision Disparity
- Trial name
- NCT00785135
- Testing
- Lenses containing prismatic correction, Lenses not containing prismatic correction
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Vision Specialists of Birmingham
Vision, Low, Mobility Limitation
Evaluating Stairway Designs for Individuals With Vision Impairment
The goal of this study is to learn if contrast frequency on step tread-edges influences foot clearance measures, a marker of fall risk, in older adults with and without visual impairments.
- Trial name
- NCT07337317
- Testing
- Frequency of contrast marking on stair steps
- Where
- United States
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- The University of Alabama in Huntsville
Albinism, Vision Loss
Nitisinone for Type 1B Oculocutaneous Albinism
Background: Oculocutaneous albinism, type 1B (OCA1B) is a genetic disease caused by problems in the gene that makes tyrosine. Tyrosine is an amino acid needed to produce pigment in the skin, hair, and eyes.
- Trial name
- NCT01838655
- Testing
- Nitisinone
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- National Eye Institute (NEI)
Color Blindness, Red, Reaction Time
Effect of Protanopia on the Brightness Perception of Brake Lights
The aim of the offered project is to investigate the influence of protanopia (red blindness) or protanomaly (red vision weakness) on the recognizability of red brake lights with the help of a test person study.
- Trial name
- ProLight (NCT04060238)
- Testing
- Anomaloscope (colour vision test)
- Where
- Germany
- Volunteers
- 16 people
- Sponsor
- Aalen University
Out of Hospital Cardiac Arrest, Neurologic Symptoms
Can Optic Nerve Sheath Diameter Measurement Predict Negative Neurological Outcome ?
This study is designed as a multicenter, prospective, cohort clinical study. The out of hospital cardiac arrest (OHCA) patients presenting to the adult emergency departments of the participating hospitals will render the study…
- Trial name
- NCT02637258
- Testing
- Ultrasonographic Measurements of Optic Nerve Sheath Diameter
- Where
- 19 sites in Turkey (Türkiye)
- Volunteers
- 203 people
- Sponsor
- Emergency Medicine Association of Turkey
Retinitis Pigmentosa
Coloured-light in Retinitis Pigmentosa.
This study will assess the effect of 2 different colours of light on colour vision in adults with retinitis pigments (RP). Participants will be 18 years or above with a genetically confirmed molecular diagnosis of RP.
- Trial name
- CLIRP (NCT06224114)
- Testing
- Coloured-light torch, Different coloured-light torch
- Where
- United Kingdom
- Volunteers
- 70 people
- Sponsor
- University College, London
Cognitive Impairment, Dementia
Determinants of Cognitive Impairment Among Geriatrics
This study aims to explore the determinants of cognitive impairment among Indonesian geriatrics in an Old Age Home.
- Conditions
- Cognitive Impairment, Dementia, Hearing Impairment, Vision Impairment and Blindness
- Trial name
- NCT03669536
- Where
- Indonesia
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Tarumanagara University
Color Blindness, Color Vision Defects
Impact of Color Correcting Lenses on Color Vision Deficiency
To demonstrate improved color vision in subjects with color vision deficiencies while wearing color-correcting lenses and after color-correcting lense use.
- Conditions
- Color Blindness, Color Vision Defects, Color Blindness, Green, Color Blindness, Red
- Trial name
- NCT05463016
- Testing
- Experimental Group 1: Color Correcting Lenses, Color Correcting Lenses in Subjects with Normal Color Vision
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- University of the Incarnate Word
Nystagmus, Dizziness
Effects of Cervical and Oculomotor Exercises in Young Adults With Benign Paroxysmal Positional Vertigo
Benign paroxysmal positional vertigo (BPPV) is the most common type of dizziness disorder in the community.Its cardinal symptoms include vertigo which is induced by change in position of head, turning over in bed, looking up…
- Trial name
- NCT07587528
- Testing
- Occulomotor exercises, Cervical Exercises
- Where
- Pakistan
- Volunteers
- 56 people
- Sponsor
- Foundation University Islamabad
Vision Impairment, Eye Diseases
The Proactive Ophthalmic Examination Cohort
The Proactive Ophthalmic Examination Cohort of Older Adults is a prospective cohort study recruiting community-dwelling older adults aged 65 years or older.
- Trial name
- POEC (NCT05851287)
- Where
- China
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- Zhongshan Ophthalmic Center, Sun Yat-sen University
Prader-Willi Syndrome, PWS-like Syndrome
GROWing Up With Rare GENEtic Syndromes
Introduction Rare complex syndromes Patients with complex genetic syndromes, by definition, have combined medical problems affecting multiple organ systems, and intellectual disability is often part of the syndrome.
- Conditions
- Prader-Willi Syndrome, PWS-like Syndrome, Silver Russel Syndrome, Congenital Hypopituitarism
- Trial name
- GROW UR GENES (NCT04463316)
- Testing
- Retrospective file studies
- Where
- Netherlands
- Volunteers
- 600 people
- Sponsor
- dr. Laura C. G. de Graaff-Herder
Ocular Surface Symptom, Ocular Surface Disease
Efficacy and Safety of Topical Cyclosporine 0.05% and Lifitgrast on the Ocular Surface Symptom After Photorefractive Keratectomy in Feiz Hospital, Isfahan, 2024
The goal of this clinical trial is to compare the administration of 2 drugs, cyclosporine 0.05% (Restasis) and Lifitgrast (Xiidra) before PRK, in reducing the ocular surface symptom of patients after PRK.
- Conditions
- Ocular Surface Symptom, Ocular Surface Disease, Eye Pain, Eye Inflammation
- Trial name
- NCT06624384
- Testing
- Group 1 drug, Group 3: Drug and palcebo
- Where
- Iran
- Volunteers
- 150 people
- Sponsor
- Mohsen Pourazizi
Non 24 Hour Sleep Wake Disorder
Safety Study of Tasimelteon for Treatment of Non-24-Hour-Sleep-Wake Disorder in Blind Individuals With No Light Perception
The purpose of this study is to evaluate the safety of a one year open-label treatment of tasimelteon in male and female subjects with Non-24-Hour Sleep-Wake Disorder.
- Trial name
- NCT01218789
- Testing
- tasimelteon
- Where
- 7 sites in France
- Volunteers
- 140 people
- Sponsor
- Vanda Pharmaceuticals
Vision Disorder, Stroke
Visual Impairment and Functional Visual Performance Following Acquired Brain Injury: A Cross-Sectional Study
This cross-sectional observational study aims to characterize acquired visual impairment in adults with acquired brain injury and to examine the relationship between objectively identified visual impairment and self-reported…
- Conditions
- Vision Disorder, Stroke, Brain Injuries
- Trial name
- NCT07858708
- Where
- Czechia
- Volunteers
- 108 people
- Sponsor
- Charles University, Czech Republic
Macular Edema Secondary to Branch Retinal Vein Occlusion
Ranibizumab Intravitreal Injections Versus Sham Control in Patients With Branch Retinal Vein Occlusion (BRVO)
Provided efficacy and safety data on intravitreal injections of ranibizumab 0.5 mg in patients with visual impairment due to macular edema secondary to BRVO
- Trial name
- Blossom (NCT01976338)
- Testing
- Ranibizumab 0.5 mg
- Where
- 33 sites in China, Hong Kong and 4 more
- Volunteers
- 283 people
- Sponsor
- Novartis Pharmaceuticals
Disorder of Consciousness
Neurorehabilitation in Patients With Disorders of Consciousness: Multidimensional Ambispective Study on the Impact of Single and Combined Approaches
Disorders of consciousness (DOC), such as the vegetative state/unresponsive wakefulness syndrome (VS/UWS) and the minimally conscious state (MCS), represent severe clinical conditions arising from acquired brain injury (ABI)…
- Trial name
- NCT07385508
- Testing
- Multidisciplinary neurorehabilitation
- Where
- Italy
- Volunteers
- 140 people
- Sponsor
- IRCCS Centro Neurolesi Bonino Pulejo
ROP, Jaundice, Neonatal
Hyperbilirubinemia and Retinopathy of Prematurity in Preterm Infants: a Retrospective Study.
The goal of this retrospective observational study is to [learn about the correlation between hyperbilirubinemia and retinopathy of prematurity in preterm infants.
- Conditions
- ROP, Jaundice, Neonatal, Premature, Very Low Birth Weight Infant
- Trial name
- biliROP (NCT05806684)
- Testing
- ROP
- Where
- Italy
- Volunteers
- 1,586 people
- Sponsor
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Central Visual Impairment
Peripheral Reading
The purpose of this study is to evaluate reading performance in the visual periphery by simulating central vision loss using a computer-controlled gaze-contingent display with an eye tracker.
- Trial name
- NCT03640130
- Testing
- Gaze-contingent text enhancement
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- University of Houston
Amblyopia
The Role of Interactive Binocular Treatment System in Amblyopia Therapy
Purpose: of determining the role of Interactive Binocular Treatment (I-BiTTM) as a complementary method of patching in amblyopia therapy.
- Trial name
- NCT02740725
- Testing
- Patching Therapy, Interactive Binocular Treatment System
- Where
- Iran
- Volunteers
- 50 people
- Sponsor
- Shahid Beheshti University of Medical Sciences
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