Clinical trials: Eye--Refractive Errors
Presbyopia
A Phase 3 Efficacy Study of Pilocarpine HCl Ophthalmic Solution (AGN-190584) in Participants With Presbyopia
This clinical study will evaluate pilocarpine hydrogen chloride (HCl) ophthalmic solution (AGN-190584) in an expanded participant population to establish efficacy, safety, and tolerability versus the vehicle-control when…
- Trial name
- GEMINI 2 (NCT03857542)
- Testing
- Pilocarpine HCl Ophthalmic Solution, Vehicle
- Where
- 35 sites in United States
- Volunteers
- 427 people
- Sponsor
- Allergan
Bilateral Cataract
ACRYSOF® Toric NATURAL T9 Intraocular Lens (IOL)
The purpose of this study is to describe rates of spatial distortions related to intraocular lens (IOL) misalignment for ACRYSOF® Single-Piece Toric NATURAL IOL Model SN60T9 when implanted bilaterally into the capsular bag…
- Trial name
- NCT00967473
- Testing
- ACRYSOF® Single-Piece NATURAL Toric IOL Model SN60T9 and Model SN60T8.
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Alcon Research
Refractive Errors
Clinical Performance Evaluation of Two Daily Disposable Silicone Hydrogel Toric Contact Lenses
The purpose of this study is to evaluate the rotational behavior of DT1 Toric contact lenses.
- Trial name
- NCT04254003
- Testing
- DT1 Toric contact lenses, AO1DfA contact lenses
- Where
- 2 sites in United States
- Volunteers
- 48 people
- Sponsor
- Alcon Research
Cataract, Corneal Astigmatism
Post-Approval Study of the TECNIS SYMFONY® Toric Lenses
This study is a prospective, multicenter, bilateral, non-randomized, open-label, comparative, 6-month clinical study conducted at up to 50 sites in the USA.
- Trial name
- ANCORA (NCT03791619)
- Testing
- Higher Cylinder Toric IOL, Lower Cylinder Toric IOL
- Where
- 23 sites in United States
- Volunteers
- 475 people
- Sponsor
- Johnson & Johnson Surgical Vision, Inc.
Aphakia, Presbyopia
Exploratory Clinical Study for Techniques Associated With the Fluid Accommodating IOL
The purpose of this clinical study is to assess the repeatability of objective refraction using auto refraction on subjects bilaterally implanted (implanted in both eyes) with the Fluid Accommodating IOL (FAIOL).
- Trial name
- NCT04330001
- Testing
- Alcon Fluid Accommodating Intraocular Lens, Top Con Autorefractor
- Where
- 2 sites in El Salvador, Panama
- Volunteers
- 99 people
- Sponsor
- Alcon Research
Presbyopia
Safety and Efficacy Study of Pilocarpine HCl Ophthalmic Solution in Participants With Presbyopia
A study to evaluate the efficacy, safety, and pharmacokinetics of pilocarpine HCl ophthalmic solution when administered bilaterally, once daily for 30 days in participants with presbyopia.
- Trial name
- NCT06451666
- Testing
- Pilocarpine HCl Ophthalmic Solution, Vehicle
- Volunteers
- 330 people
- Sponsor
- CSPC Ouyi Pharmaceutical Co., Ltd.
Aphakia, Presbyopia
Clareon PanOptix Pro vs. Clareon PanOptix - Study B
The purpose of this study is to evaluate the safety and effectiveness of Clareon™ PanOptix™ Pro Trifocal Intraocular Lens (IOL) compared to Clareon™ PanOptix™ Trifocal IOL.
- Trial name
- NCT06401551
- Testing
- CPO Pro IOL, CPO IOL, Cataract Surgery
- Where
- 8 sites in United States
- Volunteers
- 71 people
- Sponsor
- Alcon Research
Astigmatism
Clinical Evaluation of Two Toric Soft Contact Lenses
The aim of this study is to compare the short-term clinical performance of two toric contact lenses.
- Trial name
- NCT06490302
- Testing
- Lens A (ocufilcon D), Lens B (fanfilcon A)
- Where
- Mexico
- Volunteers
- 40 people
- Sponsor
- CooperVision, Inc.
Astigmatism
Toric Eye Strain and Stability Study
The purpose of this study is to determine the benefits of fitting low astigmats with soft toric contact lenses versus spherical contact lenses with regard to visual comfort, eyestrain, fitting efficiency, and visual performance.
- Trial name
- NCT01857102
- Testing
- etafilcon A, etafilcon A for Astigmatism
- Where
- United States
- Volunteers
- 159 people, healthy volunteers welcome
- Sponsor
- Johnson & Johnson Vision Care, Inc.
Myopia
A One-Week Crossover Dispensing Evaluation of New Daily Wear Soft Contact Lenses
The purpose of this study is to validate the clinical performance of a new contact lens design when worn over a period 1 week compared to nelfilcon A (control).
- Trial name
- NCT03306641
- Testing
- Test Contact Lens, Nelfilcon A
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- CooperVision, Inc.
Refractive Error
Comparison of Lotrafilcon B Lenses With Different Packaging Solutions
The purpose of this study is to evaluate AIR OPTIX® plus HYDRAGLYDE® (AOHG) contact lenses compared to AIR OPTIX® AQUA (AOA) contact lenses in overall lens fit.
- Trial name
- NCT02699684
- Testing
- Lotrafilcon B contact lenses with EOBO-41, Lotrafilcon B contact lenses, Hydrogen peroxide-based lens care solution
- Volunteers
- 82 people
- Sponsor
- Alcon Research
Astigmatism
Evaluate the Safety and Effectiveness of the Biotrue ONEday for Astigmatism
Comparing Test Lens for Astigmatism Soft Contact Lens (Test) to 1-Day Control for Astigmatism contact lenses (Control).
- Trial name
- NCT03681808
- Testing
- Control, Test
- Where
- 13 sites in United States
- Volunteers
- 242 people, healthy volunteers welcome
- Sponsor
- Bausch & Lomb Incorporated
Myopia
Multi-Center 2-Week Clinical Evaluation of Three Silicone Hydrogel Contact Lenses
The purpose of this study is to compare the clinical performance of three silicone hydrogel contact lenses over a 2 week period.
- Trial name
- NCT01244516
- Testing
- galyfilcon A, BC 8.30, lotrafilcon B, BC 8.60, comfilcon A, BC 8.60
- Where
- 35 sites in United States
- Volunteers
- 540 people
- Sponsor
- Johnson & Johnson Vision Care, Inc.
Refractive Errors, Myopia
Clinical Comparison of 2 Daily Disposable Contact Lenses - Pilot Study 1
The primary objective of this study is to evaluate the overall performance of PRECISION1 contact lenses when compared to Biotrue ONEday contact lenses.
- Trial name
- NCT04527978
- Testing
- Verofilcon A contact lenses, Nesofilcon A contact lenses
- Where
- 4 sites in United States
- Volunteers
- 56 people
- Sponsor
- Alcon Research
Refractive Errors
Clinical Evaluation of a Daily Wear Frequent Replacement Silicone Hydrogel Lens
The purpose of this clinical study is to demonstrate the safety and performance of an investigational soft contact lens compared to a commercially available soft contact lens when worn in a daily wear modality.
- Trial name
- NCT03920280
- Testing
- LID015385 contact lenses, Comfilcon A soft contact lenses, CLEAR CARE
- Where
- 8 sites in United States
- Volunteers
- 120 people
- Sponsor
- Alcon Research
Presbyopia, Near Vision
Comparative Study and Validation of New Methodologies for Measuring Addition
The aim of this research is to collect comprehensive data on a presbyopic population that may require near vision correction, in order to identify the most useful tests to accurately determine the value of an addition.
- Conditions
- Presbyopia, Near Vision, Refraction Error
- Trial name
- NCT06963138
- Testing
- Visual Acuity, Objective refraction, Standard Subjective refraction
- Where
- France
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Essilor International
Myopia, Astigmatism
Clinical Study to Evaluate Effectiveness of Digital Refraction
Prospective, comparative, randomized, non-masked clinical study to compare the a digital refraction with LogMAR VA testing utilizing trial lenses, to standard manual refraction using a Phoropter, and LogMAR VA testing, in…
- Trial name
- NCT03502863
- Testing
- Digital refraction, Manual Refraction
- Where
- 3 sites in United States
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- Visibly
Presbyopia
Safety and Efficacy of an Intrastromal Transform™ Corneal Allograft (TCA) for Presbyopia Correction
The objective of this clinical study is to evaluate the safety and effectiveness of intrastromal implantation of the Allotex TransForm corneal allograft (TCA) for improving near vision in presbyopic subjects.
- Trial name
- NCT03671135
- Testing
- TCA Intrastromal Inlay
- Where
- 4 sites in Belgium, Ireland and 1 more
- Volunteers
- 121 people, healthy volunteers welcome
- Sponsor
- Allotex, Inc.
Astigmatism
A Clinical Comparison of Two Soft Toric Contact Lenses
The aim of this study is to compare the short-term clinical performance of two toric contact lenses.
- Trial name
- NCT06758089
- Testing
- Lens 1 (ocufilcon D), Lens 2 (somofilcon A)
- Where
- United Kingdom
- Volunteers
- 42 people
- Sponsor
- CooperVision International Limited (CVIL)
Presbyopia, Myopia
Comparison of Two Multifocal Contact Lenses Worn on a Daily Disposable Basis
The purpose of this trial is to evaluate and compare the clinical performance of two multifocal contact lenses.
- Trial name
- NCT01254760
- Testing
- Nelfilcon A multifocal contact lens, investigational, Nelfilcon A multifocal contact lens, commercial
- Volunteers
- 79 people
- Sponsor
- CIBA VISION