Clinical trials: Eye--Refractive Errors
Astigmatism
Safety and Effectiveness of Wavefront-guided LASIK for the Correction of Mixed Astigmatism
To demonstrate that wavefront-guided LASIK with measurements from iDesign is safe and effective in the treatment of mixed astigmatism.
- Trial name
- NCT01675492
- Testing
- LASIK
- Volunteers
- 126 people, healthy volunteers welcome
- Sponsor
- Abbott Medical Optics
Ametropia
The Clinical Comparison of Somofilcon A 1 Day and Nelfilcon A Daily Disposable Contact Lenses
This subject-masked, randomized, bilateral crossover study will compare the clinical performance and subjective acceptance of the somofilcon A 1 day soft contact lens with the nelfilcon A daily disposable lens when used on a…
- Trial name
- NCT04067141
- Testing
- somofilcon A, nelfilcon A
- Where
- United Kingdom
- Volunteers
- 70 people
- Sponsor
- CooperVision, Inc.
Cataract, Lens Opacities
A Comparison of FineVision Intraocular Lenses vs Symfony Intraocular Lenses
This is a prospective randomised open-label study with the aim to compare the visual performance of the trifocal FineVision® IOL versus the extended range of vision Symfony® IOL after phaco-emulsification cataract surgery.
- Conditions
- Cataract, Lens Opacities, Presbyopia
- Trial name
- NCT03974451
- Testing
- IOL implantation experimental, IOL implantation active comparator
- Where
- Egypt
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Beaver-Visitec International, Inc.
Myopia, Hyperopia
Evaluation of the Performance of Monthly Replacement Sphere Lens Designs in Habitual Soft Contact Lens Wearers
The objective of the study is to evaluate the clinical performance of two monthly silicone hydrogel contact lenses in habitual wearers of frequent replacement (FRP) lenses when worn for one month.
- Trial name
- NCT05114564
- Testing
- Lens A (comfilcon A lens), Lens B (lehfilcon A lens)
- Where
- 4 sites in United States
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- CooperVision, Inc.
Aphakia, Cataract
A Clinical Study to Evaluate The Safety and Effectiveness of The RxSight Light Adjustable Lens (LAL) In Subjects Desiring an Extended Depth of Focus
The primary objective of this study is to evaluate, for the visual correction of aphakia and presbyopia, the safety and effectiveness of the RxSight Light Adjustable Lens (LAL) to provide an extended depth of focus (improve…
- Conditions
- Aphakia, Cataract, Presbyopia
- Trial name
- NCT04177771
- Testing
- Light Adjustable lens (LAL) and Light Delivery Device (LDD) - Pre-COVID Population, SofPort LI61AO IOL, Tecnis ZCB00 or ZTC150 IOL
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- RxSight, Inc.
Presbyopia
Comparison of a Multifocal Contact Lens to a Traditional Multifocal Contact Lens
The purpose of the trial is to compare the performance of two multifocal contact lens systems/products in established presbyopic subjects.
- Trial name
- NCT00886119
- Testing
- Lotrafilcon B multifocal contact lens, Omafilcon A multifocal contact lens
- Volunteers
- 48 people
- Sponsor
- CIBA VISION
Refractive Error, Myopia
A Comparison of Two Daily Disposable Contact Lenses
This study seeks to evaluate the clinical performance of a new CE marked daily disposable contact lens that contains a wetting agent to a recently improved daily disposable contact lens.
- Trial name
- NCT00634101
- Testing
- nelfilcon A, narafilcon A
- Where
- 20 sites in United Kingdom
- Volunteers
- 129 people
- Sponsor
- Johnson & Johnson Vision Care, Inc.
Refractive Errors
Air Optix® Night and Day® Aqua Continuous Wear
The purpose of this retrospective, Post-Market Clinical Follow-Up (PMCF) study is to assess the long term performance and safety of Air Optix® Night and Day® Aqua (AONDA) contact lenses in a real-world setting when worn as 30…
- Trial name
- NCT05992675
- Testing
- Lotrafilcon A contact lenses, Balafilcon A contact lenses
- Where
- 8 sites in United States
- Volunteers
- 1,256 people
- Sponsor
- Alcon Research
Astigmatism, Myopia
Evaluation of Two Monthly Silicone Hydrogel Multifocal Toric in Soft Contact Lens Wearers
To compare the performance of two leading soft multifocal Toric contact lenses.
- Trial name
- NCT07829419
- Testing
- Lens A ( comfilcon A), Lens B ( lehfilcon A)
- Where
- 3 sites in United States
- Volunteers
- 60 people
- Sponsor
- CooperVision International Limited (CVIL)
Presbyopia
Safety & Efficacy of Pilocarpine Eye Solutions for Temporary Improvement of Near Vision in Presbyopic Adults
Volunteer participants are evaluated for eligibility during a Screening Visit; those meeting study inclusion/exclusion criteria are scheduled for 3 treatment visits.
- Trial name
- VISION-1 (NCT04657172)
- Testing
- Pilocarpine Ophthalmic
- Where
- 9 sites in United States
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Eyenovia Inc.
Presbyopia
Safety and Efficacy of Pilocarpine Ophthalmic Topical Cream for the Treatment of Presbyopia
This is a Multicenter, Randomized, Double-Masked Placebo-Controlled, Parallel Group Phase 2 Trial Evaluating the Safety and Efficacy of Pilocarpine Ophthalmic Topical Cream for the Treatment of Presbyopia.
- Trial name
- NCT05124275
- Testing
- Pilocarpine Ophthalmic Topical Cream, Dose 1, Pilocarpine Ophthalmic Topical Cream, Dose 2, Pilocarpine Ophthalmic Topical Cream, Dose 3
- Where
- 10 sites in United States
- Volunteers
- 123 people
- Sponsor
- Glaukos Corporation
Refractive Errors
Air Optix Plus HydraGlyde Multifocal Daily/Extended Wear Contact Lenses
The purpose of this Post-Market Clinical Follow-Up (PMCF) study is to assess long term performance and safety of Air Optix plus HydraGlyde Multifocal soft contact lenses in a real-world setting when worn as daily wear or extended…
- Trial name
- NCT05886894
- Testing
- Lotrafilcon B multifocal soft contact lenses, Comfilcon A multifocal soft contact lenses
- Where
- 8 sites in United States
- Volunteers
- 351 people
- Sponsor
- Alcon Research
Ametropia, Myopia
Clinical Performance Evaluation of Two Frequent Replacement Silicone Hydrogel Toric Contact Lenses
The primary objective of this study is to evaluate the axis orientation of LID226397 toric contact lenses.
- Conditions
- Ametropia, Myopia, Hyperopia, Astigmatism
- Trial name
- NCT05959200
- Testing
- Serafilcon A toric contact lenses, Senofilcon A toric contact lenses, CLEAR CARE
- Where
- 7 sites in United States
- Volunteers
- 92 people
- Sponsor
- Alcon Research
Myopia, Astigmatism
Safety and Efficacy Evaluation of a New Contact Lens Disinfecting Solution in Gas Permeable Contact Lens Wearers
The purpose of this study is demonstrate substantial equivalence of an investigational contact lens disinfecting solution to a commercially available contact lens solution in gas permeable lens wearers.
- Conditions
- Myopia, Astigmatism, Hyperopia, Refractive Error
- Trial name
- NCT01912781
- Testing
- FID 120947A contact lens disinfecting solution, Boston Simplus multi-action solution, Gas permeable contact lenses
- Volunteers
- 112 people
- Sponsor
- Alcon Research
Myopia
Performance of Somofilcon A Over One Week in Wearers Adapted to Omafilcon A
The objective of the study is to determine if habitual or adapted contact lens wearers of Omafilcon A can be confidently refit into Somofilcon A lenses and be successful after one week of daily wear.
- Trial name
- NCT03226353
- Testing
- somofilcon A, omafilcon A
- Where
- Canada
- Volunteers
- 77 people, healthy volunteers welcome
- Sponsor
- CooperVision, Inc.
Cataracts
AcrySof® IQ ReSTOR® +3.0 D Multifocal Toric Intraocular Lens (IOL) Clinical Study in Japan
The purpose of this study is to evaluate safety and effectiveness of AcrySof® IQ ReSTOR® +3.0 D Multifocal Toric IOL Models SND1T3, SND1T4, SND1T5, and SND1T6 when implanted to replace the natural lens in Japanese cataract…
- Trial name
- NCT01323777
- Testing
- AcrySof® IQ ReSTOR® +3.0 D Multifocal Toric IOL
- Where
- 2 sites in Japan
- Volunteers
- 65 people
- Sponsor
- Alcon Research
Presbyopia
Clinical Evaluation of Two New Silicone Hydrogel Multifocal Products
The objective of this trial is compare the visual performance, ratings, and preference of two multifocal, soft contact lenses.
- Trial name
- NCT00909792
- Testing
- Lotrafilcon B, Senofilcon A
- Volunteers
- 259 people
- Sponsor
- CIBA VISION
Myopia
Changes in Invitro and ex Vivo Lens Metrology With Daily Wear Contact Lenses
The purpose of this study is to evaluate changes in contact lens geometry after lens wear
- Trial name
- NCT01100411
- Testing
- Air Optix Aqua, Biofinity, Proclear
- Where
- Australia
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Alcon Research
Myopia
Pilot Evaluation of a New Galyfilcon A Contact Lens Compared to a Marketed Galyfilcon A Contact Lens
The purpose of this study is to compare lens surface characteristics and comfort between an experimental contact lens and a marketed contact lens.
- Trial name
- NCT01094730
- Testing
- galyfilcon A prototype lens, marketed galyfilcon A lens
- Where
- 9 sites in United States
- Volunteers
- 185 people
- Sponsor
- Johnson & Johnson Vision Care, Inc.
Presbyopia
Extended Depth of Focus Contact Lenses for Presbyopia
VTI has an FDA cleared soft contact lens product. Its optical design creates an enhanced depth of focus (EDOF), which provides clear distance, intermediate, and near vision.
- Trial name
- NCT05495971
- Testing
- NaturalVue Multifocal
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Visioneering Technologies, Inc