Clinical trials: Eye--Refractive Errors
Myopia
Brimonidine Eye Drops in the Prevention of Myopia Progression
Study to determine the efficacy of alpha-2 adrenergic drugs (brimonidine) in the prevention of myopia progression. Given that the drugs used so far have limited efficacy and side effects (loss of near vision, photophobia), it may…
- Trial name
- NCT06996236
- Testing
- Treatment with brimonidine eye drops 0.025%
- Where
- Spain
- Volunteers
- 40 people
- Sponsor
- Fundacion para la Investigacion Biomedica del Hospital Universitario Ramon y Cajal
Macular Hole, Myopia
Efficacy and Safety of Myopic Macular Hole Closure Surgery Without Endotamponade Agent
Macular hole (MH) is a common condition that affects approximately 1.6/1000 elderly Chinese population. The prevalence is expected to be even higher in individuals with high myopia (HM), an established risk factor for MH.
- Trial name
- NCT07129798
- Testing
- ILM flap with no endotamponade technique
- Where
- Hong Kong
- Volunteers
- 20 people
- Sponsor
- Chinese University of Hong Kong
Refractive Error
The Evolutionary Model of Mild-to-moderate Myopia in China
Myopia has emerged as a major health issue in east Asia, because of its increasingly high prevalence in the past few decades (now 80-90% in school-leavers), and because of the sight-threatening pathologies associated with high…
- Trial name
- NCT02667509
- Where
- China
- Volunteers
- 852,441 people, healthy volunteers welcome
- Sponsor
- Sun Yat-sen University
Myopia
Patient Reported Outcomes With WaveLight LASIK
This study is a multi-site, single-arm, ambispective, observational study of subject satisfaction, after successful bilateral LASIK surgery. Subjects will be assessed 12+ months post-operatively.
- Trial name
- NCT06668909
- Testing
- WaveLight® EX500
- Where
- 4 sites in United States
- Volunteers
- 300 people
- Sponsor
- OVO LASIK + Lens
Myopia, Progressive
To Evaluate the Efficacy and Safety of an Defocus Lens in Slowing the Progression of Myopia
To confirm the efficacy of DIMS lenses in controlling myopia progression, we planned a prospective, single-centre, randomised, double-blind, controlled, non-inferiority clinical study.
- Trial name
- NCT06405711
- Testing
- frame lens
- Where
- China
- Volunteers
- 138 people, healthy volunteers welcome
- Sponsor
- Tianjin Eye Hospital
Hyperopia, High Astigmatism
Fresh Corneal Lenticule Implantation in Hyperopic Patients With High Astigmatism
The refractive combination of high hyperopia with high astigmatism is difficult to treat surgically. In addition, there are not many suitable options to offer such patients presenting with this condition.
- Trial name
- NCT04616144
- Testing
- Fresh Corneal Lenticule Implantation using Relex-Smile VisuMax Femtosecond Laser
- Where
- Kosovo
- Volunteers
- 55 people
- Sponsor
- Eye Hospital Pristina Kosovo
Refractive Errors
Study to Evaluate the Reliability, Validity and Safety of Subjective Mobile Refraction
This study evaluates the reliability, validity and safety of a self administered, subjective refraction test via a mobile medical app (GoEyes) as compared to standard of care subjective manifest refraction performed by a health…
- Trial name
- NCT05049070
- Testing
- Mobile medical application to self administer a subjective refraction test, Standard of care refraction test
- Where
- 12 sites in United States
- Volunteers
- 349 people
- Sponsor
- 1800 Contacts, Inc.
Myopia, Hyperopia
Development of a Validated Chart for Intermediate Vision Assessment
Development of a validated computer-based instrument (software program) for the assessment of intermediate visual acuity.
- Conditions
- Myopia, Hyperopia, Presbyopia, Astigmatism
- Trial name
- NCT02279446
- Testing
- Intermediate Visual acuity (IVA) assessment
- Where
- Greece
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Democritus University of Thrace
Myopia
Comparative Study to Evaluate the Cosmetic Appearance of Two Brands (Coopervision (CVI) vs. Competitor) of Color Soft Contact Lenses.
Comparative Study to Evaluate the Cosmetic Appearance of Two Brands (Coopervision (CVI) vs. Competitor)of Color Soft Contact Lenses
- Trial name
- NCT02299869
- Testing
- Verde (Competitor-control), Green (CVI-test), Cinza (Competitor-control)
- Where
- Mexico
- Volunteers
- 41 people
- Sponsor
- CooperVision, Inc.
Myopia
Comparison of Intralase and Visumax Femtosecond Laser for Laser In Situ Keratomileusis
Emtosecond lasers are used in cutting the flap in LASIK procedures (laser corrective surgery for refractive error). Their use has decreased the incidence of serious complications when compared to the use of…
- Trial name
- NCT01252654
- Where
- Singapore
- Volunteers
- 120 people
- Sponsor
- Singapore Eye Research Institute
Pediatric Cataract, Congenital Cataract
Toric Intraocular Lens Implantation for Pediatric Aphakia
Here, we conducted a nonrandomized clinical trial aims to evaluate and compare the prognosis of visual function in children of these two types of IOL implantation over a three-year postoperative period.
- Trial name
- NCT07088796
- Testing
- Toric IOL implantation, Non-toric IOL implantation
- Where
- China
- Volunteers
- 236 people
- Sponsor
- Eye & ENT Hospital of Fudan University
Hyperopia and Myopia
Eye Imaging for the Study of Childhood Myopia
Myopia (nearsightedness) is increasing worldwide and is becoming a serious public health problem. Studies estimate that by 2050, if no action is taken, almost half of the world's population will be myopic.
- Trial name
- SELENA (NCT07335146)
- Testing
- Ophtalmic measurements to estimate geometrical distances, MRI, Ophtalmic measurements to measure wavefront aberrations
- Where
- France
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Essilor International
Presbyopia
Presbyopia in Breast Cancer Survivors
Chemotherapy drugs, used in cancer treatments, may change the timing of a vision condition known as presbyopia. Presbyopia is the inability to focus the eye on close objects, by a process called accommodation.
- Trial name
- NCT00271661
- Sponsor
- Alberta Health services
Cataract
Myopic Monovision: EDOF vs. Monofocal IOL
Comparison of EDOF IOLs versus monofocal IOLs with mini-monovision concerning intermediate and near visual acuity.
- Trial name
- NCT05194670
- Testing
- enhanced depth of focus IOL, monofocal IOL
- Where
- Austria
- Volunteers
- 62 people
- Sponsor
- Vienna Institute for Research in Ocular Surgery
Myopia
Clinical Comparison of Two Soft Contact Lenses
This study was designed to gather short-term clinical performance data for 2 soft contact lenses.
- Trial name
- NCT06251154
- Testing
- Lens 1, Lens 2
- Where
- United Kingdom
- Volunteers
- 50 people
- Sponsor
- CooperVision, Inc.
Cataract, Lens Opacities
PMCF Study on Monofocal Toric IOL (PODEYE TORIC) in Spain
This is a multicentric, prospective, open-label PMCF study whereby patients undergoing routine cataract surgery will have mono- or bilateral implantation of hydrophobic acrylic monofocal toric intraocular lens PODEYE TORIC (study…
- Conditions
- Cataract, Lens Opacities, Astigmatism
- Trial name
- PHY2103 (NCT04866719)
- Testing
- IOL implantation experimental
- Where
- 5 sites in Spain
- Volunteers
- 76 people
- Sponsor
- Beaver-Visitec International, Inc.
Myopia
Axial Length With Adult Onset Myopia (ALWAOM)
Purpose: To determine axial length progression and its relationship with myopia onset and progression in adults.
- Trial name
- ALWAOM (NCT05559567)
- Testing
- Orthokeratology
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Art Optical Contact Lens, Inc.
Refractive Errors
Morphological Characteristics of the Maxillomandibular Region in a 3D Representation and the Refractive Status of the Eye
The goal of this observational study is to learn more about the relationship between the size and shape of the eye and the shape of the face in healthy young adults.
- Trial name
- NCT07460557
- Testing
- No intervention; Observational study
- Where
- Croatia
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Zagreb
Presbyopia
Safety, Tolerability and Pharmacokinetics of LNZ101 and LNZ100 Ophthalmic Solutions in Healthy Adult Chinese With Presbyopia
Phase I Clinical Study to Evaluate the Safety, Tolerability and Pharmacokinetics of LNZ101 and LNZ100 Ophthalmic Solutions in Chinese Healthy Adult Subjects with Presbyopia
- Trial name
- NCT06270030
- Testing
- LNZ101 (Aceclidine /Brimonidine) ophthalmic solution, LNZ100 (Aceclidine) ophthalmic solution
- Where
- China
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Corxel Pharmaceuticals
Anisometropia
Ten-year Follow-up of Laser in Situ Keratomileusis in Patients 8 to 15 Years Old
The purpose of this study is to determine the safety, efficacy, predictability, and stability of laser in situ keratomileusis (LASIK) to correct high anisometropia in patients 8 to 15 years old in whom conventional treatments…
- Trial name
- NCT00800774
- Testing
- LASIK
- Where
- Brazil
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- Instituto de Olhos de Goiania
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