Clinical trials: Eye--Refractive Errors
Myopia, Astigmatism
Wavefront-guided LASIK Surgery Compared to Ray Tracing-Guided LASIK Surgery
We are enrolling participants aged 22 and older to have LASIK surgery in both eyes. We will perform wavefront-guided LASIK in one eye and ray tracing-guided LASIK in the fellow eye of each participant.
- Trial name
- NCT07078799
- Testing
- LASIK
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Stanford University
Lenses, Intraocular
Tolerance to Residual Astigmatism in Eyes With Vivity®
Low amounts of postoperative residual astigmatism may worsen the visual performance of patients implanted with presbyopia- correcting intraocular lenses (IOLs).
- Trial name
- NCT05392998
- Testing
- Cataract surgery with Vivity intraocular lens implantation
- Where
- Spain
- Volunteers
- 30 people
- Sponsor
- Clínica Rementería
Aphakia
Clinical Investigation of the AcrySof IQ Vivity Extended Vision Intraocular Lens (IOL)
The purpose of this study is to compare the visual disturbance profile of an intraocular lens (IOL) using nondiffractive optics, the VIVITY IOL, to two diffractive IOLs in subjects requiring bilateral cataract surgery.
- Trial name
- NCT04098367
- Testing
- VIVITY, SYMFONY, AT LARA
- Where
- 12 sites in Australia, New Zealand
- Volunteers
- 222 people
- Sponsor
- Alcon Research
Refractive Errors, Satisfaction
PRO Measure for Refractive Surgery IRAS Project Number 246072
The development and validation of a concise, practical, on-line, self-administered, self-archiving, and self-scoring PRO questionnaire for routine clinical use in refractive surgery is the primary study objective.
- Conditions
- Refractive Errors, Satisfaction, Cornea, Lens Diseases
- Trial name
- NCT03655743
- Testing
- LASIK, PRK, Phacoemulsification
- Where
- United Kingdom
- Volunteers
- 372 people
- Sponsor
- Moorfields Eye Hospital NHS Foundation Trust
Myopia, High Myopia
Orthokeratology for High Myopia (OHM) Study
This project aims to investigate/examine high myopic subjects on full correction ortho-k (using Topaz ortho-k lenses for high myopia) compared to subjects undergoing partial reduction ortho-k and their relationship with myopia…
- Trial name
- NCT03881358
- Testing
- ortho-k lenses and thinner spectacles, newly designed ortho-k lenses
- Where
- Hong Kong
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- The Hong Kong Polytechnic University
Wavefront Aberration, Corneal, Refractive Errors
Digital Wavefront Sensing
A holographic optical coherence tomography (H-OCT) setup is used to detect the wavefront by means of phase reconstruction.
- Trial name
- DWS (NCT04597255)
- Testing
- Holographic optical coherence tomography
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Myopia
The Effect of Hinge Position and Hinge Width on Corneal Sensation and Dry Eye After IntraLase LASIK Procedure
Corneal sensation is known to play a role in tear secretion. Decreased sensation leads to decreased tear production; and when bilateral, leads to a decreased blink rate as well. Dry eyes are a common side effect of LASIK.
- Trial name
- IDES (NCT00803478)
- Testing
- LASIK
- Where
- United States
- Sponsor
- University of Michigan
Refractive Error
Comparison of Lotrafilcon B Lenses With Different Packaging Solutions
The purpose of this study is to evaluate AIR OPTIX® plus HYDRAGLYDE® (AOHG) contact lenses compared to AIR OPTIX® AQUA (AOA) contact lenses in overall lens fit.
- Trial name
- NCT02699684
- Testing
- Lotrafilcon B contact lenses with EOBO-41, Lotrafilcon B contact lenses, Hydrogen peroxide-based lens care solution
- Volunteers
- 82 people
- Sponsor
- Alcon Research
Myopia, Hyperopia
A Prospective Safety and Effectiveness Study of the 500 Hz Technolas Perfect Vision Excimer Laser in Asian Eyes Using LASIK
This clinical study has been planned to evaluate the safety and effectiveness of common treatment algorithms using 500 Hz laser repetition rate.
- Conditions
- Myopia, Hyperopia, Presbyopia
- Trial name
- NCT01977807
- Testing
- Proscan, Zyoptix and Supracor
- Where
- Philippines
- Volunteers
- 100 people
- Sponsor
- Technolas Perfect Vision GmbH
Astigmatism, Myopia
Vision Stability and Preference for Soft Toric vs. Soft Spherical Contact Lenses
The principal hypothesis is to be tested in this work is that vision stability (the primary outcome measure) with a spherical contact lens correction vs. a toric contact lens correction will be the same.
- Trial name
- NCT04536571
- Testing
- Test Contact lens, Control Contact lens
- Where
- United Kingdom
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- CooperVision, Inc.
Myopia
Repeatability of AO-SLO (Mona IIa) Technology and Cone Cell Density of Individuals Use Repeated Low-level Red-light Therapy
To explore the repeatability of AO-SLO (Mona IIa) technology and the difference of cone cell density between individuals who used or not used repeated low-intensity red light treatment
- Trial name
- AO-SLO (NCT07160036)
- Testing
- RLRL(Model RS-200-2A, Eyerising; Suzhou Xuanjia Optoelectronic Technology Co., Ltd., Suzhou, China))
- Where
- China
- Volunteers
- 180 people
- Sponsor
- Ruihua Wei
Myopia
Changes in Eye Shape With Myopia Management Interventions
The goal of this clinical trial is to study changes in eye shape of nearsighted young adults using low-dose atropine eye drops or soft multifocal contact lenses.
- Trial name
- NCT06450132
- Testing
- Atropine Ophthalmic, MiSight 1-day disposable contact lenses
- Where
- United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Ohio State University
Myopia, Astigmatism
Correction of Myopia Wtih or Without Astigmatism Using the VisuMax™ Femtosecond Laser
The objective of this clinical trial is to evaluate the safety and effectiveness of the Carl Zeiss Meditec VisuMax™ Femtosecond Laser lenticule removal procedure for the reduction or elimination of myopia from ≥ -1.00 D to ≤…
- Trial name
- NCT02430428
- Testing
- Carl Zeiss Meditec VisuMax Femtosecond Laser
- Where
- 5 sites in United States
- Volunteers
- 357 people, healthy volunteers welcome
- Sponsor
- Carl Zeiss Meditec, Inc.
Intermittent Exotropia, Myopia
A Comparative Study of the Efficacy of Myopia Control Lenses With Different Mechanisms on Controlling Myopia Progression in Patients With Intermittent Exotropia
The goal of this clinical trial is to compare the efficacy of myopia control lenses with different working principles in patients with intermittent exotropia aged 6 to 12 years.
- Trial name
- NCT07642934
- Testing
- DIMS glasses, DOT glasses
- Volunteers
- 120 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Myopia, Pathological
VEGF Trap-Eye in Choroidal Neovascularization Secondary to Pathologic Myopia (mCNV)
VEGF Trap-Eye will be tested for safety and efficacy in patients with vision loss due to choroidal neovascularization secondary to pathologic myopia. This will be a placebo-controlled trial.
- Trial name
- Myrror (NCT01249664)
- Testing
- VEGF Trap-Eye (BAY86-5321), No Drug
- Where
- 20 sites in Hong Kong, Japan and 3 more
- Volunteers
- 122 people
- Sponsor
- Bayer
Presbyopia
Visual and Economic Profits of ReSTOR® Multifocal Intraocular Lenses (IOL) on Public Health Patients in Spain
Surgical correction of presbyopia is possible via the implantation of multifocal intraocular lenses after removal of the crystalline lens.
- Trial name
- NCT01088282
- Testing
- Cataract surgery
- Where
- 2 sites in Spain
- Volunteers
- 120 people
- Sponsor
- University of Barcelona
Cataract Bilateral, Presbyopia
Tecnis ZLB00 & Symfony Intraocular Lens Combination Outcomes
Current visual outcomes expectations of cataract patients are similar to those of refractive surgery patients. Their desire is to be spectacle independent for far, intermediate and near vision activities.
- Trial name
- NCT03771274
- Testing
- Tecnis ZLB00 & Symfony IOL
- Where
- United States
- Volunteers
- 39 people
- Sponsor
- Carolina Eyecare Physicians, LLC
Astigmatism
Clinical Performance of Atypical Contact Lens Powers on Subjects With Astigmatism
This study will evaluate the fitting characteristics and physiological response of two toric lenses manufactured by Vistakon.
- Trial name
- NCT00697190
- Testing
- senofilcon A toric, galyfilcon A toric
- Where
- United Kingdom
- Volunteers
- 39 people
- Sponsor
- Johnson & Johnson Vision Care, Inc.
Myopia, Myopic Astigmatism
A Clinical Trial Assessing the Safety and Effectiveness of Orthokeratology Lenses in Patients With Myopia and Myopic Astigmatism
This is a prospective, multi-centre, single-arm clinical trial to evaluate the effectiveness and safety of MCOK-01 lenses in patients with myopia and myopic astigmatism who need dioptric correction.
- Trial name
- SEMOA (NCT07047924)
- Testing
- MCOK-01
- Where
- 4 sites in Australia
- Volunteers
- 220 people
- Sponsor
- Menicon Co., Ltd.
Lid Wiper Epitheliopathy
Lid Wiper Epitheliopathy Trial
The purpose of this study is to evaluate the effect of contact lens lubricity on lid wiper epitheliopathy (LWE) in symptomatic contact lens wearers.
- Trial name
- NCT01870856
- Testing
- Spectacles, Delefilcon A contact lenses, Etafilcon A contact lenses
- Volunteers
- 187 people
- Sponsor
- Alcon Research
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