Clinical trials: Eye--Refractive Errors
Presbyopia
Safety and Efficacy of an Intrastromal Transform™ Corneal Allograft (TCA) for Presbyopia Correction
The objective of this clinical study is to evaluate the safety and effectiveness of intrastromal implantation of the Allotex TransForm corneal allograft (TCA) for improving near vision in presbyopic subjects.
- Trial name
- NCT03671135
- Testing
- TCA Intrastromal Inlay
- Where
- 4 sites in Belgium, Ireland and 1 more
- Volunteers
- 121 people, healthy volunteers welcome
- Sponsor
- Allotex, Inc.
Myopia
Efficacy and Safety of Defocusing Frame Glasses With Artificial Intelligence in Controlling Myopia Progression
Background: Myopia refers to the pathological state in which the external parallel light enters the eye and focuses in front of the retina, resulting in the inability to clearly image on the retina.
- Trial name
- NCT05532774
- Testing
- AI defocusing frame glasses
- Where
- China
- Volunteers
- 138 people
- Sponsor
- Shanghai Eye Disease Prevention and Treatment Center
Aphakia, Astigmatism
Clareon IOL Retrospective Data Collection
The purpose of this study is to provide real world evidence (RWE) on the performance of the Clareon ultraviolet absorbing (UVA) intraocular lenses (IOLs) to support the overall body of evidence on the Clareon IOL family.
- Trial name
- NCT05796674
- Testing
- Clareon UVA IOL, WaveTec Optiwave Refractive Analysis (ORA) System, Cataract surgery
- Where
- United States
- Volunteers
- 1,090 people
- Sponsor
- Alcon Research
Myopia
Atropine (0.02%, 0.04%) Combined With Defocus DIMS for Moderate and High Myopia Control
To evaluate the effectiveness and safety of DIMS, low concentration atropine eye drops,and atropine combined with DIMS in controlling axial length and refraction in children with moderate to high myopia.
- Trial name
- atropine (NCT06523504)
- Testing
- DIMS, The 0.02% ATP Group, The 0.04% ATP Group
- Where
- China
- Volunteers
- 410 people
- Sponsor
- Ruihua Wei
Myopia
Assessing the Impact of Streetscape Exposure on Children's Perception
The primary objective is to determine how streetscape exposure influences children's visual perception and psychological perception.
- Trial name
- NCT07761949
- Testing
- Virtual simulation of street visual environment exposure
- Where
- China
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Zhongshan Ophthalmic Center, Sun Yat-sen University
Myopia
Low-dose Atropine Eye Drops to Reduce Progression of Myopia in Children in the United Kingdom
Short-sightedness, also called myopia, makes objects in the distance, such as the television, look blurred. This is caused by the eye growing too long, something that usually happens while children are also getting taller.
- Trial name
- CHAMP-UK (NCT03690089)
- Testing
- Atropine Sulfate
- Where
- 4 sites in United Kingdom
- Volunteers
- 289 people, healthy volunteers welcome
- Sponsor
- Belfast Health and Social Care Trust
Myopia
Comparison of Clinical Performance and Subjective Preference of Three Contact Lenses
The purpose of this study is to evaluate the clinical performance and subject's preference out of three LRE (Limbal Ring Enhancing) lens types: etafilcon A (Johnson\&Johnson), methafilcon A (Interozzo), and methafilcon A…
- Trial name
- NCT03134599
- Testing
- etafilcon A, methafilcon A - Interozzo, methafilcon A - CVI (CooperVision)
- Where
- South Korea
- Volunteers
- 60 people
- Sponsor
- CooperVision, Inc.
Refractive Disorders
Anterior Stromal Changes After PRK by Using Intraoperative Mitomicin C
To evaluate the confocal microscopy changes in keratocyte density at the anterior stromal after Photorefractive keratectomy (PRK) surgery, using intraoperative mitomycin C(Mitolem, LEMERY, S.A. de C.V. Mexico D.F. Reg.
- Trial name
- NCT00599950
- Testing
- Mitomycin C and Photorefractive keratectomy (PRK)
- Where
- Mexico
- Volunteers
- 10 people
- Sponsor
- Asociación para Evitar la Ceguera en México
Presbyopia, IOL, Cataract
Evaluation of the Visual Acuity Curves of an Enhanced Monofocal Intraocular Lens
The primary objective of this study is to evaluate postoperative visual acuity curves in pseudophakic patients following unilateral or bilateral implantation of the enhanced monofocal TECNIS Eyhance IOL, using the DDARTVC.
- Trial name
- IOL-VAC (NCT07439835)
- Testing
- Phacoemulsification with enhanced monofocal IOLs
- Where
- Greece
- Volunteers
- 62 people
- Sponsor
- Democritus University of Thrace
Accomodation, Refractive Errors
Study on the Effect of Two Ways of Cycloplegia on Biological Parameters of Ciliary Muscle
Atropine has a ciliary muscle-paralysing effect and causes hyperopic drift. Besides, atropine has been proven to slow the progression of myopia. Many studies have suggested that atropine can increase the thickness of the choroid.
- Conditions
- Accomodation, Refractive Errors, Myopia, Cycloplegia
- Trial name
- NCT05449015
- Testing
- 1% atropine
- Where
- China
- Volunteers
- 144 people
- Sponsor
- Shanghai Eye Disease Prevention and Treatment Center
Ametropia
Evaluation of the Performance of Non-molded Soft Contact Lenses
To evaluate the performance of the study soft lens for vision, comfort, physiology and lens surface properties.
- Trial name
- NCT00371787
- Testing
- Soft contact lens
- Where
- Canada
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- University of Waterloo
Myopia
Evaluate the Efficacy and Safety of CTO0308 in Pediatric Patients With Myopia
This study was to evaluate the superiority of the myopia progression control effect in the treatment group compared with the control group, evaluated by the change in spherical equivalent (SE) after 12 months of administration of…
- Trial name
- NCT07790640
- Testing
- CTO0308
- Where
- South Korea
- Volunteers
- 351 people
- Sponsor
- Taejoon Pharmaceutical Co., Ltd.
Presbyopia, Refractive Errors
Safety and Efficacy of a Sub-epitheilal Transform™ Corneal Allograft (TCA) for Presbyopia Correction
The objective of this clinical study is to evaluate the safety and effectiveness of subepithelial implantation of the Allotex TransForm corneal allograft (TCA) for improving near vision in presbyopic subjects.
- Trial name
- NCT03675438
- Testing
- Sub-epitheilal TCA Inlay
- Where
- 11 sites in Austria, Belgium and 4 more
- Volunteers
- healthy volunteers welcome
- Sponsor
- Allotex, Inc.
Myopia, Astigmatism
Patient Satisfaction With Contoura Vision Topography-Guided LASIK
To evaluate patient reported outcomes associated with quality of vision before and after treatment with Contoura Vision Topography-Guided LASIK.
- Trial name
- NCT04903301
- Testing
- Contoura Vision LASIK
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Rush Eye Associates
Refractive Error, Myopia
Comparative Evaluation of Contact Lens Centering of DAILIES® AquaComfort Plus® Versus 1-DAY ACUVUE® MOIST® in Japan
The purpose of this study is to evaluate lens centration and subjective impressions of DAILIES® AquaComfort Plus® (DACP) lenses compared to 1-DAY ACUVUE® MOIST® (1DAM) lenses in ball sports players.
- Conditions
- Refractive Error, Myopia, Myopic Astigmatism
- Trial name
- NCT02103309
- Testing
- Nelfilcon A contact lenses, Etafilcon A contact lenses
- Volunteers
- 42 people
- Sponsor
- Alcon Research
Presbyopia
A Study to Evaluate a Mid Add Multi-Focal Soft Contact Lens
This study is to evaluate the product performance of the investigational LD127025 MF mid add soft contact lens compared to CIBA Vision's Air Optix Aqua MF MED add soft contact lenses when used among currently adapted soft contact…
- Trial name
- NCT01959178
- Testing
- LD127025 MF, Air Optix Aqua MF
- Where
- United States
- Volunteers
- 146 people
- Sponsor
- Bausch & Lomb Incorporated
Refraction Error, Myopia
Age and Refraction in Predicting Myopia Progression in COVID-19
To determine the longitudinal changes of age and refraction in predicting myopia progression with risk under the coronavirus disease 2019 (COVID-19) pandemic in a 3-year follow-up of a Chinese cohort.
- Trial name
- NCT05305274
- Testing
- screening
- Where
- China
- Volunteers
- 34,400 people, healthy volunteers welcome
- Sponsor
- Tianjin Eye Hospital
Myopia
Contact Lenses and Myopia
The objective of this study is to determine if multifocal contact lenses affect accommodation and/or binocular vision when worn by pediatric patients.
- Trial name
- CLAM (NCT02180347)
- Testing
- Contact lenses
- Where
- United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- State University of New York College of Optometry
Myopia, Progressive
Impact of Digital Screen Time in Progression of Myopia in Children
Research suggests that prolonged digital screen time is a significant contributing factor to the progression of myopia in children.
- Trial name
- NCT07055815
- Testing
- Progression of Myopia
- Where
- Pakistan
- Volunteers
- 79 people
- Sponsor
- Superior University
Refractive Errors, Myopia
Clinical Comparison of 2 Daily Disposable Contact Lenses - Pilot Study 2
The primary objective of this study is to evaluate the overall performance of PRECISION1 contact lenses when compared to Clariti 1-Day contact lenses.
- Trial name
- NCT04528017
- Testing
- Verofilcon A contact lenses, Somofilcon A contact lenses
- Where
- 4 sites in United States
- Volunteers
- 56 people
- Sponsor
- Alcon Research
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