Clinical trials: FAPI
Malignant Tumors, Positron-Emission Tomography
FAP PET/CT or PET/MR Production in the Diagnosis, Staging, and Efficacy Assessment of Malignant Tumors Application
This clinical trial aims to investigate the value of fibroblast activation protein PET/CT(PET/MR) in the diagnosis, staging, and evaluation of treatment outcomes in malignant tumors.
- Trial name
- NCT06270394
- Testing
- 68Ga-Fibroblast activation protein inhibitor
- Where
- China
- Volunteers
- 22 people
- Sponsor
- The First Affiliated Hospital of Anhui Medical University
Rectal Cancer
PET/MR Evaluation of Regression Grading After Neoadjuvant Therapy for Rectal Cancer
This project aims to evaluate the role of 18F-FAPI combined with 18F-FDG PET/MRI imaging in quantitatively and accurately evaluating the grading of rectal cancer after SCRT neoadjuvant therapy in patients with advanced rectal…
- Trial name
- NCT06318234
- Testing
- 18F-FAPI，18F-FDG
- Where
- China
- Volunteers
- 32 people
- Sponsor
- Xiao Chen
Malignant Solid Tumors
Study of 64Cu-FAPI-XT117 PET/CT in Patients With Malignant Solid Tumors
This is the study of 64Cu-FAPI-XT117, which is an prospective, single-arm phase I clinical study.
- Trial name
- NCT05930457
- Testing
- 2.5-3.5mCi 64Cu-FAPI-XT117, 3.5-4.5mCi 64Cu-FAPI-XT117, 4.5-5.5mCi 64Cu-FAPI-XT117
- Where
- China
- Volunteers
- 15 people
- Sponsor
- The First Affiliated Hospital of Guangzhou Medical University
Severe Aortic Valve Stenosis
A Clinical Study Using FAPI-PET Imaging to Assess the Postoperative Effects of TAVI in Patients With Aortic Stenosis
This study will include patients with severe degenerative aortic stenosis (AS) who meet the inclusion criteria and voluntarily participate (planned to undergo TAVI), as well as patients with aortic stenosis who have not undergone…
- Trial name
- NCT07335900
- Testing
- Transcatheter Aortic Valve Implantation, Optimal medication treatment
- Where
- China
- Volunteers
- 25 people
- Sponsor
- RenJi Hospital
Lung Nodules
Clinical Study of Trap-(FAPI)3 PET Imaging in the Diagnosis of Pulmonary Nodules
The excellent tumor-targeting efficacy of FAP has been confirmed by multiple clinical studies. The results unequivocally establish FAPI as a tumor-targeting ligand with significant potential, demonstrating important application…
- Trial name
- NCT07448441
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Daping Hospital and the Research Institute of Surgery of the Third Military Medical University
Allogeneic Stem Cell Transplantation, Lung Allograft Transplantation
Fibrotic Disease Activity in Cardiopulmonary Disorders Using 18F-Fibroblast Activation Protein Inhibitor (18F-FAPI-74) PET/CT Imaging
Background: Injury or diseases of the heart and lung can sometimes cause scar tissue (fibrosis) to build up in those organs. Current imaging scans can see this scar tissue once it has formed, but researchers want to find a way to…
- Conditions
- Allogeneic Stem Cell Transplantation, Lung Allograft Transplantation, Interstitial Lung Disease, Acute Lung Injury
- Trial name
- NCT07613099
- Testing
- [18F]FAPI-74, 18F-FAPI-74 PET/CT Imaging
- Where
- United States
- Volunteers
- 210 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Tumor, Solid, Positron-Emission Tomography
Positron Nuclide Labeled NOTA-FAPI PET Study in Lymphoma
To evaluate the normal physiological distribution of positron nuclide labeled NOTA-F API in human body and its detection efficiency for lymphoma
- Conditions
- Tumor, Solid, Positron-Emission Tomography, Lymphoma
- Trial name
- NCT04367948
- Testing
- 18F-FDG and 68Ga-NOTA-FAPI04 PET/CT, 18F-FDG and 18F-NOTA-FAPI04 PET/CT
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Peking University Cancer Hospital & Institute
Post-Acute COVID-19, Post-Acute COVID-19 Infection
68Ga-FAPI PET/CT to Detect Ongoing Fibroblast Activity in Post-acute COVID-19
The goal of this observational study is to investigate the role fibroblasts play in the persistent respiratory complaints after a COVID-19 infection.
- Conditions
- Post-Acute COVID-19, Post-Acute COVID-19 Infection, Post-Acute COVID-19 Syndrome, Pulmonary Fibrosis
- Trial name
- FAPI CLIMATE (NCT05981885)
- Where
- Netherlands
- Volunteers
- 18 people
- Sponsor
- University Medical Center Groningen
Myocardial Infarction, Myocardial Fibrosis
PROFILE-MI - The FAPI Fibrosis Study
The investigators here propose to investigate the timing and pattern of myocardial fibrosis activity following acute myocardial infarction using hybrid 68Ga-FAPI positron emission tomography and cardiovascular magnetic resonance.
- Trial name
- NCT05356923
- Testing
- 68Gallium FAPI PET/MR scan
- Where
- United Kingdom
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Edinburgh
Pancreatic Cancer, Adult, Gastroesophageal Cancer (GC)
BEFAST Study, [68Ga]Ga-FAPI Total Body PET/CT for Better and Faster Imaging in Cancer
The goal of this clinical trial is to learn if [68Ga]Ga-FAPI-46 Total Body PET/CT can diagnose patients suffering from gastroesophageal cancer and pancreatic cancer.
- Trial name
- BEFAST (NCT07629609)
- Testing
- [68Ga]Ga-FAPI-46
- Where
- Denmark
- Volunteers
- 90 people
- Sponsor
- Barbara Malene Fischer
Fabry Disease
Novel Diagnostic and Prognostic Predictors in Fabry Cardiomyopathy: Proof of Concept in a Rare Disease
In this work, we address the understanding of the signaling pathways involved in cardiac remodeling in human SCD through molecular imaging analysis with a fibrosis marker.
- Trial name
- FABRyCar (NCT07351136)
- Testing
- PET scan of 68Ga-FAPI
- Volunteers
- 20 people
- Sponsor
- Núcleo de Apoio à Investigação Clínica - FMUP
Tumor, Solid, FAPI, PET/CT, Metastasis
Comparison of 68Ga-DOTA-FAPI-46 and 68Ga-DOTA-2P(FAPI)2 PET/CT in Patients With Various Types of Cancer
To evaluate the potential usefulness of 68Ga-DOTA-2P(FAPI)2 positron emission tomography/computed tomography (PET/CT) for the diagnosis of primary and metastatic lesions in various types of cancer, compared with 68Ga-DOTA-FAPI-46…
- Trial name
- NCT04941872
- Testing
- 68Ga-DOTA-FAPI-46 and 68Ga-DOTA-2P(FAPI)2 PET/CT
- Where
- China
- Volunteers
- 7 people
- Sponsor
- The First Affiliated Hospital of Xiamen University
AL Amyloidosis (AL), Cardiac Amyloidosis
Multimodal Radiomics Model (18F-FAPI PET/CT + CMR) for AL Cardiac Amyloidosis Prognosis
1. Goal of the Study: The goal of this prospective observational study is to develop and validate a novel, non-invasive method for predicting the prognosis of patients with light-chain cardiac amyloidosis (AL-CA).
- Trial name
- AL-CA (NCT07103863)
- Where
- China
- Volunteers
- 49 people
- Sponsor
- Beijing Anzhen Hospital
Breast Neoplasm Female
Piloting 18F-FAPI PET/MRI for Applications in Breast Cancer
Breast cancer is the most common type of cancer in Norwegian women, with 4,224 new cases in 2022. More precise diagnosis are expected to result in more accurate assessment of treatment effect, and to contribute to both providing…
- Trial name
- NCT07180433
- Testing
- FAPI PET/MR
- Volunteers
- 60 people
- Sponsor
- St. Olavs Hospital
Peyronie's Disease
Assessment of the Value of FAPI and FDG-PET-CT in Diagnosis of Acute Phase Peyronie's Disease
The goal of this clinical trial is to learn if FAPI-PET/CT and/or FDG-PET/CT scan is able to detect active fibroblast tissue and inflammation in patients with acute or chronic phase PD.
- Trial name
- Hippocrates (NCT07903987)
- Testing
- 68Ga-FAPI (gallium-68-labeled fibroblast activation protein inhibitor)
- Where
- Netherlands
- Volunteers
- 20 people
- Sponsor
- University Medical Center Groningen
Heart Failure, Positron Emission Tomography
Visualized Monitoring of Fibrosis Formation in Heart Failure With 68GA-FAPI PET
This is a diagnostic study. Patients were included from patients with clinically suspected or confirmed heart failure, and 68Ga-FAPI and 13N-NH3 gated myocardial imaging were performed to evaluate the effectiveness of 68Ga-FAPI…
- Trial name
- NCT04982458
- Testing
- 68Ga-FAPI
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Urinary Bladder Neoplasms
FAPI and FDG PET/MRI in Diagnosis and Therapy Prediction of Bladder Cancer
The aim of this trial is to investigate the value of FAPI PET/MRI, FDG PET/MRI and MRI in diagnosing MIBC and predicting the efficacy of neoadjuvant therapy for MIBC patients, so as to guide the clinic to adjust the treatment…
- Trial name
- NCT06421142
- Testing
- imaging examinations:FAPI PET/MRI, FDG PET/MRI, MRI
- Where
- China
- Volunteers
- 80 people
- Sponsor
- First Affiliated Hospital of Fujian Medical University
Esophageal Cancer, ESCC
An Exploratory Clinical Study of Accurate Efficacy Assessment of Neoadjuvant Immunotherapy in Locally Advanced Esophageal Squamous Cell Carcinoma Based on 68Ga-FAPI ([68Ga] Fibroblast Activation Protein Inhibitor)/¹⁸F-FDG (2-Deoxy-2-[¹⁸F]Fluoro-D-glucose) Dual Imaging
This study will evaluate whether two positron emission tomography/computed tomography (PET/CT) scans performed before treatment-68Ga-FAPI and 18F-FDG-can help predict how well patients with resectable, locally advanced thoracic…
- Trial name
- NCT07770672
- Testing
- Retlirafusp Alfa Plus Chemotherapy, Adebrelimab Plus Chemotherapy
- Where
- China
- Volunteers
- 92 people
- Sponsor
- Tan Lijie
Cancer, Solid Malignancies
PET Image Exploration of Novel Tracer [68Ga]-FAPI-JNU Imaging Studies in Patients with Malignant Tumors
To investigate the biological distribution of a new tracer 68Ga-FAPI-JNU in the primary, metastatic and normal tissues of patients with malignant tumors, and to evaluate the biological distribution of 68GA-FAPI-JNU with…
- Trial name
- NCT06684028
- Testing
- 68Ga-FAPI-JNU
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Affiliated Hospital of Jiangnan University
Pancreatic Cancer, Adenocarcinoma Pancreas
FAPi PET in Pancreatic Ductal Adenocarcinoma
Pancreatic adenocarcinoma commonly referred to as pancreatic cancer is a cancer which is known to involve the pancreas and the surrounding structures like blood vessels, which makes it an aggressive cancer.
- Trial name
- FAP-1 (NCT07342231)
- Testing
- Ga-68 FAPi PET/CT
- Where
- India
- Volunteers
- 60 people
- Sponsor
- Tata Memorial Hospital