Clinical trials: FAPI
Thyroid Eye Disease
Comparative Evaluation of 68Ga-FAPI and 68Ga-DOTATATE PET/CT and PET/MRI in Thyroid Eye Disease
Thyroid eye disease is an autoimmune disorder that can cause inflammation and fibrosis of the extraocular muscles and orbital tissues.
- Trial name
- NCT07835607
- Testing
- 68Ga-FAPI PET/CT and PET/MR Imaging, 68Ga-DOTATATE PET/CT and PET/MR Imaging
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Daping Hospital and the Research Institute of Surgery of the Third Military Medical University
Right Heart Insufficiency, Tricuspid Regurgitation
Application of FAPI Visualization in the Assessment of Right Ventricular Dysfunction Due to Volume Overload
\"Bicuspid aortic stenosis represents the most prevalent form of cardiac valve disease, primarily resulting from degenerative alterations and rheumatic conditions that disrupt mitral valve function.
- Trial name
- NCT06663566
- Testing
- Diagnose the patients right heart function as well as right heart fibrosis, Diagnose the patient's right heart function as well as right heart fibrosis
- Where
- China
- Volunteers
- 90 people
- Sponsor
- Beijing Anzhen Hospital
Cancer, Peritoneal Carcinomatosis
Ga68-FAPI-46 PET/CT for Preoperative Assessment of Peritoneal Carcinomatosis
This is a prospective, phase II, non-randomized clinical imaging trial. Ga68-FAPI-46 is a novel radiotracer used in PET/CT imaging, targeting a protein of the tumor microenvironment called FAP (Fibroblast activation protein).
- Trial name
- FAPeCa (NCT06061874)
- Testing
- FAPI PET/CT
- Where
- Belgium
- Volunteers
- 80 people
- Sponsor
- Jules Bordet Institute
Mesotheliomas Pleural
Ga-68 FAPI PET Before Immunotherapy
It is aimed to evaluate FAP expression and its success in predicting treatment response before immunotherapy used in the treatment of malignant mesothelioma with Ga68 FAPI PET/CT imaging, which allows in vivo evaluation of FAP…
- Trial name
- FAPBI (NCT06451536)
- Testing
- Ga-68 FAPI PET/CT
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Ankara University
Breast Cancer, Invasive Breast Cancer
A Study of 68Ga-FAPI Breast PET/MRI Scans in People With Breast Cancer
The purpose of this study is to find out whether it is practical (feasible) to use a new type of imaging scan called 68Ga-FAPI PET/MRI (positron emission tomography/magnetic resonance imaging) to evaluate how well breast cancer…
- Trial name
- NCT07899892
- Testing
- 68Ga-FAPI-PET/MRI
- Where
- 8 sites in United States
- Volunteers
- 10 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
SSTR2, FAP
68Ga-FAPI-LM3 PET/CT Imaging in Patients With FAP/SSTR2 Positive Disease and Compared With 18F-FDG
As a new dual receptor (SSTR2 and FAP) targeting PET radiotracer, 68Ga-FAPI-LM3 is promising as an excellent imaging agent applicable to SSTR2 positive diseases.
- Conditions
- SSTR2, FAP, Positron-Emission Tomography
- Trial name
- NCT05873777
- Testing
- 18F-FDG PET/CT, 68Ga-FAPI-LM3 PET/CT
- Where
- China
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- The First Affiliated Hospital of Xiamen University
Tumor Positron-Emission Tomography
A Head-to-head Comparison of [68Ga]Ga-FAPI and [68Ga]Ga-TATE PET/CT in Patients With Nasopharyngeal Carcinoma: a Single-center, Prospective Study
Both fibroblast activation protein (FAP)-targeted imaging and somatostatin receptors (SSTR)-targeted imaging were the promising imaging modalities for the diagnosis of primary and metastatic nasopharyngeal carcinoma (NPC).
- Trial name
- NCT05990998
- Testing
- 68Ga-DOTATATE and 68Ga-FAPI
- Where
- China
- Volunteers
- 38 people
- Sponsor
- First Affiliated Hospital of Fujian Medical University
ANCA-associated Vasculitis
(68)Ga-FAPI PET/CT in Patients With ANCA-associated Vasculitis
Pulmonary and renal involvement are the most common clinical manifestations of antineutrophil cytoplasmic antibody(ANCA)-associated vasculitis (AAV).
- Trial name
- GFPIPWAAV (NCT07151521)
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Ruijin Hospital
Medullary Thyroid Carcinoma
CTR-FAPI-guided Precision Surgery for Newly Diagnosed MTC
This is a multicenter, randomized, open-label, non-inferiority Phase III clinical trial, aims to compare 68Ga-CTR-FAPI PET-CT-guided surgery to investigator-chosen surgical approaches to evaluate its efficacy in treating newly…
- Trial name
- CAST-MTC (NCT07383246)
- Testing
- 68Ga-CTR-FAPI PET-CT guided surgery, investigator choice of surgery
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences
Positron-Emission Tomography, Magnetic Resonance Imaging
Early Diagnosis of Therapy-associated Cardiotoxicity Basing on Multi-tracer Multimodality PET/MRI
Using Multi-tracer to early diagnosis of therapy-associated cardiotoxicity using multimodality PET/MRI.
- Trial name
- NCT04555642
- Where
- China
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Peking University Cancer Hospital & Institute
Esophageal Cancer, Gastric Cancer (GC)
Using 18F-FAPI PET to Detect Metastatic Disease in Patients That Have Gastric or Esophageal Cancer.
This is a multi-site, open-label, non-randomized, single dose study to assess the clinical utility of [¹⁸F]FAPI-74 PET/CT in the detection of metastatic disease in individuals with pathologically confirmed gastric…
- Conditions
- Esophageal Cancer, Gastric Cancer (GC), Gastroesophageal Junction
- Trial name
- FAPI-GO (NCT07217704)
- Testing
- [18F]FAPI-74 PET/CT
- Where
- 19 sites in United States
- Volunteers
- 200 people
- Sponsor
- SOFIE
Chronic Total Occlusion (CTO), Chronic Coronary Syndrome
FAPI Imaging Predicts Adverse Cardiac Events in Chronic Total Occlusion
Prospective, observational, single-center cohort study Hypothesis Higher myocardial FAPI uptake in CTO patients predicts a greater incidence of major adverse cardiovascular events (MACE) within 12 months after PCI.
- Trial name
- FACT-2 (NCT07020858)
- Testing
- FAPl lmaging
- Where
- China
- Volunteers
- 470 people
- Sponsor
- Lin Zhao
Cancer of Unknown Primary
[18F]F-FAPI PET-CT to Identify Carcinoma of Unknown Primary Origin
The investigators will determine the proportion of CUP patients in whom the primary tumor can be identified by [18F]F-FAPI PET-CT.
- Trial name
- FAPI for CUP (NCT06644716)
- Testing
- [18F]F-FAPI PET-CT
- Where
- 6 sites in Netherlands
- Volunteers
- 50 people
- Sponsor
- Erasmus Medical Center
IgG4-Related Diseases
A Study on the Effect of MRD Detected by FAPI PET / CT on the Recurrence of IgG4-RD
This study intends to use the new technology of fibroblast activation protein PET / CT to study whether the tiny residual lesions detected by 68Ga-FAPI PET / CT are related to the recurrence of IgG4-RD in patients with IgG4-RD…
- Trial name
- NCT07104058
- Testing
- 68Ga-FAPI PET / CT
- Where
- China
- Volunteers
- 46 people
- Sponsor
- Luo Yaping
Psoriatic Arthritis
FAPI-PET/CT in Psoriatic Arthritis
68Ga-FAPI has been developed as a tumor-targeting agent as fibroblast activation protein is overexpressed in cancer-associated fibroblasts and some inflammation, such as IgG4-related disease.
- Trial name
- NCT05686876
- Testing
- 68Ga-FAPI
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Peking Union Medical College Hospital
Hepatocellular Carcinoma, Bile Duct Cancer
FAPI PET for Response Evaluation and Prognosis Prediction in Liver and Biliary Cancer Patients Treated With PD-1 Combination Therapy
The purpose of this study is to explore the ability of positron emission tomography (PET) with [68Ga]FAPI to detect, evaluate treatment response, and predict prognosis in advanced liver and biliary cancer patients treated with…
- Trial name
- NCT05662488
- Testing
- [68Ga]FAPI PET/CT and [18F]FDG PET/CT
- Where
- China
- Volunteers
- 25 people
- Sponsor
- Peking Union Medical College Hospital
Pancreatic Ductal Adenocarcinoma (PDAC)
Cutting Edge Imaging With PET-FAPI for Earlier Pancreatic Cancer Diagnosis (INDIGO-FAPI)
Assessment of the relevance of a new medical imaging test, FAPI PET, which could detect progression or relapse earlier than other tests currently available.
- Trial name
- INDIGO-FAPI (NCT06659705)
- Testing
- 68Ga-FAPI-46 for PET / CT scan
- Where
- France
- Volunteers
- 35 people
- Sponsor
- Institut Curie
Advanced Colorectal Cancer
The Role of 18F-FDG and 68Ga-FAPI PET/CT in the Diagnosis and the Efficacy Evaluation of Advanced Colorectal Cancer (peritoneal Metastasis With/without Other Metastases)
This study aims to investigate the value of 18F-FDG and 68Ga-FAPI PET/CT in evaluating the outcome of conversion therapy and the prognosis of advanced colorectal cancer (peritoneal metastasis with/without other metastases)
- Trial name
- NCT06601075
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Ruijin Hospital
Rectal Neoplasms Malignant
FAPI in Rectal Cancer TNT
The goal of the trial is to observe the changes of 68Ga FAPI signal before and after total neoadjuvant therapy for rectal cancers, and the correlation between the image parameters, immune checkpoints expression as well as the…
- Trial name
- NCT06157463
- Testing
- Ga-68 FAPI
- Where
- Taiwan
- Volunteers
- 99 people
- Sponsor
- Chang Gung Memorial Hospital
Gastric Cancer
18F-FAPI PET/CT and MRI in Gastric Cancer
The purpose of this study was to evaluate the diagnostic efficacy and prognostic value of 18F-FAPI PET/CT combined with multiparameter MRI in gastric cancer.
- Trial name
- NCT07510867
- Testing
- patients with suspected or confirmed gastric cancer who have undergone 18F-FAPI PET/CT and MRI (non-contrast + contrast-enhanced scans)
- Where
- China
- Volunteers
- 230 people
- Sponsor
- First Affiliated Hospital of Zhejiang University