Clinical trials: FLU
Influenza
Reactogenicity, Safety and Immunogenicity of a LAIV H7N9 Influenza Vaccine
This is a single centre phase I, double-blind placebo-controlled study to assess reactogenicity, safety and immunogenicity of a live monovalent A/17/Anhui/2013/61 (H7N9) influenza vaccine in healthy male and female adults, 18…
- Trial name
- NCT02480101
- Testing
- H7N9 live influenza vaccine
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Research Institute of Influenza, Russia
Immune Deficiency, Metabolic Syndrome
Impact of Metabolic Syndrome on Flu Vaccine Efficacy
Metabolic syndrome (MetS) is a cluster of metabolic conditions associated with obesity that predispose individuals to coronary heart diseases and diabetes but obesity has been shown to increase the risks of other diseases like…
- Trial name
- NCT02653495
- Testing
- Influenza vaccine
- Where
- United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Rockefeller University
Influenza Viral Infections
Intradermal Influenza Vaccine in the Young
Influenza poses a heavy burden to our health service. The WHO estimates that seasonal influenza causes 250,000-500,000 deaths worldwide each year.
- Trial name
- NCT02103023
- Testing
- Imiquimod ointment, Aqueous cream, Intradermal influenza vaccine
- Where
- China
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- The University of Hong Kong
Influenza
Immunogenicity and Safety of PrepandrixTM in Korean Subjects Aged 18 to 60 Years Old
This study will evaluate the immunogenicity and the safety of PrepandrixTM in Korean subjects. A second group of subjects will receive FluarixTM vaccine as control.
- Trial name
- NCT01730378
- Testing
- Prepandrix™, Fluarix™
- Where
- 4 sites in South Korea
- Volunteers
- 131 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Influenza
Infectivity, Replication & Immunogenicity of Live nH1N1 Vaccine
The purpose of the study is to determine the amount of live virus that can be recovered from the nose of people who are vaccinated with the licensed live vaccine against H1N1, and to describe the immune response to vaccination.
- Trial name
- NCT01023776
- Testing
- A/California/07/09 live monovalent H1N1 vaccine
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Rochester
Respiratory Tract Infections
Comparison of Nasopharyngeal Swab v. Nasopharyngeal Saline Wash or Saliva Collection in Testing for Respiratory Viruses
Respiratory tract infections (RTIs) are prevalence community diseases and is the third leading cause of death worldwide. Rapid diagnosis of RTIs is essential as it drives decision points such as treatment, disposition, and…
- Trial name
- NCT05864118
- Testing
- Respiratory pathogen panel PCR test, COVID-19 antibody test
- Where
- United States
- Volunteers
- 1,000 people
- Sponsor
- University of Nebraska
Influenza
Human Infection Study of H3N2 Influenza in Healthy Adults
This study will examine how the immune system responds to a flu virus (H3N2) during and after infection in health adults aged between 18 and 50 while in an inpatient facility.
- Trial name
- FluCHIM (NCT06972810)
- Testing
- A/Texas/71/2017, clade 3C3a H3N2 influenza virus
- Where
- Australia
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- University of Melbourne
Influenza Vaccination
Evaluation of the Effectiveness of a Flu Vaccination Campaign for Healthcare Workers of a Teaching Hospital: a Pre-post Study
The goal of this observational study is to evaluate the effectiveness of the vaccination strategy implemented during the 2019/2020 flu vaccination campaign compared with the previous one.
- Trial name
- NCT05783713
- Testing
- Influenza Vaccination
- Where
- Italy
- Volunteers
- 10,737 people, healthy volunteers welcome
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Influenza
Response to Live Attenuated Influenza Vaccine in Tonsillar Tissues and Blood
This is one project of a larger ongoing study related to the immune system's response to the flu virus. This study is designed to investigate the immune response to a nasal flu immunization in tonsillar tissue compared to what…
- Trial name
- FLU-Tonsil (NCT03884296)
- Testing
- FluMist
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Stanford University
Influenza
Drug Use Investigation for Arepanrix® (H1N1)
This post-marketing surveillance study is designed to collect safety information such as post-vaccination adverse events and adverse reactions from recipients of Arepanrix® (H1N1) Intramuscular Injection.
- Trial name
- NCT02069496
- Testing
- Arepanrix®
- Volunteers
- 3,405 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Atrial Fibrillation
Screening for Silent Atrial Fibrillation During Influenza Vaccination
Silent atrial fibrillation is an important cause of unnecessary strokes. If diagnosed and treated in time with anticoagulants, many disabling strokes can be prevented.
- Trial name
- NCT02006524
- Testing
- 'MyDiagnostick
- Where
- Netherlands
- Volunteers
- 3,269 people, healthy volunteers welcome
- Sponsor
- UMC Utrecht
Influenza
Influenza Vaccination in Bone Marrow Transplantation
The purpose of this study is to determine whether influenza vaccination protects patients who receive a certain type of bone marrow transplantation.
- Trial name
- NCT00419224
- Testing
- inactivated split-virus influenza vaccine
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- The Cleveland Clinic
Human Influenza
Safety and Immunogenicity of One Dose of Seasonal Trivalent Influenza Virus Vaccine (TIVf, Purified Surface Antigen, Inactivated, Egg Derived) in Adults, Aged 18 Years and Above
The present study is designed to confirm the safety and immunogenicity of trivalent, surface antigen, inactivated influenza vaccine in 2 age cohorts: 18 to ≤60 years and ≥61 years and the antibody response to each influenza…
- Trial name
- NCT01885117
- Testing
- TIVf
- Where
- Germany
- Volunteers
- 125 people, healthy volunteers welcome
- Sponsor
- Novartis Vaccines
Avian Influenza
H5N8 Mix and Match With or Without AS03 or MF59 in Healthy Adults: Immunology
This is a Phase I cohort-randomized, double-blind, controlled trial designed to assess the safety, reactogenicity, and immunogenicity of a monovalent inactivated influenza A/H5N8 virus vaccine administered at different dosages…
- Trial name
- NCT03014310
- Testing
- AS03, MF59, Monovalent Influenza A/H5N8 vaccine
- Where
- 7 sites in United States
- Volunteers
- 388 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Influenza
Efficacy of MVA-NP+M1 in the Influenza H3N2 Human Challenge Model
A Phase 2, single center, randomized, double blind study evaluating the safety, efficacy, and immunogenicity of MVA NP+M1 in the H3N2 human influenza challenge model; on healthy adult volunteers.
- Trial name
- NCT03883113
- Testing
- MVA-NP+M1, Saline, H3N2 (A/Belgium/2417/2015)
- Where
- Belgium
- Volunteers
- 145 people, healthy volunteers welcome
- Sponsor
- Barinthus Biotherapeutics
Influenza, Human, Infections
Study to Evaluate Safety and Immunogenicity of Different Priming and Booster Regimens With Adjuvanted H5N8 and/or H5N6 Influenza Vaccine in Adults
This Phase 2, randomized, observer-blind clinical study is evaluating 3 different priming and booster regimens with MF59-adjuvanted H5N8 and/or H5N6 cell culture-derived influenza vaccine (aH5N8c; aH5N6c).
- Conditions
- Influenza, Human, Infections, Respiratory Tract Infections, Virus Diseases
- Trial name
- NCT05874713
- Testing
- aH5N8c on Day 1, aH5N6c on Day 1, aH5N8c on Day 22
- Where
- 9 sites in United States
- Volunteers
- 480 people, healthy volunteers welcome
- Sponsor
- Seqirus
Mamma Carcinoma, Heart Failure
Response to Influenza Virus Vaccination in Patients Immunocompromised Due to Chemotherapy
Patients treated with chemotherapy or immunosuppressives are at higher risk of influenza infection and mortality and morbidity are higher compared to healthy adults.
- Trial name
- RIFLUVAC (NCT01000246)
- Testing
- influenza virus vaccine (influvac or vaxigrip)
- Where
- 8 sites in Netherlands
- Volunteers
- 50 people
- Sponsor
- St. Antonius Hospital
Influenza
Safety and Immunogenicity of a Commercially Available Influenza Vaccine (Formulation 2006/2007) When Administered to Subjects 18 Years of Age or Older
To evaluate the antibody response to each influenza vaccine antigen when administering a single dose to subjects aged 18 years and over
- Trial name
- NCT00329966
- Testing
- Surface Antigen, Inactivated, Influenza (form.2006-07)
- Where
- 2 sites in Italy
- Volunteers
- 100 people
- Sponsor
- Novartis
Influenza
Alternative Oseltamivir Dosing Strategies
This study will determine if oseltamivir (Tamiflu(Registered Trademark)) is safe and effective given less frequently than the currently prescribed dose of twice a day for 5 days to people who have the flu, and once a day for up…
- Trial name
- NCT00334529
- Testing
- Oseltamivir
- Where
- 4 sites in United States
- Volunteers
- 48 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Vaccination, Influenza
Influenza Vaccine Attitudes, Intent, and Receipt: Pediatric
Influenza vaccine is recommended as routine care for all individuals who are at least 6 months of age and older. Recently, questions about vaccine safety and concerns for side effects have increased, contributing to both…
- Trial name
- NCT02907580
- Testing
- Local educational information, National educational information
- Where
- United States
- Volunteers
- 400 people
- Sponsor
- Columbia University
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