Clinical trials: Facial Rhytides
Dermal Fillers, Cheek Augmentation
Evaluation of Performance and Safety of Injectable KIO017 Device Range for Facial Tissue Filling
The goal of this clinical trial is to primarily evaluate the performance of KIO017 in filling/volumizing after injection in different areas in healthy women or men, older than 18 years and seeking an improvement of her/his face…
- Conditions
- Dermal Fillers, Cheek Augmentation, Lip Augmentation, Perioral Rhytids
- Trial name
- LITCHEE (NCT06872359)
- Testing
- KIO017-1, KIO017-2, KIO017-3
- Where
- 3 sites in France, Poland
- Volunteers
- 210 people, healthy volunteers welcome
- Sponsor
- Kiomed Pharma
Facial Wrinkles
Evaluation of Safety and Efficacy of the 3F Applicator (A3F) for Treatment of Facial Wrinkles
The 3F Applicator (A3F) is indicated for use in dermatological procedures requiring ablation and resurfacing of the skin, and for the treatment of facial wrinkles.
- Trial name
- NCT01566396
- Testing
- A3F
- Where
- 2 sites in United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Pollogen
Facial Rhytides
Study of the MyoScience Tissue Remodeling Device for Facial Rejuvenation
A prospective, non-randomized study to evaluate the performance of the MyoScience Tissue Remodeling Device for the treatment of glabellar lines (frown lines), lateral orbital lines (crow's feet), and frontalis lines (horizontal…
- Trial name
- NCT00842062
- Testing
- MyoScience Tissue Remodeling Device
- Where
- United States
- Volunteers
- 380 people, healthy volunteers welcome
- Sponsor
- Pacira Pharmaceuticals, Inc
Wrinkles, Folds
A Clinical Investigation Comparing the Safety and Performance of RefillHA Solid With Hydryalix Ultra Deep Lidocaine for the Correction of Moderate-to-severe Nasolabial Folds
Prospective, controlled, randomized, monocentric, double-blind, split-face non-inferiority clinical study to evaluate the safety and performance of injectable implant based on hyaluronic acid hydrogel with lidocaine for…
- Trial name
- NCT07736703
- Where
- Israel
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Glyance
Nasolabial Folds
Evaluate Efficacy, Safety & Subject Satisfaction of Pain Management With Pliaglis® Cream for Dermal Filler Injections
Pliaglis® Cream versus compounded topical anesthetic for pain management during Restylane® injections for the correction of nasolabial folds.
- Trial name
- NCT00716443
- Testing
- tetracaine 7% / lidocaine 7% cream (Pliaglis® Cream), benzocaine 20% / lidocaine 6% / tetracaine 4% ointment
- Where
- 4 sites in United States
- Volunteers
- 51 people
- Sponsor
- Galderma R&D
Lipoatrophy, Aging
Safety Study of Antria Cell Preparation Process to Enhance Facial Fat Grafting With Adipose Derived Stem Cells
The primary purpose of this study is to demonstrate the safety of injecting the Stromal Vascular Fraction (SVF) [containing Adipose Derived Stem Cells (ADSCs)] enriched fat grafts into regions of the face that require…
- Conditions
- Lipoatrophy, Aging, Wrinkles
- Trial name
- NCT01828723
- Testing
- SVF
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Antria
Wrinkles
Post-market Clinical Follow-up (PMCF) Study of Safety and Performance of 502-01 AnGelHA 2
Post-market clinical follow-up (PMCF) investigation to evaluate the performance and safety of AnGelHA 2 filler for the correction of moderate to severe wrinkles and folds and facial contour remodeling, in a routine clinical…
- Trial name
- NCT07495865
- Where
- Israel
- Volunteers
- 87 people, healthy volunteers welcome
- Sponsor
- Glyance
Facial Wrinkles
Evaluation of Safety and Efficacy of TriPollar Device for Treatment of Wrinkles
The TriPollar is intended for non invasive treatment of facial wrinkles and rhytides. This study was designed in order to evaluate the safety and efficacy of the TriPollar.
- Trial name
- NCT01858415
- Testing
- TriPollar
- Where
- 2 sites in United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Pollogen
Sin Health, Skin Hydration
Clinical Study to Evaluate the Impact of aKwa Skincare System on Skin Health
The purpose of the study was to evaluate the effectiveness of the äKwä 6-step skincare system by measuring skin moisture level, fine lines and wrinkles, porphyrin count, red spots, and red vasculature counts over a 30-day period.
- Conditions
- Sin Health, Skin Hydration, Skin Wrinkles, Skin Porphyrins
- Trial name
- NCT05476406
- Testing
- äKwä skincare system products, competitor products (control)
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- 4Life Research, LLC
Upper Facial Rhytides, Crow's Feet Lines
BOTOX® in the Treatment of Upper Facial Lines in Japan
This study will evaluate the safety and efficacy of BOTOX® (botulinum toxin Type A) for the treatment of upper facial lines (Crow's Feet Lines and Frown Lines).
- Conditions
- Upper Facial Rhytides, Crow's Feet Lines, Glabellar Lines, Frown Lines
- Trial name
- NCT01797094
- Testing
- botulinum toxin Type A (44U), botulinum toxin Type A (32U)
- Where
- Japan
- Volunteers
- 101 people
- Sponsor
- Allergan
Wrinkle
A Comparative Analysis of Two Hyaluronic Acid Fillers for Nasolabial Fold Correction
This is a randomized, split-face, subject-blinded, comparative study. Subjects will receive initial treatment with Defyne on one of the NLFs and with RHA3 on the other based on the pre-determined randomization.
- Trial name
- NCT06351293
- Testing
- Defyne Treatment in Nasolabial Fold, RHA3 Treatment in Nasolabial Fold
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Galderma R&D
Lax Skin, Improve Facial Wrinkles
In Vivo Study to Evaluate Tissue Remodeling Via Fibroblast Stimulation Following a Single SofWave Treatment
Open-label, non-randomized single-arm prospective, single-center, self-controlled clinical study.
- Trial name
- NCT07685821
- Testing
- Sofwave
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Sofwave Medical LTD
Photoaging, Wrinkle
Same-Day Combination of VI Peel and Botox for Correction of Sun Damage, Fine Lines and Wrinkles
This study is being conducted to improve standards of care in the cosmetic treatment of sun damage, fine lines, and wrinkles. VI Peels® and Botox® have been used cosmetically to improve patient concerns as monotherapies.
- Conditions
- Photoaging, Wrinkle, Sun Damaged Skin
- Trial name
- NCT05162300
- Testing
- Same Day Intervention of VI Peel (Procedure) and Botulinum Toxin (Drug)
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Vitality Institute Medical Products
Correction of Nasolabial Folds and Lip Augmentation
PREVELLE Shape (CX002) Dermal Filler Protocol
The purpose of this study was to assess PREVELLE Shape (CX002), with respect to safety and efficacy for one year following treatment, for correction of facial nasolabial folds and when applied as an intradermal implant for lip…
- Trial name
- NCT00764257
- Testing
- PREVELLE Shape, Restylane
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Mentor Worldwide, LLC
Skin Aging, Skin Wrinkling
Evaluation of the Safety and Performance Characteristics of Mesofiller Aox for the Correction of Mild and Moderate Facial Wrinkles.
The investigation is a single centre, interventional, prospective, non-randomized, open-label, uncontrolled, single arm, un-blinded investigation for evaluation of safety and performance of the medical device M-AOX-2021 in the…
- Trial name
- NCT06486740
- Testing
- mesofiller aox
- Where
- Bulgaria
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Mesoestetic Pharma Group S.L.
Temporary Correction of Wrinkles
Clinical Study to Evaluate the Correction of Facial Wrinkles and Folds and Safety of YVOIRE Volume Versus Perlane in Nasolabial Fold Injection
This study was purposed to evaluate the non-inferiority of YVOIRE volume, a hyaluronic acid product, in terms of correction of wrinkles and safety in nasolabial fold deep-dermal injection, compared to Perlane, the control…
- Trial name
- NCT03738007
- Testing
- HA IDF II, Perlane
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- LG Life Sciences
Lateral Canthal Lines, Crow's Feet
Safety and Efficacy Study of RT001 to Treat Moderate to Severe Lateral Canthal Lines
The purpose of this study is to evaluate the efficacy and safety of a single administration of RT001 compared to placebo gel for the treatment of moderate to severe lateral canthal lines.
- Conditions
- Lateral Canthal Lines, Crow's Feet, Facial Wrinkles
- Trial name
- NCT00968825
- Testing
- Botulinum Toxin Type A
- Where
- United States
- Volunteers
- 73 people, healthy volunteers welcome
- Sponsor
- Revance Therapeutics, Inc.
Upper Facial Lines (Glabellar Lines, Forehead Lines, & Lateral Canthal Lines)
Recombinant Collagen Freeze-Dried Fibre for Upper Facial Wrinkles
The goal of this clinical trial was to learn whether a collagen filler improved facial wrinkles. The study product was injectable recombinant collagen freeze-dried fibers.
- Trial name
- NCT07897773
- Testing
- Recombinant Collagen Freeze-Dried Fibers, Collagen Implant
- Where
- China
- Volunteers
- 192 people
- Sponsor
- Shaanxi Giant Biotechnology Co., Ltd
Skin Manifestations
Study to Evaluate the Safety and Effectiveness of GP0116
This is a prospective, randomized, evaluator-blinded, comparator-controlled, parallel group, multicenter study in the U.S. for correction of moderate to severe dynamic facial wrinkles and folds, such as nasolabial folds (NLFs).
- Trial name
- NLF (NCT05987163)
- Testing
- GP0116, Active Comparator: FDA approved dermal filler device (RHA 3)
- Where
- 19 sites in United States, Puerto Rico
- Volunteers
- 186 people
- Sponsor
- Galderma R&D
Skin Aging
Clinical Trial to Assess Efficacy, Safety and Tolerability of Botulinum Toxin A (Xeomin®) in Treatment of Expression Wrinkles in the Upper Third of the Face
The purpose of this study is to determinate whether Xeomin® (Botulinum toxin Type A) is safe, effective and tolerable in woman aged 30 to 50 years old for treatment of mild, moderate or severe expression lines (wrinkles) in the…
- Trial name
- XEO-001/07 (NCT00986570)
- Testing
- Botulinum Toxin A
- Where
- Brazil
- Volunteers
- 121 people, healthy volunteers welcome
- Sponsor
- Biolab Sanus Farmaceutica