Clinical trials: Failure of Extubation
Weaning Failure, Mechanical Ventilation
The Value of Repeated BIOMarker Measurements During an SBT to Predict EXtubation Failure in ICU Patients
The Value of Repeated BIOMarker Measurements During an SBT to Predict EXtubation Failure in Mechanically Ventilated ICU Patients
- Conditions
- Weaning Failure, Mechanical Ventilation, Spontaneous Breathing Trial, Extubation Failure
- Trial name
- BIOMEXIC (NCT05637099)
- Where
- Netherlands
- Volunteers
- 181 people
- Sponsor
- Henrik Endeman
Extubation Failure, Mechanical Ventilation
Swallowing Assessment for Predicting Extubation Failure in Critically Ill Patients
Extubation failure, defined as the need for reintubation after planned removal of the endotracheal tube, occurs in up to 20% of critically ill patients and is associated with prolonged mechanical ventilation, longer intensive…
- Conditions
- Extubation Failure, Mechanical Ventilation, Critical Illness
- Trial name
- APEX (NCT07659275)
- Where
- Brazil
- Volunteers
- 800 people
- Sponsor
- Universidade Federal de Pernambuco
Extubation Failure
Noninvasive Ventilation Versus High-Flow Nasal Cannula After Extubation in High-Risk ICU Patients
Extubation failure is associated with increased morbidity and mortality in critically ill patients. High-risk patients may benefit from preventive respiratory support after extubation.
- Trial name
- NIV-HFNC (NCT07630766)
- Testing
- NIV, HFNC
- Where
- Egypt
- Volunteers
- 102 people
- Sponsor
- Benha University
Post Extubation Respiratory Failure
Non-Invasive Ventilation Versus High-flow Nasal Oxygen in Intensive Care Units
In intensive care units (ICUs), around 20% of patients experience respiratory failure after planned extubation. Nearly 40-50% of them eventually require reintubation with subsequently high mortality rates reaching 30-40%.
- Trial name
- VENTILO (NCT05686850)
- Testing
- High-Flow Oxygen, Non invasive ventilation
- Where
- 47 sites in Belgium, France and 3 more
- Volunteers
- 670 people
- Sponsor
- Poitiers University Hospital
Acute Respiratory Failure, Airway Extubation
The Maximizing Extubation Outcomes Through Educational and Organizational Research (METEOR) Trial
The METEOR Trial will compare four implementation strategies-traditional online education, protocol-directed care, interprofessional education, and a combination of protocol-directed care and interprofessional education-to test…
- Trial name
- METEOR (NCT05523479)
- Testing
- Traditional online education, Interprofessional education, Clinical protocol
- Where
- 17 sites in United States
- Volunteers
- 13,018 people
- Sponsor
- University of Pittsburgh
Ventilator Weaning, Respiration, Artificial
A New Tool for Extubation Readiness in Mechanically Ventilated Patients: Readiness for EXtubation Score
Liberation from mechanical ventilation involves three steps: weaning, readiness assessment, and extubation. Readiness is determined using clinical criteria such as improvement of the underlying condition, hemodynamic stability…
- Conditions
- Ventilator Weaning, Respiration, Artificial, Respiratory Failure, Extubation Readiness
- Trial name
- REXs (NCT07098611)
- Where
- 7 sites in Chile, Egypt and 4 more
- Volunteers
- 470 people
- Sponsor
- Medipol University
Mechanical Ventilation, Extubation
Spontaneous Breathing Trials Using Pressure Support or T-Piece in Overweight and Obese Patients
This study aims to find out which method of spontaneous breathing trial (SBT) better helps overweight and obese ICU patients prepare for extubation, which is the removal of the breathing tube.
- Conditions
- Mechanical Ventilation, Extubation, Obesity &Amp; Overweight, Respiratory Failure
- Trial name
- NCT07114289
- Testing
- Spontaneous breathing trial using pressure support ventilation, Spontaneous breathing trial using T-Piece
- Where
- Taiwan
- Volunteers
- 100 people
- Sponsor
- Taipei Medical University Hospital
Extubation Failure, Ventilated Patients
Factors Associated With Extubation Failure in Kanigara ICU (Intensive Care Unit) RSUPN Dr. Cipto Mangunkusumo
Extubation is the final stage after patients undergo weaning procedure from mechanical ventilation in the ICU. Extubation failure followed by reintubation is associated with worse patient outcomes, including prolonged length of…
- Trial name
- NCT07038291
- Testing
- Not applicable- observational study
- Where
- Indonesia
- Volunteers
- 156 people
- Sponsor
- Universitas Indonesia
Respiratory Failure, Post Extubation Acute Respiratory Failure Requiring Reintubation
Effect of HFNO Therapy on Respiratory Effort After Extubation
Rationale: Despite the lack of clear clinical protocols, High Flow Nasal Oxygen (HFNO) is used as post-extubation respiratory support.
- Trial name
- T-REX (NCT05652699)
- Testing
- High Flow Nasal Oxygen, Conventional Oxygen Therapy
- Where
- 2 sites in Netherlands
- Volunteers
- 42 people
- Sponsor
- Henrik Endeman
Post Extubation Respiratory Failure
The Effectiveness of High-flow Nasal Cannula After Extubation in Patients
Observe the current status of prolonged mechanical ventilation (PMV) patients using high-flow nasal cannula oxygen therapy (experimental group) or traditional oxygen therapy (control group) after extubation, and compare the…
- Trial name
- NCT06746363
- Where
- Taiwan
- Volunteers
- 110 people
- Sponsor
- Chang Gung Memorial Hospital
Mechanical Ventilation, Spontaneous Breathing Trial
Trial of Spontaneous Breathing Test
The hypothesis is that the Spontaneous Breathing Test (SBT) without pressure support (PS) is not inferior to the SBT with pressure support in relation to the following outcomes: a) extubation failure; b) time on MV.
- Conditions
- Mechanical Ventilation, Spontaneous Breathing Trial, Extubation Readiness, Extubation Failures
- Trial name
- NCT06593288
- Testing
- Pressure Support Ventilation, continuous positive airway pressure (CPAP)
- Where
- Brazil
- Volunteers
- 170 people
- Sponsor
- University of Sao Paulo
Post Extubation Respiratory Failure
The Effectiveness of High Flow Nasal Cannula Versus Noninvasive Ventilation and Conventional Oxygen Therapy
A prospective, randomized controlled study enrolling sixty patients who fulfilled weaning criteria after requiring invasive MV. After extubation, patients were randomized into three groups (20 patients per group) :NIV group …
- Trial name
- NCT06593509
- Testing
- Maquet,Servo I., Vapotherm, venturi mask
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Ain Shams University
Extubation Failure
Risk Factors of Extubation Failure in PICU Patients
Up to 20% of MV patients experience EF [10]. EF is defined as the need to reinsert the endotracheal tube to resume MV in patients extubated for less than 48 hours.
- Trial name
- NCT06557941
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Sohag University
Anesthesia, Intubation
Impact of Extubation Location After Surgery on Perioperative Times
The additional time required to awaken a patient is one of the main reasons for not extubating him or her in the operating room (OR).
- Conditions
- Anesthesia, Intubation, Surgery, Extubation
- Trial name
- Extub_Loca (NCT06249659)
- Testing
- Extubation in operative room, Extubation in post anesthesia care unit
- Where
- France
- Volunteers
- 756 people
- Sponsor
- University Hospital, Clermont-Ferrand
Pulmonary Ultrasound, Weaning Failure
Predictive Value of Chest Ultrasound Observation on Extubation Failure
The use of mechanical ventilation in intensive care concerns the majority of patients, most often to compensate for respiratory failure, but for other organic failures requiring therapeutic artificial coma.
- Conditions
- Pulmonary Ultrasound, Weaning Failure, Ultrasound, Lung Edema
- Trial name
- ECHOEXTUB (NCT05944588)
- Testing
- Pulmonary Ultrasound
- Where
- France
- Volunteers
- 150 people
- Sponsor
- University Hospital, Caen
Dexmedetomidine, Midazolam
Prospective, Randomized, Open Label Controlled Trial To Evaluate The Safety And Efficacy Of Dexmedetomidine Use Beyond 24 Hours Compared With Midazolam In Children Admitted To Pediatric Intensive Care Unit at King Abdullah Specialist Children Hospital- Ministry of National Guard Health Affairs.
Study will be conducted in Pediatric Intensive Care Unit (PICU) in King Abdullah Specialist Children Hospital (KASCH), National Guard Health Affairs, Riyadh, Saudi Arabia.
- Conditions
- Dexmedetomidine, Midazolam, Withdrawal Symptoms, Failure of Extubation
- Trial name
- PROMISE (NCT05485519)
- Testing
- Dexmedetomidine, Midazolam
- Where
- Saudi Arabia
- Volunteers
- 430 people
- Sponsor
- King Abdullah International Medical Research Center
Extubation Failure
Ventilation Support for the PREvenTion of EXTubation Failure
Reintubation after failed extubation would be associated with increased mortality. Therefore, extubation failure remains a major concern in ICU.
- Trial name
- PRETEEXT (NCT05550259)
- Testing
- protocolized postextubation support
- Volunteers
- 1,100 people
- Sponsor
- University Hospital, Caen
Extubation Failure
Performance of the Variation in Arterial Lactatemia During a Spontaneous Breathing Trial (SBT) in the Prediction of Extubation Failure
Extubation failure (EF) is independently associated with excess mortality of critically ill patients. To avoid EF, critically ill patients being weaned from invasive mechanical ventilation (IMV) perform spontaneous breathing…
- Trial name
- PREDILACT (NCT05487573)
- Where
- France
- Volunteers
- 242 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Extubation Failure
Postextubation High-flow Therapy vs Noninvasive Ventilation in Obese or at High-risk Patients
The main aim is to demonstrate whether reintubation rate is lower with preventive conditioned noninvasive ventilation (NIV) rather than with High-flow oxygen therapy (HFOT) in obese intermediate-risk patients and in high-risk…
- Trial name
- HINFOR (NCT04125342)
- Testing
- Preventive Conditioned NIV Therapy after planned extubation, Preventive HFOT after planned extubation
- Where
- 2 sites in Spain
- Volunteers
- 326 people
- Sponsor
- Hospital Virgen de la Salud
Non-inferiority, in Terms of Extubation Failure, Continuation of Enteral Nutrition Before Extubation Versus Gastric Vacuity Peri-extubation
Non-inferiority Study of the Pursuit of Enteral Nutrition Compared to a Strategy of Gastric Emptiness Peri-extubation. Cluster Randomized Trial
Approximately 50 to 60% of ICU patients are subjected to invasive mechanical ventilation-through a tracheal tube. Extubation consists of a key moment for the patient on the road to recovery (1).
- Trial name
- AMBROISIE (NCT03335345)
- Testing
- maintaining calorie intake, maximum gastric vacuity
- Where
- 22 sites in France, Guadeloupe
- Volunteers
- 1,148 people
- Sponsor
- Centre Hospitalier le Mans