Clinical trials: Fallot Tetralogy
Tetralogy of Fallot (TOF), Ventricular Septal Defects (VSD)
Measures to Lower the Stress Response in Pediatric Cardiac Surgery
Cardiac surgery induces a measurable stress response in patients which leads to increased morbidity and mortality post-operatively.
- Conditions
- Tetralogy of Fallot (TOF), Ventricular Septal Defects (VSD), Atrioventricular Septal Defects (AVSD)
- Trial name
- NCT00848393
- Testing
- Fentanyl (High Dose), Fentanyl (Low Dose), Fentanyl (Low Dose) + Dexmedetomidine
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- Nationwide Children's Hospital
Tetralogy of Fallot, Lymphatic
Lymphatic Magnetic Resonance Imaging Abnormalities in Children With Tetralogy of Fallot: A Case-Control Study
This study examines subclinical lymphatic abnormalities in Tetralogy of Fallot patients, utilizing lymphatic magnetic resonance and near-infrared fluorescence imaging.
- Trial name
- NCT06097377
- Where
- Denmark
- Volunteers
- 10 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Tetralogy of Fallot (TOF), Ventricular Tachycardia
Validation of ECG-Based Ventricular Arrhythmia Localization Algorithms in Patients With Repaired Tetralogy of Fallot
Doctors use patterns on heart rhythm tracings (ECGs) to predict where abnormal heart rhythms originate, but these prediction methods were developed in people with normal heart structure.
- Trial name
- NCT07607821
- Testing
- RV and LV pace mapping
- Volunteers
- 30 people
- Sponsor
- Boston Children's Hospital
Heart Defects, Congenital, Tetralogy of Fallot
Physical Capacity and Activity in Children With Congenital Heart Disease
Congenital malformations correspond to defects in organ morphogenesis identifiable at birth or intrauterine life, affecting 2-3% of births.
- Trial name
- NCT03275844
- Testing
- Physical activity assessment
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Rodrigo Torres
Post Tetralogy of Fallot Repair Arrhythmias and Echocardiographic Changes
Echo, ECG and Holter Findings After Fallot Repair in Children
Aim of my study is to detect echocardiographic, ECG and Holter changes in children who have undergone surgical repair of Tetralogy of Fallot.
- Trial name
- NCT07704346
- Testing
- echocardiography , 12-lead ECG and Holter ECG
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Sohag University
Congenital Heart Disease, Coarctation of Aorta
An Integrated Prenatal and Postnatal Treatment Model for the Treatment of Newborns With Critical Congenital Heart Disease
The purpose of this two-way cohort study was to explore whether an integrated prenatal and postnatal treatment model for neonates with critical congenital heart disease (CCHD) could be effective in avoiding preoperative…
- Conditions
- Congenital Heart Disease, Coarctation of Aorta, Aortic Stenosis, Pulmonary Atresia
- Trial name
- NCT06768008
- Where
- China
- Volunteers
- 10,000 people
- Sponsor
- Beijing Anzhen Hospital
Congenital Heart Disease, Aortic Root Dilatation
Predictors of Aortic Root Dilatation in Tetralogy of Fallot Patients
To predict vulnerable patients for aortic root dilatation in TOF patients using CT as a reliable imaging modality, thus aiding early intervention, and identifying those who will require strict follow-up.
- Conditions
- Congenital Heart Disease, Aortic Root Dilatation, Tetralogy of Fallot
- Trial name
- NCT06081855
- Testing
- CT
- Volunteers
- 77 people, healthy volunteers welcome
- Sponsor
- Assiut University
Congenital Heart Disease
Imaging by 4 DFlow in Patients With Tetralogy of Fallot
Conventionnal cadiac magnetic resonance (CMR) is the reference to assess changes in right heart flow and pulmonary artery hemodynamics in patients with repaired Tetralogy of Fallot.
- Trial name
- 4DFlowFallot (NCT03542968)
- Testing
- magnetic resonance imaging
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Centre Chirurgical Marie Lannelongue
Congenital Heart Disease, Congenital Heart Defect
Myocardial FIbrosis in Repaired Tetralogy of FAllot- FIFA Study)
This study aims to study the correlation between biomarkers of myocardial fibrosis (extracellular volume fraction calculated by cardiac magnetic resonance imaging (MRI) (T1-mapping) and levels of molecular biomarkers of fibrosis)…
- Conditions
- Congenital Heart Disease, Congenital Heart Defect, Fallot Tetralogy
- Trial name
- FIFA (NCT04737135)
- Testing
- Non intervention
- Where
- 7 sites in Spain
- Volunteers
- 224 people
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
Pulmonary Disease, Transcatheter Pulmonary Valve Replacement (TPVR)
ALTERRA: SAPIEN 3 THV With the Alterra Adaptive Prestent
To demonstrate the safety and effectiveness of the Edwards Alterra Adaptive Prestent in conjunction with the Edwards SAPIEN 3 Transcatheter Heart Valve (THV) System in subjects with a dysfunctional right ventricular outflow…
- Conditions
- Pulmonary Disease, Transcatheter Pulmonary Valve Replacement (TPVR), Tetralogy of Fallot, Congenital Heart Disease
- Trial name
- NCT03130777
- Testing
- Edwards Alterra Adaptive Prestent with SAPIEN 3 THV
- Where
- 14 sites in United States
- Volunteers
- 86 people
- Sponsor
- Edwards Lifesciences
Ventricular Septal Defect, Complete Atrioventricular Canal
Optical Tissue Identification for Myocardial Architecture
The goal of this study is to test the hypothesis that fiberoptic confocal microscopy (FCM) imaging during repair of common congenital heart defects is a useful adjunct for avoidance of conduction abnormalities.
- Conditions
- Ventricular Septal Defect, Complete Atrioventricular Canal, Tetralogy of Fallot With Pulmonary Stenosis
- Trial name
- OPTIMA (NCT04017975)
- Testing
- Fluorescite, Cellvizio 100 Series System with Confocal Miniprobes
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- Aditya Kaza
Tetralogy of Fallot, Congenital Heart Disease
Pathophysiologic Mechanism for Arrhythmias and Impaired Aerobic Capacity in Tetralogy of Fallot and Other Congenital Heart Diseases
This study is being done to determine the mechanism(s) contributing to the onset of symptoms (i.e. shortness of breath and/or palpitations) as well as changes in heart structure in patients with congenital heart disease (CHD)
- Trial name
- PACT (NCT05122962)
- Testing
- Remote Heart Rhythm Monitoring
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- Mayo Clinic
Tetralogy of Fallot
Effect of Contouring Techniques on CMR Assessment of the Right Ventricle in Repaired Tetraology of Fallot
Patients with repaired tetralogy of Fallot (RTOF) develop chronic pulmonary regurgitation and require monitoring for right ventricular dilatation.
- Trial name
- NCT04359940
- Testing
- Cardiac MRI
- Where
- 2 sites in United Kingdom
- Volunteers
- 30 people
- Sponsor
- University Hospital Birmingham NHS Foundation Trust
Pneumonia, Tetralogy of Fallot Correction
Bedside PEEP Selection in by Electrical Impedence Tomography During Mechanical Ventilation in Children
This prospective study evaluates the feasibility and safety of using Electrical Impedance Tomography (EIT) to guide PEEP selection in mechanically ventilated infants and toddlers under 3 years of age.
- Conditions
- Pneumonia, Tetralogy of Fallot Correction, Caustics Ingestion, Orthotopic Liver Transplantation
- Trial name
- BePeSEIT (NCT07319624)
- Testing
- Electrical Impedence Tomography
- Where
- Italy
- Volunteers
- 14 people
- Sponsor
- Papa Giovanni XXIII Hospital
Tetralogy of Fallot, Congenital Heart Defects
Exercise Training Strategies for Children With Repaired Tetralogy of Fallot
The investigators will explore the feasibility and safety of two exercise interventions delivered both in the hospital and in participants' homes.
- Conditions
- Tetralogy of Fallot, Congenital Heart Defects, Congenital Abnormalities, Cardiovascular Diseases
- Trial name
- NCT04208893
- Testing
- Exercise training
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- The Hospital for Sick Children
Tetralogy of Fallot
Asynchrony in Operated Tetralogy of Fallot
The objective of this work is to estimate the correlation between the electrical activation of the VD measured by the CARTO electrophysiological mapping system and the mechanical activation of the VD measured by 3D…
- Trial name
- FALLOT-XI (NCT05485545)
- Testing
- Electrophysiological exploration of the right ventricle
- Where
- France
- Sponsor
- University Hospital, Bordeaux
Transposition of the Great Arteries, Tetralogy of Fallot
A Phase I Study of Dexmedetomidine Bolus and Infusion in Corrective Infant Cardiac Surgery: Safety and Pharmacokinetics
The purpose of this Phase I study is to determine the safety of a drug called dexmedetomidine (DEX) as part of a balanced general anesthetic and sedative strategy for neonates and infants undergoing corrective cardiac surgery…
- Conditions
- Transposition of the Great Arteries, Tetralogy of Fallot, Ventricular Septal Defect
- Trial name
- NCT01915277
- Testing
- Dexmedetomidine
- Where
- 4 sites in United States
- Volunteers
- 119 people
- Sponsor
- Carelon Research
Tetralogy of Fallot (TOF), Hypoplastic Left Heart Syndrome (HLHS)
3D Modalities for Medical Student Education of Congenital Heart Disease
The goal of this clinical trial is to learn if 3D-printed heart models and augmented reality can be useful modalities to teach medical students about congenital heart disease. The main questions it aims to answer are: 1.
- Trial name
- NCT07295730
- Testing
- 3D-printed heart models and augmented reality
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Case Western Reserve University
Cardiac CT TOF
Role of CT in Tetralogy of Fallot Diagnosis
To evaluate the role of MSCT in diagnosis and surgical planning in tetralogy of Fallot cases.
- Trial name
- NCT07247435
- Testing
- Computed tomography
- Volunteers
- 37 people
- Sponsor
- Assiut University
Neuromuscular Monitoring After Administration of Neuromuscular Blocking Agents in Different Types of Surgery
Observational Study to Evaluate the Current Neuromuscular Monitoring Practice Used After Different Types of Surgery, for Which Neuromuscular Blocking Agents Were Used, With or Without Blocking Reversal (P06556)
The intent of this observational study is to collect prospective data regarding neuromuscular monitoring practices and extubation standards (Train-Of-Four [TOF] value) during surgery, in countries of Central and Eastern Europe…
- Trial name
- NCT01213264
- Testing
- No neuromuscular blockade (NMB)-reversal agent used, Sugammadex, Other NMB-Reversal Agents Used in Routine Anesthesiology Practice
- Volunteers
- 659 people
- Sponsor
- Merck Sharp & Dohme LLC