Clinical trials: Familial Dementia
Family, Alzheimer Dementia
The Senior Companion Program Plus
Alzheimer's disease and related dementia (ADRD) is one of the most challenging chronic health conditions in the United States and considerable disparities exist in the diagnosis and prevalence of ADRD among communities of color.
- Trial name
- SCP Plus (NCT03602391)
- Testing
- SCP Plus
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- The University of Texas at Arlington
Dyadic Family Caregiver-person With Dementia Online Intervention
Living Memory Home-4-Dementia Care Pairs
The purpose of this study is to evaluate an online platform -- the Living Memory Home for Dementia Care Pairs (LMH-4-DCP) for persons with dementia and their family caregivers to engage in reminiscence activities together and…
- Trial name
- LMH-4-DCP (NCT06225986)
- Testing
- LMH-4-DCP, LMH-4-DCP access without reminiscence activities
- Where
- United States
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- Weill Medical College of Cornell University
Chronic Grief, Dementia Family Caregivers
Dementia Caregiver Chronic Grief Management: A Live Online Video Intervention
The exponential rise in the number of persons diagnosed with Alzheimer's disease and related dementias (ADRD) places a heavy burden on family caregivers.
- Trial name
- CGMI-V (NCT03593070)
- Testing
- Chronic Grief Management Intervention-Video
- Where
- United States
- Volunteers
- 99 people, healthy volunteers welcome
- Sponsor
- Rush University Medical Center
Alzheimer's Disease
Health Evaluation in African Americans Using RAS Therapy
The purpose of this study is to determine if telmisartan, an FDA approved blood pressure medication, may also have beneficial effects on Alzheimer's disease prevention in African Americans, who are at high risk for Alzheimer's…
- Trial name
- HEART (NCT02471833)
- Testing
- Telmisartan 20mg, Telmisartan 40mg
- Where
- United States
- Volunteers
- 61 people
- Sponsor
- Emory University
Dementia Alzheimers
Alzheimer's Family Caregiver Intervention in Vietnam
This is a single arm pilot study of 6-8 families to test the feasibility and acceptability of a Alzheimer's family caregiver intervention in Vietnam.
- Trial name
- NCT03100617
- Testing
- Psychosocial caregiver intervention
- Where
- Vietnam
- Volunteers
- 6 people
- Sponsor
- University of California, Davis
Amyloid Cardiomyopathy
Open-Label Study of AG10 in Patients With Cardiomyopathy
This prospective, multicenter open-label study will evaluate the long-term safety, tolerability, PK and PD of acoramidis administered on a background of stable heart failure therapy.
- Trial name
- NCT03536767
- Testing
- Acoramidis
- Where
- 9 sites in United States
- Volunteers
- 47 people
- Sponsor
- Eidos Therapeutics, a BridgeBio company
Alzheimer's Disease, Dementia
Webnovela for Hispanic Dementia Family Caregivers
Photozig and Stanford University are creating a new program for Hispanic dementia caregivers to help cope with caregiving, alleviate related stress, and enhance quality of life for caregivers, with funding from the National…
- Trial name
- NCT02489110
- Testing
- Webnovela, Information
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Photozig, Inc.
Alzheimer Disease, Cognitive Impairment
Negotiation Training for Caregiver Communication in AD
The purpose of this study is to design a Negotiation and Dispute Resolution (NDR) training intervention to improve communication and address resolution of conflicts that family caregivers of patients with cognitive impairment…
- Trial name
- NCT04837937
- Testing
- Caregiver vs. Patient [Beginner], Caregiver vs. Caregiver, Caregiver vs. Physician
- Where
- United States
- Volunteers
- 132 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Alzheimer's Disease and Related Dementias
Reducing Behavioral and Psychological Symptoms of Dementia: Family Caregivers (Aim 1)
Persons with Alzheimer's Disease and Related Dementias (ADRD) account for 3.2 million hospital admissions per year and have over three times more hospitalizations than those without cognitive impairment, yet hospital caregivers…
- Trial name
- NCT04481568
- Testing
- PES-4-BPSD Model, The attention control condition
- Where
- 2 sites in United States
- Volunteers
- 158 people, healthy volunteers welcome
- Sponsor
- Northwell Health
Stress, Carer Stress Syndrome
Tailored Health Self-Management Interventions for Highly Distressed Caregivers: Family Members of Persons With Dementia
How do different health self-management interventions (resourcefulness training or biofeedback training) compare to usual care (dementia education) in affecting the health risks, and physical and mental health, of family…
- Conditions
- Stress, Carer Stress Syndrome, Dementia, Alzheimer Disease
- Trial name
- NCT04247347
- Testing
- Biofeedback Training, Dementia Education, Resourcefulness Training
- Where
- United States
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- Case Western Reserve University
Loneliness, Emotional Stress
Twitter Based Social Support for Hispanic and Black Dementia Caregivers
The prevalence of dementia is higher in Hispanics and African Americans than non-Hispanic Whites. Moreover, dementia caregivers often experience loneliness as well decreased health status.
- Trial name
- Tweet-S2 (NCT03865498)
- Testing
- Twitter for Hispanic caregivers, Twitter for African American caregivers
- Where
- United States
- Volunteers
- 966 people, healthy volunteers welcome
- Sponsor
- Columbia University
Transthyretin (TTR) Mediated Familial Amyloidotic Cardiomyopathy (FAC), Amyloidosis, Hereditary
ENDEAVOUR: Phase 3 Multicenter Study of Revusiran (ALN-TTRSC) in Patients With Transthyretin (TTR) Mediated Familial Amyloidotic Cardiomyopathy (FAC)
The purpose of this study was to evaluate the safety and efficacy of revusiran (ALN-TTRSC) in patients with transthyretin (TTR) mediated Familial Amyloidotic Cardiomyopathy.
- Conditions
- Transthyretin (TTR) Mediated Familial Amyloidotic Cardiomyopathy (FAC), Amyloidosis, Hereditary, Amyloid Neuropathies, Familial, Amyloid Neuropathies
- Trial name
- NCT02319005
- Testing
- Revusiran (ALN-TTRSC), Sterile Normal Saline (0.9% NaCl)
- Where
- 61 sites in United States, Belgium and 7 more
- Volunteers
- 206 people
- Sponsor
- Alnylam Pharmaceuticals
Social Isolation, Loneliness
Mindfulness to Reduce Loneliness in Older Caregivers
The objective of this pilot study is to provide initial evidence of the role of mindfulness training in improving social disconnectedness - including social isolation and feelings of loneliness - in older caregivers for family…
- Trial name
- NCT04560088
- Testing
- Mindfulness, Breathing
- Where
- United States
- Volunteers
- 55 people
- Sponsor
- University of Rochester
Dementia
GamePlan4Care: Online Support for Family Caregivers
As the population of older adults grows, almost doubling in size from 2012 to 2040, so too will the need for family caregiving. Caregiving can lead to negative psychosocial outcomes such as depression, anxiety, and burden; social…
- Trial name
- GP4C (NCT04540198)
- Testing
- GamePlan4Care, Resources4Care
- Where
- United States
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Baylor Research Institute
Creutzfeldt-Jakob Disease
CJD (Creutzfeldt-Jakob Disease) Quinacrine Study
The purpose of this clinical trial is to determine the effectiveness of the medication quinacrine on survival in sporadic Creutzfeldt-Jakob disease (sCJD).
- Trial name
- NCT00183092
- Testing
- Quinacrine
- Where
- United States
- Volunteers
- 69 people
- Sponsor
- University of California, San Francisco
Family Caregiver, Dementia
Pair 2 Care: Peer Support for Caregivers of Black Americans Living With Dementia
The purpose of this study is to test a peer support intervention for caregivers who are caring for a loved one living with dementia.
- Conditions
- Family Caregiver, Dementia, Peer Support
- Trial name
- Pair 2 Care (NCT06064955)
- Testing
- Peer Support
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Ohio State University
Caregiver Burden
Building a Bridge (BAB) Between Clinical and Community Care
Dementia diagnosis triggers a transitional phase for the individuals and their families, often causing emotional distress and family conflicts due to the ambiguity of the illness and future trajectories.
- Trial name
- BAB (NCT03932812)
- Testing
- Options Counselor Health Educator (OC-HE) Intervention
- Where
- United States
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- Sato Ashida
Alzheimers Disease, Dementia
Dominantly Inherited Alzheimer Network Trial: An Opportunity to Prevent Dementia. A Study of Potential Disease Modifying Treatments in Individuals at Risk for or With a Type of Early Onset Alzheimer's Disease Caused by a Genetic Mutation.
The purpose of this study is to assess the safety, tolerability, biomarker and cognitive efficacy of investigational products in subjects who are known to have an Alzheimer's disease-causing mutation by determining if treatment…
- Conditions
- Alzheimers Disease, Dementia, Alzheimers Disease, Familial
- Trial name
- DIAN-TU (NCT04623242)
- Testing
- Gantenerumab, Solanezumab
- Where
- 25 sites in United States, Australia and 6 more
- Volunteers
- 194 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Dementia, Caregiver Burden
Knowledge and Interpersonal Skills to Develop Exemplary Relationships (KINDER): Pilot Study
The purpose of this study is to determine the feasibility and acceptability of delivering the KINDER intervention to family caregivers to persons living with dementia.
- Conditions
- Dementia, Caregiver Burden, Relation, Family, Elder Abuse
- Trial name
- KINDER (NCT05783102)
- Testing
- Knowledge and Interpersonal Skills to Develop Exemplary Relationships
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Case Western Reserve University
Family Caregivers, Dementia
Primary Care-based Study of an Online Workshop for Family Caregivers of PLWD
Many family and friend caregivers of persons living with dementia experience depression, stress, and other adverse health consequences due to the responsibilities of their caregiving role.
- Conditions
- Family Caregivers, Dementia, Self-management, Depression
- Trial name
- NCT06928467
- Testing
- Building Better Caregivers workshop
- Where
- 2 sites in United States
- Volunteers
- 109 people
- Sponsor
- University of California, San Francisco