Clinical trials: Familial Mediterranean Fever (FMF)
Behcet Syndrome
Upadacitinib for Refractory Behcet's Syndrome
Behçet's syndrome (BS) is a systemic autoimmune vasculitis that can affect multiple organs, including the skin, eyes, and vascular system.
- Trial name
- NCT07080346
- Testing
- Upadacitinib 15 MG
- Where
- China
- Volunteers
- 27 people
- Sponsor
- Liu Tian
Familial Mediterranean Fever
A Study to Evaluate RIST4721 in Familial Mediterranean Fever (FMF)
A 12-week Open-label, Single-arm, Phase 2 Study to Evaluate the Safety and Efficacy of RIST4721 in Subjects with Familial Mediterranean Fever followed by an additional Open-label Extension Phase.
- Trial name
- NCT05448391
- Testing
- RIST4721
- Sponsor
- Aristea Therapeutics, Inc.
Behcet Disease and Vascular Affection
Serum Elafin and Vascular Affection in Behcet Disease
To measure the level of serum elafin in patients with BD. To assess the relation between serum elafin levels and disease activity.
- Trial name
- NCT06272929
- Testing
- doppler ultrasound
- Volunteers
- 90 people
- Sponsor
- Assiut University
Behcet Syndrome
Zinc Supplementation and Behçet's Syndrome
To study the effects of zinc gluconate supplementation on patients with Behçet's syndrome, 50 patients will be randomly allocated to two groups: placebo group or zinc group (one tablet of 30 mg/day elemental zinc) for 12 weeks.
- Trial name
- NCT05098678
- Testing
- Zinc gluconate
- Where
- Iran
- Volunteers
- 50 people
- Sponsor
- Tabriz University of Medical Sciences
Hereditary Autoinflammatory Diseases, Schnitzler Syndrome
AutoInflammatory Disease Alliance Registry (AIDA)
Autoinflammatory diseases (AID) are clinical entities characterized by recurrent inflammatory attacks in absence of infection, neoplasm or deregulation of the adaptive immune system.
- Conditions
- Hereditary Autoinflammatory Diseases, Schnitzler Syndrome, Behcet Syndrome, PFAPA Syndrome
- Trial name
- AIDA (NCT05200715)
- Testing
- No intervention is foreseen by the protocol.
- Where
- 112 sites in Algeria, Australia and 20 more
- Volunteers
- 3,500 people
- Sponsor
- University of Siena
Familial Cold Autoinflammatory Syndrome (FCAS), Familial Cold Urticaria
Rilonacept for Treatment of Cryopyrin-Associated Periodic Syndromes (CAPS)
Inflammatory symptoms of Cryopyrin-Associated Periodic Syndrome (CAPS) are due to mutations in a the NLRP-3 gene (previously known as Cold Induced Autoinflammatory Syndrome-1 or CIAS1).
- Conditions
- Familial Cold Autoinflammatory Syndrome (FCAS), Familial Cold Urticaria, Muckle-Wells Syndrome (MWS), Genetic Diseases, Inborn
- Trial name
- NCT00288704
- Testing
- rilonacept 160 mg
- Where
- 24 sites in United States
- Volunteers
- 104 people
- Sponsor
- Regeneron Pharmaceuticals
Inflammation, Familial Mediterranean Fever
Interleukin-1 Trap to Treat Autoinflammatory Diseases
Autoinflammatory diseases are illnesses characterized by episodes of inflammation that, unlike autoimmune disorders, lack the production of high titer autoantibodies or antigen-specific T cells.
- Conditions
- Inflammation, Familial Mediterranean Fever, Still's Disease, Adult-Onset
- Trial name
- NCT00094900
- Testing
- IL-1 Trap
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
FMF
Randomized Controlled Trial in Patients on Long-term Colchicine With Colchicine-resistant Familial Mediterranean Fever (FMF) to Evaluate the Efficacy of On-demand Anakinra Treatment for Painful Attacks in Patients Who Refuse Continuous Daily Therapy
To evaluate the efficacy on clinical symptoms in case of FMF attack among FMF patients resistant to Colchicine of on demand anakinra treatment (100 mg/d from the prodromal phase of the attack until 24 hours of remission (during 7…
- Trial name
- KIN-ATTACK-FMF (NCT06336733)
- Testing
- ANAKINRA
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Fibromyalgia, Behcet Syndrome
Frequency of Fibromyalgia in Behcet Disease
In various studies, the incidence of fibromyalgia in Behçet's patients is widely distributed. It was aimed to investigate the frequency and severity of fibromyalgia in Behcet disease in province Bursa.
- Trial name
- NCT03514056
- Testing
- group 1:Patients diagnosed with Behcet disease, group 2: Patient diagnosed with fibromyalgia without Behcet disease
- Where
- Turkey (Türkiye)
- Volunteers
- 146 people
- Sponsor
- Bursa Yuksek Ihtisas Training and Research Hospital
Behçet Disease, Behcet's Disease Aggravated
Behçet's Disease Overall Damage Index
Damage in vasculitis, as well as in other chronic inflammatory disorders, accrues over time resulting in impairment of quality of life, development of disability and increased mortality.
- Trial name
- BODI (NCT03803462)
- Testing
- Behçet's disease Overall Damage Index (BODI)
- Where
- 10 sites in Greece, Italy and 3 more
- Volunteers
- 210 people
- Sponsor
- University of Cagliari
Familial Mediterranean Fever, Intestinal Disease
Caspase-1 Activity, IL-1beta, and IL-18 in Patients With FMF
This study aims to investigate the intestinal mucosal expression of key inflammatory markers, namely Interleukin-1 (IL-1), Interleukin-18 (IL-18), and Caspase-1, in patients with Familial Mediterranean Fever (FMF).
- Conditions
- Familial Mediterranean Fever, Intestinal Disease, Genetic Disease, Fever
- Trial name
- FMF (NCT06981520)
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Hitit University
Periodic Fever
Ilaris (Canakinumab) in Patient With Periodic Fever, Aphthous Stomatitis, Pharyngitis and Cervical Adenitis (PFAPA)
Periodic Fever, Aphthous stomatitis, Pharyngitis and cervical Adenitis (PFAPA) is one of the most common, least explored periodic fever syndrome in childhood.
- Trial name
- NCT02775994
- Testing
- Canakinumab
- Where
- Israel
- Volunteers
- 10 people
- Sponsor
- Rabin Medical Center
Muckle-Wells Syndrome, Schnitzler Syndrome
Safety and Tolerability of Rilonacept in Muckle-Wells Syndrome (MWS) or Schnitzler Syndrome (SchS)
This is a single-center open label study of the IL-1 transfusion protein rilonacept in subjects with Muckle-Wells syndrome (MWS), or Schnitzler syndrome (SchS) in Germany.
- Trial name
- ACCILTRA1 (NCT01045772)
- Testing
- rilonacept
- Where
- Germany
- Volunteers
- 10 people
- Sponsor
- Charite University, Berlin, Germany
Behcet Syndrome
A Study to Evaluate the Efficacy and Safety of Apremilast (CC-10004) in the Treatment of Behçet Disease
The purpose of this study is to assess whether Apremilast is safe and effective in the treatment of patients with Behcet Disease.
- Trial name
- NCT00866359
- Testing
- Apremilast (CC-10004)
- Where
- 7 sites in United States, Turkey (Türkiye)
- Volunteers
- 111 people
- Sponsor
- Amgen
Behçet Disease
Efficacy and Safety of Ustekinumab, a Human Monoclonal Anti-IL-12/IL-23 Antibody, in Patients With Behçet Disease
The purpose of this study is to evaluate the proof of concept of efficacy of ustekinumab in subjects with Behçet disease, including patients with oral ulcers (STELABEC-1) and patients with active posterior uveitis or panuveitis…
- Trial name
- STELABEC (NCT02648581)
- Testing
- Subcutaneous Ustekinumab
- Where
- France
- Volunteers
- 16 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Autoimmune Uveitis, Behçet Disease
Pilot Project: The Amplicon and Metatranscriptomic Study of Intra and Extra Intestinal Microbiome in Non-infectious Uveitis Disease
This study aimed to discover the composition on the microbiome in several sites of the human body; and to find out the difference in microbiome composition on ocular fluid, blood, and feces before and after therapy in uveitis…
- Conditions
- Autoimmune Uveitis, Behçet Disease, Vogt-Koyanagi-Harada Disease, Idiopathic Uveitis
- Trial name
- NCT04126850
- Where
- Indonesia
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Fakultas Kedokteran Universitas Indonesia
Cryopyrin Associated Periodic Syndrome
A Study to Evaluate VTX2735 in Patients With Cryopyrin-associated Periodic Syndrome
This is a study to understand if taking VTX2735 is safe and effective in participants diagnosed with Cryopyrin-Associated Period Syndrome (CAPS). Approximately 10 patients will take VTX2735 Dose A or VTX2735 Dose B.
- Trial name
- Explore (NCT05812781)
- Testing
- VTX2735
- Where
- 2 sites in United States
- Volunteers
- 7 people
- Sponsor
- Zomagen Biosciences Ltd.
Aneurysm, Behcet Syndrome, Vascular Type
Tocilizumab and Tofacitinib in the Treatment of Vascular Behçet's Syndrome
This project aims to evaluate the efficacy and safety of the combination of glucocorticoids with tocilizumab or tofacitinib, compared to the traditional combination of glucocorticoids with cyclophosphamide in the treatment of…
- Trial name
- NCT05845723
- Testing
- tocilizumab, tofacitinib, cyclophosphamide
- Where
- China
- Volunteers
- 81 people
- Sponsor
- Peking Union Medical College Hospital
Familial Mediterranean Fever
AGE and CALLY Index in Familial Mediterranean Fever
Familial Mediterranean Fever (FMF) is an autoinflammatory disease characterized by recurrent inflammatory attacks and persistent low-grade inflammation.
- Trial name
- NCT07439341
- Testing
- Skin Autofluorescence Measurement
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Bursa City Hospital
Vasculitis, Systemic Vasculitis
Impact of Vasculitis on Employment and Income
The purpose of this study is to learn about the impact of vasculitis on employment and income in patients with different systemic vasculitides.
- Conditions
- Vasculitis, Systemic Vasculitis, Behcet's Disease, CNS Vasculitis
- Trial name
- NCT02476292
- Testing
- online questionnaire
- Where
- United States
- Volunteers
- 426 people
- Sponsor
- University of South Florida