Clinical trials: Family, open to volunteers
Prion Disease
PrP-targeting siRNA Safety & Mechanism Study
The purpose of this trial is to evaluate safety, tolerability, pharmacokinetics and pharmacodynamic impact of PrP-siRNA in symptomatic prion disease patients and in pre-symptomatic adults at genetic risk for prion disease.
- Trial name
- PRiSM (NCT07444580)
- Testing
- PrP-siRNA
- Where
- 5 sites in United States
- Volunteers
- 45 people
- Sponsor
- Broad Institute of MIT and Harvard
Healthy Subjects, Behavior, Health
Switching Mediterranean Consumers to Mediterranean Sustainable Healthy Dietary Patterns
The population from Mediterranean countries is abandoning the Mediterranean diet (MD) traditional dietary and lifestyle pattern moving to unhealthier habits because of profound cultural and socio-economic driven lifestyle…
- Conditions
- Healthy Subjects, Behavior, Health, Family
- Trial name
- NCT06057324
- Testing
- AI-based Apps, Mediterranean-based diet toolkit and activities, Healthy plant-based snacks
- Where
- Spain
- Volunteers
- 480 people, healthy volunteers welcome
- Sponsor
- Fundació Eurecat
Contraceptive Behavior, Self Administration
Impact of Self-Care Family Planning Services on Health and Development in South Sudan (Family Planning Impact Lab)
Since 2019, the International Rescue Committee (IRC) has led family planning programming under the Women's Integrated Sexual Health (WISH) program, funded by the United Kingdom's Foreign, Commonwealth, and Development Office.
- Trial name
- FPIL (NCT07888296)
- Testing
- Self-Managed Contraceptive Care, Standard Family Planning Services (WISH-2)
- Where
- South Sudan
- Volunteers
- 2,736 people, healthy volunteers welcome
- Sponsor
- Guttmacher Institute
Family Centered, Black Ethnicity
Together Stronger: A Family-centered Lifestyle Intervention for Black Prostate Cancer Survivors and Their Caregivers
To establish the efficacy of the family-centered intervention in improving healthy lifestyle behaviors (MVPA and overall diet quality), as well as physical functioning, QoL, and family health climate, compared to survivor-only…
- Conditions
- Family Centered, Black Ethnicity, Prostate Cancer Survivors
- Trial name
- NCT07164456
- Testing
- Education sessions, Questionnaire
- Where
- United States
- Volunteers
- 648 people
- Sponsor
- M.D. Anderson Cancer Center
Eating Disorders, Anorexia Nervosa
Family-Based Treatment at Home in Adolescents With Eating Disorders and Co-occurring Mental Health Conditions
The significant impact of eating disorders on adolescents necessitates the evaluation of current treatments. Family-based Treatment (FBT) is the standard treatment but has modest remission rates, highlighting the need for…
- Conditions
- Eating Disorders, Anorexia Nervosa, Eating Disorder Not Otherwise Specified
- Trial name
- F-EET (NCT06792227)
- Testing
- FBT-H
- Where
- Netherlands
- Volunteers
- 10 people
- Sponsor
- Karakter Kinder- en Jeugdpsychiatrie
Inherited Hematological Diseases, Rare Diseases
Longitudinal Studies of Patient With FPDMM
Background: Genes tell the body and its cells how to work. Familial platelet disease (FPD) or FPD with associated malignancies (FPDMM) is caused by a variant in the gene RUNX1.
- Conditions
- Inherited Hematological Diseases, Rare Diseases, FPDMM
- Trial name
- NCT03854318
- Where
- United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- National Human Genome Research Institute (NHGRI)
Hepatocellular Carcinoma (HCC), Intrahepatic Cholangiocarcinoma (Icc)
Study Assessing PET Imaging With Zirconium-labelled Girentuximab in Patients With HCC, BTC or NEN
Precision medicine represents a major goal in oncology. It has its underpinning in the identification of biomarkers with diagnostic, prognostic, or predictive values.
- Conditions
- Hepatocellular Carcinoma (HCC), Intrahepatic Cholangiocarcinoma (Icc), Neuroendocrine Tumors
- Trial name
- ELEGANCE (NCT06735560)
- Testing
- 89Zr-TLX250 PET/CT
- Where
- 2 sites in France
- Volunteers
- 60 people
- Sponsor
- Nantes University Hospital
Pancreatic Ductal Adenocarcinoma (PDAC), Family History of Pancreas Cancer
Reach and Engagement of GENetic Education, Risk Assessment, and TEsting Feasibility Trial
This study will test a remote approach to help people who may be at higher risk for pancreatic cancer learn about and decide whether to get genetic testing and a blood test that looks for signs of several cancers (MCED testing).
- Conditions
- Pancreatic Ductal Adenocarcinoma (PDAC), Family History of Pancreas Cancer, Genetic Testing, Multi-cancer Early Detection
- Trial name
- REGENERATE (NCT07787156)
- Testing
- Telephone education session, Online educational materials
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Brigham and Women's Hospital
Pregnancy, Dietetics
Efficacy of Family-based Dietary Counseling During Pregnancy on Gestational Weight Gain in Pregnant Women in a Randomized Controlled Trial
The study aims to evaluate the efficacy of a family-based dietary monitoring during pregnancy on gestational weight gain in pregnant women.
- Trial name
- FAM-DIET (NCT06646965)
- Testing
- individual dietetic counseling, family-based dietetic conseling
- Where
- 3 sites in France
- Volunteers
- 1,374 people
- Sponsor
- University Hospital, Toulouse
Type 1 Diabetes, T1D
DASH-Obesity: Explainable AI for Family-Centric Personalized Weight Control in Adolescents and Young Adults With Obesity and Chronic Conditions
This prospective single-arm feasibility study evaluates the Adhera Caring Digital Program for Obesity (ACDP-O), a family-centered digital health intervention designed to support adolescents and young adults with…
- Conditions
- Type 1 Diabetes, T1D, Obesity & Overweight, Obesity Type 2 Diabetes Mellitus
- Trial name
- DASH-Obesity (NCT07638345)
- Testing
- Adhera Caring Digital Program-Obesity (ACDP-O)
- Where
- Spain
- Volunteers
- 280 people, healthy volunteers welcome
- Sponsor
- Adhera Health, Inc.
Asthma Childhood
Application Construction and Effect Evaluation of Family-empowered Pulmonary Rehabilitation in School-age Children With Asthma
Study Purpose: To develop a pulmonary rehabilitation intervention program suitable for school-age children with asthma, and to evaluate its effectiveness in improving asthma control in children through a prospective randomized…
- Trial name
- NCT07558954
- Testing
- Family-empowered pulmonary rehabilitation, Conventional pulmonary rehabilitation care
- Volunteers
- 92 people
- Sponsor
- The Children's Hospital of Zhejiang University School of Medicine
Progressive Familial Intrahepatic Cholestasis
A Study of the Effectiveness, Safety and the Long-term Outcomes of Participants With Progressive Familial Intrahepatic Cholestasis (PFIC) Who Take Odevixibat (Bylvay) in South Korea
This study will collect information from people with Progressive Familial Intrahepatic Cholestasis (PFIC) as they use odevixibat in their daily lives.
- Trial name
- NCT07185919
- Where
- 5 sites in South Korea
- Volunteers
- 10 people
- Sponsor
- Ipsen
Depression, Caregivers
The WeACT Program for Family Caregivers of People Living With Dementia
The goal of this clinical trial is to learn whether WeACT, a self-paced, web-based program, is feasible and helpful for adult family caregivers of a relative living with dementia.
- Conditions
- Depression, Caregivers, Dementia
- Trial name
- NCT07342569
- Testing
- WeACT
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of South Florida
Interparental Conflict, Child Mental Health
Pilot Study of an Interparental Conflict Intervention for Separating or Divorcing Parents
This pilot study will evaluate a new intervention for parents who are separated or divorced and have been court ordered to participate in a program addressing interparental conflict.
- Trial name
- NCT07816445
- Testing
- Family COMPASS, Families in Transition (FIT)
- Where
- United States
- Volunteers
- 94 people
- Sponsor
- Arizona State University
Behavioural Problems
Effectiveness of Multisystemic Therapy for Adolescents From Families With Intellectual Disabilities
The goal of this observational study is to determine the effectiveness of a specialisation of multisystemic therapy (MST) for adolescents with severe behavioural problems from families with an intellectual disability (ID…
- Trial name
- NCT06032455
- Testing
- Multisystemic therapy, Multisystemic therapy - intellectual disabilities
- Where
- 4 sites in Netherlands
- Volunteers
- 470 people
- Sponsor
- De Viersprong
Diamond Blackfan Anemia, Dyskeratosis Congenita
Cancer in Inherited Bone Marrow Failure Syndromes
Background: A prospective cohort of Inherited Bone Marrow Failure Syndrome (IBMFS) will provide new information regarding cancer rates and types in these disorders.
- Conditions
- Diamond Blackfan Anemia, Dyskeratosis Congenita, Fanconi Anemia, Shwachman Diamond Syndrome
- Trial name
- NCT00027274
- Where
- 2 sites in United States
- Volunteers
- 4,000 people, healthy volunteers welcome
- Sponsor
- National Cancer Institute (NCI)
Advanced Cancer, End of Life
Resilience-Building for Advance Care Planning
The aims of this study are to (1) assess the feasibility, acceptability, and usability of the ROCKS intervention among patients with advanced cancer and their family caregivers through a randomized controlled trial in a cancer…
- Trial name
- ROCKS (NCT07428278)
- Testing
- ROCKS, Usual Care
- Where
- United States
- Volunteers
- 152 people
- Sponsor
- University of Illinois Chicago
PTSD, Military Activity
Art Therapy and Emotional Well Being in Military Populations With Posttraumatic Stress Symptoms
Art therapy is used across the Military Health System for treatment of posttraumatic symptoms, but there is limited research on how art therapy is able to restore emotional expression and regulation in service members.
- Conditions
- PTSD, Military Activity, Post-Traumatic Headache, Posttraumatic Stress Disorder
- Trial name
- NCT05414708
- Testing
- Art Therapy
- Where
- 2 sites in United States
- Volunteers
- 40 people
- Sponsor
- Walter Reed National Military Medical Center
Hailey Hailey Disease
Efficacy of Guselkumab in Treating Hailey Hailey Disease
Hailey-Hailey disease (HHD) is a debilitating genetic skin disorder, affecting mainly body folds with erythema and painful erosions and blisters.
- Trial name
- NCT06651489
- Testing
- Guselkumab
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Yale University
Chronic Diseases in Children
Food as Medicine Study
The Food as Medicine (FAME) intervention aims to improve dietary quality in lower income, primarily ethnic minority youth through food navigation that bridges clinical care and community food resources.
- Trial name
- FAME (NCT07162350)
- Testing
- Food Navigation
- Where
- United States
- Volunteers
- 250 people
- Sponsor
- Parkland Health and Hospital System
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