Clinical trials: Fasting Conditions, open to volunteers
Colorectal Cancer, Stomach Cancer
Study of CEA Targeting CAR-T (PTC13) in the Treatment of CEA-Positive Advanced Malignant Solid Tumors
This is a phase I clinical study to evaluate the safety and tolerability of FAST targeted chimeric antigen receptor (CAR)-T cells (PTC13) in patients with carcinoembryonic antigen (CEA)-positive advanced malignant solid tumors…
- Conditions
- Colorectal Cancer, Stomach Cancer, Pancreatic Cancer, Metastatic Cancer
- Trial name
- NCT06821048
- Testing
- Intraperitoneal infusion of FAST CEA-targeted CAR-T
- Where
- China
- Volunteers
- 18 people
- Sponsor
- Weijia Fang, MD
Diabetes Mellitus, Type 2, Obesity
Time-restricted Eating, Window Timing, Type 2 Diabetes Status and Sex on Glycemic Control
This study will evaluate the effectiveness of time-restricted eating (TRE), which is a form of intermittent fasting. When performing TRE, individuals consume all of their calories within a specific time window and then only…
- Conditions
- Diabetes Mellitus, Type 2, Obesity, Prediabetic State, Hyperglycemia
- Trial name
- NCT06118931
- Testing
- Early (7:00 - 16:00) TRE, Mid (9:30 - 18:30) TRE, Late (12:00 - 21:00) TRE
- Where
- Canada
- Volunteers
- 123 people
- Sponsor
- University of Toronto
Intracerebral Haemorrhage
NICardipine for Fast Achievement of Systolic BP Targets in ICH
Quality improvement study with a quasi-randomized design. The study monitors the effect of a gradually implemented treatment algorithm prioritizing intravenous antihypertensives (e.g., nicardipine) over long-acting nitrate…
- Trial name
- NICFAST (NCT07044232)
- Testing
- Nicardipine, Glyceryl trinitrate
- Where
- Denmark
- Volunteers
- 88 people
- Sponsor
- Aarhus University Hospital
Supratentorial Brain Tumor Surgery
FASt Track in Elective Neurosurgery: the Role of Low Propofol Bis-NOL Guided General Anaesthesia for Full, Early and Safe Awakening
To evaluate the effect of intraoperative sedation dosage on awakening and recovery of consciousness after elective neurosurgical surgery.
- Trial name
- FasTrack (NCT06844838)
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta
Prediabetes, Impaired Fasting Glucose
Mazdutide for Adults With Prediabetes: A Randomized, Double-Blind, Placebo-Controlled Trial (DREAM-PRE)
Prediabetes affects millions of adults worldwide and carries a high risk of progression to type 2 diabetes. Mazdutide is a once-weekly injectable drug that activates both GLP-1 and glucagon receptors, lowering blood sugar and…
- Conditions
- Prediabetes, Impaired Fasting Glucose, Impaired Glucose Tolerance (Prediabetes)
- Trial name
- DREAM-PRE (NCT07654062)
- Testing
- Mazdutide, Standardized Lifestyle Intervention
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Shandong Provincial Hospital
Obesity & Overweight, Bariatric Surgery
Time-Restricted Eating After Bariatric Surgery
This study aims to compare the effects of time-restricted eating (TRE, 16/8) in adults with obesity who have and have not undergone bariatric surgery (BS).
- Conditions
- Obesity & Overweight, Bariatric Surgery, Weight Regain, Weight Regain Post Bariatric Surgery
- Trial name
- NCT07672821
- Testing
- Time-Restricted Eating (16:8)
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Medipol University
Cancer, Chronic Lymphocytic Leukemia
Time Restricted Eating in Haematological Malignancies
The goal of this clinical trial is to learn if time restricted eating (TRE), a form of intermittent fasting, can impact health outcomes in patients with chronic lymphocytic leukemia (CLL).
- Trial name
- NCT06862323
- Testing
- Time-Restricted Eating
- Where
- Canada
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- British Columbia Cancer Agency
Diabetes Mellitus
A Study to Evaluate the Safety and Pharmacokinetics of AD-123 Compared to Coadministration of AD-1231 and AD-1232
A Study to Evaluate the Safety and Pharmacokinetics of AD-123 Compared to Coadministration of AD-1231 and AD-1232
- Trial name
- NCT07538466
- Testing
- AD-123, AD-1231 and AD-1232
- Where
- South Korea
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Addpharma Inc.
Shoulder Injuries and Disorders, Elbow Injuries and Disorders
Cross-Cultural Adaptation, Validity, and Reliability of the Functional Arm Scale for Throwers (FAST) in Throwing Athletes
The Functional Arm Scale for Throwers (FAST) is a patient-reported outcome measure that assesses upper extremity function in overhead throwing athletes.
- Conditions
- Shoulder Injuries and Disorders, Elbow Injuries and Disorders, Athletic Injuries
- Trial name
- NCT07893899
- Where
- Turkey (Türkiye)
- Volunteers
- 217 people, healthy volunteers welcome
- Sponsor
- Elif Turgut
Healthy Volunteer
Comparison of DW-1021 and Separate Doses of Pelubi CR and Zytram CR Under Fasting Conditions
This is a Phase 1, randomized, open-label, single-dose, two-period, cross-over study to evaluate the pharmacokinetics (PK) of DW-1021, a fixed-dose combination tablet containing Pelubiprofen 45 mg and Tramadol 45.9 mg (as a…
- Trial name
- DW-1021 (NCT07032558)
- Testing
- DW-1021, Pelubi CR + Zytram CR
- Where
- 2 sites in Vietnam
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Haiphong University of Medicine and Pharmacy
Fasting, Delayed Gastric Emptying
Gastric Assessment of Pediatric Patients Undergoing Surgery
The goal of this pilot prospective cohort study is to examine the reproducibility of gastric volume and emptying as measured by gastric ultrasound and its correlation to a gold-standard test for gastric emptying in the…
- Conditions
- Fasting, Delayed Gastric Emptying, Aspiration Pneumonia, Respiratory Aspiration of Gastric Content
- Trial name
- NCT05674643
- Testing
- Gastric Ultrasound Baseline Scans, Acetaminophen Absorption Test (AAT), Gastric Ultrasound Serial Scans
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Boston Children's Hospital
Scar
Impact of Suture Type on Pigment Disturbances in Patients of Skin of Color
The present study assesses if dissolvable (fast gut) or non-dissolvable (polypropylene) epidermal sutures produce better cosmetic results in terms of dyspigmentation and scarring in patients of skin of color.
- Trial name
- NCT05408117
- Testing
- 5-0 Polypropylene epidermal suture, 5-0 Fast gut epidermal suture
- Where
- 3 sites in United States
- Volunteers
- 34 people
- Sponsor
- Melissa Pugliano-Mauro
Cardiometabolic Syndrome, Type 2 Diabetes
Circadian Intervention to Improve Cardiometabolic Health
The overall goal is to examine the efficacy of a circadian intervention in people with overweight and obesity and habitual short sleep duration (HSSD).
- Conditions
- Cardiometabolic Syndrome, Type 2 Diabetes, Sleep, Time Restricted Feeding
- Trial name
- TOCS (NCT05943626)
- Testing
- Circadian Intervention
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Utah
Brain Metastases, Adult, Brain Tumor - Metastatic
Stereotactic Radiation for Growing/Changing Brain Metastases With Same-Day Radiation Planning and Treatment With Margin Reduction
The goal of this study is to evaluate the feasibility and effectiveness of same-day radiation planning and treatment. The study will shorten the time interval between radiation planning (radiation mapping) and radiation…
- Conditions
- Brain Metastases, Adult, Brain Tumor - Metastatic, Brain Metastases From Non-small Cell Lung Cancer (NSCLC), Brain Metastases From Extra-cranial Solid Tumors
- Trial name
- NCT07132190
- Testing
- Linear accelerator-based stereotactic radiation for brain metastases using 0mm or 1mm PTV
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Ayal A. Aizer, MD
Obesity, Normal Physiology
The Effects of Increasing Caloric Intake on Diet-Induced Thermogenesis and 24h Energy Expenditure
Background: Diet-induced thermogenesis (DIT) is the amount of energy one's body uses to eat food, absorb the nutrients from the food, and process those nutrients.
- Conditions
- Obesity, Normal Physiology, Healthy Volunteers
- Trial name
- NCT05545306
- Testing
- +200% of dietary requirements, 50% of calories from carbohydrates, 20% from protein, and 30% from fat, fasting, -50% of energy balance requirements. 50% of calories from carbohydrates, 20% from protein, and 30% from fat
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Healthy, Obesity & Overweight
Growth Hormone Resistance of Beta-cells
The purpose of the research study is to better understand how beta-cells (cells in the pancreas that make insulin and help regulate blood sugar) respond to growth hormone in people with impaired fasting glucose or impaired…
- Conditions
- Healthy, Obesity & Overweight, Impaired Fasting Glucose (IFG), Impaired Glucose Tolerance (Prediabetes)
- Trial name
- GHRB-C (NCT07581860)
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Missouri-Columbia
Peripheral Arterial Disease
A Bioequivalence and Safety Study of AJU-B718 and B718R in Healthy Adult Volunteers Under Fasting Conditions
To evaluate the bioequivalence and safety of AJU-B718 and B718R in Healthy Adults.
- Trial name
- NCT07901088
- Testing
- Test Drug, Reference Drug
- Where
- South Korea
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- AJU Pharm Co., Ltd.
Critical Illness, Surgical Procedure, Unspecified
Preoperative Fasting vs. Not Fasting in Critically Ill Patients
The goal of this clinical trial is to learn if fasting or not fasting before a procedure has an effect on recovery in those who are critically ill.
- Conditions
- Critical Illness, Surgical Procedure, Unspecified, Pulmonary Aspiration, Fasting
- Trial name
- FEEDS (NCT06751043)
- Testing
- Fasting, Not fasting
- Where
- 19 sites in United States
- Volunteers
- 1,072 people
- Sponsor
- Massachusetts General Hospital
Chronic Spontaneous Urticaria
Investigation of a Remibrutinib- and Omalizumab-based Treatment Algorithm in Adult Patients With Chronic Spontaneous Urticaria Inadequately Controlled by H1-antihistamines Within 24 Weeks
The purpose of this open-label study is to assess the efficacy and safety of a novel treatment algorithm for sequencing remibrutinib and omalizumab in the treatment of adult participants with chronic spontaneous urticaria (CSU)…
- Trial name
- NCT07816328
- Testing
- Remibrutinib, Omalizumab
- Where
- 5 sites in Hong Kong, Japan and 1 more
- Volunteers
- 382 people
- Sponsor
- Novartis Pharmaceuticals
Aneurysmal Subarachnoid Hemorrhage, Vasospasm
Treatment of Vasospasm of Aneurysmal Subarachnoid Hemorrhage With Intrathecal Nicardipine - FAST-IT Trial
To investigate whether patients with cerebral vasospasm associated with aneurysmal subarachnoid hemorrhage have a better prognosis with intrathecal nicardipine injection via extraventricular drainage or lumbar drainage.
- Trial name
- NCT06329635
- Testing
- Intrathecal Nicardipine, No intervention
- Where
- 28 sites in China
- Volunteers
- 396 people
- Sponsor
- The Affiliated Hospital Of Guizhou Medical University