Clinical trials: Fat Metabolism
Obesity
Brown Adipose Tissue Activity in Response to Semaglutide Administered to Obese Subjects.
Glucagon like peptide (GLP-1) agonists, such as liraglutide, exenatide, and semaglutide, have been increasingly used as a medication to address the current twin epidemics of diabetes and obesity.
- Trial name
- NCT05419726
- Testing
- Semaglutide Injectable Product (not provided by the study)
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Osteoporosis
Determinants of Bone Mineral Density and Metabolic Syndrome in South Asian Indian Men
This study aims to examine the association between body composition with bone density and risk factors for cardiovascular disease and type 2 diabetes.
- Trial name
- NCT03600675
- Testing
- No intervention element, observational study.
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Drexel University
Obesity
GLP-1s to Enhance Lasting Optimal Weight
The goal of this study is to examine how tirzepatide affects body composition, bone health, and physical performance in older adults over a nine-month period.
- Trial name
- GLOW (NCT06861439)
- Testing
- Tirzepatide
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Wake Forest University Health Sciences
Cardiovascular Risk Factor, Metabolic Disease
Effects of Shockwave Therapy Versus Radiofrequency
The main objective of this study is to compare the effect of 6 sessions of shock wave therapy versus radiofrequency followed by a protocol of moderate aerobic exercise, in the reduction of adiposity and abdominal flaccidity, in…
- Conditions
- Cardiovascular Risk Factor, Metabolic Disease, Photoaging
- Trial name
- NCT04282057
- Testing
- Radiofrequency, Aerobic exercise, Shock wave therapy
- Where
- Portugal
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Escola Superior de Tecnologia da Saúde do Porto
Pre-diabetes
Diet Impact on Hepatic Transcriptomics and Lipidomics in Pre-diabetes
Non-alcoholic fatty liver disease (NAFLD) is one of the most common liver diseases, affecting 25% to 30% of the global population and nearly one third of the population in North America.
- Trial name
- DGENE-NAFLD (NCT05965973)
- Testing
- Low fat diet, High fat diet
- Where
- Canada
- Volunteers
- 6 people
- Sponsor
- Laval University
Type 2 Diabetes, Coronary Heart Disease
Effects of a Mediterranean Style Diet on Vascular Health in Type 2 Diabetes
In this study we will compare the effects of a Mediterranean diet, high in fruit and vegetables with the more conventional diet recommended for diabetes therapy (a high carbohydrate, low fat diet) on glycaemic and lipid control…
- Trial name
- NCT00163683
- Testing
- Dietary Therapy
- Where
- Australia
- Volunteers
- 24 people
- Sponsor
- Bayside Health
Obesity, Overweight
Effect of Calcium + Vitamin D Supplementation on Weight Management in Very-low Calcium Consumers
The purpose of the study is to determine whether calcium plus vitamin D supplementation is conducive to weight and fat loss during energy restriction in very-low calcium consumers.
- Trial name
- NCT01447433
- Testing
- Calcium Carbonate, Energy restriction
- Where
- China
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- Changhai Hospital
Obesity
Taurine Supplementation and Training Effects on Energy Metabolism, Inflammation and Oxidative Stress in Obese Women
Taurine supplementation researches have increased due to its antioxidant and anti-inflammatory actions, and its ability to modulate lipid metabolism by stimulating the expression of proteins that regulates mitochondrial…
- Trial name
- Taurine (NCT04279600)
- Testing
- Taurine, Exercise training
- Where
- Brazil
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Fatty Liver
Effect of Diet Composition on Liver Fat and Glucose Metabolism
This study is designed to determine if the amount of fat and saturated fat in the diet contributes to the development of a condition called fatty liver disease in the absence of changes in weight.
- Trial name
- DietLFAT (NCT00930371)
- Testing
- high fat/high saturated fat diet, low fat/low saturated fat diet
- Where
- 2 sites in United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of Washington
Pediatric Obesity, Insulin Resistance
Metabolic Effect of Metformin in Obese Insulin Resistant Adolescents With Normal Glucose Tolerance
The primary objective of this randomized, parallel group, double-blind, placebo-controlled study is to determine whether treatment with metformin enhances insulin sensitivity in a group of ethnically diverse obese…
- Conditions
- Pediatric Obesity, Insulin Resistance, Hyperinsulinemia
- Trial name
- NCT00667498
- Testing
- Metformin
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Yale University
Obesity, Obesity, Abdominal
Environmental Temperature and Human White Adipose Tissue
Obesity is characterized by excessive white adipose tissue (WAT) that increases risk for disease. About 700 million adults are obese worldwide, designating the need of reducing excessive WAT in humans and subsequently the risk…
- Conditions
- Obesity, Obesity, Abdominal, Obese
- Trial name
- NCT04037371
- Testing
- Cold exposure
- Where
- Greece
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Petros Dinas
Hypertension, Sleep Apnea Syndromes
Fat Gain and Cardiovascular Disease Mechanisms
Understanding the mechanisms of obesity-induced hypertension is important both for prevention and therapy. Studies of patients with established obesity have provided valuable information on pathophysiologic links between obesity…
- Conditions
- Hypertension, Sleep Apnea Syndromes, Obesity
- Trial name
- NCT00589498
- Testing
- 1000 extra calories
- Where
- United States
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Bone Diseases
Odense Androgen Study: Study of Androgens, Body Composition, and Muscle Function in Danish Men
Objective: To define a reference-population of healthy young men (20-29 years old). To establish reference-intervals for: 1. Total, bioavailable and free serum androgens (testosterone, dihydrotestosterone, androstenedione) and…
- Trial name
- NCT00150163
- Where
- Denmark
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- Odense University Hospital
Obese, Vascular Diseases
Comparison of Brachial Artery Dilatation, Uterine Artery Doppler, Umbilical Artery Doppler and 1st-trimester Visceral Adipose Tissue Measurement in Obese and Normal Pregnant Women
Brachial artery flow-mediated in obese and normal-weight pregnant women dilation of uterine artery doppler and umbilical artery doppler results comparison of
- Conditions
- Obese, Vascular Diseases, Pregnancy Related, Visceral Obesity
- Trial name
- NCT04638504
- Testing
- ultrasonography
- Where
- Turkey (Türkiye)
- Volunteers
- 240 people
- Sponsor
- Diyarbakir Women's and Children's Diseases Hospital
Obesity
Integrating Quantitative Energetics Determines the Microbiome's Contribution to Energy Balance
We propose to study the role of the gut microbiome in the development of obesity, and whether we can change the microbiome's contribution to host energy balance through diet.
- Trial name
- NCT02939703
- Testing
- Diet
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- AdventHealth Translational Research Institute
Obesity, Inflammation
Lean and Obese: Dietary Inflammation
In the Lean and Obese Dietary Inflammation (LODI) study, the primary goal is to determine the effect of short-term intake of high dietary fat (5 days) compared to low fat intake (5 days) in a cross-over design in older adults…
- Conditions
- Obesity, Inflammation, Dietary Fat
- Trial name
- LODI (NCT05327868)
- Testing
- Low Fat Diet (LFD), High Fat Diet (HFD)
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Rutgers, The State University of New Jersey
Obesity, Polycystic Ovary Syndrome
Heat Therapy and Cardiometabolic Health in Obese Women
Traditional medical treatments are often based on research done exclusively in males, and recent research efforts in the physiology community have highlighted critical sex differences in disease presentation and progression.
- Conditions
- Obesity, Polycystic Ovary Syndrome, Prehypertension, PreDiabetes
- Trial name
- CMH (NCT03644524)
- Testing
- Heat therapy
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Oregon
Lipodystrophy
Corticosteroid-induced Lipodystrophy and Adipokines
Hypothesis: systemic therapy with corticosteroid induces morphological changes (e.g., moon face, buffalo neck) called lipodystrophy (LD).
- Trial name
- ADIPOKINES (NCT00822042)
- Testing
- Samples and procedures
- Where
- France
- Volunteers
- 32 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Obese
Monounsaturated Fatty Acids and Brown/Beige Adipose Tissue in Humans
Considering the high prevalence of obesity its comorbidities in Brazil and in the world, different therapeutic measures have been suggested.
- Trial name
- NCT03024359
- Testing
- Extra virgin olive oil
- Where
- Brazil
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University of Campinas, Brazil
Prediabetes, Type 2 Diabetes
Beta Cell Restoration Through Fat Mitigation
Weight loss achieved through gastric banding will be superior to treatment with metformin in preserving or restoring pancreatic beta cell function in people with prediabetes or mild type 2 diabetes.
- Conditions
- Prediabetes, Type 2 Diabetes, Obesity
- Trial name
- BetaFat (NCT01763346)
- Testing
- Metformin, gastric banding
- Where
- United States
- Volunteers
- 88 people
- Sponsor
- University of Southern California