Clinical trials: Fat Sensitivity
Type 2 Diabetes Mellitus
Effect of Conjugated Linoleic Acid Alone and in Conjunction With Vitamin E in Patients With Type 2 Diabetes Mellitus
Conjugated linoleic acids (CLAs) comprise a family of linoleic acid (18:2n-6; LA) isomers that are formed by biohydrogenation and oxidation processes in nature.
- Trial name
- NCT01099163
- Testing
- Tonalin SG1000T FFA
- Where
- Iran
- Volunteers
- 60 people
- Sponsor
- Shahid Beheshti University of Medical Sciences
Lupus
Cardiac Imaging in Systemic Disorders: the ORACLES Registry
Autoimmune diseases affect a total of 5 to 10% of the population. These diseases are associated with an increased risk of developing cardiovascular pathologies.
- Trial name
- ORACLES (NCT07134166)
- Testing
- data collection
- Volunteers
- 1,500 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Metabolic Health, Insulin Sensitivity/Resistance
Defining the Human Insulin Resistance Molecular Network; SIGNATURE
The goal of this intervention study is to learn more about what causes insulin resistance in otherwise healthy adults, and how short-term changes in physical activity or diet may influence it.
- Trial name
- SIGNATURE (NCT07255807)
- Testing
- Physical Inactivity, Hypercaloric High-Fat Diet
- Where
- Denmark
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Heart Failure
Can a Modified Fat Diet With Low Glycaemic Load Improve Insulin Sensitivity and Inflammatory Mediators in Overweight People With Chronic Heart Failure?
This study is looking at overweight patients with chronic heart failure (CHF), to compare the effects of a modified fat diet with a reduced glycaemic load (diet 1); and a conventional low fat, high carbohydrate diet (diet 2) on…
- Trial name
- NCT00163904
- Testing
- High mono-unsaturated fat/low carbohydrate diet, High carbohydrate/low fat diet
- Where
- Australia
- Volunteers
- 50 people
- Sponsor
- Bayside Health
Appetitive Behavior, Individual Difference
The Influence of Fat Perception on Satiety From Consumption of Reduced Fat Snacks
The present study aims to investigate the effect of fat level and fat type of a snack on self-reported satiety and associated biomarkers. The relevant individual differences will also be investigated.
- Conditions
- Appetitive Behavior, Individual Difference, Food Sensitivity, Food Preferences
- Trial name
- NCT03585920
- Testing
- Expanded Corn Snack
- Where
- United Kingdom
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Reading
Insulin Sensitivity
Effect of Acute Bout of Exercise on Levels of PAHSA
Exercise represents an important tool in the prevention and treatment of metabolic disorders associated with obesity and aging, such as type 2 diabetes and cardiovascular disease.
- Trial name
- ETAPA (NCT05572905)
- Testing
- Exercise, Fasting control
- Where
- Czechia
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Lenka Rossmeislova
Non Alcoholic Fatty Liver Disease
The Effect of Exercise Intervention on Insulin Resistance in Non-alcoholic Fatty Liver Disease (NAFLD)
This project examines the effects of a 4 month structured exercise intervention program in patients with non-alcoholic fatty liver disease (NAFLD).
- Trial name
- NCT01834300
- Testing
- Unsupervised exercise training, Supervised exercise training
- Where
- 7 sites in United Kingdom
- Volunteers
- 60 people
- Sponsor
- University of Liverpool
Insulin Sensitivity, Type 2 Diabetes
Exercise and Diet in Type 2 Diabetic Women
The purpose of this study was to evaluate the effects of 12 weeks' increased daily physical activity versus diet restriction on regional fat distribution, insulin sensitivity and adipokines including retinol binding protein-4…
- Trial name
- NCT00763074
- Testing
- Standard life style modification for type 2 diabetes, Diet restriction, Exercise
- Volunteers
- 70 people
- Sponsor
- Eulji University Hospital
Ectopic Lipids, Insulin Sensitivity
The Effect of Dietary Fat Load and Physical Exercise on the Flexibility and Partitioning of Ectopic Lipids.
This study aims at assessing the effect of standardized dietary fat load and short-term aerobic exercise on systemic lipolysis, flexibility and partitioning of ectopic fat stores (intramyocellular = IMCL, intrahepatocellular =…
- Conditions
- Ectopic Lipids, Insulin Sensitivity, Aerobic Exercise, Fat Load
- Trial name
- NCT01467193
- Testing
- Fat diet, 2h standardized aerobic exercise
- Where
- Switzerland
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Low-Calorie Diet, Diet, High-Protein
The Effect of Diet Counseling for Low Calorie-High Protein on the Body Composition, Inflammation Marker, and Oxidative Stress Marker in Obese People With Weight Cycling
The world prevalence of obesity in adult population in 2014 was nearly 13% while in Indonesia, it has reached 32.9% in the same year. Obesity is an established risk factors for cardiovascular diseases.
- Conditions
- Low-Calorie Diet, Diet, High-Protein, Obesity; Pituitary, Weight Cycling
- Trial name
- NCT03374150
- Testing
- diet counseling
- Where
- 2 sites in Indonesia
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Universitas Indonesia
Type 1 Diabetes Mellitus, Glycemic Variability
Impact of Dietary Fat and Menstrual Cycle Phases in Type 1 Diabetes
This clinical trial aims to evaluate how variations in dietary fat content and hormonal status influence postprandial glycemic response in individuals with type 1 diabetes (T1D), with a special focus on women.
- Conditions
- Type 1 Diabetes Mellitus, Glycemic Variability, Sex Characteristics, Menstrual Cycle
- Trial name
- DIABETEXX/3 (NCT07278063)
- Testing
- Low Fat Mixed Meal, High Fat Mixed Meal
- Where
- Spain
- Volunteers
- 50 people
- Sponsor
- Instituto de Investigacion Sanitaria La Fe
Obesity, Pre-diabetes
The Effect of Time-Restricted Eating in Cardiometabolic Health
Time-restricted eating (TRE) is a dietary manipulation that involves restricting food intake to 6-12 h/day with no energy intake the rest of the day.
- Trial name
- NCT04484987
- Testing
- 9 hours daily eating window, 15 hours daily eating window
- Where
- United States
- Volunteers
- 55 people
- Sponsor
- University of California, Davis
Insulin Resistance, Type 2 Diabetes
Dietary Protein and Insulin Sensitivity Study
The overall objective of the Dietary Protein and Insulin Sensitivity Study is to test the hypothesis that increased protein in a diet with reduced carbohydrate (35% energy) can ameliorate insulin resistance in the absence of…
- Conditions
- Insulin Resistance, Type 2 Diabetes, Metabolic Syndrome, Cardiovascular Disease
- Trial name
- NCT00508937
- Testing
- Diet
- Where
- 2 sites in United States
- Volunteers
- 660 people, healthy volunteers welcome
- Sponsor
- UCSF Benioff Children's Hospital Oakland
Epidermal Necrolysis, Lyell Syndrome
LYell SYndrome MEsenchymal Stromal Cells Treatment
Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are rare severe cutaneous adverse reactions (SCARs) to drugs.
- Conditions
- Epidermal Necrolysis, Lyell Syndrome, Toxic Epidermal Necrolysis, Overlap Syndrome
- Trial name
- LYSYME (NCT04711200)
- Testing
- Adipose derived stromal cells intravenously injected
- Where
- France
- Volunteers
- 15 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Adipose Tissue
The Influence Of GIP (Glucose-Dependent Insulinotropic Polypeptide) Infusion On Human Adipose Tissue: An In Vivo Study
Study part-1 GIP (glucose-dependent insulinotropic polypeptide) is one of the two main incretin hormones secreted by specialized cells of the gastrointestinal tract in response to ingestion of nutrients.
- Trial name
- NCT00809029
- Testing
- GIP (glucose dependent insulinotropic peptide) infusion
- Where
- United Kingdom
- Volunteers
- 12 people
- Sponsor
- Liverpool University Hospitals NHS Foundation Trust
Insulin Resistance
Effect of Dietary SFA and Fructose on Hepatic Insulin Sensitivity
High rates of de novo lipogenesis (DNL) and high saturated fatty acid (SFA) fraction in the liver both have been associated with poor metabolic health and hepatic insulin resistance.
- Trial name
- NCT05017675
- Testing
- High fructose diet, High saturated fat diet
- Where
- Netherlands
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Type 2 Diabetes Mellitus
Effects of Triacylglycerol Structure on Gut Hormones and Haemostatic Markers
Type 2 diabetes mellitus (T2DM) is a chronic disorder determined by lifestyle and genes. It is associated with chronic hyperglycaemia along with other metabolic abnormalities.
- Trial name
- NCT01906359
- Testing
- Native palm olein (IV56), Chemically interesterified palm olein (IV56), High oleic sunflower oil
- Where
- 5 sites in Malaysia
- Volunteers
- 23 people
- Sponsor
- Malaysia Palm Oil Board
Healthy
The Relationship Between Body Composition and Growth Hormone, SIRT Signaling, Protein Turnover and Insulin Sensitivity
The purpose of this study is to investigate signaling pathways in fat and muscle, as well as turnover of protein, sugar and fat after stimulation with growth hormone and during fasting in lean and obese subjects.
- Trial name
- NCT01299831
- Testing
- 72 hour fast, control, 12 hour fast, Growth hormone
- Where
- Denmark
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Insulin Resistance and Type 2 Diabetes
Fatty Acid Metabolism and Insulin Sensitivity: the Role of Endurance Exercise
Clearly the effects of diet and exercise are beneficial for obese persons, but the underlying mechanisms for the improvements in metabolic health are not completely clear.
- Trial name
- NCT00795860
- Testing
- Weight loss - diet only, Weight loss plus exercise
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Fatty Liver, Nonalcoholic, Insulin Sensitivity
Determinants of Liver Fat Composition
Excessive fat in the liver, in absence of high alcohol consumption, is diagnosed as non-alcoholic fatty liver (NAFL). NAFL prevalence is as high as 50-70% in obese people and is associated with impairments in metabolic health…
- Trial name
- NCT03211299
- Where
- Netherlands
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center