Clinical trials: Fat Sensitivity
Metabolism, Fatty Liver
Growth Hormone During Fasting.Signaltransduktion in Muscle and Adipose Tissue and Changes in Intrahepatic Lipid Content
The purpose of this study is to examine the effects of growth hormone during fasting in healthy lean men.
- Trial name
- NCT00476879
- Testing
- Somatropin and pegvisomant
- Where
- Denmark
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Healthy Adults With Normal BMI
Fat, Inflammation and Insulin Resistance
The combination of impaired insulin sensitivity and insulin secretion is thought to be the basis of type 2 diabetes. Increased free fatty acids levels impair insulin action in muscle and liver, but also systemic inflammation…
- Trial name
- FIRE (NCT01054989)
- Testing
- Fat/Inflammation effects
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- German Diabetes Center
Overweight and Obesity, Metabolic Syndrome
Testing the Adipose Expandability Hypothesis In Vivo During Overfeeding
Adipose, or fat, tissue is a plastic organ that retains the ability to expand and store excess calories during positive energy balance in humans.
- Trial name
- EAT 2 (NCT04583514)
- Testing
- Control, Overfeeding
- Where
- United States
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Pennington Biomedical Research Center
Insulin Sensitivity, Fat; Liver
Race Adiposity Interactions Regulate Mechanisms Determining Insulin Sensitivity
This research study will examine how ethnic/racial background, body composition (%body fat), and the location of body fat affect the ability of the hormone insulin to promote uptake of blood sugar in persons who are 19 to 45…
- Trial name
- NCT03043235
- Where
- United States
- Volunteers
- 126 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Polyphenolic Compounds and Metabolism
Acute Effects of Grape Seed Extract on Insulin Sensitivity and Oxidative Stress and Inflammation Markers.
The proposed study aims to investigate that consumption of grape seed extract (GSE) would improve antioxidant status and impaired insulin action following consumption of a pro-oxidative high carbohydrate, high fat (HCHF) meal in…
- Trial name
- GSE2 (NCT01995643)
- Testing
- Active Capsule
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Clinical Nutrition Research Center, Illinois Institute of Technology
Overfeeding
Polyphenols and Overfeeding
Obesity is a complex and multifactorial disease representing a major public health challenge. Indeed, overweight and obese people carry a major risk of developing insulin resistance and type 2 diabetes mellitus.
- Trial name
- Poly-Nut (NCT02145780)
- Testing
- 2g of grape polyphenol extract
- Where
- France
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon
Long COVID, Insulin Resistance
Obesity, Insulin Resistance, and PASC: Persistent SARS-CoV-2
The investigators are studying the pathophysiologic links between obesity, insulin resistance (IR), adipose tissue infection, and post-acute sequelae of COVID-19 (PASC).
- Conditions
- Long COVID, Insulin Resistance, Insulin Sensitivity
- Trial name
- NCT05833217
- Testing
- Adipose Tissue Biopsy, Steady State Plasma Glucose (SSPG) Test
- Where
- 2 sites in United States
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Stanford University
Pre-Diabetes
Full-fat Yogurt and Glucose Tolerance
This study determines if substituting full-fat yogurt (i.e., whole, 3.25% fat) for non-fat yogurt in the diet can reduce the risk of type 2 diabetes and inflammation in association with changes in the composition of the…
- Trial name
- NCT03577119
- Testing
- Full-fat yogurt, Non-fat yogurt
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- University of Vermont Medical Center
Obesity, Non-Alcoholic Fatty Liver Disease
Effect of Timed-Restricted Eating on Metabolic Health
We aim to determine the effect of combined isocaloric time restricted eating and meal timing on metabolic health, liver fat, functional brain networks, inflammation, and sleep pattern/quality in subjects with obesity and insulin…
- Conditions
- Obesity, Non-Alcoholic Fatty Liver Disease, Insulin Resistance
- Trial name
- TREAT (NCT06061042)
- Testing
- Early time restricted eating, Late time restricted eating
- Where
- Netherlands
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Insulin Sensitivity, Weight
Effect of Low-carbohydrate/High-fat Diet on Glucose Tolerance and Lipid Profile in Lean, Healthy Women
Intervention studying the effect of a low-carbohydrate/high-fat (LCHF) diet as well as on bout of exercise in combination with either a normal diet or a LCHF diet, in relation to glucose metabolism, insulin sensitivity, lipid…
- Trial name
- LCHF (NCT02005224)
- Testing
- LCHF diet and a bout of exercise
- Where
- Norway
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Atlantis Medical University College
Type 2 Diabetes, Prediabetes (Insulin Resistance, Impaired Glucose Tolerance)
Effects of Different Fish Oil Types on Type 2 Diabetes Risk Factors in High-Risk Adults
The purpose of this clinical trial is to find out whether one type of fish oil works better than another at improving metabolic health in people who are at high risk of developing type 2 diabetes.
- Conditions
- Type 2 Diabetes, Prediabetes (Insulin Resistance, Impaired Glucose Tolerance), Prediabetes / Type 2 Diabetes, Obesity & Overweight
- Trial name
- END-T2D (NCT07575438)
- Testing
- Fish Oil, Corn oil control
- Where
- Canada
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- May Faraj, PDt, PhD
Diabetes Mellitus, Type 2, Diabetes Mellitus Type 2 in Obese
The Effect of a Low-fat Vegan Dietary Intervention on Intracellular Lipid, Insulin Sensitivity, and Glycemic Control in Type 2 Diabetes
The goal of this 16-week clinical trial is to assess the health benefits of a low-fat vegan diet on insulin sensitivity and glycemic control in type 2 diabetes.
- Trial name
- NCT06106035
- Testing
- low-fat vegan diet
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- Physicians Committee for Responsible Medicine
Non-Alcoholic Fatty Liver Disease
Effects of TOTUM-448 on Liver Fat Content, Cardiometabolic Risk Factors and Gut Microbiota Among Participants with MASLD
This clinical trial aims to investigate the effects of TOTUM-448, a mix of 5 plant extracts and choline, consumed at the daily regimen of two times per day, on liver fat content, cardiometabolic risk factors and gut microbiota…
- Trial name
- CARDIO-LIVER (NCT06704321)
- Testing
- TOTUM-448
- Where
- Canada
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Valbiotis
Menopause, Insulin Resistance
Effects of Physical Training on Adipose Tissue Metabolism and Insulin Sensitivity in the Menopausal Transition Phase
The purpose of this study is to determine if physical exercise reduces the adverse changes in adipose tissue metabolism and insulin sensitivity that occurs in women during the menopausal transition.
- Conditions
- Menopause, Insulin Resistance, Body Composition, Beneficial
- Trial name
- NCT02076932
- Testing
- Spinning
- Where
- Denmark
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Fat Sensitivity
Saliva Modification Related to Fat Perception in Human
The perception of fat represents major scientific and nutritional issues. This research aims to identify salivary markers that could predict and possibly explain this perception in healthy human being.
- Trial name
- SensInFat (NCT01532778)
- Where
- France
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement
Atopic Dermatitis
Study of ADSTEM Injection for Patients With Moderate to Severe Subacute and Chronic Atopic Dermatitis
Study of ADSTEM Injection for Patients with Moderate to Severe Subacute and Chronic Atopic Dermatitis
- Trial name
- ADSTEM Inj (NCT07377838)
- Testing
- ADSTEM Inj.
- Volunteers
- 286 people
- Sponsor
- EHL Bio Co., Ltd.
Weight Gain, Overweight
Cross-Sectional and Longitudinal Studies of "Pre-Diabetes" in the Pima Indians
Insulin resistance and a defect in early insulin secretion are risk factors for the development of type 2 diabetes mellitus. A recent longitudinal analysis which tracked the development of diabetes demonstrated that both insulin…
- Conditions
- Weight Gain, Overweight, Insulin Resistance, Obesity
- Trial name
- NCT00340132
- Where
- United States
- Volunteers
- 1,759 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Obesity, Non-obese Controls
NEFA (Non Esterified Fatty Acid) , Adipose Factors Behind Insulin Sensitivity
We want to asses the role of adipose tissue for metabolic complications to obesity before and after weight loss (surgery).
- Trial name
- NCT01727245
- Testing
- Obese, Control group
- Where
- 3 sites in Sweden
- Volunteers
- 500 people
- Sponsor
- Karolinska Institutet
Obesity, Exercise
Exercise Training and Insulin Sensitivity
Regular exercise participation is known to reduce cardiometabolic disease risk but the impact that exercise training has on adipose tissue (AT) metabolism is poorly understood, particularly in humans.
- Trial name
- NCT05930834
- Testing
- exercise
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Missouri-Columbia
Obesity
Short-term Investigation of Resveratrol on Fat Metabolism in Morbidly Obese Women Undergoing Gastric Bypass Surgery
The purpose of this study is to investigate potential metabolic effects of resveratrol in morbidly obese women undergoing gastric bypass surgery.
- Trial name
- NCT01826279
- Testing
- Resveratrol
- Where
- Denmark
- Volunteers
- 16 people
- Sponsor
- University of Aarhus