Clinical trials: Fatigue Post Viral
Long Covid19
Effectiveness of Testofen Compared to Placebo on Long COVID Symptoms
This is a double blind, randomised, placebo-controlled trial to evaluate orally-dosed Testofen (a specialised extract of Trigonella foenum-graecum (Fenugreek) seed) compared to placebo on post COVID-19 symptoms in otherwise…
- Trial name
- NCT05795816
- Testing
- Testofen, Microcrystalline cellulose
- Where
- Australia
- Volunteers
- 150 people
- Sponsor
- RDC Clinical Pty Ltd
Chronic Fatigue Syndrome, Burnout
A Longitudinal Study on Longstanding Complicated Fatigue
The purpose of the study is to investigate if there are common biopsychosocial vulnerability factors for developing and maintaining fatigue, regardless of the diagnosis.
- Conditions
- Chronic Fatigue Syndrome, Burnout, Covid19
- Trial name
- NCT04955587
- Where
- Sweden
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Stockholm University
Post-COVID-19 Syndrome, Fatigue Post Viral
Yoga Versus Health Education for the Treatment of Persistent Fatigue in Patients With Post COVID-19 Syndrome
Evaluation of the short- and medium-term effect of a yoga intervention in addition to routine care compared to health education in addition to routine care on fatigue in patients with post covid syndrome.
- Trial name
- YoFaPoCo (NCT05890599)
- Testing
- Yoga Therapy, Health Education
- Where
- Germany
- Volunteers
- 100 people
- Sponsor
- University Hospital Tuebingen
Post Viral Fatigue, Viral Myocarditis
Post-COVID-19 Outpatient Care and Biomarkers
The aims of this case-control, non-randomized study including patients with post-COVID-19 persisting symptoms are 1) to establish the large blood biobank, 2) to examine levels of circulating inflammatory biomarkers and different…
- Conditions
- Post Viral Fatigue, Viral Myocarditis, POTS
- Trial name
- POSTCOV (NCT05398952)
- Testing
- Laboratory investigations
- Where
- Austria
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Long COVID, Brain Fog
Effect of Probiotic Strain Lactobacillus Paracasei PS23 on Brain Fog in People With Long COVID
The goal of this clinical trial is to test whether the intervention of probiotics supplement can improve symptoms of long covid syndrome. Participants will be given probiotics or placebo capsules for two month.
- Conditions
- Long COVID, Brain Fog, Cognitive Change
- Trial name
- COVID-19 (NCT06348212)
- Testing
- Lactobacillus paracasei PS23, microcrystalline cellulose
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Long COVID
Evaluating the Safety and Efficacy of PNMR as Treatment for Long COVID
This will be a six-week, randomized, parallel, two group, open-label design. Patients will be treated with Paragon Novel Metabolic Regulator (PNMR) + standard of care (SOC) or SOC alone for 6 weeks for the treatment of Long…
- Trial name
- NCT07627815
- Testing
- Paragon Novel Metabolic Regulator (PNMR), Dietary and Lifestyle Recommendations
- Where
- 4 sites in Canada
- Volunteers
- 82 people
- Sponsor
- ParagonClinicals Inc.
Post-Acute COVID19 Syndrome, Long COVID
Exercise Intervention Using mHealth in Patients With Post-Acute COVID-19 Syndrome: a Randomized Clinical Trial
Post-Acute Syndrome COVID-19 is a disease resulting from infection by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).
- Conditions
- Post-Acute COVID19 Syndrome, Long COVID, Post COVID-19 Condition
- Trial name
- COVIDReApp (NCT05725538)
- Testing
- COVIDReApp Group, Control Group
- Where
- Spain
- Volunteers
- 100 people
- Sponsor
- University of Cadiz
Post COVID-19, Cognitive Dysfunction
Multimodal Investigation of Post COVID-19 in Females
The purpose of this study is to investigate the effects of transcutaneous vagus nerve stimulation (t-VNS) on Long Covid symptoms in females and to identify factors influencing susceptibility and recovery-particularly in the…
- Trial name
- NCT05225220
- Testing
- Parasym Device (of Parasym Ltd, UK) using Transcutaneous Vagus Nerve Stimulation (t-VNS)
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Casa Colina Hospital and Centers for Healthcare
Multiple Sclerosis, Long Covid
Fatigue Investigation Using Digital Outcomes
This study investigates objective methods to measure and monitor fatigue in patients with post-COVID-19 condition (long COVID) and multiple sclerosis (MS), and includes a group of healthy volunteers for comparison.
- Conditions
- Multiple Sclerosis, Long Covid, Healthy
- Trial name
- FIDO (NCT07783074)
- Where
- 6 sites in Switzerland
- Volunteers
- 122 people, healthy volunteers welcome
- Sponsor
- Liliana Barrios
Anxiety Depression, Post Traumatic Stress Disorder
Neuropsychological Sequelae and Long COVID-19 Fatigue
An association of fatigue with post-viral neuropsychological disturbs has been reported. Among patients hospitalized with COVID-19 there is an increased incidence of anxiety and depression symptoms.
- Conditions
- Anxiety Depression, Post Traumatic Stress Disorder, Mental Fatigue, COVID-19
- Trial name
- PostCoV2Psy (NCT05323318)
- Testing
- Neuropsychological Sequelae
- Where
- 6 sites in Portugal
- Volunteers
- 200 people
- Sponsor
- Centro Hospitalar Universitario do Algarve
Post-Acute COVID-19 Syndrome, Long COVID
QEEG-NEUROFEEDBACK FOR COGNITIVE REHABILITATION IN LONG COVID-19 SURVIVORS WITH BRAIN FOG
The pandemic has highlighted social, economic, educational, and political issues that have affected the health and quality of life of millions of Brazilians.
- Conditions
- Post-Acute COVID-19 Syndrome, Long COVID, Brain Fog
- Trial name
- QEEG-NFT (NCT07005921)
- Testing
- qEEG-neurofeedback
- Where
- Brazil
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Jade Carvalho Da Silva
Long COVID, Brain Fog
Long COVID Brain Fog: Cognitive Rehabilitation Trial
This study will compare two approaches to cognitive rehabilitation in adults with long COVID with persistent, mild to moderate, cognitive impairment.
- Conditions
- Long COVID, Brain Fog, Cognitive Impairment, Cognitive Dysfunction
- Trial name
- NCT06095297
- Testing
- Processing Speed Training, In-lab Instrumental Activities of Daily Living Training, In-lab Brain Health Training
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Alabama at Birmingham
Long COVID
Water-based Activity to Enhance Recovery in Long COVID-19
This two-year study will evaluate the feasibility and safety of an exercise + cognitive training program to improve neurological symptoms of long-COVID.
- Trial name
- NCT06142253
- Testing
- WATER+CT, Usual Care
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- VA Office of Research and Development
COVID-19
Neuro-inflammation and Post-infectious Fatigue in Individuals With and Without COVID-19
Neuroinflammation can be an important regulator of long COVID, specifically fatigue and cognitive complaints. There is evidence that peripheral inflammation and neuro-inflammation are involved in fatigue and cognitive complaints…
- Trial name
- COVFATI (NCT05371522)
- Testing
- [18F]DPA-714 positron emission tomography (PET) scan
- Where
- Netherlands
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Amsterdam UMC, location VUmc
Chronic Fatigue Syndrome, Long COVID
Endothelial Dysfunction in Post-infection Fatigue Syndromes
Post-infection chronic fatigue syndromes, such as myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and post-COVID-19 condition (Long Covid), are conditions primarily characterized by debilitating fatigue.
- Trial name
- NCT06463106
- Where
- Austria
- Volunteers
- 107 people, healthy volunteers welcome
- Sponsor
- FH Joanneum Gesellschaft mbH
Nervous System Diseases
Randomized, Double-blind, Placebo-controlled Trial of the Efficacy and Safety of Tianeptine in the Treatment of Covid Fog Symptoms in Patients After COVID-19.
COVID-19 is associated with a high risk of complications from the central nervous system. Syndrome of cognitive disorders- in terms of memory, attention or executive functions among COVID-19 convalescents is often called brain…
- Trial name
- COVMENT (NCT06012552)
- Testing
- Tianeptine
- Where
- Poland
- Volunteers
- 140 people
- Sponsor
- Military Institute od Medicine National Research Institute
Post-COVID-19 Syndrome
Prednisolone and Vitamin B1/6/12 in Patients With Post-Covid-Syndrome
This is a multicenter, randomized, placebo controlled, double-blind phase III trial with four parallel groups studying studying the feasibility of RCT in primary care as well as the effectiveness of treatment with prednisolone…
- Trial name
- PreVitaCOV (NCT05638633)
- Testing
- Prednisolone 20 mg/ 5 mg, Vitamin B compound (100mg B1, 50 mg B6, 500 µg B12)
- Where
- 3 sites in Germany
- Volunteers
- 321 people
- Sponsor
- Wuerzburg University Hospital
Chronic Fatigue Syndrome, COVID-19, Long Haul
Investigation of Treating Chronic Fatigue Syndrome After COVID With Pharmacotherapy (Pregabalin) or Complex Rehabilitation
This is a single-center, prospective, randomized, double-blind (pharmacotherapy), placebo-controlled, and comprehensive rehabilitation phase II clinical trial to determine the usefulness of pregabalin in a new indication…
- Trial name
- POSTCOVID (NCT05967052)
- Testing
- Pregabalin, Independent walking training, Gradual movement therapy in the ward
- Where
- Poland
- Volunteers
- 23 people
- Sponsor
- National Institute of Geriatrics, Rheumatology and Rehabilitation, Poland
Myalgic Encephalomyelitis, Chronic Fatigue Syndrome
Effect of Probiotics in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)
Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a neurological disease. Currently there is no effective treatment for ME/CFS due to unclear etiology of the disease.
- Trial name
- NCT04741841
- Testing
- GutMagnific™ H., GutMagnific™ L.
- Where
- Sweden
- Volunteers
- 74 people
- Sponsor
- ImmuneBiotech Medical Sweden AB
LONG-COVID, Post-acute Sequelae of COVID-19
Skeletal Muscle in PASC and ME/CFS Patients
Rationale: A common feature in patients with Post-Acute Sequelae of SARS-CoV-2 Infection (PASC) and Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) are skeletal muscle-related symptoms, such as muscle pain, weakness…
- Conditions
- LONG-COVID, Post-acute Sequelae of COVID-19, ME/CFS
- Trial name
- NCT05225688
- Testing
- Bike exertion test
- Where
- Netherlands
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)