Clinical trials: Fatigue Syndrome, Chronic
LONG-COVID, Post-acute Sequelae of COVID-19
Skeletal Muscle in PASC and ME/CFS Patients
Rationale: A common feature in patients with Post-Acute Sequelae of SARS-CoV-2 Infection (PASC) and Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) are skeletal muscle-related symptoms, such as muscle pain, weakness…
- Conditions
- LONG-COVID, Post-acute Sequelae of COVID-19, ME/CFS
- Trial name
- NCT05225688
- Testing
- Bike exertion test
- Where
- Netherlands
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Post-COVID Condition
Nutritional Intervention and Rehabilitation Treatment in Patients With Post-COVID Condition
SARS-CoV-2 is the coronavirus responsible for developing the disease known as COVID-19. Once the acute phase of the disease has passed, about 40% of the people who discharged continue to have symptoms, and of these, between 50…
- Trial name
- ARACOV-02 (NCT06063031)
- Testing
- Active
- Where
- Spain
- Volunteers
- 146 people
- Sponsor
- Instituto de Investigación Sanitaria Aragón
Long COVID, Post-COVID19 Condition
Amantadine Therapy for Cognitive Impairment in Long COVID
This study will look at the effects of amantadine on cognitive function in persons with Long COVID. It will also collect specimens to study possible causes of cognitive symptoms in Long COVID, and whether any lab tests can…
- Conditions
- Long COVID, Post-COVID19 Condition, Post-Acute COVID19 Syndrome
- Trial name
- AmantadineLC (NCT06055244)
- Testing
- Amantadine
- Where
- United States
- Volunteers
- 64 people
- Sponsor
- Ohio State University
Bodily Distress Syndrome, Irritable Bowel
Health Care Use and Costs of Functional Somatic Disorders
The goal of this observational case-control study is to learn about direct healthcare use and costs of functional somatic disorders.
- Conditions
- Bodily Distress Syndrome, Irritable Bowel, Fibromyalgia, Chronic Widespread Pain
- Trial name
- NCT05811663
- Where
- Denmark
- Volunteers
- 9,656 people
- Sponsor
- Aarhus University Hospital
Fibromyalgia, Chronic Fatigue Syndrome
Motor Control in Chronic Fatigue Syndrome and Fibromyalgia
This project is a comprehensive study, with main focus on motor control, comparing patients with chronic fatigue syndrome / myalgic encephalopathy (CFS/ME) and/or fibromyalgia syndrome (FMS).
- Trial name
- NCT01686074
- Where
- Norway
- Volunteers
- 90 people
- Sponsor
- Norwegian University of Science and Technology
Medically Unexplained Chronic Fatigue, Chronic Fatigue Syndrome
Fatigue Self-Management in Primary Care
This study will evaluate, in a primary care setting, the effectiveness of a brief self-management behavioral treatment in patients with medically unexplained chronic fatigue.
- Trial name
- NCT00997451
- Testing
- Cognitive-behavioral self-management, Symptom monitoring
- Where
- United States
- Volunteers
- 107 people
- Sponsor
- Stony Brook University
Asthenia, COVID-19
Efficacy of the Therapy With BRAINMAX® Using fMRI for the Treatment of Patients With Asthenia After COVID-19
to assess executive network using resting-state fMRI and patterns of brain activation using task fMRI with a cognitive paradigm, against the background of taking the drug in comparison with placebo in patients with post-COVID…
- Conditions
- Asthenia, COVID-19, Functional MRI, Cognitive Impairment
- Trial name
- NCT05939622
- Testing
- Structural and functional MRI, Ethyl methyl hydroxypyridine succinate + Meldonium
- Where
- Russia
- Volunteers
- 30 people
- Sponsor
- Promomed, LLC
Long COVID-19 Syndrome, Chronic Fatigue Syndrome
A Multicenter, Adaptive, Randomized, doublE-blinded, Placebo-controlled Study in Participants With Long COVID-19: The REVIVE Trial
IRB approval date 14-APR-2024 and public at https://plataformabrasil.saude.gov.br/login.jsf since IURB approval Long COVID is a multi-systemic condition comprising often severe and persistent symptoms (longer than 12 weeks) that…
- Trial name
- REVIVE (NCT06128967)
- Testing
- Fluvoxamine Maleate 100 MG, Metformin Extended Release Oral Tablet
- Where
- 6 sites in Brazil
- Volunteers
- 399 people
- Sponsor
- Cardresearch
Post-Acute Sequelae of SARS-CoV-2 Infection, Long COVID
Observational Study of Intranasal IVIG in Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Patients Undergoing Medical Tourism
This observational study is being conducted by Healing Hope International to collect real-world data on an emerging treatment approach for Long COVID in patients with immunodeficiency.
- Conditions
- Post-Acute Sequelae of SARS-CoV-2 Infection, Long COVID, Long COVID Fatigue, Long COVID Syndrome
- Trial name
- IVIG-LC (NCT06992401)
- Volunteers
- 50 people
- Sponsor
- Tamara C Tamas
Chronic Fatigue Syndrome
ME/CFS: Activity Patterns and Autonomic Dysfunction
The purpose of this study is to identify daily activity patterns, negative life events and autonomic abnormalities that may be related to non-improvement in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS).
- Trial name
- NCT02948556
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Stony Brook University
Long COVID
Feasibility of Personalised Health Behaviour Coaching to Support Symptoms and Activities of Daily Living in Those With Long COVID-19.
This pilot RCT aims to assess whether a simple PA behavioural modification intervention can be delivered safely and feasibly to individuals with Long COVID suffering long standing symptoms with concerns regarding their ability to…
- Trial name
- NCT05752331
- Testing
- Physical activity behavioural modification
- Where
- United Kingdom
- Volunteers
- 32 people
- Sponsor
- Bournemouth University
Chronic Fatigue Syndrome, Myalgic Encephalomyelitis
Tumor Necrosis Factor-alpha Inhibition Using Etanercept in Chronic Fatigue Syndrome
The hypothesis is that a subset of patients with chronic fatigue syndrome/ myalgic encephalomyelitis (CFS/ME), including also patients with no clinical response after B-cell depletion therapy using the anti-CD20 antibody…
- Trial name
- NCT01730495
- Testing
- Etanercept
- Where
- Norway
- Volunteers
- 4 people
- Sponsor
- Haukeland University Hospital
Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS), ME/CFS Following COVID-19
Observational Study on Immunoadsorption (IA) in Patients With Autoantibody-Positive Post-Infectious ME/CFS
Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a severe, often infection-triggered disease characterized by debilitating fatigue and post-exertional malaise lasting over 14 hours, along with pain, cognitive…
- Trial name
- IMPACT (NCT07529197)
- Testing
- IA with TheraSorb ® column (Miltenyi)
- Where
- Germany
- Volunteers
- 50 people
- Sponsor
- Charite University, Berlin, Germany
Long COVID, PASC Post Acute Sequelae of COVID 19
Brain Stimulation in Long COVID
Cognitive problems and severe fatigue are two frequently occurring symptoms in long COVID, also known as Post-Covid Condition or Post-Acute Sequelae of COVID-19 (PASC), and their causes are currently unknown.
- Conditions
- Long COVID, PASC Post Acute Sequelae of COVID 19, Post COVID-19 Condition (PCC)
- Trial name
- MALIBU (NCT07278206)
- Testing
- Repetitive Transcranial Magnetic Stimulation
- Where
- Netherlands
- Volunteers
- 66 people
- Sponsor
- Amsterdam UMC, location VUmc
Chronic Fatigue Syndrome
Thunder-Fire Moxibustion Therapy for Chronic Fatigue Syndrome on Shenque Acupoint: a Randomized Controlled Trial
Chronic fatigue syndrome is a group of syndrome and is prevalent in adult. Thunder-fire moxibustion is a commentary therapy belonged to acupuncture therapy.
- Trial name
- NCT02964533
- Testing
- thunder-fire moxibustion therapy, common moxa-stick moxibustion
- Where
- China
- Volunteers
- 70 people
- Sponsor
- Guangzhou University of Chinese Medicine
Post-Acute COVID-19 Syndrome, Biofeedback, Psychology
Prevention of Long Covid Syndrome
Biofeedback equipment is classified by the Food and Drug Administration (FDA) as medical device class II and this type of equipment/treatment has shown evidence regarding stress management in post-Covid-19 syndrome.
- Conditions
- Post-Acute COVID-19 Syndrome, Biofeedback, Psychology, Quality of Life, Depressive Symptoms
- Trial name
- NCT05793736
- Testing
- Biofeedback training, Treatment as usual
- Where
- Italy
- Volunteers
- 17 people
- Sponsor
- University of Cagliari
Fatigue Syndrome, Chronic
Epigenetics of Post-exertional Malaise in Patients With ME/CFS
Exploring epigenetic mechanisms of Myalgic Encephalomyelitis / Chronic Fatigue Syndrome (ME/CFS) is crucial to understand the mechanisms underlying its pathophysiology.
- Trial name
- EPIME (NCT04378634)
- Testing
- Exercise, Mental Stress Test
- Where
- Belgium
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- Vrije Universiteit Brussel
Sleep Apnea, Obstructive, Hypertension
Epidemiology and Intervention of Obstructive Sleep Apnea Based on Community
This observational study in a real-world community was designed to perform epidemiological investigation and assess effect of CPAP intervention of obstructive sleep apnea.
- Conditions
- Sleep Apnea, Obstructive, Hypertension, Obesity, Diabetes
- Trial name
- NCT03280914
- Testing
- Auto-CPAP
- Where
- China
- Volunteers
- 103 people
- Sponsor
- Guangdong Provincial People's Hospital
Post-COVID / Long-COVID, ME/CFS
Vagus Nerve Stimulation to the Ear to Improve Symptoms in Post-COVID-19 and ME/CFS
This study is testing whether a gentle electrical stimulation of a nerve in the ear, called the vagus nerve, can help reduce fatigue and improve symptoms in people with Post-COVID Syndrome or Myalgic Encephalomyelitis/Chronic…
- Trial name
- STIMPACT (NCT06968104)
- Testing
- transcutaneous vagus nerve stimulation
- Where
- Luxembourg
- Volunteers
- 48 people
- Sponsor
- University of Luxembourg
Post-COVID ME/CFS
Hyperbaric High Pressure Oxygen Therapy in Post-COVID Syndrome and ME/CFS
The objective of this observational study is to document symptom progression in 60 patients with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) who undergo Hyperbaric Oxygen Therapy (HBOT) following COVID or other…
- Trial name
- NCT06118138
- Testing
- Hyperbaric oxygen therapy (HBOT)
- Where
- Germany
- Volunteers
- 60 people
- Sponsor
- Charite University, Berlin, Germany