Clinical trials: Fatigue in Multiple Sclerosis
Multiple Sclerosis
Exercise Intensity and Immune Function in Multiple Sclerosis
This study aims to determine the effect of exercise intensity within a 15 week programme in moderately disabled people with multiple sclerosis (MS).
- Trial name
- NCT02264704
- Testing
- High intensity exericse, Moderate intensity exericse
- Where
- United Kingdom
- Volunteers
- 63 people
- Sponsor
- University of the West of Scotland
Multiple Sclerosis
Short and Long Term Multiple Outcomes in Persons With Multiple Sclerosis Treated by Fampridine.
This prospective monocentric open label trial was realized in the Laboratory of Clinical Functional Exploration of Movement at the University Hospital of Besancon.
- Trial name
- FAMPISEP (NCT02849782)
- Testing
- Fampridine
- Where
- France
- Volunteers
- 89 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Multiple Sclerosis
Feasibility of Web-based CBT-I Intervention in Individuals With Multiple Sclerosis
Forty individuals with multiple sclerosis (MS) will be randomly assigned to a 6-week web-based cognitive behavior therapy for insomnia intervention (wCBT-I) or to wCBT-I plus biweekly support meetings with research personnel via…
- Trial name
- NCT03783585
- Testing
- Cognitive behavioral therapy for insomnia, Cognitive behavioral therapy for insomnia + biweekly support
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- University of Kansas Medical Center
Multiple Sclerosis, MS
Evaluation of the Efficacy of Transcranial Direct Current Stimulation in Reducing Fatigue and Improving Quality of Life in Patients With Multiple Sclerosis: A Randomized Clinical Trial
The goal of this clinical trial is to evaluate whether the application of three 2-week cycles of tDCS combined with motor therapy is more effective in reducing fatigue in adult patients with multiple sclerosis, compared to the…
- Trial name
- tDCS (NCT06873464)
- Testing
- Three cycles of tDCS combined with motor tasks, Two cycles of tDCS combined with motor tasks
- Where
- Spain
- Volunteers
- 24 people
- Sponsor
- European University of Madrid
Multiple Sclerosis, Chronic Cerebrospinal Venous Insufficiency
Functional Changes Following Percutaneous Venoplasty in Multiple Sclerosis Patients
Multiple Sclerosis (MS) is a demyelinating disease of the central nervous system (CNS) that often results in reduced muscle function which produces fatigue, weakness and a decline in daily mobility.
- Trial name
- NCT01555684
- Testing
- percutaneous venoplasty to alleviate chronic cerebrospinal venous insufficiency
- Where
- United Kingdom
- Sponsor
- University of Stirling
Fatigue, Multiple Sclerosis
Acupuncture or MBSR for Patients With Fatigue and MS
The main aim of this trial is to evaluate whether additional acupuncture or mindfulness-based stress reduction is more efficacious than usual care only to reduce fatigue in patients with multiple sclerosis.
- Trial name
- MS-Fatigue (NCT01864707)
- Testing
- Usual care + acupuncture, usual care+mbsr, usual care
- Where
- Germany
- Volunteers
- 104 people
- Sponsor
- Charite University, Berlin, Germany
Multiple Sclerosis
Multiple Sclerosis and Fatigue Assessment
Fatigue in patients with Multiple Sclerosis (MS) is a problem that is seen without physical exertion and affects the majority of patients.
- Trial name
- NCT05820334
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Asli Demirtaş
Relapsing Remitting Multiple Sclerosis, Sleep Initiation and Maintenance Disorders
Eszopiclone for Improving Sleep in Multiple Sclerosis (MS)
The purpose of this study is to determine if people with multiple sclerosis (MS) and fatigue have disrupted sleep, as was suggested in previous studies, and whether treating the disruptions of sleep improves the fatigue.
- Conditions
- Relapsing Remitting Multiple Sclerosis, Sleep Initiation and Maintenance Disorders, Fatigue
- Trial name
- NCT00594087
- Testing
- eszopiclone
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Vermont
Fatigue
Effect of Melatonin on Multiple Sclerosis Related Fatigue
The purpose of this study was to evaluate the efficacy and safety of Melatonin in treatment of fatigue and Quality of Life of MS patients.
- Trial name
- NCT01718678
- Testing
- Melatonin
- Where
- Iran
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Isfahan University of Medical Sciences
Multiple Sclerosis
Dalfampridine in Egyptian Patients With Multiple Sclerosis
The only approved treatment for impaired ambulation in MS is Dalfampridine (also known as fampridine, 4-aminopyridine, 4-AP). Fampridine penetrates the blood-brain barrier and improves impaired axonal conduction by selectively…
- Trial name
- NCT05730738
- Testing
- Dalfampridine ER, 10 Mg Oral Tablet, Extended Release
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Ain Shams University
Exercise
A Single-blinded, Controlled, Multi-centre Study of Effects of Exercise in Participants With Multiple Sclerosis
The primary objective of the investigation is to determine whether the addition of exercise (resistance training or modified physiotherapy) improves functional capacity in Multiple Sclerosis (MS) participants undergoing Disease…
- Trial name
- ACTIMS (NCT01065090)
- Where
- 14 sites in Australia, Denmark and 4 more
- Volunteers
- 38 people
- Sponsor
- Biogen
Multiple Sclerosis, Fatigue
Oral Testosterone for Fatigue in Male Multiple Sclerosis Patients
Fatigue is one of the most frequent symptoms reported by multiple sclerosis (MS) patients and is often a significant source of disability.
- Trial name
- NCT01516554
- Testing
- Testosterone undecanoate
- Where
- Canada
- Volunteers
- 3 people
- Sponsor
- Health Sciences Centre, Winnipeg, Manitoba
Multiple Sclerosis
FOCUS Fatigue Outcome in Copaxone USers
The study primarily investigates the effect of copaxone on fatigue during treatment, compared to baseline in patients with relapsing-remitting multiple sclerosis.
- Trial name
- NCT00267319
- Testing
- Glatiramer acetate
- Where
- Czechia
- Volunteers
- 111 people
- Sponsor
- Sanofi
Multiple Sclerosis, Urinary Incontinence (UI)
URINARY INCONTINENCE AND PELVIC FLOOR MUSCLE ACTIVITY IN MULTIPLE SCLEROSIS
This study aims to investigate the relationship between urinary incontinence severity and surface electromyography (EMG) findings in women with multiple sclerosis.
- Trial name
- MS-UI-PFM (NCT07489794)
- Where
- Turkey (Türkiye)
- Volunteers
- 47 people
- Sponsor
- Prof. Dr. Cemil Tascıoglu Education and Research Hospital Organization
Fatigue in Multiple Sclerosis
Testing the Effects of Methylphenidate on Multiple Sclerosis
Up to 95% of individuals with Multiple Sclerosis report experiencing cognitive fatigue, characterized by a lack of energy, feelings of exhaustion, an the perception that one is unable to partake in daily activities.
- Trial name
- NCT02286557
- Testing
- Methelphenidate
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- Kessler Foundation
Multiple Sclerosis
Effect of Motor Entrainment to Auditory Cues and Music During Walking on Quality of Movement and Perceived Fatigue in Persons With Multiple Sclerosis (PwMS)
The study investigates the effect of different conditions of auditory cueing and music on walking quality and perceived fatigue in persons with multiple sclerosis compared to healthy controls.
- Trial name
- NCT03281330
- Testing
- auditory cues and music during walking
- Where
- 3 sites in Belgium
- Volunteers
- 60 people
- Sponsor
- Hasselt University
Multiple Sclerosis
Telehealth-Based Exercise Program to Treat Fatigue in MS
This is a clinical trial examining a brief motivational intervention to improve adherence to exercise among individuals with MS to improve fatigue.
- Trial name
- MS-FIT (NCT01198977)
- Testing
- Brief telephone-based counseling, Education counseling
- Where
- United States
- Volunteers
- 64 people
- Sponsor
- VA Office of Research and Development
Multiple Sclerosis, Relapsing-Remitting
NAPS-MS: NAtalizumab Effects on Parameters of Sleep in Patients With Multiple Sclerosis Experiencing Fatigue or Sleepiness
The purpose of this study is to assess the impact of Natalizumab (Tysabri) therapy on sleep efficiency, total sleep time and sleep latency, in Multiple Sclerosis (MS) patients receiving Natalizumab for 6 months relative to…
- Trial name
- NCT01591551
- Testing
- Natalizumab (Tysabri)
- Where
- 3 sites in United States
- Volunteers
- 37 people
- Sponsor
- Cornerstone Health Care, PA
Multiple Sclerosis
The Effect of Telerehabilitation Based Pilates Training in Multiple Sclerosis Patients
Multiple Sclerosis (MS) is a chronic inflammatory disease of the central nervous system characterized by myelin, oligodendrocyte, and axon damage.
- Trial name
- NCT04838886
- Testing
- Telerehabilitation-based Pilates Exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Gazi University
Multiple Sclerosis
Examining the Effects of a Telehealth Self-management Intervention in Multiple Sclerosis
The objective of this study is to conduct a randomized controlled trial to examine the effectiveness of a telehealth intervention that supports individuals in managing fatigue and increasing physical activity (PA) behavior in…
- Trial name
- NCT01572714
- Testing
- Social Support Program, Physical Activity Program, Physical Activity Plus Fatigue Management Education Program
- Where
- United States
- Volunteers
- 208 people
- Sponsor
- Case Western Reserve University