Clinical trials: Fatty Degeneration
Diabetes Mellitus, Type 2
Effect of Low-glycemic Index Meals Intake on DM2 Women Under Metformin Therapy
To compare the effect of low-glycemic index versus control lunches and dinners intake on indicators of satiety, metabolic parameters and liver steatosis degree on women with type 2 diabetes under metformin therapy.
- Trial name
- LGIM (NCT03165877)
- Testing
- Low-glycemic index, Control
- Volunteers
- 13 people
- Sponsor
- Universidad de Valparaiso
Cognitive Dysfunction, Alzheimer Disease
ALA-enriched Nutrition for Prevention of Cognitive Decline in APOE4 Older Adults
This randomized, double-blind, placebo-controlled pilot trial will evaluate the effects of alpha-linolenic acid (ALA) supplementation on cognitive function, blood-brain barrier integrity, and brain vascular health in older adults…
- Conditions
- Cognitive Dysfunction, Alzheimer Disease, Blood-Brain Barrier, Apolipoprotein E, Deficiency or Defect of
- Trial name
- NCT07392723
- Testing
- Alpha-Linolenic Acid (2.6 g/day)
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Michal Schnaider Beeri, Ph.D.
Binge Drinking, Liver Injury
Metabolic Changes in Healthy Subjects with Acute Binge Drink
The goal of this double-blinded, randomized trial is to investigate the effects of acute binge drinking on liver function, liver fat content, and lipid metabolism in healthy young subjects.
- Conditions
- Binge Drinking, Liver Injury, Hepatic Steatosis
- Trial name
- MeABD (NCT06298318)
- Testing
- Vodka, water
- Where
- China
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Zhejiang Chinese Medical University
Age-related Macular Degeneration, Cataract
Age-Related Eye Disease Study 2 (AREDS2)
Oral supplementation with the Age-Related Eye Disease Study (AREDS) formulation (antioxidant vitamins C and E, beta carotene, and zinc) has been shown to reduce the risk of progression to advanced age-related macular degeneration…
- Trial name
- AREDS2 (NCT00345176)
- Testing
- Lutein/zeaxanthin, DHA/EPA, Lutein/zeaxanthin and DHA/EPA
- Where
- 91 sites in United States
- Volunteers
- 4,203 people
- Sponsor
- National Eye Institute (NEI)
Liver Fibrosis, Fatty Liver
Comparison of iLivTouch and FibroScan for the Assessment of Liver Fibrosis and Steatosis in Adult Patients in the US
This is a multi-center, cross-sectional, and prospective study that will recruit patients from multiple hospitals or outpatient clinics in the USA to the comparison of iLivTouch and FibroScan for the assessment of liver fibrosis…
- Trial name
- NCT06051669
- Testing
- iLivTouch, FibroScan
- Where
- 4 sites in United States
- Volunteers
- 418 people
- Sponsor
- New Discovery LLC
Power, Metabolic Disturbance
Effect of 8-week Intake of 2S-hesperidin on Performance, Body Composition and Biochemicals Markers in Amateur Cyclists
This clinical study evaluates the effect of 500 mg of 2S-hesperidin for 8 weeks on performance (power generated in different metabolic zones), body composition (fat and muscle mass) and biochemical (antioxidant, inflammatory…
- Conditions
- Power, Metabolic Disturbance, Change, Body Weight, Changes Fatty
- Trial name
- HESPERFORMAN (NCT04597983)
- Testing
- 2S-hesperidin
- Where
- Spain
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Francisco Javier Martínez Noguera
Age-Related Macular Degeneration
Effect of Micronutrient Supplementation on the Intestinal Microbiota in Patients With Age-related Macular Degeneration - The Gut-Retina-axis Study
Age-related macular degeneration (AMD) is a leading cause of visual impairment in the elderly, characterized by multifactorial etiology.
- Trial name
- NCT06391411
- Testing
- a micronutrient mix containing lutein (10 mg), zeaxanthin (2 mg), saffron (20 mg), vitamin C (80 mg), vitamin E (12 mg) and zinc (10mg), anti-VEGF treatment
- Where
- Italy
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Azienda Ospedaliero-Universitaria Careggi
Non Alcoholic Steatohepatitis (NASH)
Safety, Tolerability, and Efficacy of AXA1125 in NASH With Fibrosis
This study will compare the effects of AXA1125, an orally active mixture of amino acids, compared to placebo, on improving fat and inflammation (steatohepatitis) as well as fibrosis in subjects with non alcoholic steatohepatitis…
- Trial name
- NCT04880187
- Testing
- AXA1125
- Where
- 75 sites in United States, Australia and 5 more
- Volunteers
- 273 people
- Sponsor
- Axcella Health, Inc
Diabetes Mellitus Type 2, Metabolic Syndrome
Effect of Liraglutide on Cardiovascular Endpoints in Diabetes Mellitus Type 2 Patients
The most important cause of mortality amongst DM2 patients is cardiovascular disease. An early finding of cardiovascular disease in DM2 and obesity is diastolic dysfunction.
- Conditions
- Diabetes Mellitus Type 2, Metabolic Syndrome, Cardiovascular Disease, Diastolic Dysfunction
- Trial name
- MAGNA VICTORIA (NCT01761318)
- Testing
- Liraglutide
- Where
- Netherlands
- Volunteers
- 50 people
- Sponsor
- Leiden University Medical Center
Hepatic Steatosis, Overweight and Obesity
Implementation of the Fatty Liver Index in Primary Care
This trial aims to evaluate the impact on cardiovascular risk control in individuals in risk of being affected by hepatic steatosis through the implementation of a screening test (Fatty Liver Index) in Primary Care.
- Trial name
- FLI-AP (NCT06363617)
- Testing
- FLI
- Where
- Spain
- Volunteers
- 434 people
- Sponsor
- Consorci Sanitari de l'Alt Penedès i Garraf
Metabolic Disease, Obesity
Adiposity, Cardiometabolic and Neurocognitive Health Among Ethnic Groups: a Feasibility and Pilot Study
The goal of this pilot and feasibility study is to is to test the feasibility of conducting a cross-sectional study on adiposity and cardiometabolic and neurocognitive risk factors at Kings College Hospital NHS Foundation Trust…
- Conditions
- Metabolic Disease, Obesity, Hepatic Steato-Fibrosis, Cardiovascular Diseases
- Trial name
- ACNH (NCT06435611)
- Where
- 2 sites in United Kingdom
- Volunteers
- 10 people
- Sponsor
- King's College Hospital NHS Trust
Fatty Liver, Obesity
Genetic Variant in Apolipoprotein C3 Gene and Fatty Liver in Obese Children
In the past decades, obesity in children is much more prevalent in the world. Given the increasing prevalence of pediatric obesity worldwide, fatty liver incidence is on the rise.
- Trial name
- NCT01682655
- Where
- Taiwan
- Volunteers
- 500 people
- Sponsor
- Far Eastern Memorial Hospital
Colorectal Cancer, Steatohepatitis
A Randomized, Placebo-controlled, Double-blind Phase II Study Evaluating if Glucophage Can Avoid Liver Injury Due to Chemotherapy Associated Steatosis
This multicenter randomized, placebo-controlled phase II study will enroll 132 first-line palliative treated subjects with metastatic KRAS wild type CRC.
- Trial name
- G-LUCAS (NCT01523639)
- Where
- 7 sites in Austria
- Volunteers
- 8 people
- Sponsor
- Austrian Breast & Colorectal Cancer Study Group
Chronic Hepatitis C, Insulin Resistance
Pioglitazone vs. Placebo in Association With Pegylated Interferon and Ribavirin in HCV Patients With Insulin Resistance
The purpose of this study is to test whether the correction of insulin resistance with pioglitazone, will improve the response to antiviral treatment.
- Trial name
- PEGLIST C (NCT00927290)
- Testing
- Pioglitazone
- Where
- France
- Volunteers
- 40 people
- Sponsor
- French National Agency for Research on AIDS and Viral Hepatitis
MASLD
Structured Physical Activity Intervention in Patients With MASLD Receiving a Mediterranean Diet
Lifestyle interventions based on diet and physical activity are the cornerstone of management for metabolic dysfunction-associated steatotic liver disease (MASLD), yet individual responses remain highly variable.
- Trial name
- EHMet-DIA (NCT07478588)
- Testing
- Exercise plus Mediterranean diet, At-home exercise plus Mediterranean diet
- Where
- 2 sites in Spain
- Volunteers
- 96 people
- Sponsor
- Fundación Pública Andaluza para la gestión de la Investigación en Sevilla
Fatty Liver
Randomized Study of the Use of Intravenous Choline Supplementation in Long Term Total Parenteral Nutrition
OBJECTIVES: I. Determine whether intravenous choline supplementation will reverse the hepatic steatosis and improve liver function in patients who receive long term total parenteral nutrition.
- Trial name
- NCT00004697
- Testing
- choline chloride
- Volunteers
- 15 people
- Sponsor
- University of Texas
Eating Behavior, Metabolic Syndrome
Study of Eating Patterns With a Smartphone App and the Effects of Time Restricted Feeding in the Metabolic Syndrome
SwissChronoFood - Study of eating patterns with a smartphone app and the metabolic effects of time restricted feeding in metabolic syndrome The purpose of this study is to assess eating patterns among teenagers and adults with a…
- Conditions
- Eating Behavior, Metabolic Syndrome, Obesity, Dyslipidemias
- Trial name
- NCT03241121
- Testing
- Time restricted feeding, Regular dietary advices, Eating patterns
- Where
- 2 sites in Switzerland
- Volunteers
- 235 people, healthy volunteers welcome
- Sponsor
- University of Lausanne Hospitals
Diagnoses Disease
Quantitative Ultrasound for Diagnosing Hepatic Steatosis in Nonalcoholic Fatty Liver Multicenter Study
To evaluate the diagnostic performance of quantitative ultrasound parameters for assessing hepatic steatosis in non-alcoholic fatty liver disease using histologic results as reference standard
- Trial name
- NCT04985188
- Testing
- Quantitative ultrasound (QUS) technique
- Volunteers
- 112 people
- Sponsor
- Seoul National University Hospital
Non Alcoholic Fatty Liver Disease
The Role of Obstructive Sleep Apnea in Children With Fatty Liver Disease
The purpose of this study is to examine whether CPAP therapy can reduce or eliminate hepatic fat accumulation in obese children and adolescents.
- Trial name
- NCT02134522
- Testing
- Continuous positive airway pressure (CPAP).
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Yale University
Steatosis, Obesity
Evaluation of the Diagnostic of Hepatic Fibrosis With the in Severe Obese Patients Candidates to Bariatric Surgery
Background: The XL probe of FibroScan was recently developed to realize liver stiffness measurements (LSM) in overweight patients.
- Conditions
- Steatosis, Obesity, Fibrosis, Liver
- Trial name
- NCT03548597
- Testing
- Evaluation of the Diagnostic of Hepatic Fibrosis With the XL Probe of the Fibroscan Versus Biopsies in Severe Obese Patients Candidates to Bariatric Surgery
- Volunteers
- 132 people
- Sponsor
- European Georges Pompidou Hospital