Clinical trials: Fear Extinction
Obsessive-Compulsive Disorder
Fear Conditioned Response in Healthy Subjects and in OCD Patients Pre and Post Treatment With Sertraline.
24 OCD patients and 24 healthy subjects will be submitted to a two-day fear conditioning paradigm during acquisition of functional magnetic resonance imaging (fMRI).
- Trial name
- FEARCON (NCT03068429)
- Testing
- Sertraline Hydrochloride
- Where
- Brazil
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Phobias, Claustrophobia
Effects of Low-Level Laser Stimulation With and Without Fear Extinction Training
There are two specific aims for this study. Aim 1 is to test whether low-level laser therapy (LLLT) can enhance the efficacy of fear extinction training in the modification of pathological fear.
- Conditions
- Phobias, Claustrophobia, Social Phobia
- Trial name
- NCT02926352
- Testing
- Extinction Training, Low-Level Laser Therapy
- Where
- United States
- Volunteers
- 112 people, healthy volunteers welcome
- Sponsor
- University of Texas at Austin
Social Anxiety Disorder
Cannabidiol Effects on Fear Extinction in Social Phobia
The investigators will randomly assign participants with social anxiety disorder to receive oral cannabidiol (CBD) or placebo. Participants will undergo a fear conditioning and extinction trial, and the investigators will examine…
- Trial name
- NCT06123702
- Testing
- Fear extinction, Cannabidiol Cap/Tab
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Hartford Hospital
Posttraumatic Stress Disorder, Anxiety Disorder
Pilot Study of Pharmaceutical and Behavioral Interventions to Treat Anxiety Disorders
The aim of this project is to create fear conditioning paradigm within which the relative strengths of various novel pharmacological and behavioral interventions can be tested.
- Trial name
- NCT01631682
- Testing
- Propranolol, Reactivation, Mifepristone
- Where
- United States
- Volunteers
- 186 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Fear, Stress
Epi-Genetic Modulators of Fear Extinction in Alcohol Dependence
Background: Researchers want to learn if people with alcohol dependence have more difficulty learning to feel calm, or learn to fear things more easily.
- Conditions
- Fear, Stress, Alcohol Dependence
- Trial name
- NCT02438969
- Where
- United States
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Insomnia, PTSD
The Effects of Orexin Antagonism on Fear Extinction in PTSD
PTSD affects approximately 22% of Veterans who have served in Iraq and Afghanistan. Symptoms of PTSD may include re-experiencing, avoidance of trauma reminders, negative thoughts or feelings, and hyperarousal, such as increased…
- Trial name
- NCT06788522
- Testing
- Suvorexant
- Where
- 2 sites in United States
- Volunteers
- 40,120 people
- Sponsor
- VA Office of Research and Development
Hyperalgesia, Chronic Pain Syndrome
Pain-related Fear as a Facilitator of Nocebo Hyperalgesia
Nocebo hyperalgesia is characterized by adverse pain outcomes, induced by patients' expectations. In the lab, nocebo effects are commonly studied via classical conditioning, a method that employs pairings of neutral…
- Conditions
- Hyperalgesia, Chronic Pain Syndrome, Chronic Pain, Psychogenic, Fear of Pain
- Trial name
- LFS (NCT04197154)
- Testing
- Threat manipulation (control, no threat), Threat manipulation, Conditioning of moderate pain
- Where
- Netherlands
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Leiden University Medical Center
Acrophobia
Single Session Virtual Reality Therapy in Acrophobia - and the Role of Respiration
In recent years, in the treatment of phobias, exposure therapy in virtual reality is becoming more and more popular as an alternative for in-vivo exposure.
- Trial name
- NCT03893214
- Testing
- virtual reality exposure for acrophobia, movie
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Witten/Herdecke
Phobia, Specific
Influence of Valproic Acid on Extinction-based Therapy in Patients With Fear of Spiders.
The purpose of this study is to evaluate whether valproic acid in combination with fear memory reactivation is useful to enhance treatment stability of exposure therapy for specific phobia.
- Trial name
- VALPRO (NCT02789813)
- Testing
- Valproic Acid, Fear reactivation, No fear reactivation
- Where
- Switzerland
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Prof. Dominique de Quervain, MD
Obsessive Compulsive Disorder
Fear Extinction and Mechanisms of Change in Obsessive Compulsive Disorder
The purpose of this study is to find out more about how the brain stores emotional learning in obsessive-compulsive disorder (OCD). In particular, we would like to understand how human beings learn not to fear.
- Trial name
- NCT02467374
- Testing
- Behavior Therapy
- Where
- United States
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Phobia
Unconscious Reduction of Fear Through Decoded Neuro-Reinforcement
This application investigates the efficacy of a novel method of neuro-reinforcement based on decoded fMRI activity to reduce fear responses in individuals with phobias (e.g., spiders, snakes).
- Trial name
- DecNef (NCT06420557)
- Testing
- Unconscious Neuro-reinforcement
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of California, Los Angeles
Anxiety Disorders, Social Phobia
Cerebellar Neuromodulation to Enhance Fear Extinction and Predict Response to Exposure Therapy
Emerging neuroimaging studies have shown that the cerebellum contributes to different aspects of timing, prediction, learning, and extinction of conditioned responses to aversive stimuli, factors that may be relevant to the…
- Trial name
- NCT03275337
- Testing
- Transcranial Direct Current Stimulation
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Laureate Institute for Brain Research, Inc.
Phobic Disorders
Noradrenergic Manipulation and Virtual Reality Exposure Therapy in Phobic Participants
Recent advances in animal research have identified pharmacological agents that appear to both accelerate and consolidate extinction learning. One cognitive enhancers is Yohimbine hydrochloride (YOH).
- Trial name
- NCT02007694
- Testing
- Virtual Reality Exposure Therapy (VRET)
- Where
- Netherlands
- Volunteers
- 56 people
- Sponsor
- VU University of Amsterdam
PostTraumatic Stress Disorder
Effects of Delta-9 Tetrahydrocannabinol (THC) on Retention of Memory for Fear Extinction Learning in PTSD: R61 Study
The goal of this study is to look at how a type of drug called cannabinoids are related to the processing of fear signals, the experience of emotions and fear, and the pattern of activity in the brain that is involved in these…
- Trial name
- NCT03008005
- Testing
- Dronabinol Cap 5 milligrams (MG), Dronabinol Cap 10 milligrams (MG)
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- Wayne State University
Fear, Anxiety
Social Support and Enhanced Fear Extinction
University of California, Los Angeles researchers will recruit healthy participants and anxious participants (those diagnosed with social anxiety disorder) age 18-55 years old to participate in a study examining whether the…
- Trial name
- NCT04565041
- Testing
- Social Support
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Anxiety Disorder
Effects of Verbal Instructions on Fear Extinction and Extinction Retrieval
The goal of this study is to examine if verbal instructions can improve fear extinction learning and extinction retrieval in patients with anxiety disorders (AD) and healthy controls.
- Trial name
- NCT05718271
- Testing
- Explicit instructions before extinction, Explicit instructions after extinction
- Where
- Germany
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Ruhr University of Bochum
Social Anxiety
Using the Neuroscience of Fear Extinction for Anxiety Reduction
Social anxiety disorder affects as many as 12% of Americans, resulting in significant distress and disability. Although exposure therapy is one of the best treatments available, as many as 25% of patients do not respond and we do…
- Trial name
- UNFEAR (NCT03465137)
- Testing
- Coordinated Anxiety Learning and Management (CALM)
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Stanford University
One Week Follow-up Assessment, Six Weeks Follow-up Assessment
The Effect of Time on Generalization of Exposure-based Benefit
Participants will receive a pre-assessment and an exposure with a control spider. This control spider will be presented again at post-training assessments.
- Conditions
- One Week Follow-up Assessment, Six Weeks Follow-up Assessment, Three Months Follow-up Assessment
- Trial name
- NCT06255821
- Testing
- Exposure
- Where
- Germany
- Volunteers
- 59 people
- Sponsor
- Ruhr University of Bochum
Fear of Spiders, Fear of Heights
Generalized Fear Extinction to Untreated Fear Stimuli in Specific Phobias After Exposure
This study investigates whether a one-session exposure treatment for spider-related stimuli can lead to a generalization of extinguished fear to height-related stimuli in individuals with comorbid fear of spiders and fear of…
- Trial name
- NCT03907345
- Testing
- Exposure
- Where
- Germany
- Volunteers
- 50 people
- Sponsor
- Ruhr University of Bochum
Generalized Anxiety Disorder, Social Anxiety Disorder
Level of Physical Activity and Fear Learning
The proposed experimental study will be the first to investigate whether exercise vs. sitting enhances consolidation of extinction learning in adults with high AS and anxiety disorders, and the mechanistic pathways of expectancy…
- Conditions
- Generalized Anxiety Disorder, Social Anxiety Disorder, Panic Disorder
- Trial name
- NCT05203731
- Testing
- Exercise, Sitting
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- NYU Langone Health