Clinical trials: Fear Extinction
Obsessive-Compulsive Disorder
Multimodal Assessment of Cannabinoid Target Engagement in Adults With Obsessive-Compulsive Disorder
The purpose of this research study is to test how a medication called nabilone (Cesamet) affects neurocognitive processes involved in obsessive-compulsive disorder (OCD), including threat response, processing of fear signals, and…
- Trial name
- NCT04880278
- Testing
- Nabilone
- Where
- United States
- Sponsor
- New York State Psychiatric Institute
Healthy Subjects
The Link Between Mental Imagery and the Reduction of Fear in Imaginal Extinction
Imaginal exposure is a widely used psychological treatment technique. Imaginal extinction is an experimental analogue of imaginal exposure, that allows the study of this treatment technique under controlled circumstances (Agren…
- Trial name
- NCT03989518
- Testing
- Fear acquisition, Imaginal extinction, Reinstatement
- Where
- Sweden
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Uppsala University
Fear Extinction
Amygdala-Prefrontal in Fear Extinction
The goal of this clinical trial is to understand how brain circuits involving the amygdala and prefrontal cortex contribute to fear learning and extinction.
- Trial name
- NCT07800455
- Testing
- Direct intracranial electrical stimulation, Fear conditioning
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Washington University School of Medicine
Anxiety Disorders
Transcranial Direct Current Stimulation and Fear Extinction
Psychiatric disorders characterized by pathological fear and anxiety are common and often disabling. Despite their limitations, exposure therapies are among the most efficacious treatments for these disorders.
- Trial name
- NCT03907917
- Testing
- tDCS
- Where
- 2 sites in United States
- Volunteers
- 67 people, healthy volunteers welcome
- Sponsor
- Thomas Adams
Anxiety Disorders, Public Speaking Fear
Reward Processes and Rehearsal in Exposure Therapy
The purpose of this study is to 1) examine the importance of self-reported relief following exposure and 2) test whether positive-focused rehearsal following exposure can improve treatment outcomes for participants who endorse…
- Trial name
- NCT06132425
- Testing
- Exposure, Rehearsal
- Where
- United States
- Volunteers
- 88 people
- Sponsor
- University of California, Los Angeles
Obsessive-Compulsive Disorder
Transcranial Direct Current Stimulation Potentiation of Fear Extinction in OCD
The investigators want to learn more about how human beings learn not to fear and the impact of changing the fear network in the brain using transcranial Direct Current Stimulation (tDCS) in individuals with obsessive compulsive…
- Trial name
- NCT05521074
- Testing
- Active tDCS
- Where
- United States
- Volunteers
- 86 people
- Sponsor
- Massachusetts General Hospital
Posttraumatic Stress Disorder
A Controlled Trial of Losartan in Posttraumatic Stress Disorder
This study is being conducted to determine if losartan, an angiotensin receptor blocker (ARB), is safe and effective in the treatment of posttraumatic stress disorder (PTSD) symptoms.
- Trial name
- LOSe-PTSD (NCT02709018)
- Testing
- losartan
- Where
- 6 sites in United States
- Volunteers
- 149 people
- Sponsor
- University of California, San Diego
Healthy Individuals, Highly Stressed
Could Meditation Modulate the Neurobiology of Learning Not to Fear?
It is well-established that the practice of mindfulness meditation leads to improvements in mental health and well-being and the cultivation of positive emotions.
- Trial name
- NCT01320969
- Testing
- Mindfulness-Based Stress Reduction course
- Where
- United States
- Volunteers
- 85 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital