Clinical trials: Febrile Neutropenia
Fever, Sweats, and Hot Flashes, Infection
Levofloxacin Compared With Cefepime in Treating Cancer Patients With Fever and Neutropenia
RATIONALE: Levofloxacin may be effective in reducing fever and controlling other symptoms of neutropenia in patients who are being treated for cancer.
- Conditions
- Fever, Sweats, and Hot Flashes, Infection, Leukemia, Lymphoma
- Trial name
- NCT00020865
- Testing
- cefepime hydrochloride, levofloxacin
- Where
- United States
- Sponsor
- Jonsson Comprehensive Cancer Center
Strains, Acute Lymphoblastic Leukemia
Effect of Simvastatin on Sepsis and Febrile Neutropenia in Patients With Acute Lymphoblastic Leukemia
In general, the percentage of complete remissions is 85 - 90 % for acute lymphoid leukemia (ALL). In developing countries, percentages are lower secondary to higher sepsis-related mortality.
- Conditions
- Strains, Acute Lymphoblastic Leukemia, Sepsis
- Trial name
- NCT05133310
- Testing
- Simvastatin
- Where
- Mexico
- Volunteers
- 108 people
- Sponsor
- Hospital General de Mexico
Acute Myeloid Leukemia, Acute Lymphoblastic Leukemia
PET/CT and Bacterial/Fungal PCR in High Risk Febrile Neutropenia
Patients with acute leukaemia requiring induction or consolidation chemotherapy and those requiring a haematopoietic stem cell transplant are at high risk of fever and infection when they have low white cell counts (neutropenic…
- Conditions
- Acute Myeloid Leukemia, Acute Lymphoblastic Leukemia, Haematopoietic Stem Cell Transplant, Autologous, Haematopoietic Stem Cell Transplant, Allogeneic
- Trial name
- PIPPIN (NCT03429387)
- Testing
- FDG-PET/CT, Conventional CT
- Where
- 2 sites in Australia
- Volunteers
- 147 people
- Sponsor
- Peter MacCallum Cancer Centre, Australia
Early Stage Breast Cancer
A Study to Compare Administration Schedules of G-CSF (Filgrastim) for Primary Prophylaxis of Febrile Neutropenia
In patients with early-stage breast cancer, chemotherapy has substantially improved survival rates. Improvements in outcomes, however, are compromised by the considerable toxicities associated with chemotherapy, the most notable…
- Trial name
- REaCT-G2 (NCT02816164)
- Testing
- Neupogen
- Where
- Canada
- Volunteers
- 324 people
- Sponsor
- Ottawa Hospital Research Institute
Non-Hodgkin's Lymphoma
Analysis of the Risk Factors for the Neutropenic Fever in the High Risk NHL Patients for Developing Febrile Neutropenia Who Received 3-weekly CHOP-like Chemotherapy With Primary G-CSF Prophylaxis; Prospective Multicenter Observation Study
The domestic standards of G-CSF permit the use of the G-CSF only when the ANC(absolute neutrophil count) drops to 1,000/uL or below. Therefore it is impossible to inject the G-CSF in order to prevent neutropenia.
- Trial name
- NCT01763398
- Where
- South Korea
- Volunteers
- 500 people
- Sponsor
- Yonsei University
Febrile Neutropenia
Comparing Ciprofloxacin (CPFX) With Cefepime (CFPM) in Febrile Neutropenic Patients With Hematologic Diseases
The aim of this study is to investigate whether intravenous ciprofloxacin is as effective as cefepime for the initial treatment of febrile neutropenia developed in patients with hematologic diseases.
- Trial name
- NCT00137787
- Testing
- ciprofloxacin, cefepime
- Where
- Japan
- Volunteers
- 51 people
- Sponsor
- Center for Supporting Hematology-Oncology Trials
Febrile Neutropenia
Procalcitonin Protocol to Shorten the Antibiotic Therapy in Febrile Neutropenia
In this study the investigators aim to test if a procalcitonin (PCT) - guided strategy allows to reduce the antibiotic use in patients with febrile neutropenia hospitalized in a Brazilian tertiary university hospital, causing no…
- Trial name
- NCT00928291
- Testing
- procalcitonin, antibiotic therapy
- Where
- Brazil
- Volunteers
- 60 people
- Sponsor
- Federal University of Minas Gerais
Breast Cancer, Neutropenia
A Phase II Study Comparing Pegylated rhG-CSF（HHPG-19K） and rhG-CSF in Breast Cancer Patients Receiving Chemotherapy
Neutropenia is one of the most frequent adverse effects of chemotherapy, and the main factor to limit the dosage and the continuation of chemotherapy.
- Conditions
- Breast Cancer, Neutropenia, Febrile Neutropenia
- Trial name
- NCT02119715
- Testing
- Pegylated rhG-CSF 100μg/kg, Pegylated rhG-CSF:150 μg/kg, rhG-CSF 5 μg/kg/day
- Where
- China
- Volunteers
- 182 people
- Sponsor
- Jiangsu HengRui Medicine Co., Ltd.
Primary/Secondary Prevention, High Risk for Febrile Neutropenia of Chemotherapy Regimens
Efbemalenograstim Alfa for Primary/Secondary Prevention in Patients With Solid Tumors at High Risk for Febrile Neutropenia (FN) or Intermediate Risk of Chemotherapy Regimens Associated With Other Risk Factors in FN
Efbemalenograstim alfa for primary/secondary prevention in patients with solid tumors at high risk for febrile neutropenia (FN) or Intermediate risk of chemotherapy regimens associated with other risk factors in FN
- Conditions
- Primary/Secondary Prevention, High Risk for Febrile Neutropenia of Chemotherapy Regimens, Intermediate Risk of Chemotherapy Regimens Associated With Other Risk Factors in Febrile Neutropenia
- Trial name
- NCT07187908
- Testing
- Efbemalenograstim alfa Injection
- Where
- China
- Volunteers
- 1,076 people
- Sponsor
- Henan Cancer Hospital
Haematopoietic Stem Cell Transplantation, Acute Leukemia
A Trial of Fosfomycin vs Ciprofloxacin for Febrile Neutropenia (FOVOCIP)
Prophylaxis with fluoroquinolones in high-risk neutropenic patients is currently under scrutiny due to their toxicity and the potential of selecting multirresistant bacteria.
- Trial name
- FOVOCIP (NCT07616635)
- Testing
- Fosfomycin, ciprofloxacin
- Where
- Spain
- Volunteers
- 177 people
- Sponsor
- Fundación para la Investigación Biosanitaria del Principado de Asturias
Haematological Malignancy, Leukemia
Continuous Temperature Monitoring for tHe Early Recognition of Febrile Neutropenia in Haematological MALignancies
The THERMAL study is a pilot study to determine feasibility of using two separate continuous skin temperature monitors during intensive treatment for haematological malignancies.
- Conditions
- Haematological Malignancy, Leukemia, Lymphoma, Myeloma
- Trial name
- THERMAL (NCT05203809)
- Testing
- TempTraq temperature monitor
- Where
- New Zealand
- Volunteers
- 20 people
- Sponsor
- Malaghan Institute of Medical Research
Breast Cancer
REaCT Integrated Consent Model to Compare Two Standard of Care Regimens
The Integrated Consent Model is being increasingly used internationally to improve patient care. In this feasibility study we will explore whether the model is feasible in practice; and whether it can be used to increase the…
- Trial name
- OTT14-03 (NCT02173262)
- Testing
- G-CSF, Ciprofloxacin
- Where
- Canada
- Volunteers
- 142 people
- Sponsor
- Ottawa Hospital Research Institute
Fungal Infection
A 28 - 90 Days Study to Evaluate the Safety, Tolerability, and Efficacy of Caspofungin Injection as Empirical Therapy in Indian Adults With Persistent Fever and Neutropenia (0991-053)(COMPLETED)
The purpose of this study is to evaluate the safety, tolerability and efficacy of ertapenem sodium as initial therapy for the treatment of complicated urinary tract infections, including pyelonephritis in indian adults.
- Trial name
- NCT00379964
- Testing
- caspofungin acetate
- Volunteers
- 50 people
- Sponsor
- Merck Sharp & Dohme LLC
Acute Myeloid Leukemia, Neutropenia
Safety and Efficacy of Human Myeloid Progenitor Cells (CLT-008) During Chemotherapy for Acute Myeloid Leukemia
The purpose of the study is to explore the safety and efficacy of CLT-008 as an extra supportive care measure after induction chemotherapy for patients with acute myeloid leukemia (AML).
- Conditions
- Acute Myeloid Leukemia, Neutropenia, Infection
- Trial name
- NCT02282215
- Testing
- CLT-008, G-CSF
- Where
- 22 sites in United States
- Volunteers
- 163 people
- Sponsor
- Cellerant Therapeutics
Neutropenia
A Randomized, Open Label, Comparative, Multicenter Trial of Voriconazole Vs. AmBisome for Empirical Antifungal Therapy in Immunocompromised Patients With Persistent Fever and Neutropenia
The purpose of this study is to evaluate the safety and effectiveness of 2 drugs (AmBisome versus voriconazole) in treating fungal infections.
- Trial name
- NCT00008840
- Where
- United States
- Volunteers
- 866 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Leukemia
SubCutaneous (SC) Versus Intravenous (IV) Granulocyte Colony Stimulating Factors (G-CSF) for the Treatment of Neutropenia in Hospitalized Haemato-oncological Patients
Granulocyte colony stimulating factor (G-CSF) is frequently used among patients with cancer including those with haematological malignancies.
- Trial name
- G-CSF (NCT01222819)
- Testing
- filgrastim
- Where
- Israel
- Volunteers
- 120 people
- Sponsor
- Rabin Medical Center
Leukemia, Myeloid, Acute
Granulocyte Colony Stimulating Factor (G-CSF) After Salvage Chemotherapy in Refractory AML
Granulocyte Colony Stimulating Factor (G-CSF, filgrastim) is now widely used after chemotherapy which complicates hematological toxicity involving neutropenia.
- Trial name
- DeGREE (NCT02427919)
- Testing
- G-CSF
- Where
- South Korea
- Volunteers
- 56 people
- Sponsor
- Seoul St. Mary's Hospital
Febrile Neutropenia
Pharmacist-Led Education to Improve Neutropenic Precautions in Cancer Patients
The goal of this clinical trial is to test whether pharmacist-led education can improve knowledge and adherence to neutropenic precautions and reduce infection rates in adult cancer patients receiving high-risk chemotherapy.
- Trial name
- NCT07690956
- Testing
- Pharmacist-Led Neutropenic Education Package
- Where
- 2 sites in Jordan
- Volunteers
- 300 people
- Sponsor
- Jordan University of Science and Technology
Neoplasms, Neutropenia
Profiling Neutrophil Counts in Patients on Chemotherapy
The purpose of this trial is to observe the changes in white cell counts in patients with cancer during chemotherapy and to determine if changes in the white cell count in the early days during chemotherapy can be used as a…
- Conditions
- Neoplasms, Neutropenia, Febrile Neutropenia
- Trial name
- NCT02806557
- Testing
- Home finger-prick capillary blood count monitoring
- Volunteers
- 200 people
- Sponsor
- University of Leeds
Aspergillus Infection, Febrile Neutropenia
Ampholipad Real-World Data in Taiwan
A retrospective, post-marketing, multi-center chart review study includes patients who had been prescribed Ampholipad.
- Conditions
- Aspergillus Infection, Febrile Neutropenia, Candida Infection, Fungal Infection
- Trial name
- NCT03641131
- Where
- 6 sites in Taiwan
- Volunteers
- 102 people
- Sponsor
- Taiwan Liposome Company