Clinical trials: Fecal Microbiota Therapy (FMT)
Colorectal Cancer Liver Metastasis
FMT+ QL1706+Bevacizumab+ XELOX as First-line Treatment for Advanced MSS-type Colorectal Cancer With Liver Metastasis
The investigators plan to initiate a prospective, multicenter, phase II study, recruiting 30 patients with advanced colorectal cancer patients with liver metastasis who have not received prior treatment.
- Trial name
- NCT06801665
- Testing
- FMT+QL1706+Bevacizumab+XELOX
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Hua Jiang
Diverticulitis, Diverticulitis of Sigmoid
Clinical Trial With MBK-01, Intestinal Microbiota Capsules, for the Treatment of Patients With Recurrent Diverticulitis
Patients with diverticulitis experience a prolonged course of the disease and report a variety of physical, psychological and social symptoms, which highly impacts in their quality of life.
- Trial name
- NCT06687382
- Testing
- MBK-01
- Where
- Spain
- Volunteers
- 81 people
- Sponsor
- Mikrobiomik Healthcare Company S.L.
Metastatic Colorectal Adenocarcinoma, Metastatic Small Intestinal Adenocarcinoma
Fecal Microbiota Transplant and Re-introduction of Anti-PD-1 Therapy (Pembrolizumab or Nivolumab) for the Treatment of Metastatic Colorectal Cancer in Anti-PD-1 Non-responders
This phase II trial studies the effect of fecal microbiota transplant and re-introduction of anti-PD-1 therapy (pembrolizumab or nivolumab) in treating anti-PD-1 non-responders with colorectal cancer that has spread to other…
- Conditions
- Metastatic Colorectal Adenocarcinoma, Metastatic Small Intestinal Adenocarcinoma, Stage IV Colorectal Cancer AJCC v8, Stage IV Small Intestinal Adenocarcinoma AJCC v8
- Trial name
- NCT04729322
- Testing
- Biopsy, Fecal Microbiota Transplantation, Fecal Microbiota Transplantation Capsule
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- M.D. Anderson Cancer Center
Metabolic Syndrome
Fecal Microbiota Transplantation for the Treatment of Metabolic Syndrome
Obesity is associated with changes in the composition and metabolic function of the gut microbiota. Fecal microbiota transplantation (FMT), also known as "fecal bacteriotherapy" or "fecal infusion", refers to the process of…
- Trial name
- NCT02050607
- Testing
- fecal microbiota transplantation from healthy lean donors
- Where
- Italy
- Sponsor
- Catholic University of the Sacred Heart
Intestinal Complications, Cancer
Washed Microbiota Transplantation for the Treatment of Oncotherapy-Related Intestinal Complications
Gut microbiota, known as "unrecognized organs", is closely related to the occurrence and development of tumors. Cancer is thought to occur secondary to local chronic inflammation.
- Trial name
- NCT04721041
- Testing
- Washed Microbiota Transplantation (WMT)
- Where
- China
- Volunteers
- 200 people
- Sponsor
- The Second Hospital of Nanjing Medical University
Type 1 Diabetes Mellitis, Type 1 Diabetes (T1D)
Faecal Autologous Capsule Transplantation for Type 1 Diabetes Mellitus
SUMMARY Rationale: The(small) intestinal microbiota composition has been implicated to play an important role in (human) metabolism, as well as autoimmune diseases such as type 1 diabetes mellitus.
- Conditions
- Type 1 Diabetes Mellitis, Type 1 Diabetes (T1D), Fecal Microbiota Therapy (FMT)
- Trial name
- FACT-T1D (NCT07083882)
- Testing
- freezedried autologous encapsulated fecal microbiota transplantation
- Where
- Netherlands
- Volunteers
- 110 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Colorectal Cancer Metastatic, Fecal Microbiota Transplantation
Using Healthy Gut Bacteria to Boost Immune Treatment for Advanced Bowel Cancer
This research protocol outlines an exploratory study on the combination of early-life fecal microbiota transplantation (yFMT) with immunotherapy and chemotherapy in patients with microsatellite stable metastatic colorectal cancer…
- Trial name
- NCT07486492
- Testing
- yFMT
- Volunteers
- 10 people
- Sponsor
- The First Affiliated Hospital of Xiamen University
Obesity; Familial
Assessment of the Health Improvement of Obese Patients After Fecal Microbiota Transplantation (FMT)
Search for mechanisms of the effect of fecal microbiota transplantation on patients with obesity
- Trial name
- NCT04579263
- Testing
- Fecal microbiota
- Where
- 2 sites in Russia
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- Federal Research and Clinical Center of Physical-Chemical Medicine
Ulcerative Colitis, Fecal Microbiota Transplantation
The Study of Efficacy and Mechanism in Fecal Microbiota Transplantation in the Treatment of Ulcerative Colitis
The aim of our study is to investigate the efficacy and mechanism in fecal microbiota transplantation in the treatment of ulcerative colitis.
- Trial name
- NCT02435160
- Testing
- Fecal Microbiota Transplantation
- Volunteers
- 20 people
- Sponsor
- Jun Liu
Hepatic Encephalopathy
Fecal Microbiota Transplant as Treatment of Hepatic Encephalopathy
A common complication of advanced liver disease is a condition called hepatic encephalopathy, which leads to confusion. The current treatment options cause side effects, are costly, and do not always work.
- Trial name
- NCT03420482
- Testing
- Fecal Microbiota Transplant (FMT) oral capsules
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Massachusetts General Hospital
Solid Carcinoma
FMT With Nivolumab in Patients With Advanced Solid Cancers Who Have Progressed During Anti-PD-(L)1 Therapy
This is a single-center, open-label, Phase 2 study to evaluate the efficacy and safety of FMT with nivolumab in patients with advanced, unresectable, or metastatic solid cancer who have progressed during anti-PD-(L)1 therapy.
- Trial name
- NIVO-FMT (NCT05533983)
- Testing
- fecal microbiota transplantation with Nivolumab
- Where
- South Korea
- Volunteers
- 50 people
- Sponsor
- Asan Medical Center
Clostridial Infection, Dysbiosis
Safety and Efficacy of FMT in Individuals With One or More Recurrences of Clostridium Difficile Associated Disease (CDAD)
Multi-center, randomized, placebo controlled, partially blinded trial comparing the safety and efficacy of fecal microbiota transplantation versus placebo both delivered by rectal enema in subjects 18 years of age or older with…
- Conditions
- Clostridial Infection, Dysbiosis, Probiotic Therapy
- Trial name
- NCT03548051
- Testing
- Fecal Microbiota Transplantation (FMT), Saline
- Where
- 3 sites in United States
- Volunteers
- 10 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
NAFLD, Fecal Microbiota
Dietary Counseling Coupled With FMT in the Treatment of Obesity and NAFLD - the DIFTOB Study
There are several studies performed to reveal the linkage between diet, fecal microbiota, and obesity. Human fecal microbiota transplantations in this asset are still scarce.
- Conditions
- NAFLD, Fecal Microbiota, Gut Microbiota, Obesity
- Trial name
- DIFTOB (NCT05607745)
- Where
- 3 sites in Finland
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- University of Eastern Finland
Hepatic Encephalopathy, Dysbiosis
Fecal Microbiota Transplantation by Oral Capsules for Hepatic Encephalopathy Treatment
This interventional study aims to evaluate the safety and efficacy of oral capsule fecal microbiota transplantation (FMT) for treating hepatic encephalopathy refractory to conventional rifaximin and lactulose therapy in patients…
- Trial name
- NCT06368895
- Testing
- Fecal microbiota transplantation delivery through colonoscopy, Fecal microbiota transplantation delivery through oral capsules
- Where
- Italy
- Volunteers
- 33 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Acute Graft Versus Host Disease in Intestine
FMT for Pediatric SR-aGVHD
This is a pilot, prospective, non-profit, multicenter, uncontrolled, open-label study to evaluate the safety and feasibility of FMT in patients aged between 3 months and 25 years suffering from acute intestinal GVHD resistant to…
- Trial name
- NCT07602751
- Testing
- Fecal Microbial Transplantation
- Where
- 3 sites in Italy
- Volunteers
- 20 people
- Sponsor
- Bambino Gesù Hospital and Research Institute
Fecal Microbiota Transplantation, Malignant Melanoma Stage III
The IRMI-FMT Trial
Aim of the study is to investigate the effect of Fecal Microbiota Transplantation (FMT) and Checkpoint Inhibitor (CI) re-challenge in prior CI refractory patients on Progression free survival (PFS) and tumor using donor stool of…
- Conditions
- Fecal Microbiota Transplantation, Malignant Melanoma Stage III, Malignant Melanoma Stage IV
- Trial name
- NCT04577729
- Testing
- Allogenic Fecal Microbiota Transplantation, Autologous Fecal Microbiota Transplantation
- Where
- Austria
- Volunteers
- 5 people
- Sponsor
- Medical University of Graz
Clostridium Difficile
Fecal Microbiota Transplantation for Primary Clostridium Difficile Diarrhea
Clostridium difficile associated diarrhea (CDAD) is a significant cause of morbidity and mortality, caused by loss of healthy gut flora. Conventional treatment uses antibiotics to kill Clostridium difficile.
- Trial name
- NCT02801656
- Testing
- Fecal Microbiota Transplantation, Vancomycin
- Where
- Canada
- Sponsor
- Memorial University of Newfoundland
Constipation - Functional, Chronic Constipation
The Efficacy and Safety of Microbiota Transplantation Combined With Prebiotics for Treatment of Functional Constipation
Chronic constipation is a common gastrointestinal disorder with a global prevalence of approximately 15%, severely impacting daily life and quality of life.
- Conditions
- Constipation - Functional, Chronic Constipation, Fecal Microbiota Transplantation
- Trial name
- NCT07386795
- Testing
- FMT
- Where
- China
- Volunteers
- 19 people
- Sponsor
- Peking Union Medical College Hospital
Clostridium Difficile Infection Recurrence
A Multi-center, Single-arm Trial Exploring the Safety and Clinical Effectiveness of RBX2660 Administered by Colonoscopy to Adults With Recurrent Clostridioides Difficile Infection
This trial will be initiated to explore whether RBX2660 (REBYOTA®) could be suitable for administration by the practice of colonoscopy.
- Trial name
- CDI-SCOPE (NCT05831189)
- Testing
- RBX2660
- Where
- 12 sites in United States
- Volunteers
- 41 people
- Sponsor
- Ferring Pharmaceuticals
Pouchitis, Inflammatory Bowel Diseases
Faecal Microbiota Transplantation in the Treatment of Chronic Pouchitis
Patients with the chronic bowel disease pouchitis is disabled by bloody diarrhoea and abdominal pain often followed by fever. Pouchitis is an inflammation in a pouch, a reservoir formed by the small intestine in the management of…
- Conditions
- Pouchitis, Inflammatory Bowel Diseases, Ulcerative Colitis
- Trial name
- MicroPouch (NCT04100291)
- Testing
- Faecal microbiota transplantation
- Where
- 2 sites in Denmark
- Volunteers
- 30 people
- Sponsor
- Ole Thorlacius-Ussing, MD, DMSc, Professor of Surgery