Clinical trials: Fecal Microbiota Transplantation (FMT)
Eating Disorders Symptoms
Effects of Fecal Microbiota Transplantation
The intestinal microbiota plays an essential role in digestion and, through the gut-brain axis, in the regulation of weight gain and eating behavior.
- Trial name
- Transmic-TCA (NCT07196189)
- Testing
- Patients, healthy volunteer
- Where
- France
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- University Hospital, Rouen
Arthritis, Arthritis, Rheumatoid
Fecal Microbial Transplantation for Rheumatoid Arthritis Trial
This clinical trial will investigate the effects of capsules containing stool from healthy donors, called fecal microbial transplant (FMT), in rheumatoid arthritis patients.
- Conditions
- Arthritis, Arthritis, Rheumatoid, Fecal Microbiota Transplantation
- Trial name
- FeMiTRA (NCT05790356)
- Testing
- Fecal Microbial transplant
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Pouchitis
Fecal Microbiota Transplant (FMT) for Pouchitis
This is a prospective, open label pilot study in which patients with symptoms of acute or chronic pouchitis will receive FMT therapy delivered via pouchoscopy.
- Trial name
- NCT02428361
- Testing
- Biologically active human fecal material, OpenBiome
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- Najwa Elnachef
Hepatic Encephalopathy
Fecal Microbiota Transplant as Treatment of Hepatic Encephalopathy
A common complication of advanced liver disease is a condition called hepatic encephalopathy, which leads to confusion. The current treatment options cause side effects, are costly, and do not always work.
- Trial name
- NCT03420482
- Testing
- Fecal Microbiota Transplant (FMT) oral capsules
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Massachusetts General Hospital
Melanoma Stage IV, Head and Neck Squamous Cell Carcinoma
Microbiota Transplant to Cancer Patients Who Have Failed Immunotherapy Using Faeces From Clinical Responders
This is a single-arm, single-center, open-label, phase IIa study evaluating the safety, feasibility and efficacy of Faecal Microbiota Transplant (FMT) to cancer patients not responding to ICI therapy, using ICI-responders as…
- Conditions
- Melanoma Stage IV, Head and Neck Squamous Cell Carcinoma, Cutaneous Squamous Cell Carcinoma, MSI-High
- Trial name
- MITRIC (NCT05286294)
- Testing
- Fecal Microbiota Transplant (FMT)
- Where
- Norway
- Volunteers
- 20 people
- Sponsor
- Oslo University Hospital
Clostridium Difficile
Fecal Microbiota Transplantation for Primary Clostridium Difficile Diarrhea
Clostridium difficile associated diarrhea (CDAD) is a significant cause of morbidity and mortality, caused by loss of healthy gut flora. Conventional treatment uses antibiotics to kill Clostridium difficile.
- Trial name
- NCT02801656
- Testing
- Fecal Microbiota Transplantation, Vancomycin
- Where
- Canada
- Sponsor
- Memorial University of Newfoundland
Crohn Disease
Fecal Transplant for Crohn's Disease
To determine the efficacy and safety of serial FMT at inducing and maintaining clinical and endoscopic response in patients with mild to moderate Crohn's disease
- Trial name
- NCT03078803
- Testing
- Fecal Microbiota Transplant (FMT)
- Where
- 3 sites in Canada
- Volunteers
- 38 people
- Sponsor
- University of Alberta
Infection Due to Resistant Organism
FMT for MDRO Colonization in Solid Organ Transplant
This is a pilot feasibility study to determine whether fecal microbiota transplantation (FMT) can suppress or reverse gastrointestinal carriage of MDROs in hospitalized solid organ transplant recipients with a history of one or…
- Trial name
- FMT (NCT02816437)
- Testing
- OpenBiome Fecal Microbiota Transplantation retention enema
- Sponsor
- University of Miami
Acute Graft Versus Host Disease, Hematopoietic and Lymphatic System Neoplasm
Fecal Microbiota Transplantation for the Prevention of Acute Graft Versus Host Disease in Adults Undergoing Allogeneic Hematopoietic Cell Transplantation
This randomized placebo-controlled double-blind phase II trial tests whether fecal microorganism (microbiota) transplantation prevents severe acute graft versus host disease in adults undergoing allogeneic hematopoietic cell…
- Trial name
- NCT06026371
- Testing
- Fecal Microbiota Transplantation Capsule
- Where
- United States
- Volunteers
- 157 people
- Sponsor
- Fred Hutchinson Cancer Center
Malignant Hematologic Neoplasm
Fecal Microbiota Transplantation Among Adult Patients With Hematological Malignancies
In Hungary - in comparison to other member states of the European Union - about 75000 new cases of cancer are diagnosed annually, from which approximately 4500-5000 patients suffer from so-called malignant hematological diseases.
- Trial name
- HEMAT-FMT (NCT07172191)
- Testing
- Fecal Microbial Transplantation
- Where
- Hungary
- Volunteers
- 100 people
- Sponsor
- Del-Pest Central Hospital - National Institute of Hematology and Infectious Diseases
Fecal Microbiota Transplantation, COVID-19 Infection
A Controlled Study on Regulation of Systemic Inflammation by Fecal Bacteria Transplantation in Patients With COVID-19.
A total of 30 hospitalized patients with COVID-19 over 60 years old were enrolled in this study and were divided into the experimental group (n=15) and the control group (n=15) at a ratio of 1:1.
- Trial name
- NCT05873348
- Testing
- Fecal microbiota transplantation
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Shanghai 10th People's Hospital
Patients With Nonalcoholic Steatohepatitis
Evaluate the Efficacy, Safety and Tolerability of Fecal Microbiota Transfer for the Treatment of Patients With Nonalcoholic Steatohepatitis
The EMOTION study is a multicentric, double-blind, controlled, parallel-group, phase IIa randomized Clinical trial to evaluate the efficacy, safety and tolerability of TMF capsules for the treatment of patients with NASH.
- Trial name
- EMOTION (NCT05622526)
- Testing
- Group 1 or Experimental group, Group 2 or Control group
- Volunteers
- 96 people
- Sponsor
- Instituto de Investigación Marqués de Valdecilla
Irritable Bowel Syndrome, Fecal Microbiota Transplantation
FMT for Patients With IBS With Fecal and Mucosal Microbiota Assessment
Irritable bowel syndrome (IBS) is a common functional bowel disorder of the gastrointestinal tract affecting up to 20 percent of the adolescent and adult populations.
- Trial name
- NCT03125564
- Testing
- Fecal Microbiota Transplantation, Fecal and Mucosal Microbiota Assessment
- Where
- Hong Kong
- Volunteers
- 56 people
- Sponsor
- Chinese University of Hong Kong
Ulcerative Colitis
Fecal Transplantation in Ulcerative Colitis
Adult individuals with ulcerative colitis in remission are given a single fecal microbiota transplantation (FMT) in colonoscopy.
- Trial name
- FMT-CU (NCT03561532)
- Testing
- Fecal microbiota transplantation (FMT)
- Where
- 2 sites in Finland
- Volunteers
- 48 people
- Sponsor
- Joint Authority for Päijät-Häme Social and Health Care
Ulcerative Colitis, Intestinal Bacteria Flora Disturbance
Fecal Microbiota Transplantation for Ulcerative Colitis
Ulcerative colitis is a common digestive system disease, the incidence is increasing in recent years.It is reported that the occurrence and development of ulcerative colitis is closely related to imbalance of intestinal flora…
- Conditions
- Ulcerative Colitis, Intestinal Bacteria Flora Disturbance, Fecal Microbiota Transplantation
- Trial name
- FMTFUC (NCT03016780)
- Testing
- Fecal Microbiota Transplantation, Normal Saline
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- First Affiliated Hospital of Chengdu Medical College
Autism Spectrum Disorder
Fecal Microbiota Transplantation in Children With ASD
This is a single-center, randomized, double-dummy, triple-blind, placebo-controlled, three-arm parallel-group superiority trial.
- Trial name
- NCT07381374
- Testing
- ctive FMT via Nasojejunal Tube (FMT-Upper GI), Active FMT via Colonoscopy and Transendoscopic Tube (FMT-Lower GI)
- Where
- China
- Volunteers
- 1 people
- Sponsor
- Shenzhen Children's Hospital