Clinical trials: Female Adolescents
Major Depressive Disorder
Creatine Augmentation for Adolescent Females With Treatment-Resistant Major Depressive Disorder
The primary hypothesis is that compared to placebo, 10g of daily creatine monohydrate for eight weeks will be associated with significant increases in frontal lobe phosphocreatine and beta-nucleoside triphosphate (β-NTP)…
- Trial name
- NCT02134808
- Testing
- Creatine
- Where
- United States
- Volunteers
- 71 people, healthy volunteers welcome
- Sponsor
- Perry Renshaw
Eating Disorders in Adolescence, Body Dissatisfaction
Young Athlete Body Project - Prevention of Body Dissatisfaction and Eating Disorders Among Adolescent Athletes
Body dissatisfaction is common among adolescents and is a well-established risk factor for the development of eating disorders. Young athletes may be particularly vulnerable because they are exposed to appearance-related…
- Conditions
- Eating Disorders in Adolescence, Body Dissatisfaction, Mental Health
- Trial name
- YABP (NCT07795333)
- Testing
- Young Athlete Body Project
- Where
- 2 sites in Norway
- Volunteers
- 1,740 people, healthy volunteers welcome
- Sponsor
- Norwegian School of Sport Sciences
Haematological Malignancy, Colorectal Neoplasms
DETERMINE Trial Treatment Arm 04: Trastuzumab in Combination With Pertuzumab in Adult, Paediatric and Teenage/Young Adult Patients With Cancers With HER2 Amplification or Activating Mutations
This clinical trial is looking at a combination of drugs called trastuzumab and pertuzumab. This combination of drugs is approved together as standard of care treatment for adult patients with breast cancer (often with other…
- Conditions
- Haematological Malignancy, Colorectal Neoplasms, Urinary Bladder Neoplasm, Gallbladder Neoplasms
- Trial name
- DETERMINE (NCT05786716)
- Testing
- Trastuzumab, Pertuzumab
- Where
- 27 sites in United Kingdom
- Volunteers
- 30 people
- Sponsor
- Cancer Research UK
Human Papillomavirus Virus
Observational Follow up of Prior HPV Vaccinees
HPV vaccines have been included in the national immunisation schedule since 2008, firstly as the Cervarix vaccine which protects against two HPV types and in 2012 as the Gardasil vaccine which offers protection against a further…
- Trial name
- HPVfollowup (NCT02811068)
- Testing
- venepuncture
- Where
- 2 sites in United Kingdom
- Volunteers
- 93 people, healthy volunteers welcome
- Sponsor
- Public Health England
Obstructive Sleep Apnea Syndrome, Polycystic Ovary Syndrome
Effect of Obstructive Sleep Apnea Syndrome on Insulin Sensitivity and Cardiovascular Risk in PCOS Adolescents
Polycystic ovary syndrome (PCOS) is one of the most common disease caused by hormonal imbalance and is also associated with overweight and obesity. It affects 5-10% of adolescent girls and women capable of having children.
- Conditions
- Obstructive Sleep Apnea Syndrome, Polycystic Ovary Syndrome, Sleep Apnea
- Trial name
- NCT01840618
- Testing
- Nasal Continuous positive airway pressure (CPAP)
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Albert Einstein College of Medicine
Infections, Papillomavirus
Effectiveness, Safety and Immunogenicity of GSK Biologicals' HPV Vaccine GSK580299 (Cervarix) Administered in Healthy Adolescents
Genital infections with oncogenic human papillomaviruses (HPV) are common in both men and women. The most important disease associated with oncogenic HPV infection is cervical cancer, currently the second leading cause of…
- Trial name
- NCT00534638
- Testing
- Cervarix, Engerix-B
- Where
- 6 sites in Finland
- Volunteers
- 34,412 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Depression - Major Depressive Disorder, Irritability
Teen Vulnerability to Irritability: Brain and Estrogen Changes
Purpose: Risk of severe psychopathology increases dramatically during adolescence, especially for females. Changes in ovarian steroids across the menstrual cycle produce windows of vulnerability to mood disturbances, particularly…
- Trial name
- TeenVIBE (NCT07544966)
- Testing
- Kurvelo
- Where
- 2 sites in United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
HIV Prevention
Safety and Acceptability of Tenofovir 1% Gel in Adolescent Females
The purpose of this trial is to assess the safety and acceptability of Tenofovir (TFV) 1% gel in adolescent females over 12 weeks of a minimum of twice weekly dosing following the BAT24 regimen.
- Trial name
- NCT02245945
- Testing
- TFV 1% vaginal gel
- Where
- 2 sites in United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- CONRAD
PCOS (Polycystic Ovary Syndrome), Puberty
ActiveGirls: Physical Activity, Hormone Health, and Diabetes Risk in Early Adolescence
This study explores how a physical activity program can affect hormone health and diabetes risk in girls ages 8-12 who may be at higher risk.
- Conditions
- PCOS (Polycystic Ovary Syndrome), Puberty, Insulin Resistance, Physical Activity
- Trial name
- NCT07102797
- Testing
- ActiveGirls Physical Activity Program (Full), ActiveGirls Physical Activity Program (Delayed Lower Intensity)
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Massachusetts General Hospital
Body Image, Eating Behavior
BABE(Body Appreciation and Better Eating), Add Some Self-compassion
Body dissatisfaction is most common among girls in their teenage years and young adulthood, this is also around the time where the risk of developing binge eating disorder is the highest.
- Conditions
- Body Image, Eating Behavior, Binge Eating, Nutrition, Healthy
- Trial name
- BABE (NCT05786560)
- Testing
- BABE (Body Appreciation and Better Eating)
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- University of South Carolina
Obesity, Adolescent
Turnip Consumption and Qigong Exercise Program on Weight Loss
Obesity and weight-related issues are prevalent concerns affecting individuals worldwide, with particular significance among the younger demographic, such as female students.
- Trial name
- NCT06698835
- Testing
- Turnip Consumption
- Where
- Egypt
- Volunteers
- 20 people
- Sponsor
- Assiut University
Sexually Transmitted Infection (STI), HIV
Assessing the Effects of a Multisectoral Agricultural Intervention on the Reproductive and Sexual Health of Adolescent Girls and Young Women
In Kenya, HIV incidence among adolescent girls and young women (AGYW) ages 15-24 years is 1-2 per 100 person-years and approximately 30% of AGYW have had at least one sexually transmitted infection (STI).
- Conditions
- Sexually Transmitted Infection (STI), HIV, Food Insecurity, Mental Health
- Trial name
- Vijana Shamba (NCT06953310)
- Where
- Kenya
- Volunteers
- 900 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Postprandial Hyperglycemia
Metabolic Responses to Breakfast in Adolescent Girls
Breakfast consumption (BC) is frequently associated with a healthy lifestyle, healthy body weight and favourable cardiometabolic health.
- Trial name
- NCT04476693
- Testing
- Breakfast consumption, Breakfast Omission
- Where
- United Kingdom
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University of Bedfordshire
Cardiovascular Diseases, Heart Diseases
Sex Steroids, Obesity and Lipids in Adolescent Females
To prospectively explore the relationships of endogenous sex steroid hormones and obesity and their interactions with lipoprotein cholesterol and apolipoprotein levels in nine and ten year old Black and white adolescent girls for…
- Conditions
- Cardiovascular Diseases, Heart Diseases, Obesity, Hypercholesterolemia
- Trial name
- NCT00005210
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Polycystic Ovary Syndrome, Adolescent Behavior
Adolescent Polycystic Ovary Syndrome on a Low-carbohydrate Diet
The aim of the study was to investigate the changes in the clinical and biochemical parameters of adolescents on a low-carbohydrate diet in relation to their PCOS phenotype in the 3rd trimester.
- Conditions
- Polycystic Ovary Syndrome, Adolescent Behavior, Diet Habit
- Trial name
- PCOS (NCT06429618)
- Testing
- Low carbonhydrate diet
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Etlik Zubeyde Hanım Women's Health Care, Training and Research Hospital
Class II Division 2 Malocclusion
TMJ Adaptations by Orthodontic Treatment in Adolescent Females With Angle's Class II Division 2 Malocclusion: MRI Study
The aim of this study is to document the changes brought about in the internal anatomic relationships of the TMJ complex,positional changes of glenoid fossa with respect to adjacent cranial structures after completion of fixed…
- Trial name
- NCT04744337
- Testing
- orthodontic treatment
- Where
- India
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Postgraduate Institute of Dental Sciences Rohtak
Atypical Hemolytic Uremic Syndrome (aHUS)
Study of Ravulizumab in Children and Adolescents With Atypical Hemolytic Uremic Syndrome (aHUS)
The purpose of the study is to assess the efficacy of ravulizumab to control disease activity in children and adolescents with aHUS who have not previously used a complement inhibitor (complement inhibitor treatment-naïve), as…
- Trial name
- NCT03131219
- Testing
- Ravulizumab
- Where
- 18 sites in United States, Belgium and 5 more
- Volunteers
- 34 people
- Sponsor
- Alexion Pharmaceuticals, Inc.
X-linked Hypophosphatemia
Foot Disorders in X-linked Hypophosphatemia
This study aimed to characterize foot pathologies using X-rays and clinical examination and assess related outcome scores in adolescents and adults with X-linked Hypophophatemia
- Trial name
- NCT06067932
- Testing
- Foot X rays, Clinical examination + scores
- Where
- Austria
- Volunteers
- 28 people
- Sponsor
- Orthopedic Hospital Vienna Speising
HIV Infections, Sexually Transmitted Diseases
HORIZONS HIV Intervention
The Horizons Program will test the efficacy of a multi-session HIV prevention program for African American female teens attending reproductive health clinics in Atlanta, GA.
- Trial name
- HORIZONS (NCT00633906)
- Testing
- HORIZONS HIV Intervention, enhanced standard-of-care
- Where
- 3 sites in United States
- Volunteers
- 715 people, healthy volunteers welcome
- Sponsor
- Emory University
Chronic Kidney Disease (Mild to Moderate), Albuminuria
Efficacy and Safety of Sodium-Glucose Cotransporter-2 Inhibitors in Adolescents With Early Stages of Chronic Kidney Disease
Chronic kidney disease (CKD) is highly prevalent in the state of Aguascalientes, Mexico, particularly among adolescents and young adults.
- Conditions
- Chronic Kidney Disease (Mild to Moderate), Albuminuria, Adolescent, Sodium Glucose Co-Transporter 2 Inhibitors
- Trial name
- IECA-MEX (NCT07405216)
- Testing
- Dapagliflozin (10mg Tab)
- Where
- Mexico
- Volunteers
- 200 people
- Sponsor
- Centenario Hospital Miguel Hidalgo