Clinical trials: Female Breast Neoplasms
Breast Cancer, Genitourinary Cancer
Inflammatory Response and Tissue Fibrosis/ Lymphatico-venous Bypass
The goal of this clinical research study is to measure the amount of inflammatory proteins inside the body before and after lymphatico-venular bypass surgery.
- Conditions
- Breast Cancer, Genitourinary Cancer, Malignant Female Reproductive System Neoplasm, Melanoma
- Trial name
- NCT01433302
- Testing
- Punch Biopsy
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- M.D. Anderson Cancer Center
Cancer, Breast, Cancer, Metastatic
Guided Imagery & Music in Cancer
This is an RCT pilot study to explore the potential effects of the Guided Imagery \& Music method for women with breast or gynecologic cancer, during active treatment.
- Conditions
- Cancer, Breast, Cancer, Metastatic, Cancer Ovaries, Cancer Uterus Cervix
- Trial name
- NCT03936075
- Testing
- the Guided Imagery and Music method, standard care and verbal counselling
- Where
- Greece
- Volunteers
- 20 people
- Sponsor
- Aalborg University
brca1 Mutation Carrier, brca2 Mutation Carrier
Deslorelin Combined With Low-Dose Add-Back Estradiol and Testosterone in Preventing Breast Cancer in Premenopausal Women Who Are at High Risk for This Disease
RATIONALE: Chemoprevention therapy is the use of certain drugs to try to prevent the development or recurrence of cancer. Deslorelin combined with low-dose add-back estradiol and testosterone (given to replace hormones suppressed…
- Conditions
- brca1 Mutation Carrier, brca2 Mutation Carrier, Breast Cancer
- Trial name
- NCT00080756
- Testing
- therapeutic estradiol, deslorelin, therapeutic testosterone
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- City of Hope Medical Center
Breast Cancer, Esophageal Cancer
Brodalumab in the Treatment of Immune-Related Adverse Events
The purpose of this study is to test the safety and effectiveness of using brodalumab in patients who develop side effects from cancer immune therapy.
- Conditions
- Breast Cancer, Esophageal Cancer, Kidney Cancer, Lung Cancer
- Trial name
- NCT06673329
- Testing
- Brodalumab, CT scan
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Brian Henick, MD
High Grade Epithelial Ovarian Cancer, High Grade Serous Ovarian Cancer
Rinatabart Sesutecan (Rina-S, PRO1184, GEN1184) for Advanced Solid Tumors (GCT1184-01/ PRO1184-001)
This study will test the safety, including side effects, and determine the characteristics of a drug called Rina-S in participants with solid tumors.
- Conditions
- High Grade Epithelial Ovarian Cancer, High Grade Serous Ovarian Cancer, Primary Peritoneal Carcinoma, Fallopian Tube Cancer
- Trial name
- RAINFOL-01 (NCT05579366)
- Testing
- Rina-S, Carboplatin, Bevacizumab
- Where
- 66 sites in United States, China and 1 more
- Volunteers
- 952 people
- Sponsor
- Genmab
Neoplasms, Breast
Tykerb Evaluation After Chemotherapy (TEACH): Lapatinib Versus Placebo In Women With Early-Stage Breast Cancer
This study was designed to evaluate and compare the safety and efficacy of an oral dual tyrosine kinase inhibitor, lapatinib, versus placebo in women with early-stage ErbB2-overexpressing breast cancer who have completed their…
- Trial name
- NCT00374322
- Testing
- lapatinib
- Where
- 439 sites in United States, Argentina and 31 more
- Volunteers
- 3,166 people
- Sponsor
- GlaxoSmithKline
Breast Cancer
An Impact Assessment of a Culturally Tailored Online Psychosocial Program for Chinese Immigrant Women With Breast Cancer
The purpose of the study is to evaluate the effectiveness of an online psychosocial self-help program for Chinese immigrant women with breast cancer, by comparing Chinese immigrant women who receive the online psychosocial…
- Trial name
- NCT04656353
- Testing
- Intervention Arm, Control Group
- Where
- Canada
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University Health Network, Toronto
Early-stage Breast Cancer, Obesity
BAriaTric Surgery After Breast Cancer Treatment (BATS)
This is a feasibility study to gain an understanding of the willingness of women with a history of early stage breast cancer and current obesity to enroll in a weight-loss study, accept an assigned intervention (bariatric surgery…
- Trial name
- NCT03946423
- Testing
- Bariatric Surgery with Sleeve Gastrectomy, Lifestyle Intervention
- Sponsor
- Masonic Cancer Center, University of Minnesota
Breast Cancer
Nintedanib+Letrozole in Postmenopausal Women With Breast Cancer: Clinical Trial Safety and Pharmacodynamics
Open, multicenter phase I with gradual increase in dosage to evaluate the safety and tolerability of orally administered nintedanib plus letrozole orally (2.5 mg / day) for patients with breast cancer.
- Trial name
- NCT02619162
- Testing
- Nintedanib, Letrozole
- Where
- 3 sites in Spain
- Volunteers
- 25 people
- Sponsor
- Centro Nacional de Investigaciones Oncologicas CARLOS III
Breast Cancer
Study of Ductal Lavage in Women at High Risk for Breast Cancer
RATIONALE: Collecting samples of fluid using ductal lavage and nipple aspiration from participants at high risk for breast cancer to study in the laboratory may help doctors learn more about changes that may occur in DNA and…
- Trial name
- NCT00429988
- Testing
- fluorescence in situ hybridization, polymerase chain reaction, proteomic profiling
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of California, San Francisco
Renal Impairment, Digestive Cancers
DESIR. Evaluation of the Pre-therapeutic Activity of Dihydropyrimidine dEShydrogenase (DPD) in Patients With Cancer and/or Renal Failure
Fluoropyrimidine drugs (5-Fluorouracil or 5-FU and its prodrug capecitabine) are a widely used in the treatment of numerous solid tumors in adults.
- Conditions
- Renal Impairment, Digestive Cancers, Breast Cancer
- Trial name
- DESIR (NCT07124403)
- Testing
- blood sampling
- Volunteers
- 742 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Breast Cancer, Cachexia
Effect of Dietary Counseling and Nutritional Monitoring in Reducing Cancer-related Cachexia Among Female Oncology Patients
In this parallel, two-arm randomized controlled trial (RCT), 140 female patients with advanced-stage breast cancer and clinical features of cachexia will be randomized using block-stratified allocation into an intervention group…
- Trial name
- NCT07112482
- Testing
- Standard Oncological Care + Tailored Dietary Counseling + Nutritional Monitoring
- Where
- Pakistan
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Pakistan Society of Pediatric Oncology
Breast Cancer
Randomized Phase III Trial Comparing Sequential Administration of FE75C Followed by Docetaxel Versus Paclitaxel as Adjuvant Chemotherapy in Axillary Lymph Node (+) Breast Cancer
Anthracycline-containing regimens are recommended as adjuvant treatment for women with node positive breast cancer. In at least three large randomized clinical trials the addition or sequential administration of a taxane…
- Trial name
- NCT00431080
- Testing
- Docetaxel, Paclitaxel, Epirubicin
- Where
- 10 sites in Greece
- Volunteers
- 478 people
- Sponsor
- Hellenic Oncology Research Group
Metastatic Breast Cancer
1303GCC: Trastuzmab & Pertuzumab With Hormonal Therapy or Chemotherapy in Women Aged 60 and Over.
This is a phase II study that combines Trastuzumab with Pertuzumab to see how it works in women age greater than 60 who have been diagnosed with HER2/neu overexpressed locally advanced and/or metastatic breast carcinoma.
- Trial name
- NCT02000596
- Testing
- Trastuzumab plus Pertuzumab, Hormonal Therapy with Anastrozole and Fulvestrant, Chemotherapy with Eribulin
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- University of Maryland, Baltimore
Breast Cancer
Long-Term Follow-Up in Women With Early Breast Cancer Three Years of More Post Primary Treatment
This study evaluates whether there are pre-treatment factors such as patient characteristics, specific breast cancer type, specific treatments, toxicities, or adverse events during treatment that may impact the quality of life…
- Trial name
- NCT05926024
- Testing
- Exercise Recall Patient Reported Outcomes, Health Behavior Questionnaire (HBQ)30 Patient Reported Outcomes, Functional Assessment of Cancer Therapy-General (FACT-G) Patient Reported Outcomes
- Where
- United States
- Volunteers
- 253 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Breast Cancer, Lung Cancer
Vaccine Therapy Plus Sargramostim in Treating Patients With Stage III or Stage IV Cancer
RATIONALE: Vaccines may make the body build an immune response to tumor cells. Colony-stimulating factors such as sargramostim increase the number of immune cells found in bone marrow or peripheral blood.
- Conditions
- Breast Cancer, Lung Cancer, Ovarian Cancer
- Trial name
- NCT00005023
- Testing
- HER-2/neu peptide vaccine, sargramostim
- Where
- United States
- Sponsor
- University of Washington
Breast Cancer
Simvastatin in Preventing a New Breast Cancer in Women at High Risk for a New Breast Cancer
RATIONALE: Chemoprevention is the use of certain drugs to keep cancer from forming, growing, or coming back. The use of simvastatin may keep cancer from coming back in women who are at high risk for a new breast cancer after…
- Trial name
- NCT00334542
- Testing
- simvastatin
- Where
- 2 sites in United States
- Volunteers
- 50 people
- Sponsor
- Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Glioblastoma, Renal Cell Carcinoma
Dendritic Cell Vaccination for Patients with Solid Tumors
The aim of this study is to evaluate the immunogenicity and clinical efficacy of intradermal vaccination with autologous RNA-modified dendritic cells (DCs) - engineered to express the WT1 protein - in patients with limited spread…
- Conditions
- Glioblastoma, Renal Cell Carcinoma, Sarcomas, Breast Cancers
- Trial name
- NCT01291420
- Testing
- autologous dendritic cell vaccination
- Where
- Belgium
- Volunteers
- 48 people
- Sponsor
- University Hospital, Antwerp
Breast Neoplasms
A Study of Palbociclib (PD-0332991) + Letrozole vs. Letrozole For 1st Line Treatment Of Postmenopausal Women With ER+/HER2- Advanced Breast Cancer (PALOMA-2)
The study is designed to compare the clinical benefit following treatment with letrozole in combination with PD-0332991 versus letrozole in combination with placebo in postmenopausal women with ER(+)/HER2(-) advanced breast…
- Trial name
- NCT01740427
- Testing
- PD-0332991, Letrozole
- Where
- 305 sites in United States, Australia and 16 more
- Volunteers
- 666 people
- Sponsor
- Pfizer
Breast Cancer
Combination Chemotherapy in Treating Women With Breast Cancer That is Metastatic or Cannot be Treated With Surgery
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining more than one drug may kill more tumor cells.
- Trial name
- NCT00015886
- Testing
- docetaxel, fluorouracil
- Where
- 6 sites in United States
- Volunteers
- 25 people
- Sponsor
- Wake Forest University Health Sciences
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