Clinical trials: Female Genital Disease
Vaginismus
Trial of SVTampons vs Glass Vaginal Dilators in Treatment of Vaginismus
The aim of this study is to compare the success rates of vaginismus therapy using a tampon or a dilator during exposure
- Trial name
- NCT05529407
- Testing
- Simple Vaginal Tampon, Glass Vaginal Trainer
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Bezmialem Vakif University
Endometriosis
Characterization of Immune Cells and Their Secreted Cytokines in Endometriosis Patients
The EUmetriosis project aims to address the most important unmet needs of endometriosis sufferers to advance patient care. The objectives cover all main aspects of disease management, including elucidating the pathogenesis…
- Trial name
- EUmetriosis (NCT06897436)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Medical University of Lublin
Vulvovaginal Candidiasis (VVC)
An Investigation to Evaluate the Clinical Performance and Safety of pHyph in Adult Women With Vulvovaginal Candidiasis Compared With an Untreated Control Group
The goal of this clinical trial is to learn if pHyph works to reduce signs and symptoms of vulvovaginal candidiasis (thrush). It will also learn about the safety of pHyph.
- Trial name
- NCT07405853
- Testing
- pHyph
- Where
- 3 sites in Sweden
- Volunteers
- 48 people
- Sponsor
- Gedea Biotech AB
Stage IV Cervical Cancer FIGO 2018, Adenosquamous Carcinoma of Cervix
Personalized Ultra-fractionated Stereotactic Adaptive Radiotherapy for Metastatic Cervical Cancer
To improve overall survival in patients with metastatic cervical cancer by loco-regional therapy with personalized ultra-fractionated radiation
- Conditions
- Stage IV Cervical Cancer FIGO 2018, Adenosquamous Carcinoma of Cervix, Cervical Cancer, Metastasis
- Trial name
- NCT05021237
- Testing
- Ultra-fractionated radiation therapy
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- University of Texas Southwestern Medical Center
Ovarian Neoplasms
Characterizing the Cross-sectional Approach to Investigate the Prevalence of Tissue BRCA1/2 Mutations in Newly Diagnosed Advanced Ovarian Cancer Patients
This is a multi-center, observational study in Japan. Patients with newly diagnosed FIGO stage III - IV advanced OC will be enrolled sequentially.
- Trial name
- CHRISTELLE (NCT04222465)
- Where
- 20 sites in Japan
- Volunteers
- 207 people
- Sponsor
- AstraZeneca
Depression, Anxiety
E-health Cognitive Behavioral Therapy in Women Treated by in Vitro Fertilization (IVF)
Yearly, 15,000 Dutch in vitro fertilization (IVF) cycles are performed for subfertility with a pregnancy rate of 26%. A failed cycle has great emotional impact; 20-25% of the women has relevant forms of depression/anxiety even…
- Conditions
- Depression, Anxiety, Infertility
- Trial name
- NCT01283607
- Testing
- Digicoach
- Where
- Netherlands
- Volunteers
- 120 people
- Sponsor
- University Medical Center Nijmegen
Recurrent Endometrial Carcinoma, Recurrent Fallopian Tube Carcinoma
Abemaciclib for the Treatment of Recurrent Ovarian or Endometrial Cancer
This phase II trial studies how well abemaciclib works in treating patients with ovarian or endometrial cancer that has an activation of the CDK4/6 pathway and that has come back (recurrent).
- Conditions
- Recurrent Endometrial Carcinoma, Recurrent Fallopian Tube Carcinoma, Recurrent Ovarian Carcinoma, Recurrent Primary Peritoneal Carcinoma
- Trial name
- NCT04469764
- Testing
- Abemaciclib, Anastrozole, Letrozole
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Jonsson Comprehensive Cancer Center
Ovarian Cancer, Endometrial Cancer
Predictors of Ovarian Cancer and Endometrial Cancer for Artificial-Intelligence-Based Screening Tools
The goal of this observational study is to explore the possible associated factors of ovarian cancer and endometrial cancer in Indonesia and develop screening tools that could predict the risk of both types of cancer The specific…
- Conditions
- Ovarian Cancer, Endometrial Cancer, Endometrial Hyperplasia
- Trial name
- NCT05697601
- Testing
- Artificial-Intelligence Based Screening Tools, Pathology analysis
- Where
- Indonesia
- Volunteers
- 2,905 people, healthy volunteers welcome
- Sponsor
- Hasanuddin University
Microparticle, Endometriosis
Microparticle Generation After Laparoscopic Surgical Treatment for Endometrioma.
Study objective: To evaluate serial generation of microparticles (MPs) after laparoscopic stripping or CO2 laser vaporization in surgical treatment of patients with ovarian endometrioma (OE).
- Conditions
- Microparticle, Endometriosis, Laparoscopy
- Trial name
- NCT03429881
- Testing
- Stripping versus laser CO2
- Where
- Spain
- Volunteers
- 33 people
- Sponsor
- Francisco Carmona
Primary Peritoneal Cavity Cancer, Recurrent Ovarian Epithelial Cancer
Irofulven in Treating Patients With Recurrent or Persistent Ovarian Epithelial or Primary Peritoneal Cancer
Phase II trial to study the effectiveness of irofulven in treating patients who have recurrent or persistent ovarian epithelial cancer or primary peritoneal cancer.
- Trial name
- NCT00053365
- Testing
- irofulven
- Where
- United States
- Volunteers
- 61 people
- Sponsor
- National Cancer Institute (NCI)
Hereditary Breast and Ovarian Cancer
Feasibility of Lifestyle Intervention in BRCA1/2 Mutation Carriers
BRCA1/2 mutation carriers have a considerably increased risk to develop breast and ovarian cancer during their lifetime. There is evidence from the literature that for sporadic breast cancer disease risk and the course of disease…
- Trial name
- LIBRE (NCT02087592)
- Testing
- Structured exercise training plus mediterranean diet
- Where
- 3 sites in Germany
- Volunteers
- 69 people
- Sponsor
- Technical University of Munich
Pelvic Pain
Long-term Management of Patients Surgically Treated for Chronic Pelvic Pain by Minimally Invasive Surgery
It is a retrospective observational study based on the analysis of the medical records of patients treated for chronic pelvic pain and benign gynecological pathologies at the Gynecology Unit of the University Hospital of Modena…
- Trial name
- NCT04652011
- Testing
- Minimally Invasive Gynecologic Surgery, osteopathic manipulative treatment, Pain killer
- Where
- Italy
- Volunteers
- 250 people
- Sponsor
- Azienda Ospedaliero-Universitaria di Modena
Infertility, Female
Preservation of Women's Fertility: Evaluation of Innovative Methods for Ovarian Tissue Cryopreservation
The recent innovations in cancer diagnosis and therapy have improved the five-year survival for patients. However, anticancer treatments may impair patient fertility; therefore fertility preservation is recommended before therapy…
- Trial name
- FERTIOVO (NCT06724471)
- Testing
- Human ovarian tissue cryopreservation using thermosoldered or screwed cryovials
- Where
- France
- Volunteers
- 30 people
- Sponsor
- University Hospital, Clermont-Ferrand
Cervical Adenocarcinoma, Cervical Squamous Cell Carcinoma
Radiation Therapy and Chemotherapy in Treating Patients With Locally Advanced Cervical Cancer
This phase I trial is studying the side effects and best way to give radiation therapy when given together with topotecan and cisplatin in treating patients with locally advanced cervical cancer.
- Conditions
- Cervical Adenocarcinoma, Cervical Squamous Cell Carcinoma, Stage IB Cervical Cancer, Stage IIA Cervical Cancer
- Trial name
- NCT00054444
- Testing
- Topotecan Hydrochloride Liposomes, 3-Dimensional Conformal Radiation Therapy, Cisplatin
- Where
- 10 sites in United States
- Volunteers
- 11 people
- Sponsor
- Gynecologic Oncology Group
Endometriosis
A Clinical Trial to Evaluate Dichloroacetate (DCA) as a Treatment for Endometriosis-associated Pain
This is a single-arm open label exploratory clinical trial to evaluate dichloroacetate (DCA) as a possible treatment for treatment of endometriosis-associated pain
- Trial name
- EPiC (NCT04046081)
- Testing
- Dichloroacetate
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- University of Edinburgh
Endometrioma
Effect of Prolonged GnRh Agonists on Results of Intracytoplasmic Sperm Injection (ICSI ) in Endometrioma Patients
Investigators compare ICSI results for endometrioma patients with or without cyst aspiration if more than 5cm \&with or without GnRh agonists for all endometrioma patients
- Trial name
- GnRh (NCT02737800)
- Testing
- endometrioma aspiration, GnRh agonist ( Decapeptyl ), standard long stimulation protocol
- Where
- Egypt
- Volunteers
- 88 people
- Sponsor
- Kasr El Aini Hospital
Intrauterine Adhesion
PRP Prevents Recurrence of Intrauterine Adhesions
Effect of platelet-rich plasma (PRP) on uterine scar fibrosis, endometrial receptivity and pregnancy outcome in patients with severe intrauterine adhesions
- Trial name
- RPR-IUAs (NCT03629132)
- Testing
- Platelet-rich plasma, gel
- Volunteers
- 60 people
- Sponsor
- Yanhong Deng
Recurrent Endometrial Carcinoma, Recurrent Fallopian Tube Carcinoma
Testing the Use of the Combination of Selumetinib and Olaparib or Selumetinib Alone Targeted Treatment for RAS Pathway Mutant Recurrent or Persistent Ovarian and Endometrial Cancers, A ComboMATCH Treatment Trial
This phase II ComboMATCH treatment trial compares selumetinib plus olaparib to selumetinib alone in women with endometrial or ovarian (fallopian tube and primary peritoneal) cancer that has come back (recurrent) or that remains…
- Conditions
- Recurrent Endometrial Carcinoma, Recurrent Fallopian Tube Carcinoma, Recurrent Ovarian Carcinoma, Recurrent Primary Peritoneal Carcinoma
- Trial name
- NCT05554328
- Testing
- Biopsy Procedure, Biospecimen Collection, Bone Marrow Aspiration and Biopsy
- Where
- 295 sites in United States, Puerto Rico
- Volunteers
- 165 people
- Sponsor
- National Cancer Institute (NCI)
Aplastic Anemia, Menorrhagia
Treatment of Menorrhagia in Women With Thrombocytopenia Using Platelets or Platelets and Hormones
This study will explore the role of oral contraceptive pills in managing uterine bleeding in women who have low blood platelet counts as a result of aplastic anemia.
- Conditions
- Aplastic Anemia, Menorrhagia, Amenorrhea
- Trial name
- NCT00556400
- Testing
- Lo-Ovral Oral Contraceptive Pills
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Women's Health: Cervical Neoplasm
Mobile Outreach Screening of High-Risk Human Papillomavirus Infection in Women with Limited Access to Health Services in Seine-Saint-Denis (greater Paris Area, France)
The study is a prospective cervical cancer screening intervention in the nonclinical setting of a mobile testing unit in a vehicle, using point-of-care HPV PCR tests with self-collected vaginal swabs.
- Trial name
- PAPMOBILE (NCT06656611)
- Testing
- HPV self sampling
- Where
- France
- Volunteers
- 700 people, healthy volunteers welcome
- Sponsor
- Institut de Médecine et d'Epidémiologie Appliquée - Fondation Internationale Léon M'Ba
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