Clinical trials: Female Genital Disease
Platinum-Resistant Fallopian Tube Carcinoma, Platinum-Resistant Ovarian Carcinoma
PLX038 for Treatment of Metastatic Platinum-resistant Ovarian, Primary Peritoneal, and Fallopian Tube Cancer
This phase II trial tests whether pegylated SN-38 conjugate PLX038 (PLX038) works to shrink tumors in patients with ovarian, primary peritoneal, and fallopian tube cancers that has spread from where it first started (primary…
- Conditions
- Platinum-Resistant Fallopian Tube Carcinoma, Platinum-Resistant Ovarian Carcinoma, Platinum-Resistant Primary Peritoneal Carcinoma, Stage IV Fallopian Tube Cancer AJCC v8
- Trial name
- NCT05465941
- Testing
- Biopsy, Pegylated SN-38 Conjugate PLX038, Computed Tomography
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Mayo Clinic
Cervical Cancer, Human Papillomavirus
Accuracy of Portable Colposcopy and HPV Genotypes Among HIV+ Women
This study will evaluate the effectiveness of portable colposcopy when compared to conventional colposcopy (25x magnification of the cervix, the gold standard) and Visualization Inspection with Acetic acid (VIA, with 1x…
- Conditions
- Cervical Cancer, Human Papillomavirus, Human Immunodeficiency Virus
- Trial name
- NCT02338141
- Testing
- Portable colposcopy (Cerviscope), Conventional colposcopy (Wallach Zoomscope)
- Where
- Haiti
- Volunteers
- 132 people, healthy volunteers welcome
- Sponsor
- Duke University
Papillomavirus Infections
Safety and Immunogenicity of Extended 2-dose Regimens of 9-valent Human Papillomavirus (9vHPV) Vaccine (V503-069)
This is a 96-month safety and immunogenicity study conducted in boys and girls 9 to 14 years of age and in young women 16 to 26 years of age.
- Trial name
- NCT04708041
- Testing
- 9vHPV vaccine
- Where
- 30 sites in United States, Colombia and 4 more
- Volunteers
- 700 people, healthy volunteers welcome
- Sponsor
- Merck Sharp & Dohme LLC
Advanced Solid Tumor, Head and Neck Squamous Cell Carcinoma
A Study of [225Ac]-FPI-1966 in Participants With Advanced Solid Tumours
This first-in-human study evaluates safety, tolerability and distribution of [225Ac] FPI-1966, [111In]-FPI-1967, and vofatamab in patients with FGFR3-expressing solid tumors.
- Conditions
- Advanced Solid Tumor, Head and Neck Squamous Cell Carcinoma, Bladder Carcinoma, Susceptible FGFR3 Genetic Alterations
- Trial name
- NCT05363605
- Testing
- [225Ac]-FPI-1966, [111In]-FPI-1967, vofatamab
- Where
- 6 sites in United States, Australia
- Volunteers
- 6 people
- Sponsor
- Fusion Pharmaceuticals Inc.
Endometriosis
Oral Health and Endometriosis: A Cohort Study
A survey has been conducted thanks to a questionnaire composed of 45 questions. The study group was composed of 4079 women affected by endometriosis, recruited from dedicated communities present on the social network Facebook.
- Trial name
- Oral-Endomet (NCT06753162)
- Where
- Italy
- Volunteers
- 4,079 people, healthy volunteers welcome
- Sponsor
- University of Bari Aldo Moro
Herpes, Herpes Simplex
Study of the Efficacy and Safety of Combined Treatment of Patients With Severe Herpes Simplex (HSV) Infection by Valacyclovir and Interferon Inducer Kagocel
This study examined the efficacy, safety and benefits of modern treatment and changes in the dynamics of the life of adult patients quality with severe herpes simplex in the current medical practice when combined therapy by…
- Conditions
- Herpes, Herpes Simplex, Herpes Oral, Herpes Simplex 2
- Trial name
- NCT04664127
- Testing
- Kagocel+Valacyclovir, Valacyclovir
- Where
- Russia
- Volunteers
- 45 people
- Sponsor
- Nearmedic Plus LLC
Infertility, Female
Effects of SNP of GnRH Receptor Genes in IVF Patients
Gonadotropin-releasing hormone analogue (GnRH-a) "long protocol" is a protocol for pituitary down-regulation in IVF. However, it is common in clinic that some patients are hypersensitive to pituitary down-regulation and have…
- Trial name
- NCT02979886
- Testing
- GnRH-a, Human Menopausal Gonadotropins
- Volunteers
- 1,500 people
- Sponsor
- Miao benyu
Uterine Cervical Neoplasms
Pelvic IMRT With Tomotherapy: A Phase I Feasibility Study in Post-Hysterectomy Cervical Cancer Patients
Indications for post-hysterectomy radiation therapy (RT) have been well established by clinical data. Adjuvant RT has demonstrated local control and survival benefit.
- Trial name
- NCT00359866
- Testing
- IMRT with tomotherapy
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- Washington University School of Medicine
Uterine Rupture, Mode of Delivery
Uterine Rupture During Labor Among Women With a Prior Cesarean Delivery
Although a rare event, uterine rupture during labour is one of the most serious obstetric complications because of the dramatic maternal-fetal consequences that can result.
- Trial name
- NCT04566705
- Testing
- Risks factors, maternal and neonatal outcomes/complications
- Where
- France
- Volunteers
- 95 people
- Sponsor
- University Hospital, Montpellier
Ovarian Neoplasms, Breast Neoplasms
A Study to Determine the Management of Palmar-plantar Erythrodysesthesia (PPE) in Patients With Metastatic Ovarian or Breast Cancer Treated With Caelyx (Study P05020)
The objective of this trial is to study the management of PPE in participants with metastatic ovarian or breast cancer treated with Caelyx, and determine the frequency of use of pharmacological treatment (preventive or…
- Conditions
- Ovarian Neoplasms, Breast Neoplasms, Paresthesia
- Trial name
- NCT00746694
- Volunteers
- 154 people
- Sponsor
- Merck Sharp & Dohme LLC
Malignant Neoplasms of Female Genital Organs
Feasibility of the NEXT Steps Weight Loss Intervention +/- Resistance Training for Endometrial Cancer Survivors: Effect on Lean Mass & Biomarkers
The goal of this research study is to learn if a home-based physical activity program is feasible and can help endometrial cancer survivors lose weight.
- Trial name
- NCT02774759
- Testing
- Accelerometer, Questionnaires, Fitness Test
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- M.D. Anderson Cancer Center
HIV Infections, HPV Infection
Adjuvant 5-Fluorouracil Following Thermal Ablation to Improve HPV Treatment Outcomes in Women With HIV in Kenya
This randomized, placebo-controlled trial will evaluate self-administered 5-fluorouracil (5FU) to improve human papillomavirus (HPV) clearance after thermal ablation (TA) in Women With Human Immunodeficiency Virus (HIV) (WWH) in…
- Conditions
- HIV Infections, HPV Infection, Cervix Cancer, CIN2
- Trial name
- ASCEND (NCT07545746)
- Testing
- 5% 5-fluorouracil Topical Cream
- Where
- 2 sites in Kenya
- Volunteers
- 140 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Cervical Cancer Screening
Personalized Risk-based Follow-up of Cervical Cancer Screening in Practice, RCT
The goal of this PREDICT is to assess a personalize approach to screening and management of cervical cancer testing. The investigators will evaluate patients who are due for a follow up cervical cancer screening in the primary…
- Trial name
- PREDICT (NCT06872346)
- Testing
- Visit-based IT reminders to patients and practitioners, Population outreach
- Where
- United States
- Volunteers
- 7,500 people
- Sponsor
- Massachusetts General Hospital
Hypospadias
Antibiotic Use Following Distal and Mid-shaft Hypospadias Repair
The purpose of this study is to evaluate the efficacy of prophylactic antibiotics following distal or mid-shaft hypospadias repair in influencing the rate of postoperative urinary tract infection and complications.
- Trial name
- NCT02593903
- Testing
- Septra
- Where
- United States
- Volunteers
- 67 people
- Sponsor
- Medical College of Wisconsin
Cervical Cancer, Recurrent Cervical Cancer
Cabozantinib Plus Pembrolizumab for Recurrent, Persistent and/or Metastatic Cervical Cancer
Drug: Cabozantinib Drug: Pembrolizumab
- Conditions
- Cervical Cancer, Recurrent Cervical Cancer, Metastatic Cervical Cancer, Persistent Cervical Cancer
- Trial name
- NCT04230954
- Testing
- Cabozantinib 40 MG oral once a day, Pembrolizumab 200 mg IV every 3 weeks
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- University of South Alabama
Infertility, Female, First Trimester Spontaneous Abortion
Determination of Circulating Placental Biomarkers Levels to Predict the Pregnancy Outcome of First Trimester After IVF.
This study will assess the predictive potential of circulating placental biomarkers for spontaneous miscarriage within the following month in an IVF setting.
- Trial name
- NCT04387994
- Testing
- Blood samples collection
- Where
- Portugal
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Instituto Valenciano de Infertilidade de Lisboa
Fallopian Tube Cancer, Ovarian Cancer
Carboplatin, Paclitaxel, and Surgery in Treating Patients With Advanced Ovarian Epithelial, Fallopian Tube, or Primary Peritoneal Cavity Cancer
RATIONALE: Drugs used in chemotherapy, such as carboplatin and paclitaxel, work in different ways to stop the growth of tumor cells, either by killing the cells or stopping them from dividing.
- Conditions
- Fallopian Tube Cancer, Ovarian Cancer, Peritoneal Cavity Cancer
- Trial name
- NCT00331422
- Testing
- carboplatin, paclitaxel, cytoreductive surgery
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Masonic Cancer Center, University of Minnesota
Polycystic Ovary Syndrome, Infertility
Therapy for Infertile PCOS Patients Ovulating Under Clomiphene Citrate or Metformin
Several data demonstrated that both clomiphene citrate (CC) and metformin are two safe and valid first-step options to induce ovulation in infertile anovulatory PCOS patients.
- Trial name
- NCT00502229
- Testing
- Clomiphene citrate, metformin, highly purified urinary FSH
- Where
- Italy
- Sponsor
- University Magna Graecia
Prostate Cancer, Kidney Cancer
DS Titanium Ligation Clip in Urology (Prostatectomy and Nephrectomy)
Prospective, monocentric, single arm, observational PMCF - Study on the Performance and Safety of Double-Shank Titanium Ligation Clip in Urology (Prostatectomy and Nephrectomy)
- Conditions
- Prostate Cancer, Kidney Cancer, Congenital Abnormality of Kidney, Nephrolithiasis
- Trial name
- DOSTILCU (NCT04869462)
- Where
- Germany
- Volunteers
- 67 people
- Sponsor
- Aesculap AG
Polycystic Ovarian Disease
The Influence of Polycystic Ovairan Syndrome on Embryonic Developmental Timing
Polycystic ovary syndrome is one of the most common causes of female infertility. The cause of infertility in PCOS is unknown. Factors other than anovulation, including inherited or induced changes in the embryo quality have been…
- Trial name
- PCOS (NCT01953146)
- Where
- Denmark
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
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