Clinical trials: Female Genital Disease
Solid Tumor, Adult, Colorectal Cancer
Solid Tumor Analysis for HLA Loss of Heterozygosity (LOH) and Apheresis for CAR T- Cell Manufacturing
Objective: To collect information on how often a solid tumor cancer might lose the Human Leukocyte Antigen (HLA) by next generation sequencing and perform apheresis to collect and store an eligible participant's own T cells for…
- Conditions
- Solid Tumor, Adult, Colorectal Cancer, Non Small Cell Lung Cancer, Pancreatic Cancer
- Trial name
- BASECAMP-1 (NCT04981119)
- Testing
- Apheresis, Next Generation Sequencing (NGS), Long Range NGS HLA typing
- Where
- 16 sites in United States
- Volunteers
- 500 people
- Sponsor
- A2 Biotherapeutics Inc.
Solid Tumor, Colorectal Cancer
Safety and Tolerability of DS-7423 in Subjects With Advanced Solid Malignant Tumors
This will be a Phase 1, open-label study of DS-7423 to assess its safety and tolerability, identify a RP2D, (recommended Phase 2 Dose) and assess its Pharmacokinetics (PK) (what your body does to process the drugs and how your…
- Conditions
- Solid Tumor, Colorectal Cancer, Endometrial Cancer
- Trial name
- NCT01364844
- Testing
- DS-7423
- Where
- 3 sites in United States
- Volunteers
- 42 people
- Sponsor
- Daiichi Sankyo
Infertility, Female, IVF
The Study of the Implantation Window From Endometrial Biopsy With Gene Expression Methods
The objective of the study is to gain a better understanding of the gene expression changes in the endometrial biopsy especially whether the endometrium has reached a receptive status, i.e. the implantation window, or not.
- Trial name
- NCT04052464
- Testing
- endometrium biopsy, endometrium lavage, repeated endometrium lavage
- Volunteers
- 67 people
- Sponsor
- Prelife Kft
Esophageal Neoplasms, Hepatocellular Carcinoma
A Safety and Effectiveness Study of Aroplatin in Patients With Advanced Solid Malignancies
To determine the rate of response and the duration of the response following therapy with Aroplatinin patients with advanced solid malignancies.
- Conditions
- Esophageal Neoplasms, Hepatocellular Carcinoma, Colorectal Neoplasms, Ovarian Neoplasms
- Trial name
- NCT00057395
- Testing
- Aroplatin (Liposomal NDDP, L-NDDP)
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Aronex Pharmaceuticals
Ovarian Cancer
Study of Bevacizumab/Doxil in Treatment of Platinum-Resistant/Refractory Ovarian Cancer (CA)
The purpose of this research study is to test the safety, tolerability, and effectiveness of two chemotherapy drugs, pegylated liposomal doxorubicin (Doxil) and bevacizumab (Avastin).
- Trial name
- NCT00945139
- Testing
- Doxil, Avastin
- Where
- 3 sites in United States
- Volunteers
- 46 people
- Sponsor
- New Mexico Cancer Research Alliance
Endometrial Cancer, Endometrial Neoplasms
Real-time Lymphatic Channel Visualization Improves Bilateral Sentinel Lymph Node Detection in Endometrial Cancer
Endometrial cancer is the most common malignancy of the female genital tract. Standard treatment for early-stage disease includes hysterectomy, bilateral salpingo-oophorectomy, and lymph node assessment.
- Conditions
- Endometrial Cancer, Endometrial Neoplasms, Sentinel Lymph Node Biopsy (SLNB)
- Trial name
- NCT05191212
- Testing
- indocyanine green
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Bakirkoy Dr. Sadi Konuk Research and Training Hospital
BRCA1 Gene Mutation, BRCA2 Gene Mutation
Early Salpingectomy (Tubectomy) With Delayed Oophorectomy in BRCA1/2 Gene Mutation Carriers
The purpose of this study is to determine whether an innovative preventive strategy, consisting of early salpingectomy upon completion of childbearing with delayed oophorectomy beyond current guideline age, improves…
- Conditions
- BRCA1 Gene Mutation, BRCA2 Gene Mutation, Ovarian Cancer
- Trial name
- TUBA (NCT02321228)
- Testing
- Salpingectomy with delayed oophorectomy, Risk-reducing salpingo-oophorectomy
- Where
- 13 sites in Netherlands
- Volunteers
- 510 people
- Sponsor
- University Medical Center Nijmegen
Infertility
Comparison Between Laparoscopic Ovarian Diathermy and Urinary Purified FSH in Women With Clomiphene Citrate Resistant Polycystic Ovarian Syndrome.
210 women with clomiphene resistant PCOS will be randomly divided into 3 equal groups using computer generated random numbers. Group 1 will receive combined metformin and FSH, group 2 will have LOD and group 3 will act as the…
- Trial name
- FSH (NCT02304536)
- Testing
- FSH, Laparoscopic ovarian drilling
- Where
- 2 sites in Egypt
- Volunteers
- 210 people
- Sponsor
- Cairo University
Endometriosis
Efficacy of Internet-based Cognitive Behavioral Therapy for Endometriosis
The purpose of this study is to evaluate the efficacy of an internet-based cognitive behavioral therapy in reducing the impairment caused by endometriosis.
- Trial name
- EdiTh (NCT05098444)
- Testing
- Cognitive behavioral psychotherapy, Waiting list
- Where
- Germany
- Volunteers
- 120 people
- Sponsor
- Philipps University Marburg
Infertility, Female, IVF
Effect of Intrauterine Administration of Autologous PBMC Modulated With IFNt on IVF Outcome
The goal of this clinical trial is to test the effect of modulated specialised immune cells isolated from the patients' own blood when administered to the uterus before embryo transfer on the IVF outcome (implantation, pregnancy…
- Trial name
- NCT05775198
- Testing
- PBMC immunomodulated with IFNt
- Where
- Bulgaria
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Nadezhda Women's Health Hospital
Infertility
Obesity Index That Better Predict Ovarian Response
This study is designed to assess the accuracy of Body Mass Index ,Waist Circumference ,Waist Hip Ratio or Waist Height Ratio as a predictor of ovarian response in women undergoing ICSI.
- Trial name
- NCT02520765
- Where
- Egypt
- Volunteers
- 500 people
- Sponsor
- Ain Shams University
Advanced Cancer
Dose Escalation and Expansion Study of FLX475 Monotherapy and in Combination With Pembrolizumab
This clinical trial is a Phase 1/2, open-label, sequential-group, dose-escalation and cohort expansion study to determine the safety and preliminary anti-tumor activity of FLX475 as monotherapy and in combination with…
- Trial name
- NCT03674567
- Testing
- FLX475 (tivumecirnon), pembrolizumab (KEYTRUDA®)
- Where
- 35 sites in United States, Australia and 4 more
- Volunteers
- 323 people
- Sponsor
- RAPT Therapeutics, Inc., a member of the GSK plc group of companies
Endometritis, Infertility
Fertility Outcomes After Antibiotic Treatment In Women With Chronic Endometritis
Chronic endometritis (CE) is a long-lasting inflammation of the lining of the uterus. Many women with CE do not have symptoms, but the condition may affect fertility, embryo implantation, and pregnancy outcomes.
- Conditions
- Endometritis, Infertility, Hysteroscopy, Pregnancy Disease
- Trial name
- MORE (NCT07603492)
- Where
- 2 sites in Czechia
- Volunteers
- 100 people
- Sponsor
- Faculty Hospital Kralovske Vinohrady
HIV Infections
Safety and Blood Levels of Tenofovir Disoproxil Fumarate in HIV Infected Pregnant Women and Their Babies
To prevent mother-to-child transmission (MTCT) of HIV in resource-limited countries, a simple yet effective treatment plan is needed.
- Trial name
- NCT00120471
- Testing
- Tenofovir disoproxil fumarate
- Where
- 5 sites in Brazil, Malawi
- Volunteers
- 122 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Endometrial Cancer
Fasting InTervention for Endometrial Cancer
The goal of this study is to find out if it is safe for women with endometrial cancer who are going to have surgery to fast (not eat) overnight.
- Trial name
- FIT-ENDO (NCT07622901)
- Testing
- Prolonged Overnight Fasting (POF), Blood Specimen Collection, Blood Sugar Monitor
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- University of Miami
Ovarian Cancer
Sexual Therapy and Rehabilitation After Treatment for Ovarian Cancer (START-OC): A Pilot Intervention
This research study is evaluating an educational intervention for women who have experienced changes in sexual function after treatment for ovarian cancer.
- Trial name
- START-OC (NCT02287519)
- Testing
- Group Session, Telephone Coaching Session, Webinar
- Where
- 2 sites in United States
- Volunteers
- 53 people
- Sponsor
- Dana-Farber Cancer Institute
Sexual Dysfunction, Bipolar Disorder
Study of Maca Root to Treat Sexual Dysfunction Associated With the Treatment Regimen for Bipolar Disorder in Females
The purpose of this research study is to find out whether Maca Root is effective for treating sexual dysfunction in females that is caused by the treatment for bipolar disorder.
- Trial name
- NCT00575328
- Testing
- Maca Root
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Massachusetts General Hospital
Breast Cancer, Endometrial Cancer
High-Dose Megestrol in Treating Patients With Metastatic Breast Cancer, Endometrial Cancer, or Mesothelioma
RATIONALE: Some hormones can stimulate the growth of some types of cancer cells. Hormone therapy using megestrol may fight cancer by reducing the production of these hormones.
- Conditions
- Breast Cancer, Endometrial Cancer, Malignant Mesothelioma
- Trial name
- NCT00002465
- Testing
- megestrol acetate
- Where
- United States
- Sponsor
- St. Vincent Medical Center - Los Angeles
Diminished Ovarian Reserve
Follicular Activation by Fragmentation of Ovarian Tissue
The primary objective of this study is to assess the chances of increasing the number of antral follicles in ovarian tissue of patients with diminished ovarian reserve by activation of primordial follicles through ovarian cortex…
- Trial name
- FAFOT (NCT03670407)
- Testing
- Ovarian tissue fragmentation
- Where
- Croatia
- Volunteers
- 40 people
- Sponsor
- Podobnik Maternity and Gynecology Hospital
Observational Study, Dydrogesterone
Observational Study of Dydrogesterone in Cycle Regularization
Dydrogesterone has been widely used worldwide for various gynecological and obstetric indications: Dydrogesterone is effective in cycle regulation treatment.
- Conditions
- Observational Study, Dydrogesterone, Irregular Menstrual Cycle, Abnormal Uterine Bleeding
- Trial name
- NCT02029144
- Where
- China
- Volunteers
- 114 people
- Sponsor
- Fudan University
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.