Clinical trials: Female Infertility, open to volunteers
Acute Ovarian Failure, Infertility
Biorepository in Participants Who Undergo OTC for Gonadotoxic Therapy
Background: Medical advances have improved survival rates for many cancers and other illnesses. This means that more people are coping with the long-term effects of these treatments. Some treatments can cause female infertility.
- Conditions
- Acute Ovarian Failure, Infertility, Early Menopause And Infertility In Females After Treatment For Childhood Cancer
- Trial name
- NCT05440617
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Adenomyosis of Uterus, Implantation Failure
Linzagolix in Adenomyosis and Recurrent Implantation Failure
Adenomyosis is associated with impaired endometrial receptivity and reduced implantation rates in assisted reproduction, even when using high-quality embryos.
- Conditions
- Adenomyosis of Uterus, Implantation Failure, Infertility Female, Embryo Transfer
- Trial name
- LINZA-RIF (NCT07698561)
- Testing
- Linzagolix 200 mg (Yselty)
- Where
- 3 sites in Spain
- Volunteers
- 30 people
- Sponsor
- Vida Fertility Institute
Infertility, Female, Pregnancy Related
Low TGF-β and Embryo Implantation in the Context of Assisted Reproductive Technology: Confirmation of a Biomarker Predictive of Success and Characterization of the Immune Microenvironment.
Infertility affects about one in seven couples in France. Beyond the medical and personal challenges, it has major societal implications.
- Trial name
- ImmuNoFertilit (NCT07859930)
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Female Infertility, Uterine Fibroid
The Effects of Uterine Fibroids on Pregnancy in Women
Female fertility may be affected by uterine fibroids, although this association has not been elucidated. This retrospective cohort study aims to evaluate the impact of fibroids on women fertility.
- Trial name
- NCT06020924
- Testing
- No intervention
- Where
- China
- Volunteers
- 1,658 people, healthy volunteers welcome
- Sponsor
- Wenwen Wang
Infertility (IVF Patients), Infertility
Intra-ovarian CAPA-IVM vs Standard IVM
This prospective study compares two approaches to obtaining mature oocytes for fertility treatment within the same participant. Immature oocytes are first retrieved from the right ovary and matured in the laboratory using a…
- Conditions
- Infertility (IVF Patients), Infertility, Infertility Female
- Trial name
- IO-CAPA (NCT07858435)
- Testing
- CAPA-IVM, In-House CAPA-IVM Pre-Maturation Medium, Minimal-Stimulation OS-IVF
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- New Hope Fertility Center
Functional Hypothalamic Amenorrhea, FHA
A Study to Investigate Mibavademab in Adult Women With Functional Hypothalamic Amenorrhea
This study is researching an experimental drug called mibavademab (also called "study drug"). The study is focused on participants with a condition called Functional Hypothalamic Amenorrhea (FHA).
- Trial name
- KYRIAD (NCT07235917)
- Testing
- Mibavademab
- Where
- 11 sites in United States
- Volunteers
- 34 people
- Sponsor
- Regeneron Pharmaceuticals
Infertility, Female, Ovulation Induction
Oral GnRH Antagonist (Linzagolix) Versus Injectable GnRH Antagonist in Controlled Ovarian Stimulation for In Vitro Fertilization: A Randomized Controlled Non-Inferiority Trial With a Concurrent Comparator Cohort Undergoing Progestin-Primed Ovarian Stimulation (PPOS)
Women undergoing IVF/ICSI who are candidates for a GnRH-antagonist protocol are randomly assigned 1:1 to oral linzagolix or the standard injectable GnRH antagonist (ganirelix or cetrorelix).
- Trial name
- NCT07732348
- Testing
- Ganirelix ; Cetrorelix, Medroxyprogesterone Acetate ; Micronized Progesterone, Linzagolix
- Volunteers
- 120 people
- Sponsor
- Centro A.M.B.R.A. (Associazione Medici e Biologi per la Riproduzione Assistita)
Infertility Female, Frozen Embryo Transfer (FET)
FET-LET-2x2: Clinical Pregnancy Rates After Frozen Embryo Transfer in Natural and Modified Natural Cycles
The goal of this clinical trial is to learn whether different natural approaches to preparing the uterus for frozen embryo transfer (FET) can improve pregnancy success in women undergoing in vitro fertilization (IVF) treatment.
- Trial name
- FET-LET-2x2 (NCT07425990)
- Testing
- Letrozole (Aromatase Inhibitors), Choriogonadotropin alpha (r-hCG), Progesterone
- Where
- Serbia
- Volunteers
- 120 people
- Sponsor
- University of Novi Sad
Infertility, Infertility, Female
Half-dose vs Conventional-dose Cetrorelix in ICSI Cycles
This prospective cohort study aims to compare the effectiveness of half-dose (0.125 mg/day) versus conventional-dose (0.25 mg/day) cetrorelix in GnRH antagonist ICSI cycles regarding clinical pregnancy rate in women with BMI ≥25…
- Conditions
- Infertility, Infertility, Female, Anovulation
- Trial name
- NCT07836400
- Volunteers
- 160 people
- Sponsor
- Assiut University
Female Infertility
AI-Assisted Euploid Embryo Selection for Single-Blastocyst Transfer in Women of Advanced Maternal Age
This single-center prospective randomized controlled study will enroll 500 infertile women aged 35 years or older who meet the criteria for fresh day-5 single-blastocyst transfer.
- Trial name
- NCT07833345
- Testing
- AI-assisted morphological assessment combined with euploidy prediction using EmbryoInsights™ Plus, AI-assisted morphological assessment using EmbryoInsights™
- Where
- China
- Volunteers
- 500 people
- Sponsor
- The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
Infertility, Female, Ovarian Reserve
hCG Priming in Women With Diminished Ovarian Reserve
The aim of this randomized controlled trial is to further examine the possible effects of low dose human chorionic gonadotropin (hCG) priming for eight weeks in women with diminished ovarian reserve (DOR) undergoing in vitro…
- Conditions
- Infertility, Female, Ovarian Reserve, In Vitro Fertilization (IVF)
- Trial name
- NCT07108621
- Testing
- Choriongonadotropin alfa (hCG)
- Where
- Denmark
- Volunteers
- 80 people
- Sponsor
- Kristine Loessl
Endometriosis, Adenomyosis of Uterus
Artificial Intelligence Into Ultrasound Diagnostics in Reproductive Medicine
The goal of this observational study is to develop and validate artificial intelligence (AI)-based algorithms that support ultrasound diagnosis of endometriosis, adenomyosis, myometrial masses, uterine malformations, and impaired…
- Conditions
- Endometriosis, Adenomyosis of Uterus, Leiomyoma (Uterine Fibroids), Uterine Neoplasms
- Trial name
- AUDRIE (NCT07810920)
- Where
- Hungary
- Volunteers
- 1,600 people
- Sponsor
- Semmelweis University
Infertility, Female
Impact of a Web-Based Mind-Body Awareness Program on Women Undergoing Infertility Treatment
The goal of this two-group parallel randomized controlled study is to determine the effect of a web-based mind-body-based awareness program based on Meleis Transition Theory on fertility awareness and readiness levels in women…
- Trial name
- NCT06585137
- Testing
- Web-Based Mind-Body Based Awareness Program
- Where
- Turkey (Türkiye)
- Volunteers
- 78 people
- Sponsor
- Hacettepe University
Infertility (IVF Patients), Infertility Assisted Reproductive Technology
Purpose to Evaluate the Effectiveness of the Superovulation Stimulation Protocol Using Human Chorionic Gonadotropin (hCG) by Demonstrating Its Equivalence to Standard Controlled Ovarian Stimulation Protocols in Terms of Oocytes Retrieved, Blastulation While Maintaining an Economic Advantage
This study evaluates a more affordable medication protocol for ovarian stimulation during in vitro fertilization (IVF). Standard IVF protocols use medications called gonadotropins to stimulate the ovaries to produce multiple…
- Conditions
- Infertility (IVF Patients), Infertility Assisted Reproductive Technology, Infertile Patients, Infertility Drugs
- Trial name
- NCT07771283
- Testing
- Human Chorionic Gonadotropin (hCG), GnRH antagonist, Dual trigger (human chorionic gonadotropin plus GnRH-agonist)
- Where
- 3 sites in Uganda, Ukraine
- Volunteers
- 360 people
- Sponsor
- LTD "EKODNIPRO", Medical centre Medical Plaza Dnipro
Infertility, Female, Anxiety
Multifaceted Benefits of Auricular Point Sticking for IVF Patients: Psychological Well-being, Sleep, and Treatment Outcomes
The goal of this clinical trial is to evaluate whether the complementary intervention of auricular point sticking therapy (APST) can improve pregnancy outcomes by ameliorating psychological distress and sleep quality in female…
- Conditions
- Infertility, Female, Anxiety, Assisted Reproductive Techniques, Dyssomnias
- Trial name
- NCT07409792
- Testing
- auricular point sticking therapy, Conventional Artificial Cycle Therapy
- Where
- China
- Volunteers
- 178 people
- Sponsor
- Hangzhou TCM Hospital Affiliated to Zhejiang Chinese Medical University
Polycystic Ovary Syndrome (PCOS), Female Infertility
Comparison of IVF Outcomes Between PPOS and Antagonist Protocols in Women With PCOS
This study aims to compare the outcomes of two ovarian stimulation protocols used in in vitro fertilization (IVF): the progestin-primed ovarian stimulation (PPOS) protocol and the GnRH antagonist protocol.
- Trial name
- PPOS-PCOS-IVF (NCT07394530)
- Testing
- Progestin-Primed Ovarian Stimulation (PPOS), GnRH Antagonist Protocol
- Where
- Vietnam
- Volunteers
- 400 people
- Sponsor
- Hanoi General Hospital (Vietnam)
Infertility, Female
Evaluation of a Long Versus Short Clomid Protocol for Controlled Ovarian Stimulation
The goal of this clinical trial is to evaluate a long Clomid protocol as compared to a 5-day Clomid protocol for ovarian stimulation in patients with diminished ovarian reserve undergoing ovarian stimulation for in-vitro…
- Trial name
- NCT06701071
- Testing
- Clomiphene Citrate
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- University of Southern California
Female İnfertility
Mobile Health Support Before Oocyte Pick-Up in Infertile Women
This study aims to evaluate the effect of the OPUCARE system, a structured mobile health application used before oocyte pick-up (OPU), on medication adherence and quality of life in infertile women.
- Trial name
- OPUCARE (NCT07690969)
- Testing
- OPUCARE, Routine clinical care
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Istinye University
Infertility, Female Infertility
Progesterone Luteal Support in Unexplained Infertility Management
The purpose of this study is to evaluate whether progesterone in women with unexplained infertility can increases live birth rate.
- Conditions
- Infertility, Female Infertility, Subfertility, Infertility Primary
- Trial name
- PLUIM (NCT07738068)
- Testing
- Utrogestan® 200 mg Soft Capsule
- Volunteers
- 640 people
- Sponsor
- Simone Broer
Ovarian Failure, Ovarian Insufficiency
Ovarian Tissue Allo-transplantation
Premature ovarian failure, also known as primary ovarian insufficiency (POI), or premature menopause, affects 1-2% of women under 40.
- Conditions
- Ovarian Failure, Ovarian Insufficiency, Menopause Ovarian Failure, Menopause, Premature
- Trial name
- NCT06673004
- Testing
- Ovarian tissue allo-transplantation
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University Hospitals Cleveland Medical Center