Clinical trials: Femoral Shaft Fracture
Femoral Fractures, Hemorrhage, Surgical
Effectiveness of Tranexamic Acid in Reducing Blood Loss During Femoral Nail Surgery
This clinical study aims to evaluate the safety and effectiveness of administering a single intravenous dose of tranexamic acid (TXA) before surgery to reduce blood loss in patients undergoing open intramedullary nailing for…
- Conditions
- Femoral Fractures, Hemorrhage, Surgical, Tranexamic Acid Use
- Trial name
- TXA-FemNail (NCT07261930)
- Testing
- Tranexamic Acid
- Where
- Uganda
- Volunteers
- 43 people
- Sponsor
- Masaka Regional Referral Hospital
Femoral Fractures, Tibial Fractures
Depuy Synthes Lower Extremity Shaft Nail Registry
The purpose of this post-market registry is to monitor the clinical safety and performance (union rates and time to union) of two DePuy Synthes lower extremity shaft nails: RFN-Advanced Retrograde Femoral Nailing System (RFNA)…
- Trial name
- NCT05272631
- Testing
- Retrograde Femoral Nail Advanced, Tibial Nail Advanced
- Where
- 8 sites in United States
- Volunteers
- 241 people
- Sponsor
- DePuy Synthes Products, Inc.
Femur Shaft Fracture, Tibia Fractures
Assessing Bone Fracture Healing Effect of Almonds
Femur and tibia shaft fractures are common after trauma with a burden of 5% and 20% respectively. Clinicians recommend costly bone strengthening drugs/supplements while treating bone fractures.
- Conditions
- Femur Shaft Fracture, Tibia Fractures, Vitamin D, Sweet Almonds
- Trial name
- AFHEA (NCT07153302)
- Testing
- Prunus dulcis (sweet almonds)
- Where
- Pakistan
- Volunteers
- 136 people
- Sponsor
- Aga Khan University Hospital, Pakistan
Hip Fractures, Femoral Shaft Fractures
Trial of a Distal Targeting System for Cephalomedullary Nails as Part of Surgical Repair of Hip and Femoral Shaft Fractures
This study will be a prospective, case - control trial looking at the use of a previously FDA approved device made by Stryker, a distal targeting system that eases the distal targeting of screws in cephalomedullary nails in hip…
- Trial name
- NCT03943329
- Testing
- Standard of Care, Distal targeting device technique of distal screw placement
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- NYU Langone Health
Fractures, Bone, Impending Fracture
Retrospective Study on Clinical Performance and Safety Profile of Agile Nail
This study aims to retrospectively collect data from routine clinical practice in order to evaluate the safety profile of the Agile intramedullary nail, used in pediatric patients according to the manufacturer Instructions For…
- Conditions
- Fractures, Bone, Impending Fracture, Deformity; Bone
- Trial name
- Agile (NCT06412939)
- Testing
- Agile Nail
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- Orthofix s.r.l.
Osteotomy, Trochanteric Fractures
ZNN Bactiguard Cephalomedullary Nails PMCF Study
This is a multicenter, prospective, Post-market Clinical Follow-up (PMCF) Study on the ZNN Bactiguard Cephalomedullary Nails. The objective of this study is to collect data confirming the safety, performance, and clinical benefit…
- Conditions
- Osteotomy, Trochanteric Fractures, Sub-trochanteric Fractures, Femoral Shaft Fracture
- Trial name
- NCT05362864
- Testing
- Fracture fixation via Intramedullary Nailing
- Where
- 3 sites in France, Spain
- Volunteers
- 149 people
- Sponsor
- Zimmer Biomet
Pulmonary Complications, Organ Failure
Intramedullary Femoral Reaming, Human Study
To what extent the cardiopulmonary and inflammatory response is affected by initial femoral intramedullary nailing in the already traumatized and inflammatory activated patient was analyzed in the present study with the attention…
- Conditions
- Pulmonary Complications, Organ Failure, Systemic Inflammatory Response Syndrome
- Trial name
- NCT01042132
- Testing
- the effect of delayed intramedullary reaming, the reaming of the femoral canal is performed with two different reaming devices
- Where
- Norway
- Volunteers
- 17 people
- Sponsor
- Ullevaal University Hospital
Femoral Shaft Fractures and Patellar Fractures, Knee Fractures
Development and Clinical Evaluation of a Novel Hollow Cusp Fracture Reducer for Femoral Shaft and Patellar Fractures
This study aimed to develop and clinically evaluate a novel hollow cusp fracture reducer for enhancing the precision and efficiency of closed reduction and internal fixation in patients with femoral shaft fractures and patellar…
- Conditions
- Femoral Shaft Fractures and Patellar Fractures, Knee Fractures, Femoral Fractures
- Trial name
- NCT07534904
- Where
- China
- Volunteers
- 142 people
- Sponsor
- Hanzhong Central Hospital
Femoral Shaft Fracture, Pediatric ALL
Femoral Pediatric Fractures. Walking Spica Cast vs Synthetic Pants
Femoral pediatric shaft fractures are a common orthopedic injury. Conservative treatment is still the preferred method by orthopedic surgeons.
- Trial name
- NCT04311866
- Testing
- Synthetic pants, Spica cast
- Where
- Mexico
- Volunteers
- healthy volunteers welcome
- Sponsor
- Universidad Autonoma de Nuevo Leon
Fracture Non Union, Fracture Healing
Prospective Validation Study of the CD8+TEMRA Cells As a Prognostic Biomarker of Healing Outcome After Fracture
In approx. 10-15% of all fracture patients, there is a prolonged healing time or even a complete absence of fracture healing (non-union).
- Conditions
- Fracture Non Union, Fracture Healing, Long Bone Delayed-Union Fracture, Humerus Shaft Fracture
- Trial name
- BioBone (NCT06658379)
- Testing
- CD8+TEMRA
- Where
- 7 sites in Germany
- Volunteers
- 640 people
- Sponsor
- Charite University, Berlin, Germany
Femoral Neck Fractures, Intertrochanteric Fractures
Opioid-Free Pain Treatment in Trauma Patients
Analgesic drug study that will compare pain outcomes of opioid analgesia and opioid-free analgesia in post-operative orthopedic patients.
- Conditions
- Femoral Neck Fractures, Intertrochanteric Fractures, Femoral Shaft Fracture, Distal Femur Fracture
- Trial name
- NCT06078371
- Testing
- Opioid-free pain treatment
- Where
- United States
- Volunteers
- 250 people
- Sponsor
- University of Kansas Medical Center
Femoral Shaft Fracture
Titanium Elastic Nailing Versus Hip Spica Cast in Treatment of Femoral Fractures in Children
The purpose of this study is to determine which method is better for treatment of femoral fracture in children in outcomes.
- Trial name
- NCT01190696
- Testing
- titanium elastic nailing, Hip spica casting
- Where
- Iran
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Isfahan University of Medical Sciences
Embolism, Femoral Fractures
Effect of a Novel Reamer-Irrigator-Aspirator on the Incidence of Fat Embolism
The purpose of this study is to determine the effect on the incidence of fat emboli when using a Reamer-Irrigator Aspirator during reamed IM nail fixation of femoral shaft fractures
- Trial name
- RIA (NCT00509171)
- Testing
- Reamer Irrigator Aspirator
- Where
- Canada
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Femoral Fractures
Standard Reaming Versus Reaming/Irrigating/Aspirating for Intramedullary Nailing of Femoral Shaft Fractures
Reaming (enlarging of the bone canal) is commonly performed prior to the insertion of intramedullary nails for the fixation of long bone fractures.
- Trial name
- STAFF (NCT00534326)
- Testing
- Standard Reaming, Reaming/Irrigating/Aspirating
- Where
- 9 sites in United States
- Volunteers
- 158 people
- Sponsor
- Prisma Health-Upstate
Femoral Shaft Fracture, Tibial Shaft Fracture
MAGIK for Femoral/Tibial Shaft Fractures
The purpose of this phase 2 randomized control trial will be to evaluate the effect of glucose-insulin-potassium (GIK) therapy in the setting of lower extremity trauma to reduce short- and long-term muscle damage, acute…
- Trial name
- MAGIK (NCT05627479)
- Testing
- GIK solution, Isotonic Normal Saline Solution
- Where
- United States
- Sponsor
- NYU Langone Health
Fracture
Optimal Vitamin D3 Supplementation Strategies for Acute Fracture Healing
The objective is to determine the effect of vitamin D3 supplementation on fracture healing at 3 months.
- Trial name
- Vita-Shock (NCT02786498)
- Testing
- Vitamin D3
- Where
- 2 sites in United States, Canada
- Volunteers
- 102 people
- Sponsor
- University of Maryland, Baltimore
Femoral Shaft Fracture
IMN Diameter to Femoral Canal Diameter and Union
To Detect the Relation Between the Intramedullary Nail Diameter to Canal Ratio and the Incidence of Non-union
- Trial name
- NCT04195334
- Testing
- internal fixation by IMN
- Volunteers
- 100 people
- Sponsor
- Assiut University
Ipsilateral Neck and Shaft Fractures and Internal Fixation Method and Follow Up At One Year Postoperative for Radiological and Functional Outcomes
Radiological and Functional Outcomes of Internal Fixation Methods for Ipsilateral Femoral Neck and Shaft Fractures in Young Adult Patients
Does the single construct produce more favourable radiological and functional outcomes with less complication when it is compared to dual constructs for fixation of ipsilateral femoral neck and shaft fractures in young adult…
- Trial name
- NCT06826521
- Testing
- Single construct versus dual constructs will give satisfactory radiological and functional outcomes
- Where
- Egypt
- Volunteers
- 24 people
- Sponsor
- Assiut University
Shaft Femure Fracture in Adolescents
Fixation of Shaft Femure Fracrture by Ender Versus Plate
The aim of this study is to compare the functional outcomes, fracture healing time, rate of complications, and long-term growth outcomes between intramedullary nail and plating in adolescent.
- Trial name
- NCT07067333
- Testing
- intramedullary nails for group A, plate for group B
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Sohag University
Femoral Fracture
Retrograde Femoral Nail-Advanced Outcomes for Fixation of Distal Femur and Femoral Shaft Fractures
This project consists of a prospective and retrospective case series design. Study candidates will include all patients 18 years or older, who were evaluated at UCSD and found to have a distal femur or femoral shaft fracture…
- Trial name
- NCT05680987
- Testing
- RFN-Advanced Retrograde Femoral Nailing System
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego