Clinical trials: Fertility
Fertility Disorders, Infertility (IVF Patients)
The Effect of Mindfulness-Based Lifestyle Support Program on Infertile Women
This randomized controlled trial aimed to determine whether a mindfulness-based lifestyle support program would improve quality of life, lifestyle, mindfulness, attention and meditation level and treatment outcomes in women…
- Trial name
- NCT06799507
- Testing
- Interventions Based on Mindfulness, Routine clinical procedure
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 92 people
- Sponsor
- Dokuz Eylul University
Carcinoma, Endometrioid, Fertility Preservation
Fertility Sparing Therapy for Patients With Stage IA G2 Endometrial Cancer
Endometrial cancer (EC) is a prevalent gynecological cancer with an escalating global incidence and a decreasing age of onset. In the era of precision medicine, there is an increasing emphasis on tailoring treatments to different…
- Trial name
- NCT06468215
- Testing
- Treatment Option 1 is a single-drug regimen, with oral medroxyprogesterone acetate (MPA) 500mg/d or MA 320mg/d.
- Where
- China
- Volunteers
- 16 people
- Sponsor
- Peking University People's Hospital
Fertility Preservation, Lymphoma
AMH as a Predictor of Infertility Risk in Children With Cancer (CHANCE)
While most of the children spontaneously recover menstruation or experienced normal puberty after chemotherapy, their ovarian reserve may be impaired by treatment inducing future infertility.
- Conditions
- Fertility Preservation, Lymphoma, Pediatrics Cancer, Gonadotropin-releasing Hormone Agonist
- Trial name
- CHANCE (NCT02595255)
- Testing
- No intervention
- Where
- 8 sites in Belgium, France
- Volunteers
- 275 people
- Sponsor
- Erasme University Hospital
Ovarian Cysts, Endometriosis
Using INDOcyanine Green to Analyse Ovarian Vascularization After Ovarian Laparoscopic CYStectomy
To evaluate the feasibility of using Indocyanine Green in the laparoscopic surgical treatment of benign organic ovarian cysts (dermoid, serous, mucinous and endometriotic) in patients with a short-term desire for pregnancy.
- Conditions
- Ovarian Cysts, Endometriosis, Fertility
- Trial name
- KYSINDO (NCT04355312)
- Testing
- Use of Indocyanine Green in laparoscopic ovarian cystectomy
- Where
- France
- Volunteers
- 51 people
- Sponsor
- University Hospital, Clermont-Ferrand
Sperm Preservation in Oncological Patients, Fertility
Presence of SARS-CoV-2 (COVID-19) in Semen: Impact on Fertility Preservation in Male Oncological Patients ?
During the COVID-19 pandemic, the French Agency of Biomedicine has recommended maintaining fertility preservation for patients requiring immediate oncological treatments exhibiting gonadotoxic effects.
- Conditions
- Sperm Preservation in Oncological Patients, Fertility, Cryopreservation
- Trial name
- FERTICOVID (NCT04487639)
- Testing
- SARS-CoV-2 research in nasopharyngeal swab, sperm and serologics
- Where
- 16 sites in France
- Volunteers
- 129 people
- Sponsor
- University Hospital, Clermont-Ferrand
Female Infertility, Reproductive Health
A Clinical Trial to Evaluate the Effects of a Supplement on Markers of Female Fertility
This study evaluates the effects of a daily dietary supplement (WeNatal For Her) on markers of female fertility, reproductive health, and sexual health over three menstrual cycles.
- Conditions
- Female Infertility, Reproductive Health, Fertility, Hormonal Imbalance
- Trial name
- NCT07740187
- Testing
- WeNatal For Her Supplement
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- WeNatal
Cancer, Fertility Issues
Impact of Gonadotoxic Therapies on Fertility
The goal of this observational study is to learn how gonadotoxic treatments (chemotherapies, radiotherapies or immunotherapies) affect the fertility status of participants with cancer.
- Conditions
- Cancer, Fertility Issues, Fertility Preservation, Toxicity Due to Chemotherapy
- Trial name
- FertiTOX (NCT05885048)
- Testing
- Blood samples for analysis, Sperm samples for analysis, Satisfaction evaluation
- Where
- Switzerland
- Volunteers
- 7,000 people
- Sponsor
- Michael von Wolff
Fertility Issues, Preconception Injuries
Health Promotion Model, Fertility Awareness, Preconception Knowledge and Attitude
The effect of education given to preconceptional women in line with the health promotion model on fertility awareness, preconceptional knowledge and attitude levels
- Conditions
- Fertility Issues, Preconception Injuries, Health Behavior
- Trial name
- NCT06690554
- Testing
- Education Group
- Where
- Turkey (Türkiye)
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- Selcuk University
Fertility, Mobile Applications
Smartphone vs Manual Interpretation of Biomarkers for Ovulation and Luteal Phase Detection (SMOM Study)
This study will compare different combinations of fertility signs (cervical mucus (CM), luteinizing hormone [LH], pregnanediol glucuronide [PDG], and basal body temperature [BBT]) to determine which are most reliable for…
- Conditions
- Fertility, Mobile Applications, Artifical Intelligence, Cervical Mucus
- Trial name
- SMOM (NCT07248046)
- Testing
- Premom App-Assisted Fertility Tracking
- Where
- Canada
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Bruyère Health Research Institute.
Neoplasm, Cancer
Digital Psychoeducational Intervention for Young Adults With Fertility Related Distress Following Cancer Diagnosis
The goal of this randomized controlled trial is to evaluate the effectiveness of a digital psychoeducational intervention for young adults experiencing fertility-related distress following a cancer diagnosis.
- Conditions
- Neoplasm, Cancer, Psychoeducational Intervention, Young Adults
- Trial name
- NCT07729696
- Testing
- Digital psychoeducational intervention
- Where
- Indonesia
- Volunteers
- 38 people
- Sponsor
- Gadjah Mada University
Gynecological Cancer, Oocyte Cryopreservation
Digital Health Literacy and Oocyte Cryopreservation Among Women With Gynecological Cancer
This study evaluated a digital health literacy education intervention related to oocyte cryopreservation among newly diagnosed women with gynecological cancer.
- Conditions
- Gynecological Cancer, Oocyte Cryopreservation, Digital Health Literacy, Fertility Preservation
- Trial name
- NCT07701252
- Testing
- Digital Health Literacy Education Intervention
- Where
- Egypt
- Volunteers
- 158 people
- Sponsor
- Benha University
Ovulation, Female Fertility
FemiClock: Non-invasive Tools Development (Salivary and Hair Progesterone) for Ovulation Detection in Heathy Women With Regular Menstrual Cycles Without Contraception.
Currently, the gold standard to confirm ovulation is measuring LH and/or progesterone in blood. However, because confirmation requires a blood sample, this approach is not suitable for epidemiological studies evaluating the…
- Conditions
- Ovulation, Female Fertility, Menstrual Cycle
- Trial name
- FemiClock (NCT07687823)
- Testing
- Diagnostic Test: Non-invasive ovulation biomarker assessment - Smartwatch, Diagnostic Test: Non-invasive ovulation biomarker assessment - Questionnaires, Hormonal blood assessment
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University Hospital, Strasbourg, France
Infertility, Fertility Issues
Optimal Timing of Euploid Day 6 Blastocyst Transfer in Frozen HRT Cycles, Day 6 or Day 7 of Progesterone Administration.
The goal of this study is to compare the difference in clinical pregnancy, miscarriage and livebirth rate between day 6 euploid blastocyst transfer on the 6th and the 7th day of progesterone exposure in Hormonal Replacement…
- Conditions
- Infertility, Fertility Issues, Infertility, Female
- Trial name
- NCT05980091
- Testing
- Transvaginal ultrasound, Serum LH, E2, P4, Estradiol Valerate 2 MG
- Where
- 2 sites in United Arab Emirates
- Volunteers
- 316 people, healthy volunteers welcome
- Sponsor
- ART Fertility Clinics LLC
Fertility
Comparison of Sequential CFA vs CFA +rFSH for Elective Fertility Preservation.
This randomized was designed as non-inferiority trial aiming to compare the number of MII oocytes with 2-shot of Corifollitropin alpha (CFA) sequential administration: 150μg at stimulation day (SD) 1 and 100μg at SD 5 and 1-shot…
- Trial name
- 2-Shot (NCT06134479)
- Testing
- 150μg CFA (Elonva®) at stimulation day (SD) 1 and 100μg CFA(Elonva®) at SD 5, 150μg CFA (Elonva®) at SD 1 following by rFSH (Puregon®) 200IU daily from SD 8 until the day of the trigger
- Where
- Spain
- Volunteers
- 194 people
- Sponsor
- Fundación Santiago Dexeus Font
Fertility Preservation, Gynecologic Cancers
A Modular Cloud Platform For Fertility Preservation
The research was designed as a randomized controlled study to determine the effectiveness of a modular cloud-based training platform in increasing awareness of fertility preservation.
- Trial name
- NCT07642531
- Testing
- Developing a Modular Cloud-Based Platform to guide decision-making in fertility preservation
- Where
- Turkey (Türkiye)
- Volunteers
- 140 people
- Sponsor
- Biruni University
Fertility
Exploring and Validating Biomarkers in Menstrual Blood
This study aims to find out whether menstrual blood can provide similar useful biological information to a standard blood sample taken from a vein in the arm as well as uterine biopsies and vaginal swabs.
- Trial name
- MB1 (NCT07638085)
- Where
- United Kingdom
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Genie Fertility Ltd
Endometrial Carcinoma, Obese
Weight Management Plus Megestrol Acetate in Early-stage Endometrioid Carcinoma
To investigate the efficacy of weight management plus megestrol acetate in obese patients with early endometrioid carcinoma（EEC）asking for fertility-sparing treatment
- Conditions
- Endometrial Carcinoma, Obese, Overweight, Fertility Issues
- Trial name
- NCT05316467
- Testing
- Intensive Lifestyle Intervention (ILI), Megestrol Acetate 160 MG Oral Tablet
- Where
- China
- Volunteers
- 8 people
- Sponsor
- Xiaojun Chen
Atypical Endometrial Hyperplasia, Fertility Issues
Weight Management Plus LNG-IUS/Megestrol Acetate in Endometrial Atypical Hyperplasia
To investigate the efficacy of weight management plus levonorgestrel intrauterine system (LNG-IUS) or megestrol acetate (MA) in obese patients with endometrial atypical hyperplasia (EAH) asking for conservative therapy.
- Conditions
- Atypical Endometrial Hyperplasia, Fertility Issues, Overweight and Obesity
- Trial name
- NCT05316493
- Testing
- Intensive Lifestyle Intervention (ILI), Megestrol Acetate 160 MG Oral Tablet, Levonorgestrel-Releasing Intrauterine Contraceptive System (Mirena), 52 Mg
- Where
- China
- Volunteers
- 172 people
- Sponsor
- Xiaojun Chen
Cancer, Infertility
Late Effects of Cancer Therapies on Gonadal Function, Fertility, Efficiency of Fertility Preservation Procedures and Pregnancy Outcomes
In the past two decades, evidence-based knowledge on the prevalence and risk factors for fertility impairment, including infertility, following cancer and numerous cancer treatment regimens has significantly increased.
- Conditions
- Cancer, Infertility, Late Effects, Female Fertility
- Trial name
- Follow-AYA (NCT07622537)
- Volunteers
- 4,000 people
- Sponsor
- Karolinska Institutet
Fertility Issues, Blastocyst IVF
A Multicenter Prospective Randomized Controlled Clinical Trial Comparing Constant (5%) Versus Sequential (5%-2%) Oxygen Concentration Embryo Culture Protocols in Assisted Reproductive Technology
To evaluate whether there were significant differences in the effects of constant (5%) versus sequential (5%-2%) oxygen concentration protocols in embryo culture on term live birth rates.
- Conditions
- Fertility Issues, Blastocyst IVF, Embryo Culture
- Trial name
- NCT07050537
- Testing
- Constant oxygen concentration protocols in embryo culture, Sequential oxygen concentration protocols in embryo culture
- Where
- 6 sites in China
- Volunteers
- 980 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University