Clinical trials: Fertility Disorders
Sperm Preservation, Irradiated Semen
Impact of Ionizing Treatment on the Nuclear Structure of Human Spermatozoa.
Differentiated thyroid cancer is the third cause of cancer in young men of childbearing age. Its treatment by irradiation with Radioactive Iodine 131 therapy (RAT) could alter spermatogenesis and result in azoospermia and…
- Trial name
- NCT04715828
- Testing
- Cryopreserved semen, Acute and low irradiation, Long and low irradiation
- Where
- France
- Volunteers
- 200 people
- Sponsor
- University Hospital, Clermont-Ferrand
DSD, 46,XY, DSD, Ovotesticular
Gonadal Tissue Cryopreservation for Fertility Preservation in Children With a Disorder of Sex Development
The purpose of this study is to offer gonadal tissue freezing and storage to children who are diagnosed with a disorder of sex development (DSD), who are at increased risk of infertility and certain malignancies (cancer).
- Conditions
- DSD, 46,XY, DSD, Ovotesticular, DSD, Sex Chromosome, Disorders of Sex Development
- Trial name
- DSD (NCT06692049)
- Testing
- Gonadectomy
- Where
- United States
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Erin Rowell
Primary Ciliary Dyskinesia (PCD)
A Qualitative Study Investigating the Lived Experiences and Impact of Reproductive Issues in Adults With Primary Ciliary Dyskinesia
Study involving undertaking research interviews with adults who have primary ciliary dyskinesia in the UK about their views and experiences of fertility, pregnancy and parenthood
- Trial name
- NCT07357558
- Testing
- Interview only
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- University Hospital Southampton NHS Foundation Trust
Hyperandrogenism
Combined Use of Machine Learning and Metabolomics to Improve the Diagnosis and Management of Hyperandrogenism
Hyperandrogenism is a common reason for consultation, the causes of which can range from common conditions (PCOS) to rarer conditions with major genetic implications (NC21OHD).
- Trial name
- HYPERMETABO (NCT07253454)
- Testing
- data collection
- Volunteers
- 800 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Male Subfertility
The Impact of a Nutritional Supplement (Impryl®) on Male Fertility
Infertility is a worldwide problem and about 10%-15% of all couples will be affected by the inability to have children. In approximately 50% of infertile couples a male factor is involved.
- Trial name
- SUMMER (NCT03337360)
- Testing
- Impryl
- Where
- 21 sites in Netherlands
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Infertility, Miscarriage
International NaProTechnology Evaluation and Surveillance of Treatment for Infertility and Miscarriage (iNEST)
NaProTechnology (NPT) is a treatment option for infertility or miscarriage that identifies issues in a couple's fertility and fixes them to the extent possible by medical intervention.
- Trial name
- iNEST (NCT01363596)
- Testing
- Creighton Model System in conjunction with Natural Procreative Technology (NPT)
- Where
- 8 sites in United States, Canada and 2 more
- Volunteers
- 834 people
- Sponsor
- University of Utah
Hiv, Contraception
Mobile Phone Messaging to Improve Reproductive Health for Women Living With HIV in Kenya (Mobile WACh Empower)
Use of a mobile health (mHealth) intervention to provide reproductive life counseling to women living with HIV may improve delivery of integrated reproductive health/HIV services and prevent adverse reproductive health outcomes.
- Conditions
- Hiv, Contraception, Fertility Issues
- Trial name
- NCT05285670
- Testing
- Digital counseling plus interactive two-way SMS dialogue
- Where
- 10 sites in Kenya
- Volunteers
- 3,310 people, healthy volunteers welcome
- Sponsor
- University of Washington
Effects of Chemotherapy, Premature Ovarian Failure
Ovarian Reserve After Cancer: Longitudinal Effects
Women of reproductive age who will receive treatment for cancer that includes chemotherapy may participate in a study measuring ovarian function over time.
- Trial name
- ORACLE (NCT02467231)
- Where
- United States
- Volunteers
- 196 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Infertility
NATural Ovarian Stimulation
To overcome unsuitable effects of controlled ovarian hyperstimulation (COH )while maintaining large oocyte availability, investigators elaborated an innovative protocol (NATural Ovarian Stimulation) that dissociates E2 production…
- Trial name
- NATOS (NCT02892942)
- Testing
- Gonal-F®, Cetrotide®
- Where
- France
- Volunteers
- 129 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Fertility Issues
Home Examinations Researching and Understanding Submucosal Evaluations
To demonstrate that imaging via home ultrasound can identify submucosal fibroids. The image quality and submucosal fibroid detection specificity of the home imaging has already been demonstrated; the aim of this study is to…
- Trial name
- HER-USE (NCT05004870)
- Testing
- Transvaginal ultrasound performed by a woman herself (with HCP supervision via telemedicine)
- Where
- United States
- Sponsor
- Turtle Health, Inc.
Endocrine Disease, Infertility
Hormonal Regulation of Puberty and Fertility
Background: The body produces gonadotropin-releasing hormone (GnRH) about every 2 hours. GnRH travels through the bloodstream to the pituitary gland, where it stimulates the gland to produce hormones called gonadotropins.
- Conditions
- Endocrine Disease, Infertility, Hypogonadism, Amenorrhea
- Trial name
- NCT01511588
- Where
- 2 sites in United States
- Volunteers
- 111 people
- Sponsor
- National Institute of Environmental Health Sciences (NIEHS)
Cancer, Cancer in Pregnancy
ProspectiveFemaleAYA - Late Effects of Cancer Therapies on Gonadal Function, Fertility, Efficiency of Fertility Preservation Procedures and Pregnancy Outcomes
In the past two decades, the evidence-based knowledge on the prevalence and risk factors for gonads impairment, including infertility, following cancer and numerous cancer treatment regimen has significantly increased.
- Conditions
- Cancer, Cancer in Pregnancy, Infertility, In Vitro Fertilisation (IVF) Treatment
- Trial name
- FemFertilAYA (NCT07622420)
- Volunteers
- 3,000 people
- Sponsor
- Karolinska Institutet
Stem Cell Transplant, Stem Cell Transplantation
Fertility Protection for Children, Adolescents and Young Adults
This study focuses on improving fertility preservation and long-term care for children, adolescents, and young adults (CAYA) undergoing cancer treatments or stem cell transplantation.
- Conditions
- Stem Cell Transplant, Stem Cell Transplantation, Oncological Outcomes, Oncological Patients
- Trial name
- FeProCAYA (NCT06692868)
- Where
- Germany
- Volunteers
- 2,000 people
- Sponsor
- University of Ulm
Fertility Issues
Assisted Reproductive Techniques (ART) With Sperm Donation : an Inclusive Model of ART for All Women
This is a monocentric, retrospective, non-interventional study. The main objective is to describe the populations requesting assisted reproductive techniques (ART) with sperm donation ; and compare them between groups depending…
- Trial name
- PMAPT (NCT06163079)
- Testing
- No intervention
- Where
- France
- Volunteers
- 675 people
- Sponsor
- Central Hospital, Nancy, France
Colorectal (Colon or Rectal) Cancer, Pelvic Malignancies
Utero-ovarian Transposition in Patients With Pelvic Malignancies Undergoing Whole Pelvic Radiotherapy
This study is designed as a Phase I clinical trial enrolling female patients aged 18-40 years who have been diagnosed with pelvic malignancies requiring whole pelvic external radiation therapy (WPXRT) and who express interest in…
- Conditions
- Colorectal (Colon or Rectal) Cancer, Pelvic Malignancies, Oncofertility
- Trial name
- UOT WPXRT (NCT07419490)
- Testing
- Uteroovarian transposition
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- University of South Florida
Multiple Sclerosis, Neuromyelitis Optica Spectrum Disorders
Evaluation of the Impact of Multiple Sclerosis and Its Treatments on Women Fertility
CONTEXT A desire for pregnancy is common in young patients with multiple sclerosis (MS). The impact of MS on women fertility is debated, and the impact of disease-modifying therapies (DMTs) on fertility is not well known.
- Conditions
- Multiple Sclerosis, Neuromyelitis Optica Spectrum Disorders, Fertility
- Trial name
- FERTIMUS (NCT07164924)
- Testing
- blood sample to analyse AMH level on the serum
- Where
- 27 sites in France, Martinique
- Volunteers
- 800 people
- Sponsor
- University Hospital, Clermont-Ferrand