Clinical trials: Fertility Preservation
Endometrial Neoplasms, Endometrial Neoplasm Malignant
Fertility-sparing Therapy for Patients With Stage IA Endometrial Cancer
The goal of this clinical trial is to explore the feasibility and outcome of fertility-sparing therapy in Stage IA G1-G2 Endometrial Cancer with less than 1/2 myometrial invasion.
- Conditions
- Endometrial Neoplasms, Endometrial Neoplasm Malignant, Endometrial Neoplasm Malignant Stage I, Carcinoma, Endometrioid
- Trial name
- NCT05945407
- Testing
- Indication-extended Fertility-sparing Therapy
- Where
- China
- Volunteers
- 57 people
- Sponsor
- Peking University People's Hospital
Gynecological Cancer, Oocyte Cryopreservation
Digital Health Literacy and Oocyte Cryopreservation Among Women With Gynecological Cancer
This study evaluated a digital health literacy education intervention related to oocyte cryopreservation among newly diagnosed women with gynecological cancer.
- Conditions
- Gynecological Cancer, Oocyte Cryopreservation, Digital Health Literacy, Fertility Preservation
- Trial name
- NCT07701252
- Testing
- Digital Health Literacy Education Intervention
- Where
- Egypt
- Volunteers
- 158 people
- Sponsor
- Benha University
Cancer, Fertility Issues
Outcome Evaluation After Fertility Preservation
It is important to evaluate outcomes after different fertility preservation strategies. Therefore, this study aims to assess the outcomes after different fertility preservation strategies and identify any factors that may affect…
- Trial name
- NCT06043609
- Testing
- This is an observational cohort study
- Where
- Hong Kong
- Volunteers
- 100 people
- Sponsor
- Chinese University of Hong Kong
Fertility Disorders, Childhood Cancer
Cryopreservation of Prepubertal Testicular Tissue for Preservation of Fertility in Young Boys With Cancer
Prepubertal boys treated for cancer are at risk of infertility as a result of their treatment. At present there are no options to preserve fertility in these boys.
- Trial name
- NCT06063551
- Testing
- Testicular Biopsy
- Where
- United Kingdom
- Volunteers
- 100 people
- Sponsor
- University of Edinburgh
Pediatric Cancer
Ovarian Tissue Cryopreservation in Post Pubertal (OTC-Post Pubertal)
The purpose of this study is to safely remove ovarian tissue in pediatric patients, who are at risk for infertility from their medical treatment, for freezing for future restoration of fertility and hormone function.
- Trial name
- NCT05309746
- Testing
- Laparoscopic surgery
- Where
- United States
- Volunteers
- 250 people
- Sponsor
- Erin Rowell
Fertility Preservation
Oocyte Vitrification for In Vitro Fertilization (IVF) Patients and Women With Fertility Threatening Conditions
Vitrification is a method of cryopreserving tissue for future use. It is widely used to preserve extra, good quality embryos generated from infertility treatments.
- Trial name
- NCT01448460
- Volunteers
- 8 people
- Sponsor
- University of Louisville
Endometrioma, Fertility
Ablative Technique For Ovarian Preservation In Endometrioma
The goal of this clinical trial is to compare pregnancy rates after different surgical treatments for endometriomas in adult women who have one or more ovarian cysts (endometriomas) larger than 2 cm requiring surgery.
- Trial name
- ATOPE (NCT07119060)
- Testing
- Cystectomy, plasma vaporization, Sclerotherapy
- Where
- France
- Volunteers
- 332 people
- Sponsor
- Clinique Tivoli Ducos
Fertility Preservation, Alkylating Agents
Efficiency of Gonadotropin-releasing Hormone (GnRH) Agonist in Preventing Chemotherapy Induced Ovarian Failure
Chemotherapy drugs like alkylating agents are frequently used in various combined regimens to treat neoplastic and benign diseases.
- Conditions
- Fertility Preservation, Alkylating Agents, Lymphoma
- Trial name
- Erasme-POF (NCT01160315)
- Testing
- Triptorelin, Norethisterone acetate
- Where
- 15 sites in Belgium, France and 1 more
- Volunteers
- 118 people
- Sponsor
- Erasme University Hospital
Neuroblastoma, Ewing Sarcoma
Fertility Preservation in Children With Solid Tumors: Detection of Residual Disease by a Sensitive Method
In prepubertal patients, cryopreservation of ovarian or testicular tissue is currently the only available method for fertility preservation prior to gonadotoxic cancer treatments.
- Trial name
- PREFERPUBER (NCT07141862)
- Testing
- RT-qPCR, ddPCR
- Where
- France
- Volunteers
- 89 people
- Sponsor
- University Hospital, Clermont-Ferrand
Fertility Preservation
Hormonal Optimization: Late vs. Immediate Start After Discontinuation of Oral Contraceptives in Assisted Reproductive technologY (HOLIDAY)
HOLIDAY is a two-arm, parallel-group, multi-center, randomized trial in which subjects undergoing planned oocyte cryopreservation will be randomized to receive either a 2-month pause of Combined Hormonal Contraceptives (CHC) or…
- Trial name
- HOLIDAY (NCT07225660)
- Testing
- OCP pause
- Where
- 3 sites in United States
- Volunteers
- 394 people
- Sponsor
- Shady Grove Fertility Reproductive Science Center
Amenorrhea, Premature Ovarian Failure
GnRH Analogue for Ovarian Function Preservation in Hematopoietic Stem Cell Transplantation Patients
Primary Objectives: To determine the effectiveness of the 3-month depot leuprolide in inducing and maintaining secondary amenorrhea in patients undergo hematopoietic stem cell transplantation.
- Conditions
- Amenorrhea, Premature Ovarian Failure, Ovarian Function Insufficiency
- Trial name
- NCT00429494
- Testing
- Leuprolide Acetate, Questionnaire, Hematopoietic Stem Cell Transplantation
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- M.D. Anderson Cancer Center
Malignancy, Fertility
Ovarian Tissue Freezing For Fertility Preservation
The purpose of this study is to offer an alternative method to women who wish to preserve the possibility of fertility, as well as to learn more about the ability of human eggs to survive and function after long term storage in…
- Trial name
- NCT00902720
- Testing
- Tissue sample storage
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Endometriosis
Fertility Preservation in Case of Endometriosis
Fertility Preservation is now considered as crucial for the well-being of women battling cancer. However, others indications have more recently emerged.
- Trial name
- PREFENDO (NCT03744754)
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Breast Cancer
Increasing Access to Fertility Preservation for Women with Breast Cancer
The EVAPREF project aims to increase access to fertility preservation by developing an approach to improve and evaluate existing information and coordination tools developed by the Pays-de-la-Loire and Occitanie Regional Cancer…
- Trial name
- EVAPREF (NCT05989776)
- Testing
- Informational brochure for patients and brief training for oncologists
- Where
- 2 sites in France
- Volunteers
- 750 people
- Sponsor
- University Paul Sabatier of Toulouse
Fertility Preservation
Intranasal Nafarelin For Triggering Oocyte Maturation
This is a non-inferiority randomised, controlled clinical trial comparing subcutaneous triptorelin to intranasal nafarelin for the final maturation of oocytes in women undergoing fertility preservation cycles with oocyte…
- Trial name
- INFORM (NCT06763926)
- Testing
- Subcutaneous Triptorelin, Intranasal nafarelin
- Where
- 5 sites in Spain
- Volunteers
- 154 people
- Sponsor
- Fundacion Dexeus
Obesity-related Male Infertility
Can Fat-Burning Shots Boost Fertility? Comparing Weight-Loss Injections vs. Healthy Habits for Obese Men With Low Sperm Health
Why is this study being done? Obesity can harm men's fertility by lowering sperm quality and hormone levels, making it harder to have children. Weight loss through diet and exercise helps, but it's often hard to stick with.
- Trial name
- NCT07179120
- Testing
- Semaglutide (Rybelsus®), Tirzepatide, Standardized Lifestyle Intervention
- Volunteers
- 180 people
- Sponsor
- First Affiliated Hospital of Wenzhou Medical University
Minimal Residual Disease, Fertility Preservation
Contamination of Testicle Tissue by RT-PCR in Participants With Solid Tumors
For prepubertal patients, cryopreservation of testicular tissue is the only option available to preserve their fertility before cancer treatment.
- Trial name
- TESTIMAR (NCT02400970)
- Testing
- malignant cells
- Where
- France
- Volunteers
- 40 people
- Sponsor
- University Hospital, Clermont-Ferrand
Cancer in Pregnancy, Fertility Preservation
Advisory Board on Cancer, Infertility and Pregnancy
The Advisory Board on Cancer, Infertility and Pregnancy provides a platform where physicians from all over the world can request recommendations regarding the medical care of pregnant women diagnosed with cancer or regarding…
- Conditions
- Cancer in Pregnancy, Fertility Preservation, Cancer, Pregnancy
- Trial name
- ABCIP (NCT04904263)
- Where
- Belgium
- Volunteers
- 100 people
- Sponsor
- University Hospital, Gasthuisberg
Infertility, Obesity
IVF Outcome After Bariatric Surgery
This case-control study compares IVF results and live birth rates in women undergoing IVF with a history of bariatric surgery as compared to 2 age-matched control groups composed of (A) non-operated women matched on cases'…
- Trial name
- NCT02884258
- Where
- France
- Volunteers
- 249 people, healthy volunteers welcome
- Sponsor
- Clinique Mathilde
Fertility Preservation
Ovarian Tissue Cryopreservation for Fertility Preservation in Girls and Women
This study will compare efficacy of ovarian tissue freezing using slow-freeze versus vitrification methods.
- Trial name
- NCT05434936
- Testing
- Oophorectomy
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Baylor College of Medicine