Clinical trials: Fertilization
Infertility, Female, Reproductive Techniques, Assisted
SISTER: Sibling Oocyte Insemination With Frozen Sperm From Third Party Donors: Evaluation of Reproductive Techniques
The goal of this clinical trial is to learn whether two different methods of helping eggs and sperm join-intracytoplasmic sperm injection (ICSI) and conventional in vitro fertilization (IVF)-lead to better embryo development when…
- Conditions
- Infertility, Female, Reproductive Techniques, Assisted, Fertilization in Vitro
- Trial name
- SISTER (NCT07175571)
- Testing
- Intracytoplasmic Sperm Injection (ICSI), Conventional Insemination (IVF)
- Where
- United States
- Volunteers
- 95 people
- Sponsor
- Shady Grove Fertility Reproductive Science Center
Infertility
Safety and Efficacy Study in in Vitro Fertilisation (IVF) Patients
The purpose of the non-inferiority study is to evaluate the clinical efficacy and the safety of two different subcutaneous hMG preparations when administered to patients undergoing controlled ovarian stimulation for IVF.
- Trial name
- NCT01312766
- Testing
- Menotropins
- Where
- 6 sites in Denmark, France and 3 more
- Volunteers
- 270 people
- Sponsor
- IBSA Institut Biochimique SA
Dietary Supplements
Effectiveness of Adjuvant Supplements Prior to in IVF
To investigate the effect of combined DHEA, CoQ10 and tocotrienol on IVF cycles in poor ovarian responders
- Trial name
- NCT05471453
- Testing
- DHEA, DHEA+CoQ10+Tocotrienol
- Where
- Taiwan
- Volunteers
- 70 people
- Sponsor
- Kaohsiung Veterans General Hospital.
Infertility, Infertility (IVF Patients)
Endometrial Receptivity Prediction During in Vitro Fertilization Using Artificial Intelligence
The investigators plan to use artificial intelligence to analyse vaginal ultrasound images of the uterine lining (endometrium) taken during routine IVF treatment, which may predict implantation success during IVF treatment.
- Trial name
- NCT06717802
- Where
- Hungary
- Volunteers
- 1,500 people
- Sponsor
- Gottsegen National Cardiovascular Institute
Infertility
Stress Level and the Relationship With IVF Outcomes.
The effect of stress on IVF outcomes.
- Trial name
- NCT02638662
- Testing
- Observational
- Where
- United States
- Volunteers
- 276 people
- Sponsor
- Weill Medical College of Cornell University
Infertility, Assisted Reproductive Technology Outcomes
The Impact of Having a Tattoo on Fertility Treatment Outcome
Tattoos are increasingly common among women of reproductive age, yet their potential systemic inflammatory effects and impact on fertility treatment outcomes are unknown.
- Trial name
- NCT07405879
- Where
- Canada
- Volunteers
- 328 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Primary Infertility Unspecified, Infertility
Routine Hysteroscopy in IVF/ICSI Cycles in Patients With Primary Unexplained Infertility
The aim of the present study is to evaluate the impact of hysteroscopy prior to starting the IVF (in vitro fertilisation) cycle on treatment outcome in women with unexplained primary infertility.
- Conditions
- Primary Infertility Unspecified, Infertility, Ovarian Hyperstimulation, Pregnancy
- Trial name
- NCT02416596
- Testing
- Hysteroscopy, Hysteroscope
- Volunteers
- 680 people, healthy volunteers welcome
- Sponsor
- Ain Shams Maternity Hospital
Subfertility
Prognostic Value of Progesterone for In Vitro Fertilization (IVF) Outcome
This observational study attempts to investigate the potential role of serum progesterone levels on the day of hCG administration (thus, the end of the follicular phase) on the probability of pregnancy, in patients undergoing IVF…
- Trial name
- PROG2 (NCT01067664)
- Where
- Greece
- Volunteers
- 130 people
- Sponsor
- Aristotle University Of Thessaloniki
Infertility
Intralipid Therapy for Women 35-40 Years With Positive Natural Killer Cells Undergoing Intracytoplasmic Sperm Injection (ICSI)
Intralipid can suppress natural killer cells that are known to be involve in repeated implantation failure and recurrent miscarriages.Intralipid is made of purified soybean oil, egg phospholipids, glycerol and water.
- Trial name
- NCT01916798
- Testing
- Intralipid infusion
- Where
- Egypt
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Cairo University
Infertility
Ultrasound-guided Hydrosalpinx Aspiration During Egg Collection
· What we know: Hydrosalpinx and IVF About 40% of patients undergoing IVF have tubal disease and in 25%-30% of tubal disease patients there is fluid collection within the tube; hydrosalpinx.
- Trial name
- NCT00566956
- Testing
- Hydrosalpinx needle aspiration to arm 1
- Where
- United Kingdom
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Birmingham Women's NHS Foundation Trust
Fertilization
Mechanical Stimulation Improve the Fertilization in ICSI Cycle
Most fertilization failures after ICSI are caused by failure of oocyte activation defects. But, to date, there is no effective method to overcome this obstacle.
- Trial name
- NCT03810001
- Testing
- Mechanical Stimulation
- Where
- China
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Tang-Du Hospital
In Vitro Fertilisation Outcome
Triple-arm pH Comparison
The culturing human embryo in vitro is a process of myriad contributing elements. From these factors is the pH of embryo culture media, which is crucial for embryo development.
- Trial name
- Tri-pH (NCT02896777)
- Testing
- Transfer embryo from pH 7.20±0.02 on either Day 3 or day 5/6, Transfer embryo from pH 7.3±0.02 either Day 3 or day 5/6, Transfer embryo from pH of 7.4±0.02 on either Day 3 or day 5/6
- Where
- 6 sites in Egypt
- Volunteers
- 2,273 people
- Sponsor
- Ibn Sina Hospital
Infertility, IVF Treatment
Early Follicular Supplementation of Ganirelix in IVF 2004
Our goal was to investigate whether early follicular supplementation of the GnRH antagonist to the flexible GnRH antagonist protocol, has a potential to improve IVF-ET clinical results
- Trial name
- NCT00461422
- Testing
- Ganirelix
- Where
- Israel
- Volunteers
- 50 people
- Sponsor
- The Baruch Padeh Medical Center, Poriya
Infertility
Hypnopuncture for In Vitro Fertilization (IVF)
Infertility is a common and distressful problem for many couples, with assisted reproductive techniques (ART) such as IVF and ICSI, with slightly more than 34% pregnancies per cycle.
- Trial name
- NCT00544401
- Testing
- Hypnopuncture (Hypnosis+Acupuncture)
- Where
- Israel
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Shaare Zedek Medical Center
Female Infertility, Embryo Development
Day-4 Embryo Defragmentation: Blastocyst Rate and clInical Outcomes
Background: Embryo fragmentation is one of the main morphological parameters assessed during in vitro culture in assisted reproductive technology (ART).
- Conditions
- Female Infertility, Embryo Development, In Vitro Fertilization
- Trial name
- DEBRIS (NCT07500337)
- Testing
- Mechanical embryo defragmentation at Day 4 (morula stage), Standard embryo culture without intervention
- Where
- Italy
- Volunteers
- 320 people
- Sponsor
- Momo Fertilife
Infertility
Early Luteal Progesterone Profile After hCG Triggering
This pilot-study will help characterize the serum progesterone profiles in IVF patients and correlate progesterone levels to ovarian follicles obtained after stimulation with exogenous gonadotropins.
- Trial name
- NCT02798146
- Testing
- blood collection
- Volunteers
- 20 people
- Sponsor
- Vietnam National University
Fertilization, Fertilization in Vitro
BEst Size for Ovulation Triggering in Poseidon 4 Patients (BEST 4 Study)
This observational clinical study aims to determine the optimal timing of ovulation triggering in women aged 35 and above with poor ovarian reserve.
- Trial name
- BEST (NCT06433518)
- Testing
- Ovulation Trigger Timing Based on Leading Follicle Size in POSEIDON Group 4 IVF Patients
- Where
- Turkey (Türkiye)
- Volunteers
- 200 people
- Sponsor
- Centrum Clinic IVF Center
Infertility
Perifollicular Vascularity Assessment in in-Vitro Fertilization
On February 2004, a law (n. 40/2004) regulating assisted reproduction techniques (ARTs) was approved in Italy. This law aimed to regulate the treatment of infertility in Italy, contains several restrictions, such as the…
- Trial name
- NCT00458380
- Testing
- Controlled ovarian stimulation, perifollicular vascularity assessment, IVF, embryo transfer.
- Where
- Italy
- Volunteers
- 116 people
- Sponsor
- University Magna Graecia
Infertility
Experience of Pain During Oocyte Retrieval- a Comparison Between Two Aspiration Needles
The purpose of the study is to compare the pain experience between the patients that have had their transvaginal oocytes retrieval with ultrasound guidance performed with reduced single lumen needle (Vitrolife Sweden AB…
- Trial name
- NCT00924885
- Testing
- Swemed Follicle Aspiration Set Reduced Single Lumen, Swemed Follicle Aspiration Set Single Lumen (1.4 mm)
- Where
- 4 sites in Sweden
- Volunteers
- 257 people
- Sponsor
- Vitrolife
Infertility
Vaginal Culture Using INVOcell Compared to Traditional IVF Incubation
The purpose of this study is to evaluate intravaginal culture using the medical device INVOcell to generate day 5 blastocysts in comparison to traditional IVF.
- Trial name
- NCT02363426
- Testing
- INVOcell Culture Device, IVF Incubation
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Invaron Pharmaceuticals Inc.