Clinical trials: Fetal Death
Stillbirth
Research On Advanced Diagnostics and Management of All Pregnancies to Prevent Stillbirth (ROADMAPS)
The primary objective of the Stillbirth Research Consortium (SBRC) longitudinal cohort study is to develop and evaluate a robust multivariable prediction model to identify pregnancies at <14 weeks gestation that are at increased…
- Trial name
- ROADMAPS (NCT07745101)
- Where
- 5 sites in United States
- Volunteers
- 7,000 people, healthy volunteers welcome
- Sponsor
- RTI International
Pregnancy, Preterm Labor
Biomarkers in Obstetrical Complications
Objective: To study the natural history of normal pregnancy and the most frequent pregnancy complications responsible for the excessive rate of perinatal morbidity and mortality, in order to develop models to predict the…
- Conditions
- Pregnancy, Preterm Labor, Maternal Fetal Factors, Preterm Birth
- Trial name
- NCT03480139
- Where
- United States
- Volunteers
- 746 people
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Maternal Death, Infant Death
Effects of a Health Workforce Capacity Building and Quality Improvement Intervention in Kinshasa
The aim of the study is to evaluate a health workforce capacity building and quality improvement intervention focused on integrated day-of-birth and post-pregnancy care at 16 hospitals in Kinshasa, Democratic Republic of Congo.
- Conditions
- Maternal Death, Infant Death, Stillbirth
- Trial name
- NCT03363308
- Testing
- training for health care workers supplmented by QI teams
- Where
- Democratic Republic of the Congo
- Volunteers
- 250 people
- Sponsor
- Jhpiego
PTSD
Yoga Online Feasibility to Reduce PTSD
Each year more than 26,000 pregnancies in the United States end in stillbirth (late fetal death at >20 weeks of gestation). A 2011 issue of the Lancet, dedicated entirely to stillbirth, recognized it as a "too-often-ignored"…
- Trial name
- NCT02925481
- Testing
- Moderate Online yoga participation, Stretching and toning, Low dose online yoga participation
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Arizona State University
Vitamin D Deficiency, Pre Eclampsia
Evaluation of the Effectiveness of Vitamin D Supplementation to Pregnant Women and Their Infants in Pakistan.
Vitamin D deficiency is wide spread in South Asian population and is contributing to burden of disease in this region including Pakistan.
- Conditions
- Vitamin D Deficiency, Pre Eclampsia, Stillbirths, Low Birth Weight
- Trial name
- NCT01229189
- Testing
- Vitamin D
- Where
- Pakistan
- Volunteers
- 460 people
- Sponsor
- Aga Khan University
Pregnancy Complications
Measuring sVAP-1 as a Predictor of Pregnancy Problems
Pre-eclampsia is a common pregnancy disorder defined as high blood pressure and protein in the urine after 20 weeks of pregnancy.
- Trial name
- NCT04891315
- Testing
- Blood test for soluble VAP-1 (sVAP-1).
- Where
- United Kingdom
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- University of Leicester
Stillbirth, Neonatal Death
Intermittent Auscultation Using Handheld Doppler: a Randomized Controlled Trial Comparing Perinatal Outcomes in Uganda
A novel handheld Doppler has been developed which is rugged and is powered only by a hand crank. This study aims to test the use of this Doppler versus the Pinard horn to monitor the fetal heart rate in labour in a hospital…
- Trial name
- NCT02273037
- Testing
- Fetal heart rate Doppler, Partograph
- Where
- 2 sites in Canada, Uganda
- Volunteers
- 1,987 people, healthy volunteers welcome
- Sponsor
- The Hospital for Sick Children
Pregnancy, Pregnancy Complications
AI-POCUS for Maternal and Neonatal Health in Ethiopia
Maternal and neonatal health remains one of the most pressing global health challenges, particularly in low- and middle-income countries (LMICs).
- Conditions
- Pregnancy, Pregnancy Complications, Preterm Birth, Fetal Growth Restriction
- Trial name
- AIM-ETH (NCT07171086)
- Testing
- AI-POCUS (BabyChecker, Delft Imaging), AI-POCUS (Edan, China)
- Where
- Ethiopia
- Volunteers
- 1,059 people, healthy volunteers welcome
- Sponsor
- Tsinghua University
Pregnancy Loss, Infant Death
In-utero Death and Birth Mortality in Reunion Island
Infant mortality is still relevant despite the improvement and the accessibility of hospital care. Premature birth are two fold higher than in metropolitan France.
- Trial name
- RAMIR (NCT03354832)
- Testing
- Foetal death, New-born death, Birth control for foetal death
- Where
- Reunion
- Volunteers
- 45 people
- Sponsor
- Centre Hospitalier Universitaire de la Réunion
Fetal Membranes, Premature Rupture
Perinatal Outcome After Premature Rupture of Membranes
Premature rupture of membranes is an important cause of neonatal morbidity and mortality, mainly because of the complications associated with this pathology (oligohydramnios, cord compression or prolapse, infection).
- Trial name
- NCT01538030
- Where
- Panama
- Volunteers
- 80 people
- Sponsor
- Saint Thomas Hospital, Panama
Preeclampsia, Fetal Death
Comparing the Effect of Vaginal Misoprostol With Dinoprostone in Term Pregnancies
Hypothesis (H0): Labor duration and obstetric complications are not significantly different in the three groups (misoprostol-dinoprostone-oxytocin).
- Conditions
- Preeclampsia, Fetal Death, Fetal Membranes, Premature Rupture
- Trial name
- NCT00432588
- Testing
- misoprostol, dinoprostone
- Where
- Iran
- Sponsor
- Hormozgan University of Medical Sciences
Health Literacy, Stillbirth
The MAMAACT Intervention
Inequalities in stillbirth, infant and child mortality as well as other reproductive health outcomes have been reported among ethnic minority groups in Denmark.
- Conditions
- Health Literacy, Stillbirth, Apgar; 0-3 at 1 Minute, Apgar; 4-7 at 1 Minute
- Trial name
- MAMAACT (NCT03751774)
- Testing
- MAMAACT
- Where
- 19 sites in Denmark
- Volunteers
- 4,153 people
- Sponsor
- University of Copenhagen
Cytomegalovirus Congenital, Hearing Loss
Epidemiology of Congenital Cytomegalovirus in a High HIV Prevalence Setting, South Africa
The aim of this project is to determine the epidemiology of congenital cytomegalovirus (CMV) infection and incidence of subsequent permanent neurological sequelae in a high HIV prevalent setting in Soweto, Johannesburg.
- Conditions
- Cytomegalovirus Congenital, Hearing Loss, Neurodevelopmental Disorders, Immunogenicity
- Trial name
- NCT03722615
- Where
- South Africa
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- University of Witwatersrand, South Africa
Maternal Death Affecting Fetus or Newborn, Delivery Complication
Impact of a Smartphone Intervention on Tanzanian Women's Childbirth Location
This study investigates whether training Community Health Workers (CHW) to use a smartphone-based prenatal counseling application as a "job aid" instead of the existing paper based standard is associated with increased women's…
- Conditions
- Maternal Death Affecting Fetus or Newborn, Delivery Complication, Obstetric Complication, Birth Injuries
- Trial name
- SUSTAIN1 (NCT03161184)
- Testing
- SUSTAIN Smartphone training of CHW (SP+), SUSTAIN Paperbased training of CHW (SOC)
- Volunteers
- 572 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Repeated Spontaneous Miscarriages, Fetal Deaths in Utero
Determinants of Repeated Spontaneous Miscarriages and Unexplained Fetal Deaths
The DEFI-1 study recruited 625 women witnesses and 299 of their spouses. With regard to case couples, 271 cases were recruited from the spontaneous repeated miscarriages (SRM) subgroup (≥3 spontaneous miscarriage (SM) from…
- Trial name
- DEFI-2 (NCT04207814)
- Testing
- biological sample
- Where
- France
- Volunteers
- 200 people
- Sponsor
- University Hospital, Brest
Heart Failure With Preserved Ejection Fraction (HFPEF)
Association of Heterogeneous Circulating Biomarkers and Anamnestic Factors of Pregnancy Adverse Course and Outcomes With the Prognosis of Heart Failure With Preserved Ejection Fraction
The primary purpose of this study is to evaluate possible association of some heterogeneous circulating biomarkers and anamnestic factors of pregnancy adverse course and outcomes with the prognosis of heart failure with preserved…
- Trial name
- CARPO-HF (NCT06803849)
- Where
- Russia
- Volunteers
- 100 people
- Sponsor
- National Medical Research Center for Therapy and Preventive Medicine
Preterm Birth, Small for Gestational Age (SGA)
Asymptomatic Bacteriuria in Pregnancy in Low- and Middle-IncomE Countries
This study, Asymptomatic Bacteriuria in Pregnancy in Low- and Middle-IncomE Countries (ABLE), is designed as a 2-arm randomized controlled trial (RCT) focused on pregnant individuals and newborn infants.
- Conditions
- Preterm Birth, Small for Gestational Age (SGA), Stillbirth, Bacteriuria (Asymptomatic) in Pregnancy
- Trial name
- ABLE (NCT06723392)
- Testing
- Oral nitrofurantoin monohydrate/macrocrystals
- Where
- 7 sites in Bangladesh, Democratic Republic of the Congo and 4 more
- Volunteers
- 1,134 people, healthy volunteers welcome
- Sponsor
- NICHD Global Network for Women's and Children's Health
Preeclampsia (PE), Fetal Growth Restriction
The Combined First Trimester Screening
The project is a national, prospective, multicenter pilot project. The project is focus on setting up the combined first trimester screening in the Czech Republic.
- Conditions
- Preeclampsia (PE), Fetal Growth Restriction, Congenital Abnormalities, Preterm Labor
- Trial name
- NCT07015203
- Where
- 3 sites in Czechia
- Volunteers
- 2,000 people
- Sponsor
- Institute of Health Information and Statistics of the Czech Republic
Stillbirth and Fetal Death, Perinatal Death
Mothers Working to Prevent Early Stillbirth Study 20-28
This project aims to identify factors linked to pregnancy losses occurring between 20 and 28 weeks of pregnancy that can be modified by changing mother's behaviour or healthcare provision.
- Trial name
- MiNESS20-28 (NCT06005272)
- Testing
- Questionnaire
- Where
- United Kingdom
- Volunteers
- 948 people, healthy volunteers welcome
- Sponsor
- University of Manchester
Extremely Premature Infant, Anemia Neonatal
Heterologous Cord Blood-Derived Red Blood Cell for Transfusion in Extremely Preterm Infants
Anemia is a condition in which there are not enough red blood cells to carry oxygen throughout the body. It is very common in extremely preterm infants (born before 28 weeks of pregnancy), and many of these babies require red…
- Conditions
- Extremely Premature Infant, Anemia Neonatal, Blood Transfusion, Umbilical Cord Blood
- Trial name
- NCT07502781
- Testing
- Cord Blood Red Blood Cells, Standard Adult Donor Red Blood Cells
- Where
- Spain
- Volunteers
- 176 people
- Sponsor
- Hospital Clinic of Barcelona