Clinical trials: Fetal Development
Retardation, Fetal Growth, Macrosomia, Fetal
Antenatal Development Evaluated Prospectively
Fetal growth abnormalities is one of the most common problems faced in modern obstetrics. The association between low birth weight and perinatal death as well as severe morbidity is well known.
- Trial name
- ADEPT (NCT02478554)
- Testing
- Customized fetal growth curves
- Volunteers
- healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center, Houston
Pregnancy, Child Development
Improving Maternal and Child Health Through Prenatal Fatty Acid Supplementation
The purpose of the study is to test whether nutritional supplementation during pregnancy is associated with 1) improved maternal health during pregnancy; 2) improved infant birth and neurodevelopmental outcomes, and 3) whether…
- Trial name
- NAPS (NCT02647723)
- Testing
- DHA, Sugar pill
- Where
- United States
- Volunteers
- 168 people, healthy volunteers welcome
- Sponsor
- University of Chicago
Infant Malnutrition, Fetal Growth Retardation
DEUX OEUFs: Cracking the Potential of Eggs to Improve Child Growth and Development
This proposed randomized controlled trial aims to investigate the effect of maternal egg consumption during pregnancy on birth length.
- Trial name
- NCT06405360
- Testing
- Egg consumption
- Where
- Rwanda
- Volunteers
- 464 people, healthy volunteers welcome
- Sponsor
- University of Florida
Fetal Growth Restriction
A Randomized Air Filter Intervention Study of Air Pollution and Fetal Growth in a Highly Polluted Community
The purpose of this study is to use an air filter intervention to evaluate the relationship between particulate matter air pollution exposure during pregnancy and fetal growth.
- Trial name
- NCT01741051
- Testing
- HEPA Filter
- Where
- Mongolia
- Volunteers
- 540 people, healthy volunteers welcome
- Sponsor
- Simon Fraser University
Pregnant Women, Gestational Diabetes
Physical Acvitiy in Pregnancy
The goal of this observational study is to learn how a physically active lifestyle during pregnancy affects placental development and function.
- Conditions
- Pregnant Women, Gestational Diabetes, Obese But Otherwise Healthy Participants, Overweight (BMI > 25)
- Trial name
- NCT07356180
- Testing
- Pregnancy Physical Activity Questionnaire (PPAQ)
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Maryland, Baltimore
Trisomy 13, Trisomy 18
Multiple Gestation Study
The objectives of the clinical study are to demonstrate the accuracy of our new NATUS diagnostic method to determine the genetic health of the developing fetuses in a multiple gestation pregnancy from a maternal blood sample.
- Conditions
- Trisomy 13, Trisomy 18, Trisomy 21, Sex Chromosome Abnormalities
- Trial name
- NCT02278536
- Where
- 8 sites in United States, India and 1 more
- Volunteers
- 354 people, healthy volunteers welcome
- Sponsor
- Natera, Inc.
Congenital Adrenal Hyperplasia
Tweens to Teens Project at Penn State
The goal of this study is to help investigators to understand more about the development of characteristics related to being male or female (what is called gender development).
- Trial name
- T2T@PSU (NCT01184651)
- Testing
- Questionnaires/Interviews
- Where
- United States
- Volunteers
- 188 people, healthy volunteers welcome
- Sponsor
- Penn State University
Endocrinology, Disorders of Sexual Development
Retrospective Analysis of the Neonatal Management of Patients with an Antenatal Diagnosis of Genital Development Variation At the Hospital of Lyon
Variations in genital development (VDG) account for 0.5% to 1% of births. Advances in ultrasound techniques, as well as in prenatal diagnosis techniques, particularly in genetics, have led to improvements in the prenatal…
- Conditions
- Endocrinology, Disorders of Sexual Development, Prenatal Diagnosis, Psychology
- Trial name
- PECAN-VDG (NCT06687252)
- Where
- France
- Volunteers
- 170 people
- Sponsor
- Hospices Civils de Lyon
Trisomy 13, Trisomy 18
Prenatal Non-invasive Aneuploidy Test Utilizing SNPs Trial
This prospective blinded study will assess the diagnostic capability of an informatics enhanced SNP based technology (Parental Support) to identify pregnant women who are carrying a fetus with an aneuploidy from fee floating DNA…
- Conditions
- Trisomy 13, Trisomy 18, Trisomy 21, Aneuploidy
- Trial name
- PreNATUS (NCT01545674)
- Testing
- Blood Draw
- Where
- 29 sites in United States, Canada and 4 more
- Volunteers
- 937 people, healthy volunteers welcome
- Sponsor
- Natera, Inc.
Hereditary Diseases
Development of New Prenatal Diagnostic Tests From Maternal Blood
After extraction of the cell-free DNA circulating in maternal plasma, we aim at developing new techniques for fetal DNA enrichment to perform fetal gender determination, and indirect diagnosis of inherited diseases like Cystic…
- Trial name
- NCT00314691
- Testing
- Blood samples
- Where
- France
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University Hospital, Strasbourg, France
Pregnancy Related, Maternal-Fetal Relations
Maternal and Fetal Metabolic Changes
The goal of this observational prospective project is to study the metabolic alterations during normal and complicated pregnancies, obtaining an early detection of metabolic changes, offering new insights into future prevention…
- Conditions
- Pregnancy Related, Maternal-Fetal Relations, Metabolism Disorder, Glucose
- Trial name
- MoMM-FET (NCT06288126)
- Where
- Italy
- Volunteers
- 457 people, healthy volunteers welcome
- Sponsor
- Azienda Ospedaliero, Universitaria Pisana
Pregnancies At Increased Risk of Preterm Birth
Development of a Predictive Model of Fetal PH At Birth from Novel Variables Derived from Cardiotocographic Tracing
The goal of this observational study is to build a predictive model of fetal acidosis based on variables from the cardiotocographic tracing recorded during labor in participants undergoing spontaneous or induced delivery with…
- Trial name
- NCT06720363
- Where
- Italy
- Volunteers
- 5,000 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Fetal Lung Maturity
Can Ultrasound Replace Amniocentesis for Confirming Fetal Lung Maturation Among Premature Fetuses?
The purpose of this study is to measure prenatally with ultrasound the intratracheal flow volume displaced during breathing cycle in premature fetuses and to check whether a relationship exists between the inspired fluid and…
- Trial name
- NCT00720252
- Testing
- Ultrasound
- Where
- Israel
- Volunteers
- 10 people
- Sponsor
- HaEmek Medical Center, Israel
Pregnancy
Development of a Non-invasive Prenatal Test
This is an observational study to aid in the development of a non-invasive prenatal test that may be used to aid in detection of fetal aneuploidy.
- Trial name
- NCT01451684
- Where
- United States
- Volunteers
- 15,000 people
- Sponsor
- Cindy Cisneros
Pregnancy, Premature Birth
Development of a Nationally Scalable Model of Group Prenatal Care to Improve Birth Outcomes: "Expect With Me"
This study addresses the intractable challenges of adverse birth outcomes, including preterm delivery and low birthweight, by proposing the development, implementation and evaluation of a model of group prenatal care that could…
- Conditions
- Pregnancy, Premature Birth, Infant, Low Birth Weight, Postpartum Period
- Trial name
- NCT02169024
- Testing
- Expect With Me group prenatal care, Standard individual prenatal care
- Where
- 2 sites in United States
- Volunteers
- 2,402 people, healthy volunteers welcome
- Sponsor
- Yale University
Pregnancy
Stress and Fetal Brain Development
The current proposal aims to investigate the impact of acute stress on the fetal autonomic nervous system.
- Trial name
- NCT03831126
- Testing
- Betamethason Sodium Phosphate
- Where
- Germany
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University Hospital Tuebingen
Pulmonary Hypertension, Familial Persistent, of the Newborn
A Study To Evaluate Safety And Efficacy Of IV Sildenafil In The Treatment Of Neonates With Persistent Pulmonary Hypertension Of The Newborn
This study will evaluate whether IV sildenafil can reduce the time on inhaled nitric oxide treatment and reduce the failure rate of available treatments for persistent pulmonary hypertension of the newborn.
- Trial name
- NCT01720524
- Testing
- iv sildenafil
- Where
- 42 sites in United States, Belgium and 10 more
- Volunteers
- 59 people
- Sponsor
- Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
Preterm Birth
Maternal and Fetal/Neonatal Pharmacokinetics and - Dynamics of Corticosteroids During Pregnancy
Improving pregnancy outcome is essential in improving health of both parents and their offspring during the life course. Preterm birth (PTB) occurs in 10-15% of all pregnancies, is the leading cause of perinatal mortality and…
- Trial name
- MaDyCo (NCT06264973)
- Where
- Netherlands
- Volunteers
- 100 people
- Sponsor
- Erasmus Medical Center
Neonatal Asphyxia, Intrapartum Fetal Distress
Intrapartum Sildenafil in Laboring Mothers
The goal of this feasibility pilot clinical trial is to learn if sildenafil citrate 50mg orally, up to three times during labor, can be appropriately administered, with limited clinical side effects, to laboring mothers to…
- Conditions
- Neonatal Asphyxia, Intrapartum Fetal Distress, Development, Infant, Intrapartum Asphyxia
- Trial name
- PRISM (NCT06377098)
- Testing
- Sildenafil 50 mg Oral Tablet
- Where
- 3 sites in Cameroon, Kenya and 1 more
- Sponsor
- University of Alabama at Birmingham
22q11 Deletion Syndrome, DiGeorge Syndrome
SNP-based Microdeletion and Aneuploidy RegisTry (SMART)
This multi-center prospective observational study is designed to track birth outcomes and perinatal correlates to the Panorama prenatal screening test in the general population among ten thousand women who present clinically and…
- Conditions
- 22q11 Deletion Syndrome, DiGeorge Syndrome, Trisomy 21, Trisomy 18
- Trial name
- SMART (NCT02381457)
- Where
- 21 sites in United States, Australia and 4 more
- Volunteers
- 20,960 people, healthy volunteers welcome
- Sponsor
- Natera, Inc.