Clinical trials: Fetal Growth
Preeclampsia, Preterm Birth
Prediction of Preeclampsia and Other Pregnancy Complications Following Combined Iterative Screening
Preterm birth (PTB), preeclampsia (PE), fetal growth restriction (FGR) and intra-uterine fetal death (IUFD) constitutes the main causes of perinatal morbidity and mortality and are called "Great Obstetrical Syndromes".
- Conditions
- Preeclampsia, Preterm Birth, Fetal Growth Restriction, Intra Uterine Fetal Death
- Trial name
- PREDICTION2 (NCT03067298)
- Where
- Canada
- Volunteers
- 805 people, healthy volunteers welcome
- Sponsor
- Emmanuel Bujold
IUGR
Viagra for the Treatment of IUGR
It has been suggested that Viagra (or other drugs that inhibit PDE-5, the enzyme that normally inhibits blood vessels' ability to expand) may have beneficial effects in hypertensive pregnancy and, possibly, preeclampsia.The…
- Trial name
- NCT00347867
- Testing
- Viagra administration in IUGR/PET pregnancies
- Where
- Israel
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Rambam Health Care Campus
Fetal Growth Complications
WHO Fetal Growth Charts
Perinatal mortality and morbidity continue to be major global health challenges strongly associated with prematurity and reduced fetal growth, an issue of further interest given the mounting evidence that fetal growth in general…
- Trial name
- NCT03755024
- Testing
- ultrasound
- Volunteers
- 102 people
- Sponsor
- Assiut University
Hemoglobin SC Disease, Sickle Cell Anemia
A Phase I/II Trial of Recombinant-Methionyl Human Stem Cell Factor (SCF) in Adult Patients With Sickling Disorders
Sickle cell anemia is a genetic disorder that results from a single nucleotide substitution in codon 6 of the beta-globin gene which, in the homozygous state, produces an abnormal hemoglobin that is prone to polymer formation…
- Trial name
- NCT00005783
- Testing
- Recombinant-methionyl human stem cell factor
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Respiratory Distress Syndrome, Transient Tachypnea of Newborn
The Possible Effect Of Amniotic Fluid pH On Neonatal Morbidities In Maternal Inflammation/Infection Associated Pregnancies
Amniotic fluid (AF) pH can be affected by the maternal and/or fetal conditions such as PPROM, prematurity or fetal distress. It is known that fetal urine is the major content of AF since 20th gestational week.
- Conditions
- Respiratory Distress Syndrome, Transient Tachypnea of Newborn, Intrauterine Growth Retardation
- Trial name
- NCT02691559
- Testing
- Amniotic fluid analysis by blood gas device
- Where
- Turkey (Türkiye)
- Volunteers
- 184 people, healthy volunteers welcome
- Sponsor
- Kanuni Sultan Suleyman Training and Research Hospital
Pregnancy, Eclampsia
A Cluster-Randomized Trial of Ultrasound Use to Improve Pregnancy Outcomes in Low Income Country Settings
In many low-income countries, the use of ultrasound by medical officers and non-physician health care staff (e.g., midwives) for antenatal identification of high risk pregnancies is a new intervention requiring authoritative…
- Conditions
- Pregnancy, Eclampsia, Placenta Previa, Stillbirth
- Trial name
- NCT01990625
- Testing
- Antenatal Ultrasound Scan
- Where
- 5 sites in Guatemala, Kenya and 3 more
- Volunteers
- 45,038 people, healthy volunteers welcome
- Sponsor
- NICHD Global Network for Women's and Children's Health
Healthy Pregnant Women, Obese Pregnant Women
Pregnancy Cohort Study: Pregnancy as a Window to Future Health
The goal of this observational cohort study is to gain deep insights into how metabolic disorders such as obesity or diabetes during pregnancy affect the metabolic and cardiovascular health of mother and child in the short and…
- Conditions
- Healthy Pregnant Women, Obese Pregnant Women, Gestational Diabetes
- Trial name
- PregWin (NCT06925815)
- Where
- Austria
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- Medical University of Graz
Pre-Eclampsia, Premature Birth
PREPARE, Prematurity Reduction by Pre-eclampsia Care
Investigators will test a novel system of integrated care, to promote the use of the WORLD HEALTH ORGANIZATION Guidelines for the management of pre-eclampsia and initiate the use of a structured risk assessment strategy to reduce…
- Trial name
- PREPARE (NCT03073317)
- Testing
- FullPIERS and sFlit/PLGF (Soluble fms-Like Tyrosine Kinase-1-to-Placental Growth Factor Ratio)
- Where
- 8 sites in Brazil
- Volunteers
- 1,250 people, healthy volunteers welcome
- Sponsor
- Instituto Fernandes Figueira
Fetal Growth Retardation
Management of Fetal Growth Restriction at Term: Angiogenic Factors Versus Feto-placental Doppler
Open randomized non-inferiority controlled trial to examine the use of angiogenic factors (instead of feto-placental Doppler) for fetal growth restriction at term to reduce the rate of labor inductions, without worsening…
- Trial name
- GRAFD (NCT04502823)
- Testing
- Management based on sFlt-1/PlGF values
- Where
- 20 sites in Spain
- Volunteers
- 1,088 people
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
Neonatal Hypoglycemia, Infant, Small for Gestational Age
Effect of Tahneek on Hypoglycemia in Newborn Infants
Tahneek is an Arabic word which means putting something sweet such as dates, in the infant's mouth after the birth. Neonatal hypoglycemia is common in the first few days after birth.
- Conditions
- Neonatal Hypoglycemia, Infant, Small for Gestational Age, Macrosomia, Fetal, Intrauterine Growth Restriction
- Trial name
- THIN (NCT03726697)
- Testing
- Tahneek
- Where
- Saudi Arabia
- Volunteers
- 324 people
- Sponsor
- King Abdullah International Medical Research Center
Intrauterine Retardation
Levels of Endocan in Umbilical Cord Blood Samples of Pregnant Females With Intrauterine Growth Retardation
As a proteoglycan secreted from endothelial cells, expression, and secretion of endocan increases in the endothelium of several tissues secondary to inflammation. It can be regarded as an indicator of endothelial damage.
- Trial name
- NCT04630223
- Testing
- endocan in umbilical cord blood
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Van Bölge Eğitim ve Araştırma Hastanesi
Intrauterine Growth Restriction, Preeclampsia
Is Serum YKL-40 Capable of Predicting Intrauterine Growth Restriction (IUGR) and Preeclampsia?
Objective: To investigate the role of maternal serum YKL-40 and uterine artery doppler, at gestational age 12, 20, 25 and 32 weeks, and the relation to preeclampsia and intrauterine growth restriction.
- Trial name
- NCT00836524
- Testing
- ultrasound
- Where
- Denmark
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Zealand University Hospital
Fetal Growth Restriction, Placental Insufficiency
Patterns of Aortic Isthmus Doppler in Early Fetal Growth Restriction , and the Changes in Aortic Isthmus Doppler Parameters With Every Changes of Other Early Iugr Parameters Like EFW, Uterine Artery Doppler, Cerebroplacental Ratio and Ductus Venosus Doppler in Comparison With Normal Group .
This study aims to evaluate the patterns of aortic isthmus Doppler in fetuses diagnosed with early fetal growth restriction (FGR) and to correlate these findings with the severity of FGR and other Doppler parameters.
- Conditions
- Fetal Growth Restriction, Placental Insufficiency, Aortic Isthmus Doppler, Cerebroplacental Ratio
- Trial name
- NCT07676708
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Assiut University
Preeclampsia
Randomizated Open-label Control Trial to Evaluate if the Incorporation of sFlt1/PlGF Ratio in the Diagnosis and Classification of PE Improves Maternal and Perinatal Outcomes in Women With the Suspicion of the Disease
Preeclampsia is a leading cause of maternal and neonatal morbidity and mortality worldwide. The morbidity and mortality of this condition arises from two main causes: 1) the lack of specific and sensible methods for its diagnosis…
- Trial name
- EuroPE (NCT03231657)
- Testing
- Placental biomarkers
- Where
- Spain
- Volunteers
- 2,536 people
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Hypertensive Disorder of Pregnancy, Pulmonary Arterial Hypertension
A Prospective Longitudinal Observational Cohort Study of Pregnant Women Residing at High Altitude in Bolivia
In this study, the investigators will follow two small cohorts of pregnant women: a cohort of healthy women with uncomplicated pregnancies residing at high altitude, a control group of healthy women with uncomplicated pregnancies…
- Conditions
- Hypertensive Disorder of Pregnancy, Pulmonary Arterial Hypertension, Intrauterine Growth Restriction
- Trial name
- NCT07312227
- Where
- 2 sites in United States, Bolivia
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Pregnancy, Obesity
Fitness Improvement in Obese, Pregnant Women: an Intervention Trial
In pregnancy, the adoption or pursuit of a sedentary lifestyle contributes to the development of co-morbid conditions such as hypertension, maternal and childhood obesity, gestational diabetes, pre-eclampsia, cesarean section and…
- Conditions
- Pregnancy, Obesity, Physical Activity
- Trial name
- InterGOFIT (NCT01610323)
- Testing
- Exercise intervention, Standard Care
- Where
- Canada
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- CHU de Quebec-Universite Laval
Premature Birth of Newborn, Malnutrition; Intrauterine or Fetal, Small-for-dates
The BabyGrow Longitudinal Study of Nutrition and Growth in Preterm Infants
This is a longitudinal, observational study on nutrition, growth and body composition in preterm infants. Aims to determine the adequacy of actual nutrient intake during the preterm period by investigating associations between…
- Trial name
- BabyGrow (NCT01881256)
- Volunteers
- 70 people
- Sponsor
- University College Cork
IUGR
Intrauterine Fetal Growth Restriction and Fetuin-B
Brief Summary This study aims to evaluate the relationship between fetuin-B levels and intrauterine growth restriction (IUGR). Maternal serum fetuin-B levels will be compared between pregnant women with IUGR and those with…
- Trial name
- IUGR-Fetuin-B (NCT07869004)
- Testing
- measure fetuin b
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Karadeniz Technical University
Maturity-Onset Diabetes of the Young
Impact on Birth Weight of Two Therapeutic Strategies (Insulin Therapy From the Beginning of Pregnancy vs. Insulin Therapy Initiated According to Fetal Growth Evaluated by Ultrasonography Measurements) in Pregnant Women With Monogenic Diabetes
Maturity-onset diabetes of youth (MODY) are the most frequent monogenic diabetes with autosomic dominant inheritance (2% of diabetes).
- Trial name
- MODY2 (NCT02556840)
- Testing
- insulin therapy
- Where
- France
- Volunteers
- 46 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Fetal Growth Retardation, Induction of Labor Affected Fetus / Newborn
Mode of Induction in Fetal Growth Restriction and Its Affects on Fetal and Maternal Outcomes
to compare methods of induction of labor in fetal growth restriction and its effect on maternal and neonatal outcome
- Trial name
- NCT03625518
- Testing
- prostaglandins E2, intracervical balloon catheter combined with pitocin
- Where
- Israel
- Volunteers
- 280 people
- Sponsor
- Tel-Aviv Sourasky Medical Center