Clinical trials: Fetal Growth
Pre-Eclampsia, HELLP Syndrome
Evaluation of the Serum Markers sFLt1 and PlGF for the Prediction of the Complications of the Placental Vascular Pathologies in the 3rd Quarter of the Pregnancy.
The pre-eclampsia is a frequent pathology, concerning approximately 5 % of the pregnancies.The pre-eclampsia can evolve into severe maternal and\or foetal complications and is a major cause of mortality.
- Conditions
- Pre-Eclampsia, HELLP Syndrome, Fetal Death, Eclampsia
- Trial name
- PRECOPE (NCT03455387)
- Testing
- sampling of the serum marker sFlt1 and PlGF
- Where
- 7 sites in France
- Volunteers
- 233 people
- Sponsor
- Centre Hospitalier Metropole Savoie
Premature Birth, Fetal Growth Retardation
NACER II: Reducing Prenatal Exposures to Household Air Pollution in Rural Guatemala Through a Gas Stove/Behavior Intervention to Improve Neonatal Health
Greater efforts are needed to bring affordable, clean stoves and adaptive behavioral strategies to the millions of households worldwide that continue to burn solid cooking fuels using inefficient stoves.
- Conditions
- Premature Birth, Fetal Growth Retardation, Infections, Respiratory, Exposure to Environmental Pollution, Non-occupational
- Trial name
- NCT02812914
- Testing
- Low-cost gas stove, Peer education classes, Resource-intensive behavioral intervention approach
- Where
- Guatemala
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Growth Charts
Development of Italian Fetal Growth Charts
There is an ongoing international discussion regarding which fetal growth charts should be used. As a matter of fact, an extensive and clinically significant variability among different growth charts has been proved, even between…
- Trial name
- METRICS (NCT05774912)
- Testing
- Ultrasound evaluation
- Where
- 3 sites in Italy
- Volunteers
- 2,500 people
- Sponsor
- IRCCS Burlo Garofolo
Pre-Eclampsia, Intrauterine Growth Restriction
Inter- and Multidisciplinary, Cross-sectoral Feto-neonatal Pathway
Due to the fetoneonatal pathway it is possible to identify pregnant women with an increased risk of fetal growth restriction or pre-eclampsia in early stages (from 10th week of pregnancy).
- Conditions
- Pre-Eclampsia, Intrauterine Growth Restriction, Maternal Care for Known or Suspected Poor Fetal Growth
- Trial name
- NCT04514276
- Testing
- consecutive fetoneonatal healthcare pathway
- Where
- 2 sites in Germany
- Volunteers
- 828 people
- Sponsor
- Technische Universität Dresden
Fetal Hypoxia
Evaluation of Fetal Cardiac Function and Vascular Hemodynamics in Intrauterine Growth Restriction
Intrauterine growth restriction (IUGR) is one of the major contributors to perinatal mortality and morbidity and is characterized by complex hemodynamic changes involving placental and fetal arterial, cardiac and venous…
- Trial name
- NCT03108040
- Where
- Egypt
- Volunteers
- 534 people
- Sponsor
- Assiut University
Intrauterine Growth Restriction
Impact of Antioxidant Juice Intake on Brain Injury and Placental Pathology in Infants With Intrauterine Growth Restriction (IUGR)
Infants diagnosed with intrauterine growth restriction are at increased risk for brain injury in the neonatal period, and eventually increased risk for adverse long-term neurodevelopmental outcomes.
- Trial name
- NCT04394910
- Testing
- Pomegranate Juice
- Where
- United States
- Volunteers
- 103 people
- Sponsor
- Brigham and Women's Hospital
Condition of Fetal Growth or Malnutrition (Diagnosis)
Sonographic Evaluation of Fetal Growth in the Third Trimester of Low-risk Pregnancy: a Randomized Trial
Sonographic fetal weight estimation at the last weeks of third trimester in low-risk pregnancies is an effective method for diagnosis of fetal growth restriction (FGR) permitting close surveillance and timely delivery.
- Trial name
- NCT03200665
- Testing
- Ultrasound 35-36 (6 / 7 days weeks)
- Where
- Portugal
- Volunteers
- 1,093 people, healthy volunteers welcome
- Sponsor
- Hospital de Santa Maria, Portugal
Intrauterine Growth Restriction
Thromboelastography (TEG) In the Intrauterine Growth Restriction (IUGR) Neonatal Population by Gestational Age
The investigators aim to improve the understanding of TEG in this population in an effort to improve outcomes in a population at high risk in both the presence and absence of blood product transfusions.
- Trial name
- NCT04907578
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Pregnancy Complications, IVF
The START Clinic: a Feasibility Study
This is a study of the feasibility of a translational research clinic for pregnancies conceived by in vitro fertilisation (IVF).
- Conditions
- Pregnancy Complications, IVF, Fetal Growth Retardation, Preeclampsia
- Trial name
- START (NCT04488861)
- Testing
- Non-interventional cohort study
- Where
- United Kingdom
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Manchester Academic Health Science Centre
Intrauterine Growth Restriction, Cardiopulmonary Disease
IUGR, Respiratory Muscle Function, and Exercise Capacity in Childhood
The study hypothesis is that intrauterine growth restriction (IUGR) may have long-term effects on respiratory muscle (RM) function, thus leading to reduced exercise capacity later in life.
- Trial name
- NCT03368755
- Testing
- Cardiopulmonary Exercise Testing, Respiratory Muscle Strength and Endurance
- Where
- Greece
- Volunteers
- 150 people
- Sponsor
- University of Patras
Fetal Growth Abnormality, Amniotic Fluid; Disorder
Serial Third Trimester Abdominal Circumference and Amniotic Fluid Measurements Versus Routine Care
The purpose of this study us to compare the rate of prenatal identification of abnormal fetal growth or amniotic fluid between clinical evaluation of uterine size by symphysis fundal height (SFH) measurements versus point-of-care…
- Trial name
- STAR (NCT03857659)
- Testing
- Point-of-care ultrasound (POC-US), Routine antenatal care, Formal ultrasound
- Where
- United States
- Volunteers
- 113 people
- Sponsor
- The University of Texas Health Science Center, Houston
Infant Malnutrition, Fetal Growth Retardation
DEUX OEUFs: Cracking the Potential of Eggs to Improve Child Growth and Development
This proposed randomized controlled trial aims to investigate the effect of maternal egg consumption during pregnancy on birth length.
- Trial name
- NCT06405360
- Testing
- Egg consumption
- Where
- Rwanda
- Volunteers
- 464 people, healthy volunteers welcome
- Sponsor
- University of Florida
Pregnancy Complications
Comparing Artificial Intelligence and Standard Ultrasound Methods for Estimating Fetal Weight in Pregnancy. Patients Eligible for Inclusion Are Women With a Gestational Age Between 24-42 Weeks Undergoing a Growth Scan. The Image Data From the Scan Are Used to Calculate Fetal Weight.
The primary aim of this observational study is to compare the accuracy of two artificial intelligence (AI) models with the traditional Hadlock formula for estimating fetal weight from ultrasound scans performed in pregnant women…
- Trial name
- NCT06314178
- Where
- Denmark
- Volunteers
- 283 people, healthy volunteers welcome
- Sponsor
- Copenhagen Academy for Medical Education and Simulation
Birth Weight
Effect of Caffeine on Fetal Growth
The purpose of this study is to determine whether caffeine has any effect on birth weight.
- Trial name
- NCT00131690
- Testing
- Nescafé Gold Blend (exposed), Nescafé Decaffeinated (controls)
- Where
- Denmark
- Volunteers
- 1,200 people
- Sponsor
- The Danish Epdiemiology Science Centre
Low Birth Weight Infants
Alkaline Phosphatase Level in Pregnancy and Its Association With Birth Weight
Alkaline phosphatase is known to be produced by syncytiotrophoblasts in the placenta and its levels are normally increased in pregnancy.
- Trial name
- NCT03187938
- Testing
- Testing of Alkaline Phosphatase Levels
- Where
- United States
- Volunteers
- 292 people, healthy volunteers welcome
- Sponsor
- TriHealth Inc.
Premature Birth, Preeclampsia
A Randomized Trial of Docosahexaenoic Acid Supplementation During Pregnancy to Prevent Deep Placentation Disorders
This study evaluates the effectiveness of maternal supplementation with Docosahexaenoic acid (DHA) early in pregnancy to reduce the incidence of deep placentation disorders: preterm birth, preterm labor, preterm premature rupture…
- Conditions
- Premature Birth, Preeclampsia, Fetal Growth Retardation, Stillbirth
- Trial name
- NCT02336243
- Testing
- Docosahexaenoic acid (DHA)
- Where
- 5 sites in Chile
- Volunteers
- 2,400 people, healthy volunteers welcome
- Sponsor
- Pontificia Universidad Catolica de Chile
Respiratory Distress Syndrome, Transient Tachypnea of Newborn
The Possible Effect Of Amniotic Fluid pH On Neonatal Morbidities In Maternal Inflammation/Infection Associated Pregnancies
Amniotic fluid (AF) pH can be affected by the maternal and/or fetal conditions such as PPROM, prematurity or fetal distress. It is known that fetal urine is the major content of AF since 20th gestational week.
- Conditions
- Respiratory Distress Syndrome, Transient Tachypnea of Newborn, Intrauterine Growth Retardation
- Trial name
- NCT02691559
- Testing
- Amniotic fluid analysis by blood gas device
- Where
- Turkey (Türkiye)
- Volunteers
- 184 people, healthy volunteers welcome
- Sponsor
- Kanuni Sultan Suleyman Training and Research Hospital
Fetal Growth Retardation
Non-invasive Placental Chromosome Exploration of Intrauterine Growth Restriction
The objective of this project is the non-invasive prenatal detection of placenta-limited aneuploidies, in patients whose fetuses have a intrauterine growth restriction below 3rd percentile, in parallel with an amniocentesis.
- Trial name
- DPNI-RCIU (NCT05023161)
- Testing
- Blood samples
- Where
- 3 sites in France
- Volunteers
- 300 people
- Sponsor
- University Hospital, Bordeaux
Pre-Eclampsia, Fetal Growth Retardation
Comparison of Doses of Acetylsalicylic Acid in Women With Previous History of Preeclampsia
Placental insufficiency is the source of preeclampsia (PE) and intrauterine growth retardation (IUGR). Current data demonstrate a significant beneficial effect of prophylactic use of aspirin on the recurrence of placental…
- Conditions
- Pre-Eclampsia, Fetal Growth Retardation, Premature Birth, Placental Insufficiency
- Trial name
- NCT01352234
- Testing
- Acetylsalicylic Acid 160 mg, Acetylsalicylic Acid 80 mg
- Where
- Canada
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- CHU de Quebec-Universite Laval
Pregnancy Complication
Effect of Sildenafil Citrate on Uteri- Placental Perfusion, Doppler Indices in Growth Restricted Fetuses
To detect the effect of sildenafil citrate on Doppler parameters in fetuses suffering from growth restriction to support its use later as prolonged therapy in those pregnancies at higher risk for such complication.
- Trial name
- NCT02362399
- Testing
- sildenafil citrate
- Where
- Egypt
- Volunteers
- 54 people
- Sponsor
- Al Hayat National Hospital