Clinical trials: Fetal Growth Complications
Fetal Growth Restriction (FGR)
Melatonin and Perinatal Outcomes in MVM-Related Fetal Growth Restriction (MIMVMFGR)
The goal of this clinical trial is to evaluate the efficacy and safety of melatonin in the treatment of early-onset severe maternal vascular malperfusion-related fetal growth restriction (MVM-FGR), and to determine its effects on…
- Trial name
- MIMVMFGR (NCT07549295)
- Testing
- Melatonin
- Where
- China
- Volunteers
- 240 people
- Sponsor
- Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
Fetal Growth Retardation
Melatonin to Prevent Brain Injury in Unborn Growth Restricted Babies
Intrauterine growth restriction is the term used to describe a condition where an unborn baby does not reach its optimum size. In the short and long term, intrauterine growth restricted babies have a higher risk of serious…
- Trial name
- NCT01695070
- Testing
- Melatonin
- Where
- Australia
- Volunteers
- 16 people
- Sponsor
- Monash University
Fetal Growth Retardation, Induction of Labor Affected Fetus / Newborn
Mode of Induction in Fetal Growth Restriction and Its Affects on Fetal and Maternal Outcomes
to compare methods of induction of labor in fetal growth restriction and its effect on maternal and neonatal outcome
- Trial name
- NCT03625518
- Testing
- prostaglandins E2, intracervical balloon catheter combined with pitocin
- Where
- Israel
- Volunteers
- 280 people
- Sponsor
- Tel-Aviv Sourasky Medical Center
Intrauterine Growth Retardation, Prematurity
Severe Intrauterine Growth Retardation: Developmental Newborn Intensive Care Unit (NICU) Care
The purpose of the study is to learn more about the development of small for gestational age (SGA) preterm infants and whether focusing on the infant's behavior has a positive effect on outcome.
- Trial name
- NCT00914108
- Testing
- Newborn Individualized Developmental Care
- Where
- 2 sites in United States
- Volunteers
- 30 people
- Sponsor
- Boston Children's Hospital
GDM, Preterm Preeclampsia
Advancing Stillbirth Prevention Through Innovative Risk Evaluation (ASPIRE) Clinical Study
ASPIRE will be a multi-site, prospective, two-part longitudinal, noninterventional observational cohort study of nulliparous singleton pregnant women to evaluate biomarkers from blood and ocular imaging for prediction of…
- Conditions
- GDM, Preterm Preeclampsia, Preeclampsia, Fetal Growth Restriction (FGR)
- Trial name
- ASPIRE (NCT07669935)
- Testing
- None (this is an observational study with no intervention)
- Where
- 2 sites in United States
- Volunteers
- 5,500 people, healthy volunteers welcome
- Sponsor
- Medicines360
Fetal Growth Retardation
Study Aimed At Improving Height With Genotonorm In Children Born Little And/Or Light With Growth Retardation At The Age
To estimate the percentage of children with serum IGF-1 > 2 standard deviation (compared to a child of the same gender and age and without growth hormone (GH) deficiency) 9 months and 12 months after initiation of GH treatment.
- Trial name
- NCT00174252
- Testing
- Genotonorm (Somatropin)
- Where
- 22 sites in France
- Volunteers
- 57 people
- Sponsor
- Pfizer
Small for Gestational Age Infant, Fetal Growth Restriction
Developing and Testing AI Models for Fetal Biometry and Amniotic Volume Assessment in Fetal Ultrasound Scans.
Routine fetal ultrasound scan during the second trimester of the pregnancy is a low-cost, noninvasive screening modality that has been proven to lower fetal mortality by up to 20%.
- Conditions
- Small for Gestational Age Infant, Fetal Growth Restriction, Oligohydramnios, Polyhydramnios
- Trial name
- NCT05059093
- Testing
- Classification and segmentation deep learning models
- Where
- 6 sites in Morocco
- Volunteers
- 122 people, healthy volunteers welcome
- Sponsor
- Deepecho
Intrauterine Growth Restriction
IUGR; Cause and Relationship
Intrauterine growth restriction (IUGR) is a pregnancy complication in about 3-5% of all pregnancies in Sweden. IUGR fetuses are at high risk of morbidity and death.
- Trial name
- NCT05142644
- Testing
- ultrasound
- Where
- Sweden
- Volunteers
- 80,000 people
- Sponsor
- Karolinska Institutet
Growth Disorders, Malnutrition, Fetal
Evolutionary Nutrition Pilot: Enhancing Fetal Growth and Brain Development
Globally, 250 million children do not reach their developmental potential and 155 million are stunted, yet few population-based studies have examined the direct effects of nutrient deficiencies on early brain development.
- Conditions
- Growth Disorders, Malnutrition, Fetal, Stunting, Development; Delayed, Malnutrition
- Trial name
- NCT05242224
- Testing
- Evolutionary Nutrition Package
- Where
- Ecuador
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Fetal Growth Retardation
Doppler and AFV for Outcome Prediction ın FGR
The investigator contrived a prospective study of AUCR to compare its association to adverse perinatal outcomes with other established doppler parameters, such as CPR and UCR within a population of suspected FGR fetuses at term.
- Trial name
- NCT05295667
- Testing
- Doppler measurement in combination with amniotic fluid volume
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Istanbul Bakirkoy Maternity and Children Diseases Hospital
Pre-eclampsia, Oocyte Donation
PRIOR Study (Pre-eclampsia Risk In Oocyte Recipients)
The aim of this prospective observational cohort study is to investigate the pathophysiological mechanisms behind and risk of pre-eclampsia in women pregnant after fertility treatment with oocyte donation.
- Conditions
- Pre-eclampsia, Oocyte Donation, Pre-Eclampsia; Complicating Pregnancy, Pre-Eclampsia; Mild
- Trial name
- PRIOR (NCT07263490)
- Where
- 6 sites in Denmark
- Volunteers
- 462 people
- Sponsor
- Copenhagen University Hospital, Hvidovre
Intrauterine Growth Restriction
Intra Uterine Growth Restriction
Intrauterine growth restriction (IUGR) is associated with an increase in perinatal mortality and morbidity, as well as longer-term neurological, cognitive, cardiovascular and endocrine complications.
- Trial name
- IUGR (NCT03866863)
- Testing
- Intrauterine growth restriction (IUGR)
- Where
- France
- Volunteers
- 31,052 people
- Sponsor
- Hospices Civils de Lyon
Early Fetal Growth Restriction (FGR)
Characterization of Neonatal Clinical Risk Profiles in Relation to Prenatal Obstetric Characteristics in Infants With Early-FGR Secondary to Doppler Flowmetry Alterations
This study aims to characterize neonatal clinical risk profiles in relation to prenatal obstetric characteristics in infants with early fetal growth restriction (early-FGR) secondary to Doppler flowmetry alterations.
- Trial name
- NEO-FGR (NCT07466693)
- Where
- Italy
- Volunteers
- 600 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Preeclampsia, Intrauterine Growth Restriction
Fetal, Obstetrics and Reproduction Genomics
The purpose of this study is to determine the impact of a clinical screening strategy and genomic analysis of the factors involved in Placental Dysfunction (Preeclampsia and IUGR) in women of advanced maternal age undergoing…
- Conditions
- Preeclampsia, Intrauterine Growth Restriction, Placental Disease
- Trial name
- FORgenomics (NCT05720169)
- Testing
- Doppler ultrasound, Blood sample
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Fundación Ginemed
Fetal Growth Restriction (FGR), Placental Insufficiency
Placental Imaging Techniques
The goal of this proof-of-concept, case-control, clinical trial is to evaluate the efficacy of using two newer ultrasound technologies, quantitative ultrasound (QUS) and ultrafast power Doppler imaging (uPDI), to evaluate the…
- Conditions
- Fetal Growth Restriction (FGR), Placental Insufficiency, Preeclampsia, Still Births
- Trial name
- NCT06861309
- Testing
- ultrafast power Doppler imaging (uPDI) / quantitative ultrasound (QUS)
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Carilion Clinic
Healthy
Fetal Aortic Pulsewave Velocity: A Novel Doppler Ultrasound Method of Measuring the Biophysical Properties of the Fetal Aorta
We are interested in determining if we can measure the blood flow in the descending aorta (large blood vessel in the abdomen) of healthy fetuses and fetuses with growth restriction. An increasing number of adult diseases (e.g.
- Trial name
- NCT00359034
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of British Columbia
Fetal Growth Restriction, USCOM
USCOM in Newly Diagnosed FGR Cases
The purpose of this research study is to study the use of an ultrasound measurement system (USCOM) for patients with newly diagnosed fetal growth restriction (FGR).
- Trial name
- USCOM FGR (NCT06343051)
- Testing
- USCOM
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Preeclampsia
LMWH to Prevent Preeclampsia and Fetal Growth Restriction
The objective of this trial will be to determine whether prophylactic low-molecular weight heparin therapy in pregnant women with the heterozygous Factor V Leiden and G20210A prothrombin gene mutations thrombophilia and a history…
- Trial name
- NCT00260520
- Testing
- Dalteparin
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Florence
Fetal Growth Retardation
Can Low Molecular Weight Heparin During Pregnancy With Intrauterine Growth Restriction Increase Birth Weight?
The purpose of the study is to investigate if treatment with an anticoagulant drug increases birth weight in pregnancies complicated by fetal growth restriction.
- Trial name
- IUGR (NCT01390051)
- Testing
- Innohep (Tinzaparin), tinzaparin
- Where
- 3 sites in Denmark
- Volunteers
- 50 people
- Sponsor
- University of Aarhus
Metabolic Disease, Neurological and Mental Health Conditions
Singapore PREconception Study of Long-Term Maternal and Child Outcomes
We aim to test the following primary hypothesis that nutrition, lifestyle, and maternal emotional health prior to pregnancy and/or during the first trimester alter the expression of metabolic or neurodevelopmental endophenotypes…
- Conditions
- Metabolic Disease, Neurological and Mental Health Conditions, Genetics Predisposition, Skin Condition
- Trial name
- S-PRESTO (NCT03531658)
- Where
- Singapore
- Volunteers
- 1,054 people, healthy volunteers welcome
- Sponsor
- KK Women's and Children's Hospital