Clinical trials: Fetal Outcomes
Anxiety, Pregnancy Related
MoodUP in Improving Psychological Outcomes Among Perinatal Women
Dramatic physiological, psychological, and social changes during the antenatal period may significantly affect a woman's psychosocial and physical conditions, thereby resulting in stress, anxiety, and depressive symptoms.
- Conditions
- Anxiety, Pregnancy Related, Perinatal Depression, Prenatal Stress
- Trial name
- NCT03970057
- Testing
- Internet-based Cognitive Behavioural Therapy, Usual Care
- Where
- Singapore
- Volunteers
- 368 people, healthy volunteers welcome
- Sponsor
- National University of Singapore
Labor Pain, Nutrient Intake
The Effect of Nutrition and Fluid Intake in the First Stage of Labor
Birth is a process that requires large amounts of energy. As a result of skeletal and smooth muscle contractions at birth, the body's basal metabolic rate, energy requirement, hydration requirement, and insensible fluid loss are…
- Conditions
- Labor Pain, Nutrient Intake, Fluid Therapy
- Trial name
- NCT06547177
- Testing
- fruit juice
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Hilal Yuvacı
Pregnancy, Pregnancy Complications
AI-POCUS for Maternal and Neonatal Health in Ethiopia
Maternal and neonatal health remains one of the most pressing global health challenges, particularly in low- and middle-income countries (LMICs).
- Conditions
- Pregnancy, Pregnancy Complications, Preterm Birth, Fetal Growth Restriction
- Trial name
- AIM-ETH (NCT07171086)
- Testing
- AI-POCUS (BabyChecker, Delft Imaging), AI-POCUS (Edan, China)
- Where
- Ethiopia
- Volunteers
- 1,059 people, healthy volunteers welcome
- Sponsor
- Tsinghua University
Maternal Death, Neonatal Death
Integrated Community Engagement and Audit Systems
The goal of this implementation research project is to determine the feasibility of establishing and implementing an acceptable and robust audit system with community representation at secondary health facilities to improve…
- Conditions
- Maternal Death, Neonatal Death, Stillbirth
- Trial name
- NCT05640050
- Testing
- Audit Implementation
- Where
- Pakistan
- Volunteers
- 1,000 people
- Sponsor
- Aga Khan University
High-risk Pregnancy, Pregnancy
AI-Powered CURAᵀᴹ Application for Identifying At-Risk Pregnancies in Obstetric Management
It is important to identify high pregnancies early through screening so that appropriate care and intervention may be instituted.
- Conditions
- High-risk Pregnancy, Pregnancy, Antenatal Health
- Trial name
- CURAte (NCT06974188)
- Testing
- AI-risk Stratification
- Where
- Singapore
- Volunteers
- 1,700 people, healthy volunteers welcome
- Sponsor
- National University Hospital, Singapore
Alcohol and Tobacco/Cannabis Use
FASD Prevention R33
This R33 application proposes to adapt and test an evidence-based behavioral intervention to decrease polysubstance use (i.e., alcohol and tobacco/cannabis) during pregnancy and lactation and prevent adverse clinical outcomes…
- Trial name
- R33 (NCT07828275)
- Testing
- Intervention, Usual Care
- Where
- South Africa
- Volunteers
- 184 people
- Sponsor
- Philadelphia College of Osteopathic Medicine
Breastfeeding, Dietary Intervention
Effect of Prenatal and Postnatal Intervention Strategies on Breastfeeding Outcomes in Women With Excessive Weight (Ready, Set, Nourish Study)
This study is about preparing women with excessive weight to have better breastfeeding outcomes. By doing this study, the investigators hope to learn more about how hand expression of breast milk or colostrum during pregnancy can…
- Conditions
- Breastfeeding, Dietary Intervention, Milk Expression, Breast
- Trial name
- RSN (NCT06929091)
- Testing
- Lactation Support and ABME, Lactation Support and meal plan, Lactation Support
- Where
- United States
- Volunteers
- 240 people
- Sponsor
- Arkansas Children's Hospital Research Institute
Hypertension in Pregnancy
The Outcomes of Hypertension in Obese Versus Non-obese Pregnant Women
Hypertensive disorders of pregnancy, include pre-existing and gestational hypertension, preeclampsia, and eclampsia, it complicates up to 10% of pregnancies and represents a significant cause of maternal and perinatal morbidity…
- Trial name
- NCT05673135
- Testing
- Anti-Hypertensive, Ultrasound, Doppler ultrasound
- Where
- Egypt
- Volunteers
- 260 people
- Sponsor
- Assiut University
Developmental Delay
Improving Neurodevelopmental ouTcomes After Prenatal Cannabinoid in uTero Exposure
The INTACT trial is a multisite pilot feasibility study aimed at testing the effectiveness of the INTACT Intervention program in improving neurodevelopmental outcomes in infants prenatally exposed to cannabinoids.
- Trial name
- INTACT (NCT06423664)
- Testing
- Play and Learn Strategies (PALS) Program
- Where
- 3 sites in United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- IDeA States Pediatric Clinical Trials Network
Pregnancy
SmartMom: Teaching by Texting to Promote Health Behaviours in Pregnancy
The goal of this randomized clinical trial is to evaluate the effectiveness of SmartMom, a text messaging-based mobile health program for prenatal education.
- Trial name
- NCT05793944
- Testing
- SmartMom text messaging, Control text messaging
- Where
- Canada
- Volunteers
- 3,078 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Maternal Psychological Distress, Prenatal Stress
Roo Study on Mom and Baby Well-Being
This study employs a randomized controlled trial of an established intervention, Mindfulness Based Cognitive Therapy (MBCT) adapted for pregnancy, to examine effects on various aspects of maternal psychological stress during…
- Conditions
- Maternal Psychological Distress, Prenatal Stress, Infant Development, Functional Neuroimaging
- Trial name
- NCT03809598
- Testing
- Mindfulness Based Cognitive Therapy
- Where
- United States
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Twin Pregnancy
Twins With Specific vs. Traditional Fetal Growth Charts
This study aims to compare how well two different types of fetal growth charts work in tracking the growth of twins during pregnancy. These charts help doctors decide if a fetus is growing normally.
- Trial name
- TWiST (NCT07164001)
- Testing
- Twin-Specific Growth Chart Interpretation, Singleton-Based Growth Chart Interpretation
- Volunteers
- 150 people
- Sponsor
- Indiana University
Prenatal Stress
Measuring Outcomes of Maternal COVID-19-related Prenatal Exposure
The rapidly spreading coronavirus Covid-19 pandemic is a major concern worldwide and Italy is at the forefront of this emergency.
- Trial name
- MOM-COPE (NCT04540029)
- Testing
- Maternal stress
- Where
- Italy
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- IRCCS National Neurological Institute "C. Mondino" Foundation
Fetal Distress, Perinatal Asphyxia
Sildenafil Citrate to Improve Maternal and Neonatal Outcomes in Low-resource Settings
The PRISM pilot feasibility study consists of two phases to determine: 1) to delivery practices, rates of primary and secondary outcomes, and feasibility of enrollment rates, and 2) to assess the feasibility and acceptability of…
- Conditions
- Fetal Distress, Perinatal Asphyxia, Birth Asphyxia, Stillbirth
- Trial name
- PRISM (NCT05946681)
- Where
- Zambia
- Volunteers
- 1,017 people, healthy volunteers welcome
- Sponsor
- NICHD Global Network for Women's and Children's Health
Pregnancy, Anticoagulation
Evaluation of Maternal and Fetal Outcomes in Pregnancies in Women With Prosthetic Heart Valves
The ability to diagnose and surgically repair poorly functioning heart valves has yielded a significant population of women that are of childbearing age with mechanical/ bioprosthetic heart valves.
- Conditions
- Pregnancy, Anticoagulation, Prosthetic Heart Valves
- Trial name
- NCT00329290
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of California, Irvine
Labor, Premature, Preterm Premature Rupture of the Membranes
N-acetylcysteine in Intra-amniotic Infection/Inflammation
The aim of the study is to determine if N-acetylcysteine (a potent free radical scavenger) prevents the occurrence of adverse neonatal outcomes in preterm deliveries complicated by infection associated with preterm labor or…
- Conditions
- Labor, Premature, Preterm Premature Rupture of the Membranes, Infection, Inflammation
- Trial name
- NCT00397735
- Testing
- amniocentesis
- Where
- 2 sites in United States
- Volunteers
- 68 people
- Sponsor
- Ohio State University
Fetal Clavicle Length, Fetal Scapular Width
Ultrasound Assessment of Fetal Growth Parameters
The goal of this observational study is to establish reference value ranges for normal fetal biometric parameters at different gestational weeks for the domestic population, and evaluate their clinical application to predict…
- Conditions
- Fetal Clavicle Length, Fetal Scapular Width, Fetal Sternal Length, Fetal Scapular Length
- Trial name
- NCT07018362
- Testing
- restricted fetal growth
- Where
- China
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- The First Affiliated Hospital of Xiamen University
Pregnancy Diabetic
Predictive Value of Fetal Modified Myocardial Performance Index for Adverse Perinatal Outcomes in Late Onset Preeclampsia and Diabetes Mellitus
High-Risk Pregnancies complicated by gestational diabetes mellitus (GDM) and preeclampsia (PE) represent a significant global health challenge, affecting approximately 15-20% of all pregnancies.
- Trial name
- NCT07811050
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- Assiut University
Heart Failure With Preserved Ejection Fraction (HFPEF)
Association of Heterogeneous Circulating Biomarkers and Anamnestic Factors of Pregnancy Adverse Course and Outcomes With the Prognosis of Heart Failure With Preserved Ejection Fraction
The primary purpose of this study is to evaluate possible association of some heterogeneous circulating biomarkers and anamnestic factors of pregnancy adverse course and outcomes with the prognosis of heart failure with preserved…
- Trial name
- CARPO-HF (NCT06803849)
- Where
- Russia
- Volunteers
- 100 people
- Sponsor
- National Medical Research Center for Therapy and Preventive Medicine
Premature Birth
Group Antenatal Care: Effectiveness and Contextual Factors Linked to Implementation Success in Malawi
In this study, we test the effectiveness of an evidence-based model of group antenatal care by comparing it to individual (usual) antenatal care (Aim 1) across 7 antenatal clinics in Blantyre District, Malawi.
- Trial name
- NCT03673709
- Testing
- Antenatal Care
- Where
- 7 sites in Malawi
- Volunteers
- 1,887 people, healthy volunteers welcome
- Sponsor
- University of Illinois Chicago