Clinical trials: Fibrinolysis
Hyperfibrinolysis
Evaluation of the Minimum Concentration of Tranexamic Acid Required to Inhibit Fibrinolysis in a Population of Pregnant Women at Term.
Pregnancy induces a physiological change of hemostasis to a prothrombotic state : protein S decrease and increase of virtually all the clotting factors, in particular fibrinogen, von Willebrand factor and factor VIII.
- Trial name
- NCT02579941
- Testing
- Blood sampling (pregnant), Blood sampling (non pregnant)
- Where
- Belgium
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Brugmann University Hospital
Subarachnoid Hemorrhage, Aneurysmal, Vasospasm, Cerebral
Brain Aneurysms: Utility of Cisternal Urokinase Irrigation
Despite the efforts made in its treatment, aneurysmal subarachnoid haemorrhage continues to induce high mortality and morbidity rates. Today there are treatment protocols in all hospitals.
- Conditions
- Subarachnoid Hemorrhage, Aneurysmal, Vasospasm, Cerebral, Hydrocephalus
- Trial name
- BA&UK (NCT04792944)
- Testing
- Urokinase, Endovascular treatment, Clipping
- Where
- Spain
- Volunteers
- 247 people
- Sponsor
- University of Valencia
ST Elevation Myocardial Infarction
Study of Efficacy and Safety of GNR-060 vs Metalyse in Patients With ST Elevation Myocardial Infarction
GNR-060(JSC "GENERIUM", Russia) is a proposed biosimilar to the referent product Metalyse. This study is to compare the clinical efficacy and safety of GNR-060 vs Metalyse as a thrombolitic agent in patients with with ST…
- Trial name
- NCT05601999
- Testing
- GNR-060, Metalyse
- Where
- 11 sites in Russia
- Volunteers
- 244 people
- Sponsor
- AO GENERIUM
Ischaemic Heart Diseases
The Effect of Ischaemic-reperfusion on the Endogenous Fibrinolysis in Man
Heart attacks are usually caused by a blood clot blocking an artery supplying blood to the heart. Current treatments are designed at relieving this blockage as quickly as possible to minimise damage to the heart muscle.
- Trial name
- NCT00789451
- Testing
- Forearm vascular study
- Where
- United Kingdom
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Edinburgh
Myocardial Infarction
Randomized Multicenter Trial of Prehospital Initiated Facilitated Percutaneous Coronary Intervention (PCI) Versus Primary PCI in ST-segment-Elevation MI (STEMI)
Prehospital initiated facilitation of primary percutaneous coronary intervention by fibrinolysis might be helpful in re-opening the infarct related artery prior to percutaneous coronary intervention.
- Trial name
- LIPSIA STEMI (NCT00359918)
- Testing
- fibrinolysis, Primary PCI
- Where
- Germany
- Volunteers
- 162 people
- Sponsor
- Holger Thiele
Covid19, Interstitial Pneumonia
Identification of Predictors for the Evolution of COVID-19 Related Pneumonia by Transcriptomic and Seroproteomic
The investigating group aims at performing an observational, prospective study that involves the evaluation of circulating biomarkers predictive of clinical evolution in patients suffering from COVID-19 disease.
- Trial name
- COVID_OMICS (NCT04441502)
- Where
- Italy
- Volunteers
- 204 people, healthy volunteers welcome
- Sponsor
- IRCCS Policlinico S. Donato
Thrombosis
Study Investigation Pharmacokinetics and Pharmacodynamics of CS1
SAD study: Eighteen subjects will be included in the SAD study (single dose) in 3 parallel arms, each with 6 subjects. The 3 arms will receive a single dose of one of the CS1 formulations I, II or III.
- Trial name
- NCT03903302
- Testing
- CS1-Sodium Valproate
- Where
- Sweden
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Cereno Scientific AB
Cirrhosis
Correlation of Hepatitis C, Alcoholic Liver Disease, and Renal Failure With Hyperfibrinolysis in Liver Failure
1. Further characterize the incidence of hyperfibrinolysis in cirrhotics 2. Correlate hyperfibrinolysis with 1. hepatitis C 2. alcoholic liver disease 3. the subset of a\&b with renal failure with and without dialysis 3.
- Trial name
- NCT02737345
- Testing
- Rotem
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- Scott Allen
Pathologic Fibrinolysis
Fibrinolysis Before Cardiopulmonary Bypass?
It is common practice to use antifibrinolytic agents before and during cardiopulmonary bypass. They are not without side effects.
- Trial name
- NCT01981863
- Testing
- Epsilonaminocaproic acid
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Stanford University
Myocardial Infarction, Intracoronary Thrombus
Intracoronary Thrombus Assessed by OFDI After Successful Fibrinolysis And Its Impact On Myocardial Reperfusion
The pharmacoinvasive approach after thrombolysis is the standard treatment of myocardial infarction when deadlines are too long for primary angioplasty.
- Trial name
- AODIS (NCT02850315)
- Testing
- optimal coherence tomography
- Where
- France
- Volunteers
- 29 people
- Sponsor
- University Hospital, Caen
Fibrin Blood Clot, Pregnancy
Pregnancy and Fibrin Clot Properties
1. The structure of fibrin clot and thrombin generation may vary between trimesters of pregnancy. 2. Unfavorably altered fibrin clot properties along with enhanced thrombin generation may lead to the development of complications…
- Conditions
- Fibrin Blood Clot, Pregnancy, Pregnancy Complicated by Cardiovascular Disorders as Postpartum Condition, Delivered During Previous Episode
- Trial name
- NCT07275476
- Testing
- analysis of fibrin clot properties and thrombin generation
- Where
- Poland
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Jagiellonian University
Aortic Disease
Dosing of Amicar and Measure of Fibrinolysis by TEG During Cardiac Surgery
This study hopes to determine the optimal antifibrinolytic dosing to decrease bleeding and blood transfusion after cardiac surgery without increasing adverse events
- Trial name
- EACA (NCT01965730)
- Testing
- epsilon-aminocaproic acid (EACA)
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- University of Pennsylvania
Abdominal Abscess, Tissue Plasminogen Activator
Treatment of Abdominal Abscesses With or Without Fibrinolysis
The objective of this study is to evaluate the utility of fibrinolysis when draining an abdominal abscess as defined by length of stay after drainage.
- Trial name
- NCT01597336
- Testing
- Tissue plasminogen activator abscess flush, Saline flush of abscess
- Where
- United States
- Volunteers
- 92 people
- Sponsor
- Children's Mercy Hospital Kansas City
Coronary Artery Disease
Effects Contrast on Platelet Activity, Thrombosis and Fibrinolysis in Patients Undergoing Coronary Angiography
The aim of this study is to determine how two different types of iodinated contrast media (CM) agents, low-osmolar ionic ioxaglate and iso-osmolar non-ionic iodixanol, affect specific markers of thrombogenesis and platelet…
- Trial name
- NCT01848899
- Testing
- Iodixanol, Ioxaglate, Bivalirudin
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- NYU Langone Health
Heart Diseases, Vascular Diseases
Goal-directed vs. Empirical Tranexamic Acid Administrationin Cardiovascular Surgery
The present study is a multi-center randomized prospective placebo-controlled non-inferiority trial. The study's primary objective is to compare the amounts of postoperative bleeding using two different TXA administration…
- Conditions
- Heart Diseases, Vascular Diseases, Transfusion Related Complication, Coagulation Disorder, Blood
- Trial name
- NCT05806346
- Testing
- TXA administration
- Where
- 3 sites in South Korea
- Volunteers
- 764 people
- Sponsor
- Konkuk University Medical Center
Acute Pulmonary Embolism, Fibrinolytic Deficit
Fibrinolytic Deficit in Patients With Acute PE
Fibrinolysis is the body's process that prevents blood clots. The investigators hypothesize that patients presenting with acute pulmonary embolism (PE) or blood clots in the lungs differ in their fibrinolytic deficit phenotype.
- Trial name
- NCT04480892
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Loyola University
Prehypertension, Hypertension
Nebivolol and Endothelial Regulation of Fibrinolysis (NERF)
The investigators hypothesize that nebivolol will improve endothelial t-PA release in adult humans with elevated blood pressure to a greater extent than either metoprolol or placebo.
- Trial name
- NCT01595516
- Testing
- Nebivolol, Metoprolol, Bradykinin
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Boulder
ST-segment Elevation Myocardial Infarction (STEMI)
Bivalirudin with Prolonged Infusion During PCI Versus Heparin After Fibrinolytic Therapy
This multicenter, randomized controlled trial in China aims to enroll 2,400 patients with ST-segment elevation myocardial infarction undergoing percutaneous coronary intervention (PCI) within 24 hours post-fibrinolysis.
- Trial name
- BRIGHT-FIT (NCT06861374)
- Testing
- Bivalirudin, Unfractionated heparin
- Volunteers
- 2,400 people
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University
Retinal Artery Occlusion, Central Retinal Artery Occlusion
The GEIR (Grupo español de Ictus Retina) Registry: Rationale and Design of the First Nationwide Multicentre Retinal Stroke Registry in Spain
Retinal stroke is a time-dependent neurovascular emergency associated with severe visual loss, increased risk of cerebrovascular events and substantial variability in clinical management.
- Conditions
- Retinal Artery Occlusion, Central Retinal Artery Occlusion, Retinal Ischemia, Cilioretinal Arteries
- Trial name
- GEIR (NCT07900230)
- Volunteers
- 500 people
- Sponsor
- Germans Trias i Pujol Hospital
Ischaemic Heart Diseases
The Effect of Ischaemic-Reperfusion and Ischaemic Preconditioning on the Endogenous Fibrinolysis in Man
Heart attacks are usually caused by a blood clot blocking an artery supplying blood to the heart. Current treatments are designed at relieving this blockage as quickly as possible to minimise damage to the heart muscle.
- Trial name
- NCT00789243
- Testing
- Forearm vascular study
- Where
- United Kingdom
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Edinburgh