Clinical trials: Fibrosis; Skin
Keloid, Stem Cell
The Effect of Intralesian Injection of Umbilical Cord Mesenchymal Stem Cells, Its Conditioned Medium, and Triamcinolone Acetonide on Type 1:3 Collagen Ratio and Interleukin-10 Levels in Keloid: A Randomised Controlled Trial
The objective of this study is to observe the potency of umbilical cord-derived mesenchymal stem cells (UC-MSC) and umbilical cord-derived conditioned medium (UC-CM), or triamcinolone acetonide (TA) in keloid therapy, measured by…
- Trial name
- NCT05939817
- Testing
- umbilical cord-derived mesenchymal stem cells (UC-MSC), umbilical cord-derived mesenchymal stem cells conditioned medium (UC-CM), Triamcinolone Acetonide (TA)
- Where
- Indonesia
- Volunteers
- 24 people
- Sponsor
- Rumah Sakit Pusat Angkatan Darat Gatot Soebroto
Pulmonary Fibrosis
Pilot Study of Pirfenidone in Pulmonary Fibrosis With Anti-myeloperoxydase Antibodies
The purpose of this study is to determine wether pirfenidone is safe and effective in the treatment of pulmonary fibrosis with anti-myeloperoxydase (MPO) antibodies or pulmonary fibrosis with anti-MPO associated vasculitis.
- Trial name
- PIRFENIVAS (NCT03385668)
- Testing
- Pirfenidone
- Where
- France
- Volunteers
- 7 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Keloid
Trial of Juvista (Avotermin) Following Removal of Ear Lobe Keloid Scars
This trial will assess the safety and efficacy of 50 and 200ng Juvista per linear cm of wound margin administered by intradermal injection following the excision of keloid scars on the ear lobe.
- Trial name
- NCT00469235
- Testing
- Avotermin
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Renovo
Chronic Pain, Fungal Infection
Study to Evaluate Outcomes of Patients Receiving Treatment for Wound Care, Pain Management or Surface Skin Scar Therapy
This observational study is designed to evaluate the reported outcomes for patients receiving topical therapy for the treatment of pain, fungal infections or skin scars.
- Trial name
- SOPWS (NCT02445235)
- Testing
- Patient Reported Outcome Survey Tool
- Where
- 3 sites in United States
- Volunteers
- 88 people
- Sponsor
- Bracane Company
Interstitial Lung Disease, Scleroderma
Rituximab Versus Cyclophosphamide in Connective Tissue Disease-ILD
Interstitial lung disease (ILD) is characterised by inflammation and scarring of the lung and is the leading cause of death in patients with systemic sclerosis, and contributes significantly to morbidity and mortality in many…
- Conditions
- Interstitial Lung Disease, Scleroderma, Idiopathic Inflammatory Myositis, Mixed Connective Tissue Disease
- Trial name
- RECITAL (NCT01862926)
- Testing
- Rituximab, Cyclophosphamide
- Where
- United Kingdom
- Volunteers
- 104 people
- Sponsor
- Royal Brompton & Harefield NHS Foundation Trust
Hypertrophic Scarring, Pain, Postoperative
Topical Heparin for Prevention of Hypertrophic Scarring in Split-Thickness Skin Graft Donor Sites
This study is testing whether applying a special dressing soaked with heparin (a medicine that improves blood flow and reduces scar formation) can help prevent thick, raised scars (called hypertrophic scars) and reduce pain at…
- Conditions
- Hypertrophic Scarring, Pain, Postoperative, Wound Healing
- Trial name
- HepScar (NCT07196358)
- Testing
- Standard dressing, Topical Heparin Dressing
- Where
- Pakistan
- Volunteers
- 400 people
- Sponsor
- Dr. Ruth K.M. Pfau Civil Hospital, Karachi
Hypertrophic Scars
Using Skin Blood Flow to Measure the Effect of Different Doses of Negative Pressure Therapy
Introduction. Skin blood flow (SBF) is crucial for transporting nutrients during healing to treat scarring. Negative pressure therapy (NPT) is a promising option to enhance SBF.
- Trial name
- Negative press (NCT06690749)
- Testing
- Negative pressure therapy, NPT
- Where
- Taiwan
- Volunteers
- 36 people
- Sponsor
- Asia University
Wrinkle, Rosacea
Evaluation of Cutera Excel V™ Laser With Green Genesis and Micro-Lens Array (MLA)Attachment
Evaluate the Cutera excel V™ Laser with Green Genesis and a Micro-Lens Array (MLA) Attachment
- Conditions
- Wrinkle, Rosacea, Scarring
- Trial name
- NCT03424304
- Testing
- Excel V™ Laser With Green Genesis
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Cutera Inc.
Systemic Sclerosis Pulmonary, Pulmonary Hypertension
Infusion of Allogeneic Mesenchymal Stem Cells in Patients With Diffuse Cutaneous Systemic Sclerosis With Refractory Pulmonary Involvement
Progressive SSc is an entity with limited therapeutic alternatives and with asurvival rate of less than 45% in the first 3 to 5 years.
- Conditions
- Systemic Sclerosis Pulmonary, Pulmonary Hypertension, Pulmonary Fibrosis
- Trial name
- NCT04432545
- Testing
- Mesenchymal Stem Cells from Wharton ́s jellyintravenous infusion of Mesenchymal Stem Cells from Wharton ́s jelly
- Where
- Colombia
- Sponsor
- Universidad de la Sabana
Scar, Surgical Wound
Correlation of Early Postoperative Scar Appearance With Long-term Scar Outcomes
A retrospective cohort study of early and late period postoperative scars using previously validated survey measures and clinical photographs.
- Conditions
- Scar, Surgical Wound, Quality of Life, Mohs Micrographic Surgery
- Trial name
- NCT04015453
- Testing
- Mohs micrographic surgery
- Volunteers
- 113 people, healthy volunteers welcome
- Sponsor
- Abramson Cancer Center at Penn Medicine
Keloid
Fractional Laser Assisted Steroid Therapy vs Intralesional Steroids in the Treatment of Keloids
The purpose of this study is to compare the effects of fractional carbon dioxide (CO2) laser therapy immediately followed by intralesional steroid therapy against intralesional steroid therapy alone for the treatment of keloids.
- Trial name
- NCT02996097
- Testing
- The Lutronic electronic carbon dioxide (eCO2) Plus laser system, Intralesional Triamcinolone Acetonide
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Johns Hopkins University
Keloid
Study of Psycho-Social Impact of Keloid
Despite their benign nature, keloids may constitute a severe aesthetic, and in some cases, functional problem which translates to various repercussions on person's quality of life, including much stress and insecurities.
- Trial name
- NCT01478243
- Where
- United States
- Volunteers
- 1,000 people
- Sponsor
- Tirgan, Michael H., M.D.
Acne Vulgaris, Scar
Acne Scarring in Skin of Color: Laser vs Microneedling
Atrophic acne scars are a common and important sequelae of acne that affect up to 43-55% of patients with acne. Scarring impacts quality of life with reports of diminished self-esteem and frustration/sadness; additionally, some…
- Trial name
- NCT03395678
- Testing
- Microneedling, Fractional non-ablative 1,540nm laser
- Where
- United States
- Sponsor
- Boston University
Asthma, Atrial Fibrillation
The Living With a Long-Term Condition Study
Psychological distress (anxiety and depression) is common in and experienced differently by people living with long-term health conditions (LTCs).
- Conditions
- Asthma, Atrial Fibrillation, Cancer, Cerebrovascular Disorders
- Trial name
- LTC (NCT06072287)
- Testing
- Living with LTC Questionnaire
- Where
- United Kingdom
- Volunteers
- 600 people
- Sponsor
- King's College London
Keloid
Analyse of Diagnosis Value of Keloid on 68Ga-RGD PET-CT
Keloids are often described as benign dermal fibroproliferative lesions characterized by increased growth beyond the boundaries of the original wound margin.Fibroblasts are considered to be the key cellular mediators of…
- Trial name
- NCT07660406
- Testing
- 68Ga-RGD
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Peking Union Medical College Hospital
Knee Replacement Arthroplasty, Fibrosis
Knee Stiffness in Fibrosis Diathesis
At the standard follow-up moment one year after primary TKA for gonarthrosis, all patients will be checked for signs of fibrosis diathesis.
- Conditions
- Knee Replacement Arthroplasty, Fibrosis, Dupuytren's Disease
- Trial name
- NCT02294890
- Testing
- Total knee arthroplasty
- Volunteers
- 60 people
- Sponsor
- University Hospital Pellenberg
Breast Cancer, Benign Breast Disease
Johns Hopkins Breast Cancer Program Longitudinal Repository
The Breast Cancer Program Longitudinal Repository (BCPLR) is being established to fulfill the research mission of the Breast Cancer Program at Johns Hopkins and to serve investigators affiliated with it - to develop a repository…
- Trial name
- NCT01937039
- Testing
- Sample collection
- Where
- United States
- Volunteers
- 810 people, healthy volunteers welcome
- Sponsor
- Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Breast Carcinoma
Trial Comparing Prone and Supine Intensity-modulated Radiotherapy (IMRT) After Breast-conserving Surgery in Patients With Large Breast Volume at High Risk for Skin Toxicity and Fibrosis
84 patients with a cup size C or more will be randomized to receive intensity-modulated radiotherapy in supine or prone position.
- Trial name
- NCT00887523
- Testing
- radiation in prone position, radiation in supine position
- Where
- Belgium
- Volunteers
- 100 people
- Sponsor
- University Hospital, Ghent
Scleroderma
MRI Quantification of Pulmonary Fibrosis in Scleroderma Patients
Assessment of pulmonary fibrosis is currently based on high-resolution CT (HRCT) and pulmonary function tests (PFT) such as forced vital capacity, (FVC) and carbon monoxide diffusion (DLCO).
- Trial name
- IRMSCLERO (NCT03207997)
- Testing
- unenhanced MR sequences
- Where
- France
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Intellectual Disability, Rubinstein-Taybi Syndrome
Functional Tests to Resolve Unsolved Rare Diseases. Rares.
Rares diseases are a heterogeneous group of conditions which need important tools for diagnosis. The use of high-throughput sequencing is able to diagnose half of the patients.
- Conditions
- Intellectual Disability, Rubinstein-Taybi Syndrome, Cystic Fibrosis, Congenital Heart Defect
- Trial name
- RID (NCT05696912)
- Testing
- Ex-vivo approach concerning 25 patients, In-vitro approach concerning 25 patients
- Where
- France
- Volunteers
- 50 people
- Sponsor
- University Hospital, Bordeaux